Case Report: Clinical impact of BRCA1 and BRIP1 vs. BRCA1 and BRCA2 germline double heterozygosity in ovarian cancer: a comparative case study by Limei Zheng, Qianyuan Zhu, Qianyuan Zhu, Fenglan Zhang, Hao Qiu, Lan Qin, Jianhua Yang, Ming Qi, Ming Qi, Ming Qi, Ming Qi

“…Future research should focus on expanding sample sizes and conducting in-depth functional analyses to further clarify the clinical implications of different GDH types, ultimately refining treatment approaches for GDH-associated OC.…”
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Inoculum of Endophytic <i>Bacillus</i> spp. Stimulates Growth of Ex Vitro Acclimatised Apple Plantlets by Jurgita Vinskienė, Inga Tamošiūnė, Elena Andriūnaitė, Dalia Gelvonauskienė, Rytis Rugienius, Muhammad Fahad Hakim, Vidmantas Stanys, Odeta Buzaitė, Danas Baniulis

“…Root zone microbiota functional diversity analysis implied that growth stimulation was not related to improved nutrient uptake but could involve a pathogen-suppressing effect. …”
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Optimized Nitrogen Foam Flooding System for Enhanced Oil Recovery: Development and Field Test in Mu146 Block Medium-High Permeability Reservoir, China by Jia-Yang Luo, Zhen-Jun Wang, Xin-Yuan Zou, Quan Xu, Bo Dong, Song-Kai Li, Zhu-Feng Wang, Jie-Rui Liu, Xian-Feng Wang, Xiao-Hu Xue

“…This study presents a tailored nitrogen foam flooding system developed for the Mu146 block’s medium-high permeability reservoir conditions. …”
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Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu... by Katharina J. Ost, Mark Arentshorst, Bruno M. Moerschbacher, Mareike E. Dirks-Hofmeister, Arthur F.J. Ram

“…To determine whether the ags and crh gene families have redundant functions, both gene families were deleted using iterative CRISPR/Cas9 mediated genome editing. …”
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The temporal onset of associations of cortical proteins with cognitive resilience vary during late life by Andrea R. Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Aron S. Buchman

“…We first used linear mixed-effects models to identify cortical proteins associated with cognitive resilience. We then used functional mixed-effects models to examine non-linear associations between proteins and cognitive resilience to identify their temporal onset. …”
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Ferro-aluminosilicate composite generated from coal gasification fine slag for the preconcentration and adsorptive removal of selected artificial sweeteners from water by Xoliswa Cingo, Azile Nqombolo, Buhle Xakalashe, Xolisa Goso, Luthando Nyaba, Odwa Mapazi, Philiswa Nosizo Nomngongo

“…This work presents the development of ferro-aluminosilicate nanocomposites derived from CGFS. …”
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FlyPhoneDB2: A computational framework for analyzing cell-cell communication in Drosophila scRNA-seq data integrating AlphaFold-multimer predictions by Mujeeb Qadiri, Ying Liu, Ah-Ram Kim, Myeonghoon Han, Eric Zhou, Austin Veal, Tzu-Chiao Lu, Hongjie Li, Yanhui Hu, Norbert Perrimon

“…However, the utility of FlyPhoneDB was limited by the relatively small number of available L-R pairs.Here, we present FlyPhoneDB2, a major upgrade featuring a significantly expanded knowledgebase that includes a greater number of L-R pairs, incorporating annotations from mammalian species and structural predictions from AlphaFold-Multimer. …”
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Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis by Jing Shi, Zhenzhen Feng, Qian Song, Aijia Wen, Tianyu Liu, Liqiao Xu, Zonghang Ye, Simin Xu, Fei Gao, Liuxiang Xiao, Jiapeng Zhu, Kalyan Das, Guoping Zhao, Jie Li, Yu Feng, Wei Lin

“…However, the molecular mechanisms underlying the transcriptional regulation that define its differential functions remain largely unclear. In the present study, we determine three cryo-EM structures of Mycobacterium tuberculosis (Mtb) PhoP-dependent transcription activation complexes (PhoP-TACs) and build one preliminary cryo-EM structure model of Mtb PhoP-dependent transcription repression complex (PhoP-TRC). …”
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Landscape of the immune infiltration and identification of molecular diagnostic markers associated with immune cells in patients with kidney transplantation by Zhangxiao Xu, Xun Sun, Xiaobo Ma, Bo Tao, Jian Wu, Yunpeng He, Yuan Zhao, Hexiang Mao, Jie Yang, Dehui Jiang, Lijun Wang, Chao Song

“…Moreover, infiltrating immune cell-related genes were identified using weighted gene co-expression network analysis (WGCNA), and enrichment analysis was conducted to observe their biological functions. Extreme Gradient Boosting (XGBoost) and Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression algorithms were used to screen hub genes. …”
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Clarification of a unique mucosal vaccination route for improved systemic and mucosal immune response in broiler by Rupa Akter, Md Abdul Masum, Subrato Biswas, Md Zahir Uddin Rubel, Sujan Kumar Sarkar, Mohammad Saiful Islam, Hossain M. Golbar, Md Emtiaj Alam, Md Abdur Rakib, Md Zahirul Isalm Khan

