Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway: in vivo and in vitro studies by Yahui Wang, Xiaopeng Wang, Yifei Qian, Mingming Sun, Huiju Yang, Lianlin Su, Shuai Yan

“…BackgroundSlow-transit constipation (STC) is a widespread functional gastrointestinal condition distinguished by decreased colonic motility as an essential clinical characteristic. …”
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Comparison of clinical outcomes in acute versus staged open reduction-internal fixation of OTA/AO type 43C tibial pilon fractures by Austin C. Stewart, Richard Phan, Thomas Cho, Jiayong Liu, Chris G. Sanford

“…Introduction: AO/OTA Type 43C tibial pilon fractures are severe high-energy injuries of the distal tibia, marked by complete articular disruption and separation from the tibial diaphysis. These injuries present significant treatment challenges due to extensive soft tissue damage and articular comminution, often resulting in functional impairments and high rates of complications. …”
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Morphophysiological attributes of AMF inoculated tomato (Lycopersicon esculentum Mill.) ameliorated by resorcinol, biochar and nanobiochar by Sakina Bibi, Rehman Ullah, Tanvir Burni, Zakir Ullah, Jamal Uddin, Mohammad Nur-e-Alam, Mohsin Kazi

“…In contrast, proline levels (3.55 ± 0.02, 3.02 ± 0.00 mg/g) declined in both tomato varieties. The present research showed that resorcinol-functionalized nanobiochar has a beneficial influence on germination parameters and that nanobiofertilizer has a synergistic influence on the morphophysiological properties of tomato plants. …”
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Association of microtubule-based processes gene expression with immune microenvironment and its predictive value for drug response in oestrogen receptor-positive breast cancer by Zhenfeng Huang, Minghui Zhang, Nana Zhang, Mengyao Zeng, Yao Qian, Meng Zhu, Xiangyan Meng, Ming Shan, Guoqiang Zhang, Feng Liu

“…Transwell and cell viability assays were used to examine the biological functions of CHORDC1.ResultsTwo molecular subgroups with significantly different survival outcomes were identified. …”
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The efficacy of core decompression combined with regenerative therapy in early femoral head necrosis: a systematic review and meta-analysis involving 954 subjects by Haiwei Tang, Tingxian Ling, Enze Zhao, Mingke You, Xi Chen, Gang Chen, Kai Zhou, Zongke Zhou

“…In the reported data, the regenerative group demonstrated significantly higher rates of subjective improvement in pain and functional outcomes compared to those in the CD group (71.74% (66/92) vs. 56.38% (53/94). …”
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Defining the relationship between clinician-rated ECOG performance status and patient-reported health-related quality of life scores in men with metastatic hormone-naïve prostate c... by Ikenna I. Nnabugwu, Eric N. Obikeze, Chinwe A. Nnabugwu, Solomon K. Anyimba, Okwudili C. Amu, Okezie M. Mbadiwe, Kevin S. N. Echetabu, Ijeoma L. Okoronkwo

“…Methods An analytical cross-sectional study recruiting patients presenting with mPCa in Enugu, southeast Nigeria. Two clinicians agreed on an ECOG-PS score for each study participant who in turn completed the Functional Assessment in Cancer Therapy – Prostate (FACT-P) and the EuroQol EQ-5D-5 L questionnaires with interviewer-assistance where necessary. …”
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Innovation and Risk Avoidance of Smart Library Services Based on Generative Artificial Intelligence by Jia LIU

“…The emergence of generative artificial intelligence (Generative AI) presents unprecedented opportunities and challenges for innovation in smart library services. …”
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Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages by Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu

“…Differentially m5C-methylated genes (DMMGs) were functionally annotated via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. …”
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Cryo-EM reveals a double oligomeric ring scaffold of the CHIKV nsP3 peptide in complex with the NTF2L domain of host G3BP1 by Yuanzhi Liu, Jie Wang, Yinze Han, Xiaoyan Xia, Rui Zeng, Xinyu Fan, Bo Zhang, Kaituo Wang, Jian Lei

“…Overall, our findings present the structural and functional mechanisms on CHIKV nsP3 modulating host G3BP1 and provide a potential antiviral target based on the protein–protein interaction interface.IMPORTANCEChikungunya virus (CHIKV) is an arbovirus responsible for causing fever, headache, and severe joint pain in humans, with widespread outbreaks affecting millions worldwide. …”
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Phylogenetic Relationships of Three Ramaria Species Based on Mitochondrial Genome Analysis by Xianyi Wang, Zhongyao Guo, Jiawei Tao, Gongyou Zhang, Guoyu Wang, Yaping Wang, Yaohang Long, Hongmei Liu

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Antibiofilm properties of 4-hydroxy-3-methyl-2-alkenylquinoline, a novel Burkholderia-derived alkaloid by McKinley D. Williams, Taylor R. Sweeney, Sabrina Trieu, Ravi Orugunty, Abdelahhad Barbour, Fereshteh Younesi, Michael Glogauer, Nopakorn Hansanant, Ronald Shin, Shi-En Lu, Kevin Cao, Abraham Tenorio, Sigmund J. Haidacher, Anthony M. Haag, Thomas D. Horvath, Leif Smith

