Patient Reported Outcome Measures in cancer care: a hybrid effectiveness-Implementation trial to optimise Symptom control and health service Experience (PROMISE)–protocol for a ran... by David Wyld, Afaf Girgis, Elizabeth Miller, Penelope M Webb, Gunter Hartel, Karen Martin, Rahul Ladwa, Melissa Eastgate, Suzanne O’Brien, Sabe Sabesan, Raymond J Chan, Amy Brown, Robert Mason, Mark B Pinkham, Bena Brown, Louisa G Collins, Fiona Crawford Williams, Kerrie Doupain, Vicki Fennelly, Peter McGuire, Rebecca Packer, Jasotha Sanmugarajah, Georgia Slapp, Doreen Tapsall, Jeanie White, Laurelie R Wishart

“…The primary outcomes are unplanned hospital presentations and physical/functional well-being at 6 months. …”
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A report of the Iranian Parkinson’s disease registry by Mehri Salari, Masoud Etemadifar, Alireza Vakilian, Ahmad Chitsaz, Kaveh Shafiei, Seyed Masoud Nabavi, Afshin Samaei, Atiye Riasi, Fatemeh Hojjatipour

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Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier by Sheng Ding, Yinghua Wei, Minglong Yang, Jinyi Shi, Kaiyuan Ren, Xinli Li, Zhuo Tang

“…Ribonuclease H (RNase H), a critical functional protein in replication and genome stability, is emerging as a crucial therapeutic target for various diseases, including immune disorders. …”
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Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer by Li Wen, Chengxue He, Yanhui Guo, Nina Zhou, Xiangxi Meng, Yuwen Chen, Cheng Ma, Hua Zhu, Zhi Yang, Lei Xia

“…Fibroblast activating protein (FAP) is up-regulated in cancer-associated fibroblasts (CAFs) of more than 90 % of tumor microenvironment and also highly expressed on the surface of multiple tumor cells like glioblastoma, which can be used as a specific target for tumor diagnosis and treatment. At present, small-molecule radiotracer targeting FAP with high specificity exhibit limited functionality, which hinders the integration of theranostics as well as multifunctionality. …”
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SPAT inhibits LUAD metastasis by targeting SF1-mediated splicing by Yun Ma, Xiaoxu Zhou, Mengqian Yu, Xiang Cheng, Juze Yang, Jiayi Ren, Chengcai Zheng, Jia Li, Xinyi Qian, Jiani Yi, Honghe Zhang, Yan Lu, Pengyuan Liu

“…However, the precise interactions within this landscape remain inadequately understood. Here, we present a functional characterization of a novel long non-coding RNA (lncRNA), SPAT (splice associated transcript). …”
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ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level by Kexiu Song, Yingchun Han, Linhua Zhang, Guoqing Liu, Peng Yang, Xiaoyun Cheng, Le Bu, Hui Sheng, Shen Qu

“…HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. …”
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All arthroscopic management of an Hoffa fracture of the medial femoral condyle: case report by Catarina Silva Souto, Diana Bicas Machado, Nuno Rodrigues, Nuno Tavares

“…Due to their intra-articular location, anatomical reduction of this fractures must be achieved and articular congruence restored for the patient to achieve optimal functional results. Case report: The authors present a case of a 38-year-old male patient who sustained a high energy trauma to his right knee. …”
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Age-Matched, Case-Controlled Comparison of Clinical Indicators for Development of Entropion and Ectropion by Kevin S. Michels, Craig N. Czyz, Kenneth V. Cahill, Jill A. Foster, John A. Burns, Kelly R. Everman

“…Entropic and ectropic lids demonstrate clinically and statistically significant anatomical and functional differences from normal, age-matched lids. …”
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Opportunities for <i>Helicobacter pylori</i> Eradication beyond Conventional Antibiotics by Camilia Metadea Aji Savitri, Kartika Afrida Fauzia, Ricky Indra Alfaray, Hafeza Aftab, Ari Fahrial Syam, Masrul Lubis, Yoshio Yamaoka, Muhammad Miftahussurur

“…This review aims to present reports on various compounds, either new or combined with current antibiotics, and their pathways to counteract <i>H. pylori</i> resistance.…”
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Erector spinae plane block for intractable, nonsurgical abdominal pain: a scoping review by Ashley Meyer, Campbell Belisle Haley, Eisa Razzak, Amanda Dos Santos, Kyle Dornhofer, Edmund Hsu, Soheil Saadat, John Christian Fox, Megan Guy

