Streptomyces rare codon UUA: from features associated with 2 adpA related locations to candidate phage regulatory translational bypassing by Ivan V. Antonov, Sinéad O’Loughlin, Alessandro N. Gorohovski, Patrick B.F. O’Connor, Pavel V. Baranov, John F. Atkins

“…UUA codons are exceptionally rare in Streptomyces, and its functional cognate tRNA is not present in a fully modified and acylated form, in the early and vegetative phase of the cell cycle though it is aminoacylated later. …”
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Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury by Roxana Surugiu, Bogdan Catalin, Danut Dumbrava, Andrei Gresita, Denisa Greta Olaru, Dirk M. Hermann, Aurel Popa-Wagner

“…However, to date, no effective therapy exists that targets the functional recovery after stroke. After necrosis, neuroinflammation is a common feature of the acute stroke and a major obstacle to tissue restoration. …”
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A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells by Xiaobing Han, Liangxin Chen, Peng Sun, Xiuqing Wang, Qian Zhao, Lingfeng Liao, Dejin Lou, Nan Zhou, Yujun Wang

“…Analysis of protein expression was done by western blot or immunofluorescence assay. The functions of the polypeptide were determined by detecting its effects on cell viability, proliferation, migration, invasion, and pemetrexed (PEM) sensitivity. …”
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ScreenSafeFuture: A parent-empathetic and pragmatic mhealth application for toddlers' brain development addressing screen-addiction challenges by Nafisa Anjum, Md. Mehedi Hasan, Syeda Umme Salma, Liang Zhao, Maria Valero de Clemente, Nazmus Sakib

“…The solution includes essential features designed to enhance the experience between parents and their children under 3 years old encompassing an alternative activity advocator for a personalized parent-offspring scenario, screen time tracking based on current standards, an educational reservoir for parents, and a rewarding system for long-term user engagement. This paper presents a functional ScreenSafeFuture iOS prototype, that will undergo parent usability testing, followed by continuous advancements based on user feedback. …”
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Repositioning Perindopril for Mitigation of Methotrexate-Induced Hepatotoxicity in Rats by Hanan Abdelmawgoud Atia, Hemat A. Elariny, Marwa H. Abdallah, Amany M. Khalifa, Remon S. Estfanous, Maaly A. Abd Elmaaboud, Ahmed M. Kabel

“…<b>Conclusions:</b> This study presents perindopril as a promising remedy for mitigation of the hepatotoxic effects that occur as a consequence of treatment with methotrexate.…”
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Cyber-Physical Systems Enabled Transport Networks in Smart Cities: Challenges and Enabling Technologies of the New Mobility Era by Amit Pundir, Sanjeev Singh, Manish Kumar, Anil Bafila, Geetika J. Saxena

“…The development of urban structures, functionality, and prosperity are intricately connected to how the city designs its mobility infrastructure. …”
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Exophytic pancreatic lymphoepithelial cyst incidentally detected in a differentiated thyroid cancer patient on whole-body I-131 scan: a case report by Takahiro Murokawa, Takehiro Okabayashi, Kazuyuki Oishi, Kenta Sui, Motoyasu Tabuchi, Jun Iwata

“…Abstract Background Radioiodine (I-131) whole-body scintigraphy (WBS) is a useful modality for identifying functionally preserved thyroid tissue and metastases from differentiated thyroid cancer (DTC); however, the specificity of I-131 uptake is limited, and its accumulation in the pancreas has not been well described. …”
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Scrolling to Success: A Systematic Analysis of Social Media&#x2019;s Role in Scholarly Communications by Nur Syazwani Ahmad, Ali Fauzi, Samsul Farid Samsuddin, Shamshul Bahri

“…This study presents the first comprehensive systematic literature review examining the patterns and trends of social media use among Asian scholars for scholarly communication and the advancement of digital scholarship. …”
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Rapid Identification of Constituents in <i>Polygonatum cyrtonema</i> Hua Using UHPLC-Q-Exactive Orbitrap Mass Spectrometry by Qingrui Yang, Jieyao Ma, Shenlong Yan, Suyu Yang, Lingxuan Fan, Yanghui Huo, Bowen Gao, Wei Cai

“…As a traditional tonic herb, the rhizome of PCH has been widely used as a functional food and traditional Chinese medicine, mainly for the treatment of spleen and lung Qi deficiency, essence and blood deficiency, internal heat, and thirst. …”
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Modeling of Chemiresistive Gas Sensors: From Microscopic Reception and Transduction Processes to Macroscopic Sensing Behaviors by Zhiqiao Gao, Menglei Mao, Jiuwu Ma, Jincheng Han, Hengzhen Feng, Wenzhong Lou, Yixin Wang, Teng Ma

