Impact of noninsulin-dependent diabetes mellitus (level of control) on sex hormone profile and erectile function by Abdullah A. Khawaji, Hossam S. El-Tholoth, Muath A. Albarakati, Bander A. Binjabaan, Abdulaziz Alzahrani, Abdulmajeed Althobity, Abdulmalik Almardawi, Khaled Bedaiwi, Mussa AlNuami

“…Introduction: Type 2 diabetes mellitus (T2DM) is a well-established risk factor for erectile dysfunction (ED); the precise impact of glycemic control on male sexual function, including hormonal profiles, remains to be fully elucidated. …”
Get full text

The availability and functionality of medical equipment and the barriers to their use at comprehensive specialized hospitals in the Amhara region, Ethiopia by Alem Endeshaw Woldeyohanins, Nigatu Mihretu Molla, Abibo Wondie Mekonen, Abrham Wondimu

“…To analyze the quantitative data, descriptive statistics were employed, and qualitative data were analyzed using a thematic approach.ResultsThe study revealed that the availability of medical equipment in at least one hospital was 55.93% on average, and the availability of at least one piece of medical equipment in the surveyed hospitals was only 25.6%. The overall functional status of medical equipment was 74.68%. The present study also indicated that 75% of the surveyed facility's biomedical engineers did not receive on-the-job training regularly. …”
Get full text

The effect of fall-proof training on functional capacities, working memory and Muscle strength of the elderly with stroke by Farahnaz Ayatizadeh Tafti, Saeed Abedinzadeh Masuleh, Mohammad Reza Sadeghian Shahi, Hamidreza Maleki nezhad

“…Background and purpose: Despite the advances in modern medicine, drugs and medical technology, stroke diseases cause significant complications to people and always result in a decrease in performance, working memory and muscle strength. The aim of the present study was to investigate the effect of fall-proof training on functional capacities, working memory and Muscle strength of the elderly with stroke.Materials and Methods: 24 elderly patients suffering from a stroke were divided into two experimentally equal groups and control. …”
Get full text

Functional evaluation of novel compound heterozygous variants in SLC12A3 of Gitelman syndrome by Na Wang, Yuanxing Yang, Xiong Tian, Hongjun Fu, Shuaishuai Chen, Juping Du, Mengyi Xu, Haixia He, Bo Shen, Jiaqin Xu

“…Conclusion Our study presents the genetic and functional evidence for the novel compound heterozygous loss-of-function variants in SLC12A3 that may synergistically cuase GS, and expands the mutation spectrum of SLC12A3 variants in patients with GS.…”
Get full text

Characterising grey-white matter relationships in recent-onset psychosis and its association with cognitive function by Yoshito Saito, Christos Pantelis, Vanessa Cropley, Liliana Laskaris, Cassandra M.J. Wannan, Warda T. Syeda

Get full text

Neurobiological correlates of personality dimensions in borderline personality disorder using graph analysis of functional connectivity by Francesca D’Adda, Giovanni Sighinolfi, Micaela Mitolo, Mauro Scala, Lucia Guidi, Lorenzo Motta, Lorenzo Cirignotta, David Neil Manners, Caterina Tonon, Raffaele Lodi, Marco Menchetti

“…The Personality Inventory for the Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition (PID-5) provides a dimensional assessment of maladaptive domains associated with personality disorders, improving the understanding of their complex clinical presentations. While altered brain functional connectivity (FC) has been reported in BPD, neurobiological-clinical correlations remain debated. …”
Get full text

Composition and predicted functions of dairy cattle's endometrial and rumen microbiome against the background of chronic endometritis by Elena A. Yildirim, Valentina A. Filippova, Larisa A. Ilina, Georgy Yu. Laptev, Andrey V. Dubrovin, Vasily A. Zaikin, Ksenia A. Kalitkina, Elena A. Korochkina, Irina A. Klyuchnikova, Ekaterina S. Ponomareva, Evgeny A. Brazhnik, Tatyana S. Smetannikova, Daria G. Tyurina

“…Reconstruction and prediction of the functional content of gene and enzyme families were carried out using the PICRUSt2 software package (v.2.3.0). …”
Get full text

E-Health rehabilitation on clinical, quality of life, and functional capacity in cardiovascular disease: preliminary results by Cássia da Luz Goulart, Marcela Lopes Alves, Fernando D’Angelo Medeiros, Robson Fernando Borges, Maurício Milani, Luciana Bartolomei Orru D’Ávila, Claudia Cristina Conde Holanda Sobra, Ana Cleides, Graziella França B. Cipriano, Gerson Cipriano Junior

“…Abstract This study aims to evaluate the preliminary effects of an e-health-based rehabilitation program delivered by a new technological solution, named eHeart, on functional capacity domains by assessing pre- and post-effects on cardiorespiratory fitness, quality of life, strength, and flexibility. …”
Get full text

A Complete Functional Characterization of Patients with Severe Knee Osteoarthritis in Need of Total Knee Replacement by Vinicius Taboni Lisboa, Bruno de Paula Leite Arruda, Rafael de Andrade Tambascia, Alessandro Rozin Zorzi, Alberto Cliquet, Gustavo Constantino de Campos

