DYRK1A in blood and immune function: implications in leukemia, inflammatory disorders, infection and Down syndrome by Esteban J. Rozen, Robin D. Dowell, Robin D. Dowell, Mary A. Allen

“…Here, we present a detailed review of the literature summarizing all the information linking DYRK1A to blood and immune function, as well as leukemia, inflammation and viral infections, with a special focus on their potential associations to T21. …”
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Digitoflavone Ameliorates Acute Lung Injury via Disturbing the Formation of Functional Stimulator of Interferon Genes Signalosome by Jun-Jie Li, Qing Yao, Ming Dong, Yan Wang, Ye Xiu, Zhi-Xin Wu, Xiao-Mei Zhao, Yin-Kang Wang, Xian-Ling Wang, Yu-Xuan Tian, Xiao-He Xiao, Zhao-Fang Bai

“…Natural products from traditional Chinese medicine are an important source for modern drug development; digitoflavone (DG), a natural flavonoid present in a variety of plants, has been shown to have anti-inflammatory effects. …”
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Propofol‐Induced Moderate–Deep Sedation Modulates Pediatric Neural Activity: A Functional Connectivity Study by Qiang Zheng, Yiyu Zhang, Lin Zhang, Jian Wang, Jungang Liu

“…However, the mechanism of propofol‐induced moderate–deep sedation (PMDS) in modulating pediatric neural activity remains unknown, which therefore was investigated in the present study based on functional magnetic resonance imaging (fMRI). …”
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Validity and Reliability of Dynamic and Functional Balance Tests in People Aged 19-54: A Systematic Review by Kim J Lesch, Sanni Tuomisto, Heikki O Tikkanen, Mika Venojärvi

“…This systematic review concentrated on dynamic and functional balance assessment methods and their validity in healthy adults aged 19-54. …”
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The functional, social and economic impact of acute encephalitis syndrome in Nepal--a longitudinal follow-up study. by Michael J Griffiths, Jennifer V Lemon, Ajit Rayamajhi, Prakash Poudel, Pramina Shrestha, Vijay Srivastav, Rachel Kneen, Antonieta Medina-Lara, Rupa R Singh, Tom Solomon

“…<h4>Background</h4>Over 133,000 children present to hospitals with Acute Encephalitis Syndrome (AES) annually in Asia. …”
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Impact of Standardised Order Sets on Functional Outcome of Acute Ischaemic Stroke Patients: A Research Protocol by Sarang Dilip Videkar, Tushar Patil

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Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy by Chen Y, Yue S, Yu L, Cao J, Liu Y, Deng A, Lu Y, Yang J, Li H, Du J, Xia J, Li Y, Xia Y

“…These modifications are interconnected and collectively influence pathway functionality. We summarize the functions of cGAS-STING and its PTMs in immune and non-immune cells across various diseases, and explore potential clinical applications.Keywords: cGAS, STING, immunity, immunotherapy, post-transcriptional regulation…”
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Onion peel color extract incorporation in pasta and effect on functional, phytochemical, structural, thermal, and storage stability by S. Abinaya, Anil Panghal, Navnidhi Chhikara, Priya Bishnoi, Ronak Tanwar, Ravi Gupta

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Flavor Quality and Lipid-Lowering Function of Mixed Fermented Pu-erh Tea with Various Monascus Species by Xiaomin Chen, Yao Hu, Zhen Zeng, Xu Zhang, Yahui Huang

“…The research results provide a scientific basis for the deep processing and functional development of Pu-erh raw tea.…”
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Assessing executive functioning in higher education: development and structural validation of a new self-report scale by Samuel Zamora-Lugo, Vicenta Reynoso-Alcántara, Javier Sanchez-Lopez, Samana Vergara-Lope, Elizabeth Ocampo-Gómez, María Luisa García-Gomar, Cynthia Torres-González, Gloria Nélida Avecilla-Ramírez, Cintli Carolina Carbajal-Valenzuela, Melissa Calderón, Almitra Vázquez-Moreno, Rubén Flores-González, Carlos César Contreras-Ibáñez, Félix Ángel Montero-Domínguez, Aurora de Jesús Mejía-Castillo, Alicia Abundis-Gutierrez, José Elías Sánchez-Cid, María Iliana Osorio-Guzmán, Gregorio García-Aguilar, Agustín Jaime Negrete-Cortes, Naghelli Cisneros Báez, Luz María Martell Ruiz, Paulina Campos Romero, Rossana de Fátima Cuevas-Ferrera

“…However, few assessment tools provide psychometrically validated and contextually appropriate measures for university populations.MethodsThis study presents the development and structural validation of the Executive Functions Scale in Higher Education (EFEES), a self-report instrument designed to evaluate university students’ self-perceived executive functioning. …”
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Endophytic Bacterial Community, Core Taxa, and Functional Variations Within the Fruiting Bodies of <i>Laccaria</i> by Kaixuan Zhang, Xin Chen, Xiaofei Shi, Zhenyan Yang, Lian Yang, Dong Liu, Fuqiang Yu

