Multi-omics-based subtyping of melanoma suggests distinct immune and targeted therapy strategies by Changchang Li, Xiaoqiong Lin, Jinhui Wang, Qiaochu Zhou, Fangfang Feng, Jie Xu

“…Multi-layered data, including transcriptomic, genomic, epigenetic, and immune landscape profiles, were analyzed using unsupervised clustering and machine learning approaches to define molecular subtypes. Functional assays and in silico drug screening were employed to explore subtype-specific vulnerabilities.ResultsThree robust molecular subtypes (CS1, CS2, CS3) were identified, each with distinct genomic alterations, tumor microenvironment characteristics, and clinical outcomes. …”
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The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus. by Joseph C Ward, Lidia Lasecka-Dykes, Chris Neil, Oluwapelumi O Adeyemi, Sarah Gold, Niall McLean-Pell, Caroline Wright, Morgan R Herod, David Kealy, Emma Warner, Terry Jackson, Donald P King, Tobias J Tuthill, David J Rowlands, Nicola J Stonehouse

“…In particular, pseudoknot (PK) structures, which are present in a wide range of RNA molecules, have a variety of roles. …”
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Developing and Implementing a Risk Analysis-Based Model for Effective Management of Protected Areas by Yehia Miky, Usama Hamed Issa, Kamil Faisal, Moataz Nael Kordi, Khalaf Finassani Alshammari

“…Managing protected areas (PAs) supports protecting biodiversity and preserves ecological functions. Many risks associated with PAs management affect the most important goals of PAs including sustainability, effectiveness, and ecological balance. …”
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RAFU’s Network Diplomacy: Cultivating the BRICS Spirit in Education by ZALYVSKIY Maxim Nikolaevich, DE OLIVEIRA BUNDER Tulio Cezar

“…In their article, the Russian and Brazilian researchers present a theoretical overview of the concept of network diplomacy, focusing on its importance for the development of cooperation in science, culture, and education. …”
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Musculoskeletal Ultrasound Assessment of the Clinical Efficacy of the Combination of Acupressure and “Three Methods of Neck Movement (TCM)” Therapy in the Treatment of... by Zuo J, Zeng X, Ma H, Chen P, Cai X, Fan Z, Qu J

“…Assessments will be conducted using musculoskeletal ultrasound, the McGill Pain Scale, and the Neck Disability Index (NDI) at three-time points: before treatment, at the end of treatment, and after 12 and 16 weeks of treatment.Conclusion: This paper investigates the utility of musculoskeletal ultrasound as a tool for evaluating the therapeutic efficacy of an integrated Traditional Chinese Medicine (TCM) strategy in alleviating pain and enhancing functional outcomes for patients with NTCS. The objective is to present a clinically viable and long-term treatment option.Trial Registration: Chinese Clinical Trial Registry, ChiCTR2300072648. …”
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A comprehensive review on the adsorptive removal of pharmaceutical pollutants: Occurrence, toxicology, molecular simulation and mechanistic insights by Mochamad Lutfi Firmansyah, Yousef Alwan, Nisar Ullah

“…Moreover, the influence of porosity, surface area, and functional groups on the adsorption efficiency has been discussed. …”
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Automated Geographic Information System Multi-Criteria Decision Tool to Assess Urban Road Suitability for Active Mobility by Bertha Santos, Sandro Ferreira, Pollyanna Lucena

“…The Model Builder functionality available in ArcGIS^® was used to automate the various processes required to calculate walking, cycling, and e-biking travel times, as well as the mobility indices. …”
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TECAR Therapy: A Clinical Commentary on its Evolution, Application, and Future in Rehabilitation by Lewis G. Lupowitz, Laura Ramus, Frederic Delacour, Ken Johnson

“…This technique utilizes radiofrequency energy to promote tissue healing, pain management, and functional recovery, offering a unique approach to address musculoskeletal injuries and conditions…”
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Exploring local knowledge and perceptions on zoonoses among pastoralists in northern and eastern Tanzania. by Peter Ernest Mangesho, Moses Ole Neselle, Esron D Karimuribo, James E Mlangwa, Kevin Queenan, Leonard E G Mboera, Jonathan Rushton, Richard Kock, Barbara Häsler, Angwara Kiwara, Mark Rweyemamu

“…A number of social and cultural practices aimed at maintaining specific cultural functions including social cohesion and rites of passage involve animal products, which present zoonotic risk.…”
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Evaluating and supporting leadership, management, and mentoring: a framework for catalyzing responsible research and healthy research environments by Tristan McIntosh, Alison L. Antes

