A nanoluciferase complementation-based assay for monitoring β-arrestin2 recruitment to the dopamine D3 receptor by Viktor Burström, Kuiying Xu, Emilio Garro-Martínez, Robert H. Mach, Kristoffer Sahlholm, Nibal Betari

“…In summary, the present report demonstrates the utility of nanoluciferase complementation for studying D3R pharmacology in living cells.…”
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System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain—an explorative study by Mika Jönsson, Emmanuel Bäckryd, Stefan Ljunggren, Nina Ottosson, Amaia Jauregi-Miguel, Sara I. Liin, Antonio Checa, Craig E. Wheelock, Bijar Ghafouri

“…Conclusion:. These results present a previously unexplored network of integrated alterations of lipoproteins, octadecanoids, and cytokines in patients suffering from NeuP, indicative of deviant immuno-protective functioning across several biological systems including lipid metabolic processes, inflammation, and Kv7.2/7.3 signalling.…”
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Optimization of the encapsulation of arazá pulp by spray drying: Physicochemical, morphological and in vitro digestion studies by Greilis Quintero-Gamero, Francis S. Sánchez-Garzón, Aureliano Rodríguez-Cortina, María Hernández-Carrión, Luz Stella Nerio

“…Morphological analysis showed semi-spherical particles without agglomeration with an average diameter of 7.1 ± 3.4 μm. This study presents an optimized method to obtain microencapsulates from arazá pulp (not obtained before), with a great potential for the development of functional foods.…”
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Living with Atypical Hemolytic Uremic Syndrome in the Netherlands: Patient and Family Perspective by Romy N. Bouwmeester, Leonie J. Engel, Wim Altena, Caroline Renette, Clim van Daelen, Evy van Kempen, Renée de Wildt, Nicole C.A.J. van de Kar

“…Despite efforts to optimize and personalize health care for patients with aHUS, understanding the individual experiences, needs, and desires of patients with aHUS and their relatives remains limited. Methods: Here, we present a nationwide, exploratory, qualitative interview study with a direct content analysis approach. …”
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The Effect of Mental Rotation Training on the Balance and Falling of the Elderly Women with Physical Training Method by Mohammad Taghi Aghdasi, Seyed Hojjat Zamani Sani, Saba Mohammad Alinezhad, Sahand Eslami, Fatemeh Farrokhzad 5

“…Tools included: mental rotation questionnaire and functional reach test. The participants included: 36 patients (12 subjects in three groups of physical training, mental rotation and control group) have been randomly selected among the elderly women of an elderly Centre in Tabriz. …”
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A novel integrated TDLAVOA-XGBoost model for tool wear prediction in lathe and milling operations by Zhongyuan Che, Chong Peng, Chi Wang, Jikun Wang

“…This work advances predictive maintenance strategies and presents a novel integrated framework for tool wear modeling.…”
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First‐In‐Human Study of Safety, Tolerability, Efficacy, and Pharmacokinetics of CPNE7‐Derived Peptide (Selcopintide) for Dentin Hypersensitivity by Myung Jin Lee, Yoon Seon Lee, Joo‐Cheol Park, Hyun Chul Kim, So Hyun Park, Howard Lee, Won Jun Shon

“…Copine7 (CPNE7) induces odontoblast differentiation and physiologic dentin regeneration, enabling biological dentin sealing and presenting a novel therapeutic approach. This study reports the first‐in‐human results of a randomized, double‐blind, dose‐escalation phase 1/2a clinical trial evaluating the safety, tolerability, preliminary efficacy, and pharmacokinetics of the CPNE7‐derived functional peptide (selcopintide) in patients with dentin hypersensitivity. …”
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Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice by Ruiyu Zhang, Hui Du, Zhi Liu, Yuxi Lei, Huizhi Hu, Junwen Zheng, Pu Yang, Dongchi Zhao

“…Molecular profiling of CCR5 and inflammatory mediators was performed through real-time quantitative reverse transcription PCR (qRT-PCR) and immunofluorescence staining. Functional assessments of macrophage migration were carried out using scratch wound healing assays and transwell migration assays. …”
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A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques by Awadalkareem Adam, Courtney Woolsey, Hannah Lu, Kenneth Plante, Shannon M. Wallace, Leslie Rodriguez, Divya P. Shinde, Yingjun Cui, Alexander W. E. Franz, Saravanan Thangamani, Jason E. Comer, Scott C. Weaver, Tian Wang

“…Both EILV/CHIKV and the live attenuated CHIKV 181/25 vaccine protected macaques from wild-type (WT) CHIKV infection 1 year after a single dose vaccination. Transcriptome and functional analyses reveal that EILV/CHIKV triggered T cell, memory B cell and antibody responses in a dose-dependent manner. …”
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Antioxidant Capacity and Phenolic Profile of Defatted Seed Powder Derived from Organically Grown Vine Crops by Daniela GITEA, Manuel Alexandru GITEA, Andrei-Flavius RADU, Manuela Bianca PASCA, Simona Gabriela BUNGAU, Delia Mirela TIT

