Evaluation of bronchial hyperresponsiveness in asthmatic paediatric patients using mannitol challenge test – Impacts of body mass index by Sharon S. Y. Leung, Helen S. L. Tsang, Jasmine Chan, Oliver Y. H. Kui, Ping Zeng, Yin Ting Cheung, James-Wesley Cheng, Kate C. C. Chan, Michelle Yu, Patricia Tang, John D. Brannan, Jenny K. W. Lam, Hak-Kim Chan, Albert M. Li

“…While patients with mild AHR had comparable lung functions to those without AHR, patients with moderate AHR showed slightly but significantly lower FEV1 and FEV1/FVC values. …”
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Hemoadhican-based self-leveling Janus patch for comprehensive prevention of postoperative adhesions by Rui Fang, Ning Yu, Simeng Chen, Xi Xu, Jianfa Zhang

“…This patch consists of three distinct functional layers: an anti-adhesion layer, a reinforcement layer, and a wet tissue adhesion layer. …”
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Novel peptide-based oncolytic vaccine for enhancement of adaptive antitumor immune response via co-engagement of innate Fcγ and Fcα receptors by Sari Pesonen, Sara Feola, Manlio Fusciello, Vincenzo Cerullo, Firas Hamdan, Jacopo Chiaro, Michaela Feodoroff, Gabriella Antignani, Salvatore Russo, Jeanette Leusen, Mikaela Grönholm, Federica D'Alessio, Riikka Mölsä, Virpi Stigzelius, Paolo Bottega

“…We coated AdCab with major histocompatibility complex (MHC-I)-restricted tumor peptides, generating a vaccine platform (named PeptiCab); the latter takes advantage of viral immunogenicity, peptide cancer specificity to prime T-cell responses, and antibody-mediated effector functions.Results As proof of concept, PeptiCab was used in murine models of melanoma and colon cancer, resulting in tumor growth control and generation of systemic T-cell-mediated antitumor responses. …”
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A High-Sensitivity, Bluetooth-Enabled PCB Biosensor for HER2 and CA15-3 Protein Detection in Saliva: A Rapid, Non-Invasive Approach to Breast Cancer Screening by Hsiao-Hsuan Wan, Chao-Ching Chiang, Fan Ren, Cheng-Tse Tsai, Yu-Siang Chou, Chun-Wei Chiu, Yu-Te Liao, Dan Neal, Coy D. Heldermon, Mateus G. Rocha, Josephine F. Esquivel-Upshaw

“…However, IHC requires invasive biopsies and time-intensive laboratory procedures. In this study, we present a biosensor integrated with a reusable printed circuit board (PCB) and functionalized glucose test strips designed for rapid and non-invasive HER2 detection in saliva. …”
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Phyto-fabrication of copper oxide nanoparticles (NPs) utilizing the green approach exhibits antioxidant, antimicrobial, and antifungal activity in Diospyros kaki fruit by Iftikhar Hussain Shah, Irfan Ali Sabir, Muhammad Ashraf, Asad Rehman, Zishan Ahmad, Muhammad Azam, Ghulam Abbas Ashraf, Haroon ur Rasheed, Guohui Li, Jeridi Mouna, Mohammad Faizan, Muhammad Ahsan Altaf, Awais Shakoor, Cheng Song, Muhammad Aamir Manzoor

“…The FTIR analysis revealed the functional groups present in plant extracts. XRD was carried out to demonstrate the crystalline nature and size of nanoparticles using the Scherrer formula. …”
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Segregation-guided alloy design via tailored solidification behavior by Ahmet Turnali, Dilay Kibaroglu, Nico Evers, Jaqueline Gehlmann, Lennart Sayk, Nicolas J. Peter, Abdelrahman Elsayed, Mehdi Noori, Tarek Allam, Johannes Henrich Schleifenbaum, Christian Haase

“…This study presents an alloy design perspective guided by elemental segregation during solidification to determine the site-specific chemistry and related local thermodynamic properties of dendritic microstructures. …”
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Proteomic analysis of infiltrating neutrophils from rheumatoid arthritis synovial fluid and their contribution to protein carbamylation by Xueting Chen, Rong Du, Pan Wang, WenLin Qiu, Lu Chen, Jian Wan, Hui Qiu, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Rikard Holmdahl, Hui Geng

