Germline PARN Variants in Telomere Biology Disorders and Challenges in Variant Curation by Hasset T. Nurelegne, Mone't B. Thompson, Kelvin C. deAndrade, Ashley S. Thompson, Lisa J. McReynolds, Marena R. Niewisch, Sharon A. Savage

“…Conclusion The extent to which specific PARN variants can be associated with TBD etiology is limited due to incomplete literature, clinical data, lack of robust functional assays, and high frequency of rare variants.…”
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Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fates by Seth D. Fortmann, Awalpreet S. Chadha, Blake F. Frey, Asif Elahi, Vidya Sagar Hanumanthu, Shanrun Liu, Andrew Goldsborough, P. Brent Ferrell, Jr., Maria B. Grant, Casey T. Weaver, Robert S. Welner

“…By integrating transcriptional and phospho-signaling information at single-cell resolution, we identify a hyperactivated Th17 cellular state associated with early IL-2 production that has downstream consequences on functional plasticity.…”
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The immunopeptidome of colon cancer cells treated with topoisomerase inhibiting drug reveals differential as well as common endogenous protein sampling and display of MHC I-associa... by Deepa Bedi, Mohammed Hassan, Alehegne Yirsaw, Biba Vikas, Pran Datta, Temesgen Samuel

“…Gene Ontology analysis of MHC I-displayed proteins revealed a treatment-induced increase in extracellular vesicle- and nuclear-derived proteins, alongside reduced cytosolic protein sampling. Overall, we present evidence for treatment-inducible differential display of peptides, some of which may affect interactions and functions of immune cells. …”
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Storage Temperature Effect on Quality and Shelf-Life of <i>Hericium erinaceus</i> Mushroom by Mafalda Silva, Manuela Vida, Ana Cristina Ramos, Fernando J. Lidon, Fernando H. Reboredo, Elsa M. Gonçalves

“…<i>Hericium erinaceus</i>, commonly known as Lion’s Mane mushroom, presents a challenge for maintaining quality and shelf-life during post-harvest storage. …”
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Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019 by Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya Brijmohan Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis

“…Currently, there is insufficient evidence about the efficacy and safety of hydroxychloroquine in COVID-19.KEY MESSAGESHCQ, initially an antimalarial agent, is used as an immunomodulatory agent for managing several autoimmune diseases, for which its efficacy is linked to inhibiting lysosomal antigen processing, MHC-II antigen presentation, and TLR functions.HCQ is generally well-tolerated although severe life-threatening adverse effects including cardiomyopathy and conduction defects have been reported.HCQ use in COVID-19 should be discouraged outside clinical trials under strict medical supervision.…”
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MbbHLH93, a transcription factor associated with cold and drought tolerance in Malus baccata by Lihua Zhang, Yu Xu, Long Lv, Tianhe Wang, Wanda Liu, Xingguo Li, Wenhui Li, Junwei Huo, Deguo Han

“…Furthermore, quantitative expression analysis indicated that overexpression of MbbHLH93 improved the expression levels of LsCBFs, which were positive functional genes in response to cold and drought stress, enhancing plant tolerance. …”
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Printed Recyclable and Flexible Thermocouple Temperature Sensors by Xiaotao Wang, Lin Guo, Qihao Zhang, Yevhen Zabila, Rui Xu, Denys Makarov

“…Importantly, the gentle recycling conditions preserve the functional fillers, preventing degradation or oxidation and thus enabling the reprocessed sensors to retain their original performance. …”
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Design, Synthesis, and Evaluation of 1-Benzylpiperidine and 1-Benzoylpiperidine Derivatives as Dual-Target Inhibitors of Acetylcholinesterase and Serotonin Transporter for Alzheime... by Juan Pablo González-Gutiérrez, Damián Castillo-Ríos, Víctor Ríos-Campos, Ignacio Alejandro González-Gutiérrez, Dánae Flores Melivilu, Emilio Hormazábal Uribe, Felipe Moraga-Nicolás, Kerim Segura, Valentina Hernández, Amaury Farías-Cea, Hernán Armando Pessoa-Mahana, Miguel Iván Reyes-Parada, Patricio Iturriaga-Vásquez

“…Due to the multisymptomatic nature of AD, there is a growing interest in developing multitargeted ligands that simultaneously enhance cholinergic and serotonergic tone. This study presents the synthesis of novel ligands based on functionalized piperidines, evaluated through radioligand binding assays at the serotonin transporter (SERT) and AChE and butyrylcholinesterase (BuChE) inhibition. …”
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Balancing the Aggregation of Cobalt Phthalocyanine on Carbon Nanohorn for Efficient H2O2 electrosynthesis in Neutral Electrolyte by Yiqi Ding, Zhuo Xing, Chunguang Kuai, Feng Ryan Wang, Yuzheng Guo

“…Abstract Oxygen reduction reaction (ORR) driven by renewable electricity in neutral electrolyte presents a promising way for generating H2O2, which is suitable for daily sanitation and hygiene management. …”
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Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved? by F. A. Moreira, D. C. Aguiar, A. C. Campos, S. F. Lisboa, A. L. Terzian, L. B. Resstel, F. S. Guimarães