“…By analyzing bacterial diversity, community structure, and function through 16S rRNA sequencing, we observed the following: (1) In total, 4,840,291 high-quality bacterial sequences obtained from the fruiting bodies were grouped into 16,577 amplicon sequence variants (ASVs), and all samples comprised 23 shared bacterial ASVs. (2) The <i>Allorhizobium</i>-<i>Neorhizobium</i>-<i>Pararhizobium</i>-<i>Rhizobium</i> complex was found to be the most abundant and presumably coexisting bacterium. (3) A network analysis revealed that endophytic bacteria formed functional groups, which were dominated by the genera <i>Allorhizobium</i>-<i>Neorhizobium</i>-<i>Pararhizobium</i>-<i>Rhizobium</i>, <i>Novosphingobium</i>, and <i>Variovorax</i>. (4) The diversity, community structure, and dominance of ecological functions (chemoheterotrophy and nitrogen cycling) among endophytic bacteria were significantly shaped by geographic location, habitat, and fungal genotype, rather than fruiting body type. (5) A large number of the endophytic bacteria within <i>Laccaria</i> are bacteria that promote plant growth; however, some pathogenic bacteria that pose a threat to human health might also be present. …”
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Identification of a functional vitamin D response element in the promoter of goose anti-Müllerian hormone gene by Rong Chen, Chen Chen, Yifei Qin, Jie Liu, Mingming Lei, Huanxi Zhu, Zhendan Shi

“…These results suggest that vitamin D3 downregulates AMH mRNA expression via a functional VDRE that binds the VDR/RXR heterodimer in goose ovarian prehierarchical follicles. …”
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Neuroplastin 65 deficiency leads to the impairment of visual function through affecting ribbon synapse in retina of mice by Jiu-jiang Zeng, Jiu-jiang Zeng, Ling Chen, Ling Chen, Li-fen Liu, Li-fen Liu, Jia-lu Wang, Jie Cheng, Jie Cheng, Ya-ni Zheng, Ya-ni Zheng, Lei Zhang, Lei Zhang, Xiao-ming Zhang, Xiao-ming Zhang, Qiong-lan Yuan, Qiong-lan Yuan

“…Neuroplastin 65 (NP65) is a synapse-enriched glycoprotein in the central nervous system and is implicated in synaptic plasticity. In the present study, we found that NP65 knockout (NP65 KO) mice exhibit impaired visual function, including reductions in the amplitude of b-wave in scotopic flash electroretinogram (fERG), the amplitude of N1 and P1 waves in flash visual evoked potentials (fVEP), and the constriction rate in pupillary light reflexes (PLR). …”
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Synthesis and physical-chemical properties of functional derivatives of 3-benzyl-8-propylxanthinyl-7-acetic acid by E. K. Mikhal’chenko, K. V. Аleksandrova, S. V. Levich, A. S. Korzhova

“…Substituted acetamide and ester fragments are also present in the structures of aprofen, spasmolitin, acetylidine and β-lactam cephalosporins and penicillins antibiotics.Aim of our research was the synthetic method development for functional derivatives of 3-benzyl-8-propylxanthinyl-7-acetic acid and the study of their physical-chemical properties. …”
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How health mediation can function effectively on the fostering of healthcare utilization? : a realist qualitative study by Elodie Richard, Leila Ramiz, Mara Oltean, Vanina Troussier, Caroline Ulracher, Olivia Speed, Muriele Conort, Cécile Coutant, Fréderique Chaves Quirino, Judith Martin Fernandez, Stéphanie Vandentorren, Linda Cambon

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The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia by Sagarika Bhattacharjee, P. T. Sivakumar, Ganesan Venkatasubramanian, Kenichi Oishi, Kyrana Tsapkini, S. H. Annabel Chen, Brenda Rapp, John E. Desmond, T. N. Sathyaprabha, Kaviraja Udupa, Rajan Kashyap

“…Grey matter volume and functional entropy were analysed across 116 brain regions. …”
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Associations of functional and biochemical parameters of endothelial dysfunction in postmenopausal women with a different state of carbohydrate metabolism by Lyudmila Aleksandrovna Ruyatkina, Irina Sergeevna Iskhakova, Konstantin Yuryevich Nikolaev, Dmitriy Sergeevich Ruyatkin

“…Consequently, in the literature, there is no information about the function of endothelial vasomotion during occlusion. …”
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Data-driven multi-fault detection in pipelines utilizing frequency response function and artificial neural networks by Hussein A. M. Hussein, Sharafiz B. Abdul Rahim, Faizal B. Mustapha, Prajindra S. Krishnan, Nawal Aswan B. Abdul Jalil

“…This research presents a data-driven structural health monitoring (SHM) approach for pipeline systems that leverages frequency response function (FRF) signals and artificial neural network (ANN) algorithms to accurately identify and classify diverse pipeline fault conditions. …”
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Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML by Yulun Zhong, Rou Zhang, Lingzi Lu, Huijian Tan, Yuyu You, Yang Mao, Yanqiu Yuan

“…Abstract Background Protein arginine methylations are crucial post-translational modifications (PTMs) in eukaryotes, playing a significant regulatory role in diverse biological processes. Here, we present our investigation into the detailed arginine methylation pattern of the C-terminal RG-rich region of METTL14, a key component of the m6A RNA methylation machinery, and its functional implications in biology and disease. …”
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Structural and functional insights into the nuclear role of Parkinson’s disease-associated α-synuclein as a histone chaperone by Sneha Jos, Archanalakshmi Kambaru, Thazhe Kootteri Prasad, Shylaja Parthasarathi, Neelagandan Kamariah, Sangeeta Nath, Balasundaram Padmanabhan, Sivaraman Padavattan

“…The chaperoning assay supports αSyn’s function as a histone chaperone, suggesting the potential role of αSyn in the nucleosome assembly/disassembly process.…”
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