“…In addition, we specifically identified many carbamylated proteins and observed an increased frequency of protein carbamylation in RA-SF samples. Functionally, neutrophils from RA-SF showed a significantly increased level of MPO release and HH2O2 generation. …”
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In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication by Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha

“…The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins. …”
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Comparative Genomics Reveals Ancient and Unique Pathogenicity Features in Australian <i>Fusarium oxysporum</i> f. sp. <i>vasinfectum</i> by Angel David Popa-Baez, Linda J. Smith, Warwick N. Stiller, Melanie Soliveres, Gunjan Pandey, Christopher A. Saski, Don C. Jones, Iain W. Wilson

“…Comparative genomics analysis identified four accessory chromosomes unique to the Australian isolates. Functional annotations revealed 14,495 and 15,342 genes in VCG-01111 and VCG-01112, respectively, with accessory chromosomes containing significantly fewer genes than core chromosomes. …”
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Comparative transcriptomic analysis reveals the important role of hepatic fatty acid metabolism in the acute heat stress response in chickens by Zi Mei, Zhenquan Song, Haobo Zhou, Bin Zheng, Yiwei Xiong, Zheya Sheng, Yanzhang Gong

“…Fatty acid metabolic pathway-associated DMHGs were significantly correlated with rectal temperature, serum GLU, TG, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST). Functional validation in primary hepatocytes demonstrated that overexpression of FASN attenuated heat stress-induced reductions in triglyceride levels. …”
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Toward Specialized Wireless Networks Using an ML-Driven Radio Interface by Kamil Szczech, Maksymilian Wojnar, Katarzyna Kosek-Szott, Krzysztof Rusek, Szymon Szott, Dileepa Marasinghe, Nandana Rajatheva, Richard Combes, Francesc Wilhelmi, Anders Jonsson, Boris Bellalta

“…By integrating AI/ML functionalities, SpecNets will fully leverage the concept of AI/ML-defined radios (MLDRs) that are able to autonomously establish their own communication protocols by acquiring contextual information and dynamically adapting to it. …”
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Effects of pH/<i>p</i>CO₂ fluctuations on photosynthesis and fatty acid composition of two marine diatoms, with reference to consequences of coastal acidification by Y. Shang, J. Qiu, Y. Weng, X. Wang, D. Zhang, Y. Zhou, J. Xu, J. Xu, F. Li, F. Li

“…Together with the altered nutritional quality of prey for higher trophic levels, coastal acidification might have far-reaching consequences for marine ecosystem functioning.</p>…”
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Protocol of BRICS: Brazilian multicentric pragmatic randomised trial of surgical interventions for displaced diaphyseal clavicle fracture study: MIPO versus ORIF for the treatment... by Rafael Fuchs Lazarini, Fabio Teruo Matsunaga, João Carlos Belloti, Marcel Jun Sugawara Tamaoki, Oreste Lemos Carrazzone, Adriano Fernando Mendes Jr., Rodrigo Fleury Curado, Jair Moreira Dias Jr., José Da Mota Neto, Alexandre Rosa Pagan, Pedro José Labronici, Gustavo José Labronici, Matheus Pires De Araújo Goes, Guilherme Grisi Mouraria, Daniel Romano Zogbi, Rafael Mulatti Brigatto, Anderson Uehara, Otávio Costa Parro, Fernando Mitsuo Hisano, Bruno De Souza Teixeira, Rafael Waldolato Silva, André Couto Godinho, Pedro Couto Godinho, Flavio De Oliveira França, Glaydson Gomes Godinho, José Marcio Alves Freitas, Carlos Alberto Menezes Mariosa, Bruno Gonçalves Schröder e Souza, Valdeci Manoel De Oliveira, Leandro Furtado De Simoni, Camila Corrêa Pereira, Jurandir Antunes Filho

“…Surgery is associated with a lower risk of non-union and better functional outcomes but a higher risk of complications. …”
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Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression by Kepu Zheng, Leiyang Dai, Shengning Zhang, Yingpeng Zhao, Wang Li, Yang Gao, Yuanyi Mang, Lingfeng Jiao, Yu Tang, Jianghua Ran

