Magnitude and durability of ProC6C-AlOH/Matrix-Mtm vaccine-induced malaria transmission-blocking antibodies in Burkinabe adults from a Phase 1 randomized trial by Mohammad Naghizadeh, Kazutoyo Miura, Ebenezer Addo Ofori, Carole Long, Issaka Sagara, Alfred B. Tiono, Jordan Plieskatt, Michael Theisen

“…The Phase 1 clinical trial (PACTR202201848463189) conducted in Burkina Faso, showed ProC6C-AlOH/Matrix-M was safe, well tolerated, immunogenic and generated a functional antibody response to all three constituent antigens at the primary output (D70). …”
Get full text

The minor allele rs2295613(A), protective against systemic lupus erythematosus, makes a differential contribution to the activity of the <i>SLAMF1</i> gene promoter in T helpers an... by A. N. Uvarova, L. V. Putlyaeva, E. A. Zheremyan, E. M. Stasevich, M. M. Murashko, E. A. Bogomolova, K. V. Korneev, D. E. Demin, A. M. Schwartz, D. V. Kuprash

“…Impaired interaction of SLAMF1 receptors on T and B lymphocytes reduces the production of IL-6 and differentiation of plasmablasts in SLE. In the present work, we performed a functional analysis of single nucleotide promoter polymorphisms rs2295614(A&gt;T) and rs2295613(G&gt;A) of the SLAMF1 gene in the models of T-regulatory lymphocytes (MT-2 cell line) and T helpers (Jurkat cell line). …”
Get full text

Analysis of the CRK expressions in bottle gourd (Lagenaria siceraria) under Fusarium oxysporum f. sp. lagenariae stress by using genome-wide identification strategy by Preetinanda Sahoo, Ikram Ullah, Debarpita Sahoo, Chirasmita Bose, Muhammad Amir Zia, Sumaira Salahuddin Lodhi, Mahmoud F. Seleiman, Nawab Ali, Gagan Kumar, Suhail Asad, Satyabrata Nanda

“…Abstract Background The cysteine-rich receptor-like kinases (CRKs) family in plants have been reported to perform multiple functions against various stresses. However, the CRK family in bottle gourd (Lagenaria siceraria) has not been well-explored. …”
Get full text

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas by Xiaodong Shao, Shaolei Guo, Jia Yang, Junjie Dai, Kaihua Cao, Xia Cai, Tianshi Song, Shun Yao, Umar Raza, Kun Chen

“…Differential gene and protein expression, functional annotation and pathway enrichment, gene set enrichment, network construction, CRSISPR-based functional dependency, transcription factor prediction, correlation, clinical association and survival analyses were conducted to identify, develop and validate endoplasmic reticulum (ER) stress-driven unfolded protein response (UPR) as key aging-related molecular mechanism driving tumor aggressiveness in gliomas. …”
Get full text

‘Effects of a home-based bimodal lifestyle intervention in frail patients with end-stage liver disease awaiting orthotopic liver transplantation’: study protocol of a non-randomise... by Hans Blokzijl, Vincent E de Meijer, Rienk Dekker, Joost M Klaase, Coby Annema, Bart C Bongers, Allard G Wijma, Job AM van der Palen, Frans JC Cuperus

“…The programme is patient tailored and comprises high-intensity interval and endurance training, and functional exercises three times per week, combined with nutritional support. …”
Get full text

Identificación y Control Wavenet de un Motor de CA by L. E. Ramos Velasco, J. C. Ramos Fernández, O. Islas Gómez, J. García Lamont, M.A. Espejel Rivera, M.A. Márquez Vera

“…Resumen: En el presente artículo se muestra un esquema de identificación y control que sintoniza en línea las ganancias proporcional, integral y derivativa de un controlador PID discreto aplicado a un sistema dinámico SISO. …”
Get full text

On the effect of fluid temperature in hydrodynamic cavitation on a chip reactors by Seyedreza Tebyani, Farzad Rokhsar Talabazar, Morteza Ghorbani, Ali Koşar

Get full text

Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis by Zhi-ying Lin, Zhi-ying Lin, Shan-shan He, Zi-tong Mo, Xiao-tian Liao, Zhou-shan Feng, Juan Kong, Lu Zhu, Ying Li, Hui-yuan Tan, Zhi-wen Su, Chun-hong Jia, Chun-hong Jia, Fan Wu, Fan Wu

“…Correspondingly, KEGG functional gene analysis demonstrated impaired metabolism in NEC-D. …”
Get full text

A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

“…., reading and phonology, among others), but few examine possible strengths. In the present study, we investigated semantic fluency as a cognitive strength in English-speaking children with dyslexia aged 8–13.MethodsNinety-seven children with dyslexia completed tests of letter and semantic verbal fluency, standardized measures of reading and cognitive functions, and task-free resting-state functional magnetic resonance imaging (rs-fMRI). …”
Get full text