“…These findings suggest potential applications in pharmaceuticals, functional foods, and cosmetics, offering sustainable solutions for grape pomace utilization. …”
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Monitoring <i>Moringa oleifera</i> Lam. in the Mediterranean Area Using Unmanned Aerial Vehicles (UAVs) and Leaf Powder Production for Food Fortification by Carlo Greco, Raimondo Gaglio, Luca Settanni, Antonio Alfonzo, Santo Orlando, Salvatore Ciulla, Michele Massimo Mammano

“…Plate count analyses confirmed the absence of pathogenic bacterial colonies in the <i>M. oleifera</i> leaf powders, highlighting their potential application as natural and functional additives in food production.…”
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Finite-Difference Analysis of Influence of Borehole Diameter and Spacing on Reduction in Rockburst Potential of Burst-Prone Coal Seams by Mikhail O. Eremin, Artyom O. Chirkov, Albert Pazhin, Sergey A. Laptev, Dmitriy V. Chanov

“…The results also indicate that the curves of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>K</mi></mrow><mrow><mi>I</mi><mi>r</mi><mi>b</mi></mrow></msub></mrow></semantics></math></inline-formula> dependence on spacing between the boreholes and their diameter are nonlinear and non-monotonic functions, which allows for optimizing of the drilling technology.…”
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Deep-Learning-Driven Insights into Nitrogen Leaching for Sustainable Land Use and Agricultural Practices by Caixia Hu, Jie Li, Yaxu Pang, Lan Luo, Fang Liu, Wenhao Wu, Yan Xu, Houyu Li, Bingcang Tan, Guilong Zhang

“…Nitrate leaching from soil presents a significant threat to soil health, as it can result in nutrient loss, soil acidification, and structural damage. …”
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Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory by Jeyanthan Charles James, Hannah Schulze, Nadine Siems, Christian Prehn, Daniel R. Quast, Nadine Trampe, Ralf Gold, Simon Faissner

“…Self-reported cognitive deficits of patients with neurologic PCS including fatigue, concentration, and memory deficits, are well mirrored in impaired performance of cognitive domains of concentration and working memory. The present results should be considered to optimize treatment algorithms for therapy and rehabilitation programs of PCS patients with neurologic symptoms.…”
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The landscape and clinical impact of tumor-associated macrophages and PD-L1 in primary breast cancers and their brain metastases by Yannik Nicola Zimmer, Benjamin Hanke, Belal Neyazi, Ali Rashidi, Anna Schaufler, Claudia Alexandra Dumitru, Atanas Ignatov, Christian Mawrin, I. Erol Sandalcioglu, Klaus-Peter Stein

“…Macrophages were consistently found to be more frequently present in the tumor stroma compared to the tumor nest. …”
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Research of tomatoes Solanum lycopersicum L. originating from different climatic-geographical regions and identification of metabolites by tandem mass spectrometry by O. A. Chunikhina, M. P. Razgonova, A. M. Zakharenko, K. S. Golokhvast

“…The findings will help to intensify future research into the development and production of various functional food products containing targeted extracts of Solanum lycopersicum L.…”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…Additionally, MARCKSL1 is linked to tumour resistance to multiple anticancer drugs.DiscussionThis study sheds light on the molecular characteristics and functional heterogeneity of MVI-associated malignant cell subpopulations. …”
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Carbon and water footprints within an environmental laboratory: Water, energy, and packaging management strategies by María F. Manobanda-Lisintuña, Cristina A. Villamar-Ayala

“…The objective of this study is to evaluate the carbon and water footprints present in an environmental laboratory based on water, energy, and resource (packaging) management. …”
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Halogenated 2,4-diphenyl indeno[1,2-B]pyridinol derivatives as potential inhibitors of the androgen receptor (PDB ID: 58TE): A study of QSAR modeling, molecular docking, and pharma... by Auwal Salisu Isa, Adamu Uzairu, Umar Mele Umar, Muhammad Tukur Ibrahim, David Ebuka Arthur, Samuel Ndaghiya Adawara

“…The present research was centered on the development of a predictive model aimed at assessing the responses of prostate tumors to a range of compounds within the scope of the pIC50 project. …”
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Impact of temperature humidity index-based climate services for Murrah buffaloes of India on operational decision-making and economic outcome of the farm by K.V. Manjunath, Sanjit Maiti, Sanchita Garai, D. Anilkumar Reddy, Mukesh Bhakat, Anjali Aggarwal, Goutam Mondal

“…Climate change is likely to affect both the productive and reproductive functions of Murrah buffaloes, the major milch breed of India. …”
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