HNF4α inhibits the malignancy of intrahepatic cholangiocarcinoma by suppressing the Wnt signaling pathway by Bo-Nan Xu, Cheng-Hong Ding, Yi-Long Liu, Yuan-Yuan Luo, Juan Deng, Shu-Qing Liu, Meng-Chao Xiao, Nan Jiang, Xin Zhang, Wen-Ping Xu, Wei-Fen Xie

“…Upregulation of HNF4α inhibited proliferation, migration, invasion and colony-formation ability, increased the expression of hepatocyte functional genes in ICC cells in vitro, and suppressed the growth of subcutaneous tumors in vivo. …”
Get full text

Quantifying Streambed Grain Size, Uncertainty, and Hydrobiogeochemical Parameters Using Machine Learning Model YOLO by Yunxiang Chen, Jie Bao, Rongyao Chen, Bing Li, Yuan Yang, Lupita Renteria, Dillman Delgado, Brieanne Forbes, Amy E. Goldman, Manasi Simhan, Morgan E. Barnes, Maggi Laan, Sophia McKever, Z. Jason Hou, Xingyuan Chen, Timothy Scheibe, James Stegen

“…Abstract Streambed grain sizes control river hydro‐biogeochemical (HBGC) processes and functions. However, measuring their quantities, distributions, and uncertainties is challenging due to the diversity and heterogeneity of natural streams. …”
Get full text

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…This article describes a conceptual framework for testing different radiation therapy regimens as separate models of how radiation itself functions as an immunomodulatory ‘drug’ to provide alternatives to the widely adopted ‘one-size-fits-all’ strategy of frequently used 8 Gy×3 regimens immunomodulation.…”
Get full text

Photothermal Bacterial Clearance Using Gold Nanoshells Grown on Chitosan Nanoparticles Dielectric Templates by Patricia Dolores Martinez-Flores, Marisol Gastelum-Cabrera, Manuel G. Ballesteros-Monrreal, Pablo Mendez-Pfeiffer, Marco Antonio Lopez-Mata, Gerardo García-González, Gerardo Erbey Rodea-Montealegre, Josué Juárez

“…<b>Conclusions</b>: TCNP@Au demonstrated favorable photothermal properties, presenting a novel nanoplatform for antibacterial applications, particularly against Gram-negative bacteria. …”
Get full text

Duodenal Adenocarcinoma Is Characterized by Acidity, High Infiltration of Macrophage, and Activated Linc01559–GRSF1 Axis by Xinxin Huang, Ying Shi, Zekun Liu, Yihang Wu, Xiaotong Luo, Dongwen Chen, Zhengyu Wei, Chong Chen, Huaiqiang Ju, Xiaojian Wu, Xuanhui Liu, Zhanhong Chen, Peishan Hu

“…<b>Results</b>: The present study revealed that DA exhibits a significantly upregulated expression of acidic environment markers and a high degree of macrophage infiltration. …”
Get full text

On-Demand Gait-Synchronous Electrical Cueing in Parkinson&#x0027;s Disease Using Machine Learning and Edge Computing: A Pilot Study by Ardit Dvorani, Constantin Wiesener, Christina Salchow-Hommen, Magdalena Jochner, Lotta Spieker, Matej Skrobot, Hanno Voigt, Andrea Kuhn, Nikolaus Wenger, Thomas Schauer

“…We demonstrate the system&#x0027;s functionality and safety during on-demand gait-synchronous electrical cueing in two patients, performing freezing of gait assessments. …”
Get full text

The Transcription Factor BrNAC19 Acts as a Positive Regulator of the Heat Stress Response in Chinese Cabbage by Shuai Yuan, Xiaoping Yong, Yuxin Lu, Yuxin Lei, Weijian Li, Qiuli Shi, Xiuhong Yao

“…NAC (NAM, ATAF1/2, and CUC2) transcription factors (TFs) play key regulatory roles in the abiotic stress responses of plants. However, the functional roles of NAC TFs in the heat stress response of Chinese cabbage remain elusive. …”
Get full text

Non-feature-specific elevated responses and feature-specific backward replay in human brain induced by visual sequence exposure by Tao He, Xizi Gong, Qian Wang, Xinyi Zhu, Yunzhe Liu, Fang Fang

“…To address these questions, participants were exposed to a predefined sequence of four motion directions for about 30 min, followed by the presentation of the start or end motion direction of the sequence as a cue. …”
Get full text

Phosphite inhibits Phytophthora cinnamomi by downregulating oxidoreductases and disrupting energy metabolism by S. Ashok Prabhu, S. Ashok Prabhu, Previn Naicker, Tuan A. Duong, Ireshyn Selvan Govender, Juanita Engelbrecht, Juanita Engelbrecht, Robert Backer, Robert Backer, Stoyan Hristov Stoychev, Noëlani van den Berg, Noëlani van den Berg

“…This research furthers our limited understanding of the direct in vitro effects of phosphite on P. cinnamomi and has identified potential candidates for molecular functional investigation.…”
Get full text

Concurrent Validity of Wearable Nanocomposite Strain Sensor With Two-Dimensional Goniometer and Its Reliability for Monitoring Knee Active Range of Motion in Multiple Participants by Han-Byeol Choi, Yongjun Kim, Ji Young Lim, Seonghee Kim, Sang Yul Yang, Kihyeon Kim, Hyouk Ryeol Choi, Seunghyun Baik, Ji Hye Hwang

“…The range of motion (ROM) of joints in the human body is essential for movement and functional performance. Real-time monitoring of joint angles is crucial for confirming pathologic biomechanics, providing feedback during rehabilitation, and evaluating the treatment efficacy. …”
Get full text

Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model by Alexander A. Oliver, Alexander A. Oliver, Alexander A. Oliver, Cem Bilgin, Jonathan Cortese, Jonathan Cortese, Esref A. Bayraktar, Daying Dai, Yong Hong Ding, Kent D. Carlson, Adam J. Griebel, Jeremy E. Schaffer, Mitchell L. Connon, Dan Dragomir-Daescu, Dan Dragomir-Daescu, Ramanathan Kadirvel, Roger J. Guillory, David F. Kallmes, David F. Kallmes

“…We previously prototyped BRFDs using an iron-manganese-nitrogen (FeMnN) alloy and demonstrated their flow diversion functionality, radial strength, bioresorbability, and MRI compatibility in benchtop tests. …”
Get full text

Biotransformation of tobacco-derived Z-abienol into precursors of ambrox by newly identified Acinetobacter tjernbergiae LSC-2 by Gaolei Xi, Wenyuan Qi, Aamir Rasool, Aamir Rasool, Yongzhen Zhao, Qingfu Wang, Liuke Zhang, Haoyang Chen, Xinlong Zhang, Shen Huang, Zhifi Chen

“…Z-abienol is a labdane diterpene present in tobacco leaves and is a key precursor for producing valuable aroma compounds such as ambrox. …”
Get full text

Migration, Urbanism and Health: Moving Toward Systems-Informed Policy and Practice [version 2; peer review: 1 approved, 2 approved with reservations] by Karen Lau, Furio Honsell, Sally Hargreaves, Rita Sà Machado, Palmira Immordino, Cathy Zimmerman, Anna Ziersch, Yang Xiao, Irene Torres, Stefania Pascut

“…Despite these challenges, migration remains crucial to the functioning of urban environments. Migrant workers consistently contribute to the healthy operation of cities, underpinning key infrastructure and services. …”
Get full text

Exploration of metastasis-related signatures in osteosarcoma based on tumor microenvironment by integrated bioinformatic analysis by Shiyao Liao, Xing Gao, Kai Zhou, Yao Kang, Lichen Ji, Xugang Zhong, Jun Lv

“…DEGs with similar biological functions were grouped into the same module by Gene Ontology (GO) analysis and MCODE analysis. …”
Get full text

The Bacterial and Viral Communities Associated with Onion Bacterial Bulb Rot by Christopher Liakos, Verushka Ibanez, Pedro H. Lebre, Mike L. Derie, Jacquie van der Waals, Lindsey du Toit, Bhabesh Dutta, Brian Kvitko, Don A. Cowan, Teresa A. Coutinho

“…The aim of this study was to identify bacteria and viruses present in storage onion bulbs that were symptomatic and asymptomatic for bacterial bulb rot from crops grown in Georgia and Washington states, and to assess their potential role in the bulbs based on the functions of bacterial and viral genes detected. …”
Get full text

APOLLO-Live: A multi-criteria-based webtool for synchronous group decision making and consensus support in energy and climate policy deliberations [version 3; peer review: 1 approv... by Anastasios Soursos, Konstantinos Koasidis, Álvaro Labella, Georgios Xexakis, Alexandros Nikas, Anastasios Karamaneas

“…We highlight the functionalities of the webtool, including how it can be used to advance stakeholder dialogues, in two pilot use cases targeting the preferences of the youth in terms of (a) actions to advance climate action and (b) investments to be prioritised. …”
Get full text

S‐Block Metal Mg‐Mediated Co─N─C as Efficient Oxygen Electrocatalyst for Durable and Temperature‐Adapted Zn–Air Batteries by Henan Wang, Xinxin Niu, Wenxian Liu, Ruilian Yin, Jiale Dai, Wei Guo, Chao Kong, Lu Ma, Xia Ding, Fangfang Wu, Wenhui Shi, Tianqi Deng, Xiehong Cao

“…Herein, an innovative s‐block metal modulation is reported to refine the electronic structure and catalytic behavior of Co─NC catalysts. Employing density functional theory (DFT) calculations, it is revealed that incorporating Mg markedly depresses the d‐band center of Co sites, thereby fine‐tuning the adsorption energy of the oxygen reduction reaction (ORR) intermediate. …”
Get full text

The golden genome annotation of Ganoderma lingzhi reveals a more complex scenario of eukaryotic gene structure and transcription activity by Lining Wang, Peiqi Shi, Zhaohua Ping, Qinghua Huang, Liqun Jiang, Nianfang Ma, Qingfu Wang, Jiang Xu, Yajie Zou, Zhihai Huang

“…A total of 5,412,158 genetic variations were identified among 13 G. lingzhi strains, and the manually corrected gene sets resulted in enhanced functional annotation of these variations. More than 60% of G. lingzhi genes were alternatively spliced. …”
Get full text

Enhancing Medium-Chain Fatty Acid Delivery Through Bigel Technology by Manuela Machado, Eduardo M. Costa, Sara Silva, Sérgio C. Sousa, Ana Maria Gomes, Manuela Pintado

“…This study presents the development and characterization of medium-chain fatty acid (MCFA)-loaded bigels, using coconut oil as the MCFA source. …”
Get full text

Mineral fertilization reduces the drought resistance of soil multifunctionality in a mountain grassland system through plant-soil interactions by Piton, Gabin, Foulquier, Arnaud, Bernard, Lionel, Bonin, Aurelie, Pommier, Thomas, Lavorel, Sandra, Geremia, Roberto, Clement, Jean Christophe

“…Increasing droughts threaten soil microbial communities and the multiple functions they control in agricultural soils. These soils are often fertilized with mineral nutrients, but it remains unclear how this fertilization may alter the capacity of soil multifunctionality (SMF) to be maintained under drought, and how plant-soil interactions shape these effects.  …”
Get full text