Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…Experimental validation of gene expression was performed via immunohistochemistry (IHC) and functional assays in gene-modified melanoma cell lines.ResultsTwenty-two genes involved in KRAS signaling were identified as critical for patient survival. …”
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Towards the mechanical stability of biocrusts in drylands: Insights from inorganic ions and organic compounds and their interactions by Xingxing Yu, Bo Xiao, Yousong Cao, Stephen R. Hoon, Giora J. Kidron

“…Biocrusts are an important component of dryland ecosystems as they perform crucial ecological functions like stabilizing soils, mediating the hydrological cycle, and improving nutrient availability. …”
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Western Mediterranean shelf-incised submarine canyons: multi-proxy evidence of Late Holocene natural and human-induced environmental changes by Adrián López-Quirós, Ángel Puga-Bernabéu, Francisco José Lobo, Elvira Ruíz-Caballero, Elvira Ruíz-Caballero, Javier Cerrillo-Escoriza, José N. Pérez-Asensio, Isabel Mendes, Anxo Mena, Natalia Puche-Polo, Natalia Puche-Polo, Tomás Alberjón-Peñas, Tomás Alberjón-Peñas, Lukas Wacker

“…The Motril Canyon primarily functioned as a river-fed sediment trap, accumulating fine-grained terrigenous material from the Guadalfeo River. …”
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Investigation of the «Structure – analgesic activity» Relationship Using Molecular Docking for Cyclooxygenases 1 and 2 in the Series 5-<i>N</i>-arylaminocarbonyl-6-(get)aryl-4-meth... by N. A. Buzmakova, K. V. Аndryukov, T. M. Zamaraeva, I. P. Rudakova, K. V. Podchezertseva, A. S. Goman, E. V. Avdeeva, N. V. Slepova, N. V. Dozmorova

“…Molecular modeling methods are very popular in the scientific community at the present time. The value of the pharmacological action depends on the affinity of the substance to the biological target. …”
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Effectiveness of a multicomponent intervention to promote physical activity during the school day: rationale and methods of the MOVESCHOOL study by Francisco J. Bandera-Campos, Francisco J. Bandera-Campos, Alberto Grao-Cruces, Alberto Grao-Cruces, Daniel Camiletti-Moirón, Daniel Camiletti-Moirón, Fátima Martín-Acosta, Fátima Martín-Acosta, Raúl Muñoz-González, María González-Pérez, María González-Pérez, Abel Ruiz-Hermosa, Abel Ruiz-Hermosa, Miguel Vaquero-Solís, Miguel Vaquero-Solís, Carmen Padilla-Moledo, Carmen Padilla-Moledo, David Sánchez-Oliva, David Sánchez-Oliva, David Sánchez-Oliva

“…However, evidence concerning adolescents remains limited. This manuscript presents the methods and rationale of the MOVESCHOOL study, which aims was to examine the effects of a multicomponent school-based intervention during the school day on indicators of PA, sedentary time, health, executive functions and education in adolescents.MethodsA quasi-experimental study was conducted with the aim to involve a total of 800 students aged 12–14 years old from 11 schools (7th and 8th grade) in south-western Spain, five schools forming the intervention group and six schools forming the control group. …”
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Sulfur-rich deposits associated with the deep submarine volcano Fani Maoré support broad microbial sulfur cycling communities by Stéven Yvenou, Mélanie Le Moigne, Olivier Rouxel, Johanne Aubé, Blandine Trouche, Cécile Cathalot, Emmanuel Rinnert, Xavier Philippon, Sandrine Chéron, Audrey Boissier, Vivien Guyader, Yoan Germain, Anne Godfroy, Erwan G. Roussel, Karine Alain

“…Genome-resolved metagenomics, culture-based functional approaches, geochemical and mineralogical analyses were combined to characterize the geological and physico-chemical constraints of the environment surrounding the yellow deposit part of this hotspot volcano and the composition and functions of its microbial community. …”
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Comparison of Protective Effects of Polyphenol-Enriched Extracts from Thinned Immature Kiwifruits and Mature Kiwifruits against Alcoholic Liver Disease in Mice by Wen Deng, Qian-Ni Yang, Ding-Tao Wu, Jie Li, Hong-Yan Liu, Yi-Chen Hu, Liang Zou, Ren-You Gan, Hui-Ling Yan, Jing-Wei Huang

“…However, knowledge about the protective effects of polyphenol-enriched extract from TIK against ALD is still lacking, which ultimately restricts their application as value-added functional products. To promote their potential applications, phenolic compounds from TIK and their corresponding mature fruits were compared, and their protective effects against ALD were studied in the present study. …”
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Cell-Specific Vulnerability of Human Glioblastoma and Astrocytoma Cells to Mephedrone—An In Vitro Study by Marta Marszalek-Grabska, Marta Kinga Lemieszek, Michal Chojnacki, Sylwia Winiarczyk, Joanna Jakubowicz-Gil, Barbara Zarzyka, Jarosław Pawelec, Jolanta H. Kotlinska, Wojciech Rzeski, Waldemar A. Turski

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Numerical case study on thermal efficiency and predictive thermal management in Type-4 wind turbines by Wajid Khan, Feng Renhai, Abdul Aziz, Muhammad Zain Yousaf, Baseem Khan, Josep M. Guerrero

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Self‐Adaptive Reflectance Film for Passive Temperature Regulation in Diverse Environments by Shuo Yang, Sizhe Tang, Yufeng Cai, Zhiming Ye, Xiangbin Zou, Xueyu Yuan, Yujie Song, Bing Li, Dongyan Tang, Ming Liu

