Bioengineered cardiovascular bypass grafts via in vivo self-assembly of scaffold-guided tubular tissue in rats by Shiqi Hu, Xiuhong Sun, Rui Zhou, Kai Fu, Yunfei Mo, Jialin Xu, Xiaoyan Shen, Shiwen Liu, Yuqing Niu

“…However, the clinical application of traditional grafts is hampered by limited autologous vessel availability, while the translational potential of fully cellular self-assembled vascular grafts is constrained by their prolonged fabrication. Here, we present a scaffold-guided in vivo tubular tissue self-assembly strategy to rapidly engineer functional cardiovascular bypass grafts. …”
Get full text

The S-PLUS Fornax Project (S+FP): Mapping Globular Clusters Systems within 5 Virial Radii around NGC 1399 by Luis Lomelí-Núñez, A. Cortesi, A. V. Smith Castelli, M. L. Buzzo, Y. D. Mayya, Vasiliki Fragkou, J. A. Alzate-Trujillo, R. F. Haack, J. P. Calderón, A. R. Lopes, Michael Hilker, M. Grossi, Karín Menéndez-Delmestre, Thiago S. Gonçalves, Ana L. Chies-Santos, L. A. Gutiérrez-Soto, Ciria Lima-Dias, S. V. Werner, Pedro K. Humire, R. C. Thom de Souza, A. Alvarez-Candal, Swayamtrupta Panda, Avinash Chaturvedi, E. Telles, C. Mendes de Oliveira, A. Kanaan, T. Ribeiro, W. Schoenell

“…We present the largest sample (∼13,000 candidates, ∼3000 of which are bona fide candidates) of globular cluster (GCs) candidates reported in the Fornax cluster so far. …”
Get full text

Light-activated decellularized extracellular matrix-based bioinks for enhanced mechanical integrity by Minji Kim, Dayoon Kang, Hohyeon Han, Jinah Jang

“…The advent of photocrosslinking technologies marks a paradigm shift, with light-activated functional groups such as methacrylates, thiol-enes, and phenols substantially improving the gelation efficiency, mechanical properties, and spatial fidelity of the printed constructs. …”
Get full text

Assessment of the use of Unna boot in the treatment of chronic venous leg ulcers in adults: systematic review protocol by Thalita Paranhos, Caroline S B Paiva, Fernanda C I Cardoso, Priscila P Apolinário, Flavia Figueiredo Azevedo, Maria G B Saidel, Henrique C Oliveira, Ariane P Dini, Ana R S O Kumakura, Maria H Melo Lima

“…Introduction Chronic venous insufficiency (CVI) is an anomaly of the normal functioning of the venous system caused by valvular incompetence with or without the obstruction of venous flow. …”
Get full text

Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity by Chengmeng Bai, Huifang Ren, Feng Zhang, Dandan Li, Qingyu Feng, Ying Li, Ting Chen, Chengxu Li, Xuan Xiao, Hengrui Zhang, Liang Hu

“…Concurrently, sEV cargo undergoes remodeling to enrich regenerative and immunoregulatory functions. These findings demonstrate the efficacy of our established platform in advancing sEV production and improving clinical performance, providing a novel sEV-based mechanism for ocular treatments, including corneal epithelialization and even retinal neural regeneration.…”
Get full text

An Efficient pH Detector for Water Contamination Based on Mach–Zehnder Interferometer Application by Mario Angel Rico-Mendez, Romeo Selvas, Oxana V. Kharissova, Daniel Toral-Acosta, Norma Patricia Puente-Ramirez, Ricardo Chapa-Garcia, Abraham Antonio Gonzalez-Roque

“…This paper presents a pH sensor with a Mach–Zehnder Interferometer (MZI) that operates in solutions of 4.0, 7.0, and 10.0. …”
Get full text

Research Progress and Hotspots Analysis of Apoplastic Barriers in the Roots of Plants Based on Bibliometrics from 2003 to 2023 by Chongyuan Qin, Ruoqi Li, Zhuoran Tan, Jingnan Zhang, Yuyang Sun, Jinji Han, Xiaoxia Deng, Fei Wang, Qingjie Yang, Jinghong Wang, Jixiang Lin