“…Abdominal pain is one of the most common presenting chief complaints in the emergency department. …”
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The dynamic transcriptome reveals response patterns to black shank disease in tobacco (Nicotiana tabacum L.) by Zhijun Tong, Zuoqian Fan, Tianyu Du, Dunhuang Fang, Xueyi Sui, Chuyu Ye, Qian-Hao Zhu, Longjiang Fan, Bingguang Xiao, Enhui Shen

“…Several transcripts were identified to be potential candidates for further functional characterization. Our findings provide invaluable insights into the dynamic transcriptome in defense responses of tobacco against P. nicotianae infection.…”
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Classification, Diagnosis, and Prognosis of Cardiomyopathy: A Comprehensive Narrative Review by Yubin Jin, Wenjing Che, Jiuyue Yang, Shumin Chang, Wenqi Bao, Xinyue Ren, Pengyu Yu, Aijie Hou

“…Cardiomyopathy denotes a group of heart diseases caused by structural or functional heart muscle disorders, with various genetic and non-genetic etiologies. …”
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HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence by Konstantinos Sofiadis, Natasa Josipovic, Milos Nikolic, Yulia Kargapolova, Nadine Übelmesser, Vassiliki Varamogianni‐Mamatsi, Anne Zirkel, Ioanna Papadionysiou, Gary Loughran, James Keane, Audrey Michel, Eduardo G Gusmao, Christian Becker, Janine Altmüller, Theodore Georgomanolis, Athanasia Mizi, Argyris Papantonis

“…It presents an interactome rich in RBPs implicated in senescence regulation. …”
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Unraveling human transferrin-tryptamine interactions: a computational and biophysical approach to Alzheimer’s disease therapeutics by Mohammed Alrouji, Mohammed S. Alshammari, Taghreed A. Majrashi, Azna Zuberi, Moyad Shahwan, Akhtar Atiya, Anas Shamsi

“…Neurodegeneration is a progressive loss of neurons that leads to affected cognitive and motor functions and is characterized by neurodegenerative disorders (NDs). …”
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Atomically thin MoS2 with ultra-low friction properties based on strong interface interaction by Xinjian He, Tongtong Yu, Zishuai Wu, Changhe Du, Haoyu Deng, Yongkang Zhao, Shuang Li, Yange Feng, Liqiang Zhang, Zhinan Zhang, Daoai Wang

“…Moreover, combining with the density functional theory calculations, the stronger interface adhesion and higher overall charge redistribution degree of CVD-MoS2 can also be used to explain its ultralow friction state. …”
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A CRISPR/Cas9-based system using dual-sgRNAs for efficient gene deletion in Mycobacterium abscessus by Linai Li, Yuxiang Hu, Dan Wang, Xin Li, Shengjuan Bao, Taibing Deng, Qinglan Wang

“…The increasing global prevalence of Mycobacterium abscessus infections presents a significant clinical challenge due to the pathogen’s intrinsic resistance to multiple antibiotics and poor treatment outcomes. …”
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Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2 by Zongyang Lyu, Xiaoxuan Lyu, Andrey G. Malyutin, Guliang Xia, Daniel Carney, Vinicius M. Alves, Matthew Falk, Nidhi Arora, Hua Zou, Aaron P. McGrath, Yanyong Kang

“…This triggers complex intracellular signaling via G proteins and beta-arrestins, linking external protease signals to cellular functions. To date, direct structural visualization of these ligand-receptor complexes has been limited. …”
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Photodynamic therapy for precancer diseases and cervical cancer (review of literature) by A. V. Gilyadova, Yu. S. Romanko, A. A. Ishchenko, S. V. Samoilova, A. A. Shiryaev, P. M. Alekseeva, K. T. Efendiev, I. V. Reshetov

“…The paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. …”
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Fine Mapping Identifies Candidate Genes Associated with Swine Inflammation and Necrosis Syndrome by Katharina Gerhards, Sabrina Becker, Josef Kühling, Joel Mickan, Mirjam Lechner, Hermann Willems, Gerald Reiner

“…The influence of sow and boar, as well as a heritability of around 0.3, suggest a genetic component to the disease. The aim of the present study was to identify functional single nucleotide polymorphisms (SNPs) in the vicinity of gene markers previously mapped using GWAS. …”
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Neural correlates of sensorimotor adaptation: Thalamic contributions to learning from sensory prediction error by Shirin Mahdavi, Axel Lindner, Carsten Schmidt-Samoa, Anna-Lena Müsch, Peter Dechent, Melanie Wilke

“…While the previous literature has focused on cortical and cerebellar changes, the involvement of the thalamus has received less attention. This functional magnetic resonance imaging study aims to explore the neural substrates of learning from sensory prediction errors with an additional focus on the thalamus. …”
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