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Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human by Delia Susan-Resiga, Nabil G Seidah, Nathalie Labrecque, Jean-Sebastien Delisle, Leila Jafarzadeh, Chloé Porcheron, Mailys Le Devehat, Anna Roubtsova, Hadi Bayat, Alexandra Evagelidis, Vatsal Sachan, Alexie Fonta Holder, Rachid Essalmani, Gabrielle Boudreau, Annik Prat, Rebecca Cusseddu, Jean-François Côté, Abdel-Majid Khatib

“…Indeed, Pcsk9−/− mice were previously reported to exhibit reduced liver tumor metastasis. In the present studies, we report synergistic and complementary functions of PCSK7 and PCSK9, as the loss of each one of the convertases reduced by twofold the number of liver metastases, but the strongest reduction (&gt;90%) was observed in double KO (Pcsk7−/−, Pcsk9−/−) mice. …”
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Comparison of the Effect of Different Percentages of Sesame Oil and Soybean Oil on Growth Performance, the Weight of Internal Organs, and Serum Biochemical Parameters in Japanese q... by Maryam Karimi-Dehkordi, Forogh Mohammadi, Majid Gholami-Ahangaran

“…Sesame oil contains compounds called lignans, such as sisamin, sisamulin, and small amounts of sisamol, and has many different physiological functions, such as reducing blood fat, reducing the level of arachidonic acid, increasing antioxidant capacity, increasing the bioavailability of gamma-tocopherol, and anti-inflammatory functions. …”
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Large language models meet user interfaces: The case of provisioning feedback by Stanislav Pozdniakov, Jonathan Brazil, Solmaz Abdi, Aneesha Bakharia, Shazia Sadiq, Dragan Gašević, Paul Denny, Hassan Khosravi

“…A significant portion of the current use of LLMs by educators has involved using conversational user interfaces (CUIs), such as chat windows, for functions like generating educational materials or offering feedback to learners. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…These cytokines facilitate the maturation of DCs and antigen presentation, ultimately enhancing T cell-mediated anti-tumor immunity. …”
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Unveiling the chemical composition, antioxidant and antibacterial properties, and mechanistic insights of Convolvulus arvensis extract through molecular docking simulations by Fatemeh Mosallaie, Motahare Pirnia, Zahra Dehghan, Fereshteh Falah, Reihaneh Sabbaghzadeh, Behrooz Alizadeh Behbahani, Fahimeh Lavi Arab, Farideh Tabatabaei Yazdi, Alireza Vasiee

“…High Performance Liquid Chromatography (HPLC) and Fourier transform infrared (FTIR) spectroscopy were utilized to identify the chemical composition and functional groups present in the extract. The findings revealed that ultrasound-assisted extraction exhibited significantly higher extraction efficiency (p < 0.05). …”
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Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome by Anusha Chaudhuri, Soumita Paul, Mayukh Banerjea, Biswadip Das

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Abstract 073: Thrombectomy Alone Versus Bridging Intravenous Alteplase in A US Population: Regression Discontinuity Analysis by Ngoc Mai Le, Youngran Kim, Sergio Salazar‐Marioni, Arash Niktabe, Anjan Ballekere, Rania Abdelkhaleq, Ananya Iyyangar, Hussain Azeem, Diogo Haussen, Jonathan Grossberg, Jaydevsinh Dolia, Aqueel Pabaney, Mahmoud Mohammaden, Shahram Majidi, Johanna T. Fifi, Thanh Nguyen, Mohamad Abdalkader, Piers Klein, Rebecca Sugg, Ameer Hassan, Wondwossen Tekle, David Liebeskind, Italo Linfante, Hamzah Saei, Gabrielle Valestin, Santiago Ortega‐Gutierrez, James Siegler, Brijesh Mehta, Guillermo Linares, Mouhammad Jumaa, Joy Sessa, Sunil Sheth, Raul Nogueira

“…There were no substantial differences in presentation characteristics between patients treated with IV tPA and without. …”
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Habilidades técnicas del portero de hockey patines en la falta directa (The technical skills of rink hockey goalkeeper in direct free hit) by Guillem Trabal Tañá, Gabriel Daza, Joan Riera

“…Abstract. The aim of the present study was to identify the technical skills of the rink hockey goalkeeper in the direct free hits in the high competition, proposing, at the same time, the functional structure of the technical skills and highlighting the most effective chains. …”
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Immunophenotyping of colon cancer for identification of potential antigens for colon cancer vaccines by Xuan Wang, Xuan Wang, Jingjiang Lai, Dawei Wang, Keyi Wei, Jing Yang

“…Drug sensitivity, immune cell infiltration, and gene set variation were analyzed using R packages such as “pRRophetic,” CIBERSORT, and GSVA. Functional enrichment analysis was performed with GO, KEGG, and GSEA. …”
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Distonia virtual por infarto talâmico posterolateral ventral: relato de caso Virtual dystonia due to a posteroventrolateral thalamic infarct: case report by Ricardo De Oliveira-Souza, Maria Elena de Lima Martins, Pedro Ângelo Andreiuolo, Andreia Rotmeister

“…O presente trabalho relata o caso de um diabético hipertenso acometido de uma forma fragmentária da síndrome de Dejerine-Roussy e "sensação de câimbra dolorosa" nos artelhos quando se deitava ou removia o pé do contato com o chão. …”
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