Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome by Emily R. Gordon, Stephanie A. Felker, Stephanie A. Felker, Tanner F. Coleman, Tanner F. Coleman, Nadiya Sosonkina, Jada Pugh, Jada Pugh, Meagan E. Cochran, Meagan E. Cochran, Anna C. E. Hurst, Sara J. Cooper

“…Loeys-Dietz syndrome (LDS) is a connective tissue disorder representing a wide spectrum of phenotypes, ranging from isolated thoracic aortic aneurysm or dissection to a more severe syndromic presentation with multisystemic involvement. Significant clinical variability has been noted for both related and unrelated individuals with the same pathogenic variant. …”
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Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat by Tushadri Singh, Tushadri Singh, H. M. Mamrutha, Rajender Singh, J. P. Jaiswal, Zeenat Wadhwa, Rakesh Kumar, Omvir Singh, O. P. Ahlawat, Ratan Tiwari

“…By virtue of wheat being a hexaploid crop and having a large genome size with repetitive DNA, a tailor-made strategy for designing the gRNA is crucial.ResultThe manuscript explains the comprehensive strategies and methods for efficient gRNA designing by considering the physical and structural expression of the target gene in the genome and explains the on-target and off-target effects of gRNA for its precise editing through the CRISPR/Cas9-mediated SDN1 method of genome editing in wheat.ConclusionThe present manuscript is first of its kind to address the holistic approach, starting from efficient gene selection, gRNA designing, and post-gRNA designing issues like gRNA stability, binding efficiency, and functionality for SDN1-CRISPR/Cas9 genome editing in wheat. …”
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Characterization of Avocado (<i>Persea americana</i> Mill) Seed Extract from the Variety Semil 34 Cultivated in the Dominican Republic by Ramon Sanchez-Rosario, Luis Castillo, Alejandra Féliz-Jiménez, Sebastián Vargas, Ramón Pérez-Romero, Mónica Aquino, Maha T. Abutokaikah

“…This study demonstrates the potential of the avocado seed as a source of bioactive compounds and hence a functional ingredient, supporting its value in sustainable production and its possible contribution to environmental goals by reducing waste in the avocado industry.…”
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TIMP-1 associates with myelin membrane and preserves myelin in injured peripheral nerve by Hanbum Joe, Hyungseok Seo, Jennifer Dolkas, Megh Jawala, Swathi K. Hullugundi, Yang Hoon Chung, Hemal H. Patel, Andrei V. Chernov, Veronica I. Shubayev

“…TIMP-1 is a potent protease inhibitor and neurotrophic factor, traditionally known as a secreted protein. This study presents the first evidence of a myelin/membrane-associated (mm)TIMP-1 protein fraction in the nervous system. …”
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BioDeepfuse: a hybrid deep learning approach with integrated feature extraction techniques for enhanced non-coding RNA classification by Anderson P. Avila Santos, Breno L. S. de Almeida, Robson P. Bonidia, Peter F. Stadler, Polonca Stefanic, Ines Mandic-Mulec, Ulisses Rocha, Danilo S. Sanches, André C.P.L.F. de Carvalho

“…The accurate classification of non-coding RNA (ncRNA) sequences is pivotal for advanced non-coding genome annotation and analysis, a fundamental aspect of genomics that facilitates understanding of ncRNA functions and regulatory mechanisms in various biological processes. …”
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AnVILWorkflow: A runnable workflow package for Cloud-implemented bioinformatics analysis pipelines [version 1; peer review: 2 approved] by Sean Davis, Marcel Ramos, Michael C. Schatz, Kai Gravel-Pucillo, Levi Waldron, Sehyun Oh, Martin Morgan, Vincent Carey

“…AnVILWorkflow simplifies the setup of the cloud computing environment, input data formatting, workflow submission, and retrieval of results through intuitive functions. We demonstrate the utility of AnVILWorkflow for three use cases: bulk RNA-seq analysis with Salmon, metagenomics analysis with bioBakery, and digital pathology image processing with PathML. …”
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Test methods for adhesive polymer compositions in development and quality control for stoma care products on the example of adhesive baseplates (review) by I. A. Sadkovskii, L. A. Korol, A. B. Karabanova, A. V. Korolenko, E. A. Shemetova, I. I. Krasnyuk, G. V. Ramenskaya, M. A. Mandrik

“…Adhesive baseplates, designed to fix ostomy bags and protect the skin of the peristomal area of ostomy patients, are a key element of an ostomy bag or urine bag. The functionality of adhesive baseplates is ensured by a set of their technical characteristics and design features, which makes the choice of appropriate baseplate testing methods an important aspect in the development, production and quality control of these medical devices.Text. …”
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Translation, cross-cultural adaptation, and validation of the Norwegian version of the Keratoconus Outcomes Research Questionnaire by Eilin Lundanes, Svein Magne Roten, Helle Kristine Falkenberg, Lena Leren, Vibeke Sundling

“…Deletion of four items (AL3, AL3b, AL12, AL15) improved dimensionality of the “Activity limitations” subscale. Differential item functioning was present in two items (AL4 and AL6). …”
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MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Cancer remains a prominent worldwide health concern, presenting existing therapies with frequent difficulties, including major toxicity, limited effectiveness, and treatment resistance emergence. …”
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Cheby-KANs: Advanced Kolmogorov&#x2013;Arnold Networks for Applying Geometric Deep Learning in Quantum Chemistry Applications by Amgad Abdallah Mahmoud, Andreas Pester, Maha M. Muttardi, Frederic Andres, Shihori Tanabe, Nicolas Greneche, Hesham H. Ali