“…HMAQ-7 also demonstrated an ability to modulate additional cellular behaviors in Bacillus subtilis, including motility and sporulation, suggesting that this molecule is important to the interspecies dynamics present across many diverse microenvironments.IMPORTANCEThe present study furthers our understanding of the structural complexity and the biological functions of the 2-alkyl-4(1H)-quinolone metabolites produced by Burkholderia spp. …”
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How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation by Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma

“…In ‘Manicure Finger’, eight anthocyanins including malvidin‐3‐O‐glucoside, peonidin‐3‐O‐glucoside, and cyanidin‐3‐O‐glucoside were identified as color‐presenting substances, while flavones and flavonols, especially kaempferol‐3‐O‐rutinoside and quercetin‐3‐O‐glucoside, functioned as co‐pigments. …”
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Haplotype Analysis of the GL7/GW7/SLG7 Gene and Its Application in Improving the Grain Quality of Three-Line Hybrid Rice by Duo Xia, Peizhou Xu, Shuqin Zheng, Le Xue, Yuejiao Yin, Zhuchen Yao, Sikai Ding, Yusen Lai, Yipei Wang, Xiaoding Ma, Xianjun Wu, Hao Zhou

“…Among nine haplotypes of GL7 (H1-9), H1-H4, which harbored an 11-bp deletion, were designated as the functional GL7 allele and were primarily present in Geng/Japonica (GJ) rice. …”
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Comparative analysis of endometrial, vaginal, and gut microbiota in patients with and without adenomyosis by Marta Valdés‐Bango, Meritxell Gracia, Elisa Rubio, Andrea Vergara, Climent Casals‐Pascual, Cristina Ros, Mariona Rius, Maria Ángeles Martínez‐Zamora, Eduard Mension, Lara Quintas, Francisco Carmona

“…Patients with adenomyosis present immune dysregulation leading to a persistent chronic inflammatory response. …”
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Time patterns of recurrence and correlating histomorphology to delay of recurrence of benign jaw tumours: A 10-year appreciation by Zilefac Brian Ngokwe, Ntep Ntep David Bienvenue, Nokam Kamdem Stephane, Kouamou Tchiekou Audrey, Atanwo Nita Lise Dongmo, Bengondo Messanga Charles, Sando Zacharie

“…Introduction: Patients presenting a recurrent benign jaw tumour have many complications, among which increased morbidities and mortalities, malignant degeneration of these benign tumours, aesthetic as well as functional sequalae and high medical bills. …”
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A multimodal MRI-based machine learning framework for classifying cognitive impairment in cerebral small vessel disease by Guihan Lin, Weiyue Chen, Yongkang Geng, Bo Peng, Surui Liu, Minjiang Chen, Chunying Pang, Pengjun Chen, Chenying Lu, Zhihan Yan, Shuiwei Xia, Yakang Dai, Jiansong Ji

“…Abstract The heterogeneity of cerebral small vessel disease (CSVD) with mild cognitive impairment (MCI) presents a challenge for diagnosis and classification. …”
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Connectivity in the Clarion-Clipperton Zone: a review by Lara Macheriotou, Sven Rossel, Massimiliano Molari, Pedro Martinez Arbizu, Saskia Brix, Saskia Brix, Magdalini Christodoulou, Pierre-Antoine Dessandier, Ana Hilário, Felix Janssen, Erik Simon-Lledó, Lenaick Menot, Ellen Pape, Gustavo A. Ramírez, Ann Vanreusel

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Enhancing irradiation tolerance and inducing superlubricity in MoS2/W multilayer film exposed to atomic oxygen by Xin Fan, Wenhao He, Zhenao Zhang, Bo He, Yanwen Lin, Qinsheng He, Liang-Feng Huang, Siming Ren, Zhibin Lu, Jibin Pu, Qunji Xue

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Comparing the Effectiveness of Self-Compassion and Mindfulness Therapies on Affection Control of Poor Parenting Adolescents by Zahra EffatDoost Sani, Mohammad Reza Zarbakhsh Bahri, Alireza Homayuni

“…Individuals with higher levels of self- compassion can accept life’s unfortunate events easier and present precise self- assessments and reactions based on their true functions, since they are judging themselves with less strictness. …”
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A Mindfulness-Based App Intervention for Pregnant Women: Qualitative Evaluation of a Prototype Using Multiple Case Studies by Silvia Rizzi, Maria Chiara Pavesi, Alessia Moser, Francesca Paolazzi, Michele Marchesoni, Stefania Poggianella, Erik Gadotti, Stefano Forti

“…The questionnaires showed that domain experts, for instance, positively evaluated chatbot-related aspects such as empathy and comprehensibility of the terms used and rated the mindfulness traces present as supportive and functional. The target users found the content interesting and clear. …”
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