“…Cannabinoids play an important role in activity-dependent changes in synaptic activity and can interfere in several brain functions, including responses to aversive stimuli. …”
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Methylation-induced suppression of BEX1 activates AKT/ERK/STAT3 signaling pathways regulating cell cycle and apoptosis in glioma by Li-Zhi Xiao, Shi Feng, Zhen He, Rui Mao, Kai Qian, Zhi-Ying Zhou, Huabao Cai, Mengyu Zhao, Cunzhi Wang, Tianhang Yu, Zi-Yu Zhao, Jie Li

“…Targeting BEX1 methylation presents a promising therapeutic avenue for glioma treatment. …”
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Nature-inspired surface modification strategies for implantable devices by Soo-Hwan Lee, Sungjae Yoo, Sung Hoon Kim, Young-Min Kim, Sang Ihn Han, Hyojin Lee

“…Biomimetic surfaces, inspired by the chemical and physical principles found in biological systems, present potential opportunities to address these challenges. …”
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Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation by Pasquale Picone, Emanuela Muscolino, Antonella Girgenti, Maria Testa, Daniela Giacomazza, Clelia Dispenza, Domenico Nuzzo

“…Mitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including regulating metabolism and maintaining cellular homeostasis. …”
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Age‐Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All‐Cause Mortality in a Sardinian Population Cohort by Richard Oppong, Valeria Orru, Michele Marongiu, Yong Qian, Carlo Sidore, Alessandro Delitala, Marco Orru, Antonella Mulas, Maria Grazia Piras, Christopher H. Morrell, Sandra Lai, David Schlessinger, Myriam Gorospe, Francesco Cucca, Edoardo Fiorillo, Jun Ding, Edward G. Lakatta, Angelo Scuteri

“…Conclusions Because of its consistent ability to predict functional and clinical outcomes, including all‐cause mortality, we conclude that GDF‐15 serum levels serve as a robust biomarker for the continuum from health to the emergence of clinical disease during aging and, subsequently, to the likelihood of mortality.…”
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Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery by Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu

“…The synthesis of nanomedicines involves numerous parameters, and the complexity of nano–bio interactions in vivo presents further difficulties. Therefore, innovative approaches are needed to optimize nanoparticle (NP) design and functionality, enhancing their delivery efficiency and therapeutic outcomes. …”
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Development of bi-directional switched-capacitor DC-DC converter for EV powertrain application by K. Mounika Nagabushanam, Tarkeshwar Mahto, Somesh Vinayak Tewari, Ramanjaneya Reddy Udumula, Majed A. Alotaibi, Hasmat Malik, Taha Selim Ustun

“…The research presents a novel Bidirectional Switched Capacitor DC-DC (BSCD) Converter and demonstrates its application in integrating a battery with an electric vehicle’s (EV) traction motor. …”
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Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats by Hang Zhao, Zhiying He, Dandan Huang, Jun Gao, Yanfang Gong, Hongyu Wu, Aifang Xu, Xiangjun Meng, Zhaoshen Li

“…Bone marrow (BM) mesenchymal stem cells (MSCs) have been demonstrated to have plasticity of transdifferentiation and to have immunomodulatory functions. In the present study, we assessed the roles of MSCs in SAP and the therapeutic effects of MSC on SAP after transplantation. …”
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Bridging prediction and reality: Comprehensive analysis of experimental and AlphaFold 2 full-length nuclear receptor structures by Akerke Mazhibiyeva, Tri T. Pham, Karina Pats, Martin Lukac, Ferdinand Molnár

“…Notably, Alphafold 2 systematically underestimates ligand-binding pocket volumes and captures only single conformational states in homodimeric receptors where experimental structures show functionally important asymmetry. These findings provide critical insights for structure-based drug design targeting nuclear receptors and establish a framework for evaluating Alphafold 2 predictions across other protein families.…”
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Progress and Challenges in Buffer Layers Between Cathode Materials and Sulfide Solid Electrolytes in All‐Solid‐State Batteries by Yun Seong Byeon, Dongil Kim, Sang A Han, Jung Ho Kim, Min‐Sik Park

“…In this respect, various functional materials have been under exploration as buffer layers, which are intended to suppress the formation of the SCL at these interfaces. …”
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Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin‐induced type 1 diabetes in rats by Ghada Alomari, Bahaa Al‐Trad, Salehhuddin Hamdan, Alaa A. A. Aljabali, Mazhar Salim Al Zoubi, Khalid Al‐Batanyeh, Janti Qar, Gregory J. Eaton, Almuthanna K. Alkaraki, Walhan Alshaer, Saja Haifawi, Khairunadwa Jemon, Dinesh Kumar Chellappan, Kamal Dua, Murtaza M. Tambuwala

“…The present findings may help design the clinical application of ZnONPs for protection against the development of diabetic nephropathy.…”
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