The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex by Emmanuelle Gruz-Gibelli, Natacha Chessel, Clélia Allioux, Pascale Marin, Françoise Piotton, Geneviève Leuba, François R. Herrmann, Armand Savioz

“…This phenomenon would remain functional up to a point when Aβ increase and RA decrease probably lead to a pathological state.…”
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A nearly gapless, highly contiguous reference genome for a doubled haploid line of Populus ussuriensis, enabling advanced genomic studies by Wenxuan Liu, Caixia Liu, Song Chen, Meng Wang, Xinyu Wang, Yue Yu, Ronald R. Sederoff, Hairong Wei, Xiangling You, Guanzheng Qu, Su Chen

“…The derived DH genome exhibits high collinearity with P. trichocarpa and significantly fills gaps present in the latter's genome. This T2T P. ussuriensis reference genome will not only enhance our understanding of genome structure, and functions within the poplar genus but also provides valuable resources for poplar genomic and evolutionary studies.…”
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Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol by Grace Lu-Yao, Jennifer M Johnson, Amy L Shaver, Nikita Nikita, Swapnil Sharma, Daniel S Lefler, Atrayee Basu-Mallick, Meghan L Butryn

“…Sex plays an important role in both the development of cancer as well as the functioning of the immune system. Though a difference in response to immune therapy is emerging between men and women it is unclear how this difference affects cancer outcomes and what the potential underlying mechanisms are for those effects. …”
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The EMPI Code for Plasma-induced Effects on Radio Waves. I. Nonmagnetized Media and Applications to Fast Radio Bursts by Nan Xu, He Gao, Yuan-Pei Yang, Bing Zhang, Wei-Yang Wang, Tian-Cong Wang, Ran Gao

“…Electromagnetic waves undergo modifications as they propagate through plasma. We present electromagnetic wave–plasma interaction (EMPI), a three-dimensional numerical framework designed to simulate the interaction between radio signals and cold plasma. …”
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Acid-responsive CST@NPs enhanced diabetic wound healing through rescuing mitochondrial dysfunction by Xuelian Zhang, Hang Li, Yang Liu, Jie Yu, Pengfei Zhang, Peiling Yu, Yuhao Liu, Suyi Jia, Lijuan Ling, Peng Li, Lei Li, Yueyao Wang, Tengxiao Huang, Gaoxin Jin, Yunpeng Zhao, Guoli Ma, Qinghao Yuan, Lei Zhu, Zhiyue Zhang, Hao Li, Weiwei Li

“…The consequences of DUs include a decline in functional status, increased risk of infection, hospitalization, and even death. …”
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Deciphering the Oncogenic Landscape of Hepatocytes Through Integrated Single‐Nucleus and Bulk RNA‐Seq of Hepatocellular Carcinoma by Huanhou Su, Xuewen Zhou, Guanchuan Lin, Chaochao Luo, Wei Meng, Cui Lv, Yuting Chen, Zebin Wen, Xu Li, Yongzhang Wu, Changtai Xiao, Jian Yang, Jiameng Lu, Xingguang Luo, Yan Chen, Paul KH Tam, Chuanjiang Li, Haitao Sun, Xinghua Pan

“…QDM was employed to screen potential biomarkers, revealing that PDE7B functions as a key gene whose suppression promotes HCC progression. …”
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An Updated and Comprehensive Review Exploring the Gut–Brain Axis in Neurodegenerative Disorders and Neurotraumas: Implications for Therapeutic Strategies by Ahmed Hasan, Sarah Adriana Scuderi, Anna Paola Capra, Domenico Giosa, Andrea Bonomo, Alessio Ardizzone, Emanuela Esposito

“…Additionally, the GBA presents a promising therapeutic target for managing these diseases.…”
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Efficient methane production from photocatalytic CO2 reduction by InCu0.05Co0.05Ox: The synergistic effect of Co and Cu by Shuhao Li, Feng Wang, Tianhan Shen, Derrick Ng, Yuning Huo, Boxiong Shen, Zongli Xie

“…However, low efficiency limits its practical application. This study presents a bimetallic co-doping strategy using Cu and Co to enhance the photocatalytic performance of the In2O3 catalyst. …”
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MiR-451 in Inflammatory Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Applications—A Comprehensive Review Beyond Oncology by Fei-Xiang Wang, Guo Mu, Zi-Hang Yu, Zhen-Shan Qin, Xing Zhao, Zu-An Shi, Xin Fan, Li Liu, Ye Chen, Jun Zhou

“…This comprehensive review systematically analyzes miR-451’s multifaceted functions in inflammatory diseases, with particular focus on ischemia–reperfusion injury, arthritis, and acute organ injuries. …”
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Harnessing protein language model for structure-based discovery of highly efficient and robust PET hydrolases by Banghao Wu, Bozitao Zhong, Lirong Zheng, Runye Huang, Shifeng Jiang, Mingchen Li, Liang Hong, Pan Tan

“…Abstract Plastic waste, particularly polyethylene terephthalate (PET), presents significant environmental challenges, driving extensive research into enzymatic biodegradation. …”
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Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination by Mariagiovanna Russo, Amina Zahaf, Abdelmoumen Kassoussi, Ariane Sharif, Hélène Faure, Elisabeth Traiffort, Martial Ruat