“…In this work, we present an enhanced version of the Kolmogorov&#x2013;Arnold network (KAN) algorithm, called Cheby-KAN, that offers a more efficient, more reliable, and faster alternative to conventional KANs. …”
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Research on Drive and Detection Technology of CMUT Multi-Array Transducers Based on MEMS Technology by Chenyuan Li, Jiagen Chen, Chengwei Liu, Yao Xie, Yangyang Cui, Shiwang Zhang, Zhikang Li, Libo Zhao, Guoxing Chen, Shaochong Wei, Yu Gao, Linxi Dong

“…This paper presents an ultrasonic driving and detection system based on a CMUT array using MEMS technology. …”
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Community coalitions’ navigation of policies to address the opioid epidemic: insights from qualitative interviews in four states by Elizabeth N Kinnard, Ann Scheck McAlearney, Timothy Hunt, Ramona G Olvera, Allyson G Cogan, Mary Bartkus, Shoshana N Benjamin, Jill Davis, Lisa A Frazier, Brandy F Henry, Hallie Mattingly, Dean Rivera, Mari-Lynn Drainoni, Daniel M Walker

“…Introduction The opioid epidemic in the USA presents a multifaceted challenge regulated by a patchwork of federal, state and local policies. …”
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Subjective cognitive, psychiatric, and fatigue symptoms two years after COVID-19: A prospective longitudinal cohort study by Henriikka Ollila, Marjaana Tiainen, Riikka Pihlaja, Sanna Koskinen, Annamari Tuulio-Henriksson, Viljami Salmela, Laura Hokkanen, Johanna Hästbacka

“…Introduction: COVID-19 survivors may present with cognitive and psychiatric symptoms long after the acute phase of SARS-CoV-2 infection. …”
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Characteristics and nutritional value of cookies fortified with debittered salmon (Salmo salar) frame protein hydrolysate by Kartik Sharma, Mallikarjun Chanchi Prashanthkumar, Umesh Patil, Lukai Ma, Soottawat Benjakul

“…The rising demand for nutrient-enriched snacks presents an opportunity to develop functional foods to tackle malnutrition problems. …”
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Application of Eco-Feed Produced by Aurantiochytrium sp. L3W Using Solid Food Waste for Producing Hirodai-dori Products Containing Omega-3 Fatty Acids by Brilian Pamungkas, Wataru Asao, Satoshi Nakai, Takahiro Nii, Wataru Nishijima, Takehiko Gotoh, Toshikazu Suenaga, Nurlaili Humaidah, Masaoki Tsudzuki

“…These findings have demonstrated that a biomass mixture containing Aurantiochytrium sp. strain L3W could be used as a functional eco-feed to increase and maintain the content of n-3FAs in chicken meat.…”
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The Aquatic Metatron: A large‐scale experimental facility to study the combined effects of habitat fragmentation and climate change on aquatic meta‐ecosystems by Murielle Richard, Alexandre Garreau, Elvire Bestion, Julien Cucherousset, Jose M. Montoya, Simon Blanchet

“…Abstract Revealing the effects of multiple global change drivers on ecosystem dynamics and functioning is a crucial endeavour, which necessitates the use of appropriate tools. …”
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Cytokine Storm in Pathogenesis of COVID-19 Complications by Olga V. Rasputniak, Tetiana I. Gavrilenko, Olena A. Pidgaina, Liudmyla M. Shnaider, Oleksandr M. Lomakovskyi, Sviatoslav A. Kalashnikov

“…In COVID-19 patients, pyroptosis triggers the release of proinflammatory cytokines and affects macrophage and lymphocyte functions, causing peripheral lymphopenia. Cytokine storm is characterized by a clinical presentation of overwhelming systemic inflammation, hyperferritinemia, hemodynamic instability, and multi-organ failure. …”
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The Surface Water and Ocean Topography Mission (SWOT) Prior Lake Database (PLD): Lake Mask and Operational Auxiliaries by Jida Wang, Claire Pottier, Cécile Cazals, Marjorie Battude, Yongwei Sheng, Chunqiao Song, Md Safat Sikder, Xiao Yang, Linghong Ke, Manon Delhoume, Marielle Gosset, Rafael Reis Alencar Oliveira, Manuela Grippa, Félix Girard, George H. Allen, Xiangtao Xu, Xiaolin Zhu, Sylvain Biancamaria, Laurence C. Smith, Jean‐François Crétaux, Tamlin M. Pavelsky

“…Operational auxiliaries were produced from multi‐theme geospatial data to provide essential information for PLD functionality, including lake catchments and influence areas, ice phenology, relationship with SWOT prior rivers, and spatiotemporal coverage by SWOT overpasses. …”
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Analysis of mutations in precision oncology using the automated, accurate, and user-friendly web tool PredictONCO by Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Adam Dobias, Joan Planas-Iglesias, Stanislav Mazurenko, Ihor Arefiev, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Jiri Damborsky, Ondrej Slaby, David Bednar

“…Next-generation sequencing technology has created many new opportunities for clinical diagnostics, but it faces the challenge of functional annotation of identified mutations. Various algorithms have been developed to predict the impact of missense variants that influence oncogenic drivers. …”
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Simulating Image Coaddition with the Nancy Grace Roman Space Telescope. III. Software Improvements and New Linear Algebra Strategies by Kaili Cao, Christopher M. Hirata, Katherine Laliotis, Masaya Yamamoto, Emily Macbeth, M. A. Troxel

“…I mcom is an image coaddition algorithm that offers control over point-spread functions in output images. This paper presents the refactored I mcom software, featuring full object-oriented programming, improved data structures, and alternative linear algebra strategies for determining coaddition weights. …”
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