Efficacy and Safety of Intravenous Thrombolysis Beyond 4.5 Hours in Ischemic Stroke: A Systematic Review and Meta-Analysis by Muhammad Ahmad, Chavin Akalanka Ranasinghe, Mais Omar Abu-Sa’da, Durga Prasad Bhimineni, Muhammed Ameen Noushad, Talal Warsi, Ahmad Mesmar, Munikaverappa Anjanappa Mukesh, Sagar K. Patel, Gabriel Imbianozor, Ali Mustansir Bhatty, Ahmad Alareed, Quratul Ain, Eeshal Zulfiqar, Mushood Ahmed, Raheel Ahmed

“…Compared to controls, IVT significantly improved excellent functional outcomes [OR: 1.40; 95% CI: 1.21–1.62] and good functional outcomes [OR: 1.26; 95% CI: 1.06–1.50] at 90 days. …”
Get full text

Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial by Laura A Dawson, Camilla Zimmermann, Aisling Barry, Galia Jacobson, Ronen Fluss, Amira Dany-BenShushan, Talia Golan, Tikva Meron, Marcin Miszczyk, Michael Buckstein, Dayssy Diaz Pardo, Artur Aguiar, Liat Hammer, Adam P Dicker, Maoz Ben-Ailan, Ofir Morag, David Hausner, Zvi Symon, Yaacov R. Lawrence

“…Secondary endpoints include pain at 6 weeks, analgesic use, hope, qualitative of life, caregiver burden and functional outcomes, all measured using validated instruments. …”
Get full text

Identification and Expression Analysis of C2H2-Type Zinc Finger Protein (C2H2-ZFP) Genes in <i>Bougainvillea</i> in Different Colored Bracts by Yushan Wang, Yanping Hu, Wen Liu, Wengang Yu, Jian Wang, Yang Zhou

“…The next step will involve elucidating the functions of these genes in bract coloration.…”
Get full text

Identification of the Cinnamyl Alcohol Dehydrogenase Gene Family in <i>Brassica</i> U-Triangle Species and Its Potential Roles in Response to Abiotic Stress and Regulation of Seed... by Yiwei Liu, Ziwuyun Weng, Yuanyuan Liu, Mengjiao Tian, Yaping Yang, Nian Pan, Mengzhen Zhang, Huiyan Zhao, Hai Du, Nengwen Yin, Cunmin Qu, Huafang Wan

“…Cinnamyl alcohol dehydrogenase (CAD) is essential for lignin precursor synthesis and responses to various abiotic stresses in plants. However, the functions of CAD in <i>Brassica</i> species, especially in <i>Brassica napus</i>, remain poorly characterized. …”
Get full text

Impact of Solvents on the Crystal Morphology of CL-20/TFAZ Cocrystals: A Predictive Study by Yuanyuan Sun, Le Yu, Yichen Wang, Nian-Tzu Suen

Get full text

Headache in radiologically isolated syndrome: a hint toward imminent conversion: a case report by Masoud Etemadifar, Hasan Kaveyee, Parto Zohrabi, Amir Mohammad Jozaie, Mehri Salari, Yasin ebne-ali-heydari

Get full text

Self-Awareness Mechanism for Top-down Attention using Fuzzy Logic in Sustainable Business Intelligence by Muhammad Furqan Khan, Wasim Ahmad Khan, Muhammad Muzaffar Hameed, Arslan Ahmad Siddiqi

“…Findings: The results reveal that the self-awareness mechanism renders cognitive functions present in the human mind: expert systems can manage human legible knowledge and make inference upon it, such formulation allows to build a system that manages imprecise information, an artificial neural network-based cognitive structure that can learn, generalize, and prioritize all complications. …”
Get full text

Using Axiomatic Design and Fuzzy Axiomatic Design for Risk Management in Software Development by Taner Behcet Kepkep, Alptekin Durmusoglu, Turkay Dereli

“…Our paper presents an objective and mathematical roadmap for selecting the appropriate SDLC model based on AD principles.…”
Get full text

Upgrading fuzzy logic by GA-PS to determine asphaltene stability in crude oil by Saeid Ahmadi, Mohammad Sadegh Amiribakhtiar, Amin Gholami, Nader Bahrami

“…While SC solely optimizes mean of input Gaussian membership functions (GMFs), GA-PS tool optimizes both mean and variance of input GMFs. …”
Get full text

Non-Destructive Diagnostics in the Assessment of Splice Geometry in Steel Cord Conveyor Belts by Leszek Jurdziak, Ryszard Błażej, Aleksandra Rzeszowska

“…This study presents the results of an investigation into the potential use of the DiagBelt+ magnetic diagnostic system for assessing the quality of conveyor belt splices. …”
Get full text

De novo transcriptome assembly of the Mediterranean sea-rock pool mosquitoes Aedes mariae and Aedes zammitii by Valentina Mastrantonio, Daniele Porretta, Franco Liberati, Roberta Bisconti, Tiziana Castrignanò, Daniele Canestrelli

“…Homology alignments of predicted ORFs showed that 21,842 sequences from Ae. mariae and 21,944 sequences from Ae. zammitii mapped to the Nr, SwissProt, and TrEMBL databases, while 19,208 and 19,393 predicted ORFs, respectively, were functionally annotated using the COG and KEGG databases. …”
Get full text