“…The CALT contains antigen-presenting cells (dendritic cells, macrophages, B cells, MHC II molecules, and T cells) and is equipped with blood vessels and high endothelial venules, which indicate its functional status. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Although absent in melanoma 2 (AIM2) has been linked to inflammatory disorders, autoimmune diseases, and cancers, its role in the EMT of the retinal pigment epithelium (RPE-EMT) and retinal diseases remains unclear. The present study demonstrated that AIM2 functions as a potent suppressor of RPE cell proliferation and EMT to maintain retinal homeostasis. …”
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Application of Deep Learning to the Classification of Stokes Profiles: From the Quiet Sun to Sunspots by Ryan J. Campbell, M. Mathioudakis, Carlos Quintero Noda, P. H. Keys, D. Orozco Suárez

“…Asymmetrical (symmetrical) profiles are less (more) common in GREGOR than DKIST or Hinode data, consistent with narrower response functions in the 1564.85 nm line. Single-lobed profiles are extremely rare in GREGOR data. …”
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The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust by Ashwin V. Venkataraman, Pooja Kandangwa, Roos Lemmen, Rutvi Savla, Mazda Beigi, Devon Hammond, Daniel Harwood, Justin Sauer, Latha Velayudhan, Clive Ballard, Anna-Katharine Brem, Chris Kalafatis, Dag Aarsland

“…We evaluate the acceptability of the remote consultations, lumbar puncture, saliva genotyping, and remote cognitive and functional assessments. Results We present the results of the first 68 (mean age 73, 55% female, 43% minoritised ethnicity) of 146 people who enrolled for full remote clinical, cognitive, genetic, cerebrospinal fluid and neuroimaging phenotyping. …”
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Dry cacao pulp in chocolate bars: A sustainable, nutrient-rich sweetener with enhanced sensory quality through refractance windows drying by Idania Quintero, Amandine Ceccaldi, Hugo Martínez, Margareth Santander, Jader Rodríguez, Sebastián Escobar

“…Preservation of the nutritional and functional composition of the dried cacao pulp was assessed through measurements of phenolic compounds, vitamin C, colour, and sugar content. …”
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Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress by Lauren A. Hennessy, Bhedita J. Seewoo, Liz A. Jaeschke, Leah A. Mackie, Abbey Figliomeni, Yasmin Arena-Foster, Sarah J. Etherington, Sarah A. Dunlop, Paul E. Croarkin, Jennifer Rodger

“…Behaviour was assessed using the Elevated Plus Maze and Forced Swim Test, and functional, chemical, and structural brain changes measured using magnetic resonance imaging techniques. …”
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Action observation treatment may improve daily living activities and verb recovery in Parkinson’s disease-dementia: findings from a preliminary randomized controlled trial by Lucia Paciaroni, Elena Mastrosanti, Leonardo Biscetti, Susy Paolini, Sara Mauri, Paolo Fabbietti, Giovanni Renato Riccardi, Marco Bruno Luigi Rocchi, Giuseppe Pelliccioni

“…All patients underwent assessment before and after the treatment by the following tools: Unified Parkinson’s Disease Rating Scale Part III (UPDRS-Part III), Alzheimer’s Disease Cooperative Study-Activities of Daily Living Scale (ADCS-ADL), Direct Assessment of Functional Status (DAFS) and subtest Verb Naming of Analysis of Aphasic Deficit Battery (BADA). …”
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Customized 3D-Printed Mesh, Membrane, Bone Substitute, and Dental Implant Applied to Guided Bone Regeneration in Oral Implantology: A Narrative Review by Federica Di Spirito, Francesco Giordano, Maria Pia Di Palo, Cosimo Ferraro, Luigi Cecere, Eugenio Frucci, Mario Caggiano, Roberto Lo Giudice

“…<b>Conclusions:</b> While 3D printing technology has demonstrated potential in GBR, additional human studies are needed to evaluate the short- and long-term follow-up of peri-implant bone levels and volumes following prosthetic functional loading.…”
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Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin by Marya Afrin, Marya Afrin, Md Nabiul Islam, Mirza Mienur Meher, Mirza Mienur Meher, Mir Rubayet Jahan, Kanako Nozaki, Koh-hei Masumoto, Akie Yanai, Koh Shinoda, Koh Shinoda

“…These suggest that HAP1 is crucial for modulating/protecting serotonergic functions, plausibly by upholding 5-HT neuronal plasticity/integrity by raising the threshold for neurodegeneration. …”
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Genome Insights into Beneficial Microbial Strains Composing SIMBA Microbial Consortia Applied as Biofertilizers for Maize, Wheat and Tomato by Lisa Cangioli, Silvia Tabacchioni, Andrea Visca, Alessia Fiore, Giuseppe Aprea, Patrizia Ambrosino, Enrico Ercole, Soren Sørensen, Alessio Mengoni, Annamaria Bevivino

“…The annotation of the genomes revealed the presence of genes that are implicated in functions related to antagonism, pathogenesis and other secondary metabolites possibly involved in plant growth promotion and gene clusters for protection against oxidative damage, confirming the plant-growth-promoting (PGP) activity of selected strains. …”
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An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy by Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan

“…The T96F‐mutated STanD‐scTCR engager demonstrates improved antigen sensitivity, promotes multi‐functional T‐cell responses, and facilitates immune synapse formation between T cells and target cells. …”
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