“…A variety of sources and types of evaluation measures may be used to comprehensively assess the functioning of a research team and its leader(s). We illustrate key domains for measurement, example indicators of effectiveness in those domains, and examples of the types of measures that could be used for evaluation. …”
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Effect and mechanism of Dichloroacetate in the treatment of stroke and the resolution strategy for side effect by Xu Wang, Chunshu Rong, Wei Leng, Ping Niu, Ziqiao He, Gaihua Wang, Xin Qi, Dexi Zhao, Jinhua Li

“…This process is essential for the maintenance of important brain functions and has important implications for recovery after stroke. …”
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Well completion technology optimization and application effect analysis of medium-deep sandstone reinjection wells: A case study of Minghuazhen Formation in Tianjin by ZHAO Yanting,SHEN Jian,ZHAO Sumin,WEN Shuang,ZHANG Sen

“…The Minghuazhen Formation in the Cangxian Uplift of Tianjin presents a unique challenge for geothermal resource development due to its sandstone reservoirs. …”
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Effects of Hip Muscle Resistance Training With and Without Feedback on Trunk, Pelvis, and Lower Extremity Motions by Malihe Hadadnezhad, Bahram Sheikhi

“…Introduction: The present study aimed to compare hip muscle resistance training with and without feedback on trunk, pelvis, and lower extremity motions in frontal and sagittal planes among active females with dynamic valgus.Materials and Methods: Twenty-Nine active females (Mean±SD age: 22.8±2.4 years, height: 1.70±0.6 m, weight: 69±7.1 kg) were randomly assigned to a hip muscle resistance training with feedback group (n=15) or a hip muscle resistance training without feedback group (n=14). …”
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Sructural rearrangements of NTRK genes: characteristics, methods of detection and targeted therapy for cancer by A. A. Kechin, A. I. Andriyanova, M. L. Filipenko

“…The purpose of the study was to present upto-date data on the structure and functions of ntrk genes, the frequency of occurrence of rearrangements with their participation, the consequences of their occurrence at the cellular level, methods of detecting such rearrangements, as well as targeted drugs used in the presence of chimeric NTRK genes. …”
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10 MW FOWT Semi-Submersible Multi-Objective Optimization: A Comparative Study of PSO, SA, and ACO by Souleymane Drabo, Siqi Lai, Hongwei Liu, Xiangheng Feng

“…The present study aims to carry out a comparative Multi-Objective Optimization (MOO) of a 10 MW FOWT semi-submersible using three different metaheuristic optimization techniques and a sophisticated approach for optimizing a floating platform. …”
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Multi-module UNet++ for colon cancer histopathological image segmentation by Qi Liu, Zhenfeng Zhao, Yingbo Wu, Siqi Wu, Yutong He, Haibin Wang, Shenwen Wang

“…With the continuous advancement of deep learning techniques—particularly encoder-decoder architectures—and the emergence of various high-performance functional modules, multi module collaborative fusion has become an effective approach to enhance segmentation performance. …”
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Experimental and computational study on electronic and photovoltaic properties of chromen-2-one-based organic dyes used for dye-sensitized solar cells by Elshafie A.M. Gad, E.M. Kamar, Mahmoud A. Mousa

“…The polarizability (<α > ), the anisotropy of the polarizability (<Δα > ), ground-state dipole moment (µ) and the first-order hyperpolarizability (β) of the dyes were studied at Density Functional Theory (DFT) using Gaussian 09 and Gauss View v.6.0 based on keywords: “opt freq b3lyp/6-311G++(d,p) guess = mix pop=(nbo, savenbos) geom = connectivity polar = optrot. …”
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Psychological distress and coping in military cadre candidates by Nakkas C, Annen H, Brand S

“…Results: Recruits selected for promotion had lower scores for depressive symptoms and hostility, engaged more in active coping, and considered their coping to be more effective. Dysfunctional and functional coping were associated with higher and lower distress levels, respectively. …”
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Influence of Solenopsis invicta Buren on soil chemical properties, silicon pools, and phytolith assemblages in organic agricultural soils by Carlos Alberto Ribeiro de Moura, Eduardo Carvalho da Silva Neto, Marcos Gervasio Pereira, Maria Elizabeth Fernandes Correia

“…ABSTRACT Ants mediate ecosystem services that can modulate crop performance and overall agroecosystem functioning. Our study investigated how the activity of Solenopsis invicta Buren (Hymenoptera: Formicidae) influences soil chemical properties, soil silicon pools, and soil phytoliths. …”
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The conflict between oral health and patient autonomy in dentistry: a scoping review by Szilárd Dávid Kovács, Anggi Septia Irawan, Szilvia Zörgő, József Kovács

“…Adjacent to topics such as medical assistance in dying and healthy limb amputation, this ethical dilemma also manifests in the care of the maxillofacial region (the oral cavity and its surroundings), an area crucial to esthetic appearance, but also to everyday functions including mastication, speech, and facial expression, all of which are related to well-being. …”
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