“…The present study provides a further understanding of the trends in apoplastic barriers, and the data analyzed can be used as a guide for future research directions.…”
Get full text

A Comparative Study of Machine Learning Models for Accurate E-Waste Prediction by Mohammed Algafri, Mohammed Sayad, Mohammad A.M. Abdel-Aal, Ahmed M. Attia

“…The rapid growth of electrical and electronic equipment waste (e-waste) presents a major environmental challenge. Traditional linear production models fail to optimize resource recovery, while circular economy (CE) strategies remain underutilized due to inadequate forecasting methods. …”
Get full text

Nutritional profiling, phytochemical screening, cytotoxicity, and antioxidant content analysis for different crude extracts of Ulva lactuca from coast of Bangladesh by S.M. Bokhtiar, D. Sarker, Alima Akter, M.A. Salam, K.U. Ahmed, M.M. Anwar, M.F. Hossain, M. Ahmed, M.S. Bhuiyan, R.A. Kanta, A.K.M. Asaduzzaman, Khondoker Shahin Ahmed, Hemayet Hossain, S.M. Rafiquzzaman

“…Cytotoxicity was found to be present in a dose-dependent manner. These results indicated that dried powder and extracts of UL contain macro-micro nutrients, and diversified phytochemicals with potential antioxidant activity.…”
Get full text

Three‐dimensional fine structures of the maculae flavae of the human vocal fold using correlative light and electron microscopy by Kiminobu Sato, Takashi Kurita, Fumihiko Sato, Keisuke Ohta, Kiminori Sato, Shun‐ichi Chitose, Takeharu Ono, Hirohito Umeno

“…The extracellular matrices surrounding each three types of cell in the MFe differed, suggesting the cells were different in functional property. Conclusion CLEM is a useful technique to observe the three‐dimensional fine structures of the human vocal fold mucosa. …”
Get full text

New High-Affinity Peptide Ligands for Kv1.2 Channel: Selective Blockers and Fluorescent Probes by Anastasia A. Ignatova, Elena V. Kryukova, Valery N. Novoseletsky, Oleg V. Kazakov, Nikita A. Orlov, Varvara N. Korabeynikova, Maria V. Larina, Arkady F. Fradkov, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexey V. Feofanov, Oksana V. Nekrasova

“…Advanced molecular probes are required to study the functional activity of the Kv1.2 potassium channel in normal and pathological conditions. …”
Get full text

Soil and vegetation responses to biochar application in terms of its feedback on carbon sequestration under different environmental conditions—LiDELS model overview by M Maslouski, A Eschenbach, C Beer, S Thomsen, P Porada

“…LiDELS simulates the impacts of biochar on key soil functions, including water retention, thermal properties, evapotranspiration rates, and net primary production (NPP). …”
Get full text

Characterization and quantification of two acylated flavonol glycosides from Camellia sinensis and their antibacterial effect on oral pathogens by Feifei Zhou, Leiyu Yang, Yingjie Gu, Zhiwei Ge, Yanmei Huang, Hangye Zhao, Bo Li, Puming He, Jiangfan Yang, Youying Tu, Yuanyuan Wu

“…Acylated flavonol glycosides (AFGs) are a new group of flavonoids with multiple pharmacological functions. In the present work, two AFGs were isolated with a combined chromatography technology from Camellia sinensis and identified as quercetin tetraglycosides with one p-coumaryl moiety (F1) and kaempferol tetraglycosides with one p-coumaryl moiety (F2) by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) and nuclear magnetic resonance (NMR). …”
Get full text

Microfluidic Synthesis of Magnetic Silica Aerogels for Efficient Pesticide Removal from Water by Dana-Ionela Tudorache (Trifa), Adelina-Gabriela Niculescu, Alexandra-Cătălina Bîrcă, Denisa Alexandra Florea, Marius Rădulescu, Bogdan-Ștefan Vasile, Roxana Trușcă, Dan-Eduard Mihaiescu, Tony Hadibarata, Alexandru-Mihai Grumezescu