“…Here, using in vitro and in vivo rodent models, functional blockade, and mouse brain demyelination, we demonstrate that Sonic hedgehog (Shh) expression in a subset of oligodendrocyte progenitor cells precedes the expression of myelin basic protein (MBP), a major myelin sheath protein. …”
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Probing of the Interaction Between Human Serum Albumin and A New Synthesized Pd(II) Complex Using Spectroscopic Methods by A. Divsalar, S. Khodabakhshian, A.A. Saboury, H. Mansuri-Torshizi, M. Evini

“…HSA ascribed ligand-binding and transport properties, antioxidant functions and enzymatic activities. In the present study, the interaction and side effects of a new designed anti-cancer compound (1,10-phenanthroline butyl dithiocarbamato palladium(II) nitrate) on HSA have been investigated by different spectroscopic (UV-visible, fluorescence and circular dichroism (CD)) techniques at two temperatures of 25 and 37°C. …”
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Efficient Hydrolysis of Earthworm Protein and the Lipid-Lowering Mechanism of Peptides in the Hydrolysate by Mengmeng Zhang, Xiang Mai, Shanghua Yang, Yuhua Huang, Lina Zhang, Wenbin Ren, Weidong Bai, Xuan Xin, Wenhong Zhao, Lisha Hao

“…Transcriptomic analysis and validation experiments indicated that the lipid-lowering activity of EWP was associated with its suppression of inflammatory factors, such as IL-6. This study presents an efficient enzymatic hydrolysis strategy for earthworm protein utilization, laying the foundation for its application in functional foods such as protein supplements, nutraceutical capsules, hypoallergenic infant formulas, and sports nutrition products.…”
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Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper by Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu, Zhenhui Zhong, Yan Xue

“…While the large and complex genome of pepper severely hampered the understanding of its functional genome, it also indicates a rich yet unexplored reservoir of regulatory elements (REs). …”
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The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma by Mujahid Azfar, Weiman Gao, Chris Van den Haute, Lin Xiao, Mawar Karsa, Ruby Pandher, Ayu Karsa, Dayna Spurling, Emma Ronca, Angelika Bongers, Xinyi Guo, Chelsea Mayoh, Youri Fayt, Arthur Schoofs, Mark R. Burns, Steven H. L. Verhelst, Murray D. Norris, Michelle Haber, Peter Vangheluwe, Klaartje Somers

“…This finding resulted in the clinical development of polyamine transport inhibitors, including AMXT 1501, which is presently under clinical investigation in combination with DFMO. …”
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Long-read sequencing reveals absence of 5mC in Ogataea parapolymorpha DL-1 genome and introduces telomere-to-telomere assembly by Andrey Eremin, Alexander Sergeev, Alexander Sergeev, Arthur Kopylov, Arthur Kopylov, Vladimir Rodin, Daniil Malyshev, Tatiana Panova, Igor Polyakov, Maria Zvereva

“…BackgroundOgataea parapolymorpha DL-1 is a versatile thermotolerant organism with numerous applications in biotechnology, particularly in the production of recombinant proteins and the study of methanol metabolism and peroxisome functions. This study presents a comprehensive genome and methylome analysis of Ogataea parapolymorpha DL-1 using long-read sequencing technology. …”
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Development of an explainable machine learning model for Alzheimer’s disease prediction using clinical and behavioural features by Rajkumar Govindarajan, K. Thirunadanasikamani, Komal Kumar Napa, S. Sathya, J. Senthil Murugan, K. G. Chandi Priya

“…This article presents a reproducible machine learning methodology for the early prediction of Alzheimer’s disease (AD) using clinical and behavioural data. …”
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Emerging Tumor Biomarkers in Pancreatic Cancer and Their Clinical Implications by Dimitrios Stefanoudakis, Maximos Frountzas, Nikolaos V. Michalopoulos, Dimitrios Schizas, Dimitrios Theodorou, Konstantinos G. Toutouzas

“…This review aims to discuss the new functions of important biomarkers, such as miRNAs, GATA6, L1CAM, and MUC1 in pancreatic cancer. …”
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Innovative Peptide-Based Plasmonic Optical Biosensor for the Determination of Cholesterol by Ana Lia Bernardo, Anne Parra, Virginia Cebrián, Óscar Ahumada, Sergio Oddi, Enrico Dainese

“…Notably, abnormal cholesterol levels are a well-established indicator of various pathological conditions; yet, the quantitative detection of the free form of cholesterol is complicated by its small molecular size, pronounced hydrophobicity, and the necessity for mediator molecules to achieve efficient sensing. In the present study, a novel strategy for cholesterol quantification was developed, leveraging a plasmonic optical readout in conjunction with a highly specific cholesterol-binding peptide (C-pept) as a biorecognition element, anchored on a functionalized silica substrate. …”
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Single Cell‐Pair Proteomics for Decoding Immune‐Cancer Cell Interactions by Qin‐Qin Xu, Yi‐Rong Jiang, Jian‐Bo Chen, Jie Wu, Yi‐Xue Chen, Qian‐Xi Fan, Hui‐Feng Wang, Yi Yang, Jian‐Zhang Pan, Qun Fang

“…Notably, an identification depth of over 1000 protein groups in a single cell‐pair is achieved, leading to the discovery of sub‐clusters of NK cells with different functions and the identification of important biomarkers for cancer treatments. …”
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