“…For the reception process, density functional theory (DFT), molecular dynamics (MD), ab initio molecular dynamics (AIMD), and Monte Carlo (MC) methods were analyzed. …”
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Perception survey on the value of the hospital pharmacist at the emergency department by Ángeles García-Martín, Charbel Maroun-Eid, Ainara Campino-Villegas, Belén Oliva-Manuel, Alicia Herrero-Ambrosiol, Manuel Quintana-Díaz

“…They would resort more to Pharmacists if they were present at the hospital department.</p><p><strong>Conclusions:</strong> The results show the acceptance of Hospital Pharmacists in the Emergency Department; their functions are known and valued. …”
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Deciphering the crosslink mechanism of dual cure EP(D)M and CTS rubber compounds for reduced oil swell by Gina Butuc, Kees van Leerdam, Brenda Rossenaar, Auke Talma, Anke Blume

“…The role of CTS in the compound is discussed in detail, as it presents dual functions. This study represents a fundamental analysis of EP(D)M-CTS blends, starting with Thermodynamic studies and polymeric phase analysis by Scanning and Transmission Electron Microscopy (S(T)EM) hyphenated by Energy-Dispersive X-ray Spectroscopy (EDX) or Raman Spectroscopy. …”
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The interaction between metals and catecholamines: oxidative stress, DNA damage, and implications for human health by Elena Cassera, Emanuele Ferrari, Davide A.L. Vignati, Andrea Capucciati

“…Essential metals are vital for physiological functions, but imbalances in their homeostasis can be harmful. …”
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Targeted delivery of extracellular vesicles: the mechanisms, techniques and therapeutic applications by Shuang Zhao, Yunfeng Di, Huilan Fan, Chengyan Xu, Haijing Li, Yong Wang, Wei Wang, Chun Li, Jingyu Wang

“…EV engineering techniques that fulfill targeting functions includes genetic engineering, membrane fusion, chemical modification and physical modification. …”
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Etiology and mechanisms of ulnar and median forearm nerve injuries by Puzović Vladimir, Samardžić Miroslav, Jovanović Milan, Živković Bojana, Savić Andrija, Rasulić Lukas

“…Two injury mechanisms were present, transection in 85 patients and traction and contusion in 14 of the patients. …”
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Q-learning-based exponential distribution optimizer with multi-strategy guidance for solving engineering design problems and robot path planning by Fengbin Wu, Shaobo Li, Junxing Zhang, Liya Yu, Xuan Xiong, Libang Wu

“…To tackle these problems, we present a Q-learning and multi-strategy guidance-enhanced EDO (QMEDO), integrating three essential innovations into the EDO framework. …”
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Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches by Matthew Davenport, Ha Na Choe, Hiroaki Matsunami, Erich Jarvis

“…The estrogen-induced gene modules in females were enriched for anatomical development functions and strongly correlated to the expression of several Z sex chromosome genes. …”
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Association between multimorbidity and capacity impairment in the adult population of Chile: findings of the National Health Survey 2016–2017 by Pamela Serón, Maria J Oliveros, Raúl Valenzuela-Suazo, Camilo Morales, Constanza Ulloa, Álvaro Sanhueza, Ximena Neculhueque

“…For capacity impairment, the survey included 24 items in eight dimensions that represent functioning as a reflection of the overall health experience perceived by an individual with a health condition and interacting with the environment.Results The 2016–2017 ENS (Encuesta Nacional de Salud) included 6233 participants (mean age 48.9±19.3, and 62% women). …”
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Application of Lactose Co-Processed Excipients as an Alternative for Bridging Pharmaceutical Unit Operations: Manufacturing an Omeprazole Tablet Prototype via Direct Compression by Raymar Andreina Lara Garcia, Jesús Alberto Afonso Urich, Andreina Isabel Afonso Urich, Dalibor Jeremic, Johannes Khinast

“…The tablets were produced using a single punch tablet press and thoroughly characterized physically and chemically in order to assess their functionality and adherence to drug product specifications. …”
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Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer’s disease by Fabiola Paciello, Martina Battistoni, Sara Martini, Chiara Simone, Francesco Pastore, Raimondo Sollazzo, Claudio Grassi, Cristian Ripoli

“…Actin dynamics, largely regulated by the LIMK1-cofilin pathway, are central to maintaining structural and functional stability in neurons. In healthy brains, the LIMK1-cofilin-actin axis modulates actin polymerization within dendritic spines, supporting spine growth and plasticity. …”
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