“…Specifically, this study presents the novel synthesis of a magnetic silica-based aerogel using a custom-designed 3D microfluidic platform, offering enhanced control over nanoparticle incorporation and gelation compared to conventional sol–gel techniques. …”
Get full text

Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy by Veera Vijaya Basamshetty, Vijay Kumar Gangipangi, Uppulapu Shravan Kumar, Santhosh Shanthi Bhupathi, Sridhar Reddy Kaulagari, Prashant Giri, Swapnil Sinha, Utpal Mohan, Konstantinos Sdrimas

“…In vivo, our novel DNAzymes significantly suppressed tumor growth in a syngeneic mouse breast cancer model, with efficacy comparable to 5-Fluorouracil. This study presents a proof of concept for a novel strategy to evolve functional DNAzymes against native mRNA sequences and highlights their potential as gene-silencing tools in cancer therapy. …”
Get full text

An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers by Xiaoliang Qi, Yajing Xiang, Ying Li, Jiajia Wang, Yuxi Chen, Yulong Lan, Jinsong Liu, Jianliang Shen

“…Moreover, the bioactive components in ISD3 can exert anti-inflammatory functions, aiding in pressure ulcer recovery. Overall, our research introduces a hydrogel prodrug strategy activated by bacterial endogenous ATP, which precisely manages ROS generation and accelerates the recovery of MDR bacteria-infected pressure ulcers.…”
Get full text

Key Proteins in Rat Cerebral Cortex: Application of <i>Cornu aspersum</i> Extract as a Neuroprotective Agent in Alzheimer’s Type Dementia by Ventseslav Atanasov, Lyudmila Velkova, Lyubka Tancheva, Aleksandar Dolashki, Reni Kalfin, Pavlina Dolashka

“…Recently, it was found that mucus extract from <i>Cornu aspersum</i> has beneficial effects on memory and cognitive processes in a rat scopolamine model of AD. The present study elucidated the mechanisms of action of standardized mucus snail extract (SE) enriched with a fraction above 20 kDa on Alzheimer-type dementia in rats. …”
Get full text

Vaccination of a Patient with Rett Syndrome: Case Report by Tatiana A. Kaliuzhnaia, Marina V. Fedoseenko, Nato D. Vashakmadze, Nataliya V. Zhurkova, Firuza Ch. Shakhtakhtinskaya, Svetlana V. Tolstova, Arevaluis M. Selvyan, Olga Ya. Smirnova, Leonid M. Yatsik, Svetlana G. Gubanova, Svetlana E. Kondratova, Leyla S. Namazova-Baranova

“…The article presents a case report of a 5-year-old girl with Rett syndrome who was vaccinated later than the date indicated in the national calendar of preventive vaccinations of the Russian Federation and did not have all the necessary preventive vaccinations for her age. …”
Get full text

The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes by Peter A. Barbuti, Cristina Guardia-Laguarta, Taekyung Yun, Zena K. Chatila, Xena Flowers, Chantel Wong, Bruno F. R. Santos, Simone B. Larsen, James S. Lotti, Nobutaka Hattori, Elizabeth Bradshaw, Ulf Dettmer, Saranna Fanning, Vilas Menon, Hasini Reddy, Andrew F. Teich, Rejko Krüger, Estela Area-Gomez, Serge Przedborski

“…Previously, we identified that αSyn localizes, at least in part, to mitochondria-associated endoplasmic reticulum membranes (MAMs), which are transient functional domains containing proteins that regulate lipid metabolism, including the de novo synthesis of phosphatidylserine. …”
Get full text

Expose flexible conformations for intrinsically disordered protein by Jiaan Yang, Wenxin Ji, Wen Xiang Cheng, Gang Wu, Si Tong Sheng, Peng Zhang, Jun Lin, Xiaojia Chen, Qiong Shi

“…The folding conformation of native protein has flexibility in different degrees, which may bring difficulty in presenting the structures, and also it causes complexity in understanding the relationship between structure and functions. …”
Get full text