“…Key genes and pathways regulating these cells present potential therapeutic targets.…”
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Seasonal Influenza Vaccination Programs in the Americas: A Platform for Sustainable Life-Course Immunization and Its Role for Pandemic Preparedness and Response by Francisco Nogareda, Margherita Ghiselli, Martha Velandia-González, Bremen de Mucio, Jorge Jara, Paula Couto, Angel Rodriguez, Marc Rondy, Andrea Vicari, Murat Hakan Ozturk, Shoshanna Goldin, Alba Vilajeliu, Eva Leidman, Jaymin Patel, Julie Carlton, Ashley L. Fowlkes, Eduardo Azziz-Baumgartner, Daniel Salas Peraza, Alba Maria Ropero

“…Countries in Latin America have been the exception, with strong influenza vaccination programs for adults regardless of national income level. The presence of functional and effective adult influenza vaccination programs can also facilitate the acceptance and uptake of other adult vaccines targeting priority groups at higher risk for severe illness or complications.…”
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Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation by Lianling Xu, Lianling Xu, Kaixuan Zeng, Kaixuan Zeng, Zuoyue Duan, Zuoyue Duan, Jing Liu, Yan Zeng, Miao Zhang, You Yang, Qulian Guo, Yanling Jin, Wenjun Liu, Ling Guo

“…Sweet potato, a widely cultivated functional crop, is abundant in flavonoids. However, the active ingredients associated with acute myeloid leukemia (AML) treatment and their underlying mechanisms have not been reported to date.ObjectiveThis study aims to identify novel drugs against AML from sweet potato by integrating metabolomics analysis, network pharmacology, and experimental validation.MethodsFirstly, ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed to analyze the major constituents in sweet potato. …”
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Lung Cancer Management: Revolutionizing Patient Outcomes Through Machine Learning and Artificial Intelligence by Taghi Riahi, Bahareh Shateri‐Amiri, Amirhossein Hajialiasgary Najafabadi, Sina Garazhian, Hanieh Radkhah, Diar Zooravar, Sahar Mansouri, Roya Aghazadeh, Mohammadreza Bordbar, Shirin Raiszadeh

“…Training employed binary cross‐entropy and Dice loss functions. Data augmentation, dropout, and regularization were used to enhance model generalizability and prevent overfitting. …”
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Spectroscopic photoacoustic denoising framework using hybrid analytical and data-free learning method by Fangzhou Lin, Shang Gao, Yichuan Tang, Xihan Ma, Ryo Murakami, Ziming Zhang, John D. Obayemi, Winston O. Soboyejo, Haichong K. Zhang

“…This framework integrates a data-free learning-based method with an efficient BM3D-based analytical approach while preserving spectral integrity, providing noise reduction, and ensuring that functional information is maintained. The SPADE framework was validated through simulation, phantom, in vivo, and ex vivo studies. …”
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Deciphering the microbiome–metabolome landscape of an inflammatory bowel disease inception cohort by Shiva T. Radhakrishnan, Benjamin H. Mullish, Marton L. Olbei, Nathan P. Danckert, Maria A. Valdivia-Garcia, Jose I. Serrano-Contreras, Despoina Chrysostomou, Sharmili Balarajah, Robert W. Perry, John P. Thomas, Lejla Potari-Gul, Dezso Modos, Lucy C. Hicks, Nick Powell, Timothy R. Orchard, Jia V. Li, Julian R. Marchesi, Tamas Korcsmaros, James L. Alexander, Horace R. T. Williams

“…The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and the recruitment of patients with well-established disease (introducing potential confounders, such as immunomodulatory medication). …”
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Model systems for emulating human tissue and physiology in psychiatric research by Kai Cheng, Anannya Kshirsagar, John Nixon, Jonathan Lau, Kun Yang, Akira Sawa, Annie Kathuria, Annie Kathuria

“…On the other hand, 3D organoid models, including brain organoids, better recapitulate the spatial organization, cell-type diversity, and functional connectivity of brain tissue, offering a more physiologically relevant context for studying disease mechanisms and testing therapeutic interventions. …”
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