“…Poorer performance in the 6 min walk test also correlated with worse scores in the WOMAC (r = −0.35; <i>p</i> < 0.05), VAS (r = −0.48; <i>p</i> < 0.05) and SF-36. Conclusions: The present article established a functional profile of patients with severe knee osteoarthritis with indication for total knee replacement, which may help orthopedic surgeons in their decision process. …”
Get full text

eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants. by Alexis M Thornton, Lishan Fang, April Lo, Maria McSharry, David Haan, Casey O'Brien, Alice H Berger, Marios Giannakis, Angela N Brooks

“…The method distinguishes between variants that are gain-of-function, loss-of-function, change-of-function, or neutral. …”
Get full text

Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults by Simon Hass, Maxie Liebscher, Anni Richter, Anni Richter, Anni Richter, Klaus Fliessbach, Klaus Fliessbach, Christoph Laske, Christoph Laske, Sebastian Sodenkamp, Sebastian Sodenkamp, Oliver Peters, Oliver Peters, Oliver Peters, Julian Hellmann-Regen, Julian Hellmann-Regen, Julian Hellmann-Regen, Ersin Ersözlü, Ersin Ersözlü, Ersin Ersözlü, Josef Priller, Josef Priller, Josef Priller, Josef Priller, Eike Jakob Spruth, Eike Jakob Spruth, Slawek Altenstein, Slawek Altenstein, Sandra Röske, Anja Schneider, Anja Schneider, Hartmut Schütze, Annika Spottke, Annika Spottke, Anna Esser, Stefan Teipel, Stefan Teipel, Ingo Kilimann, Ingo Kilimann, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Ayda Rostamzadeh, Wenzel Glanz, Enise I. Incesoy, Enise I. Incesoy, Enise I. Incesoy, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Michael Wagner, Michael Wagner, Frank Jessen, Frank Jessen, Frank Jessen, Emrah Düzel, Emrah Düzel, Franka Glöckner, Björn Hendrik Schott, Björn Hendrik Schott, Björn Hendrik Schott, Miranka Wirth, Olga Klimecki, Olga Klimecki, for DELCODE study group

“…BackgroundIn humans, environmental enrichment (EE), as measured by the engagement in a variety of leisure activities, has been associated with larger hippocampal structure and better memory function. The present cross-sectional study assessed whether EE during early life (13–30 years) and midlife (30–65 years) is associated with better preserved memory-related brain activity patterns in older age.MethodsIn total, 372 cognitively unimpaired older adults (aged ≥60 years old) of the DZNE-Longitudinal Study on Cognitive Impairment and Dementia (DELCODE; DRKS00007966) were investigated. …”
Get full text

Functional characteristics of sleep monitoring devices in China: A real-world cross-sectional study by Le Yang, Bingtao Weng, Xingyan Xu, Zhi Huang, Run Ding, Miaomiao Si, Yingxin Fu, Yurui Zhu, Yu Jiang, Beibei Rao, Xinyi Zhang, Qingwei Zhou, Shenglan Lin, Yansong Guo, XiaoXu Xie

“…Background Sleep monitoring devices present potential improvements to address the challenges of sleep disorders. …”
Get full text

Genomic and functional characterization of a Butyricicoccus porcorum strain isolated from human gut microbiota by Ni Zhao, Peiling Geng, Alejandro Gaher Perez, Anakha Chandramana Maya, Brijesh Yadav, Yuxuan Du, Yong Ge

“…Oral administration of the bacterium profoundly altered gut microbiome composition in C57BL/6 mice, leading to controlled microbial oxidative signaling and calibrated carbohydrate metabolic function in the gut. RNA sequencing (RNA-seq) analysis demonstrated notable functional programming of colonic ECs, whereupon Bp 531D primarily restricted the biosynthesis of cholesterols and activated the pathway of antigen processing and presentation. …”
Get full text

Osteogenic and Antibacterial Response of Levofloxacin-Loaded Mesoporous Nanoparticles Functionalized with <i>N</i>-Acetylcysteine by Alberto Polo-Montalvo, Natividad Gómez-Cerezo, Mónica Cicuéndez, Blanca González, Isabel Izquierdo-Barba, Daniel Arcos

“…Herein we propose a nanosystem composed of mesoporous bioactive glass nanoparticles (MBGN) loaded with levofloxacin and functionalized with N-acetylcysteine (NAC), aiming to offer an alternative to current treatments. …”
Get full text

Meaningful to whom? Minimal clinically important differences and the priorities of individuals living with dementia for everyday function by Andrea Gilmore‐Bykovskyi, Kayla Dillon, Beth Fields, Clark Benson, Dorothy Farrar Edwards

“…Widely used measures for assessing MCID thresholds in AD/ADRD trials focus on basic and instrumental activities of daily living, presenting opportunities to expand measurement of MCID to account for other dimensions of everyday function that are prioritized by individuals living with AD/ADRD. …”
Get full text

Biological value of yak milk and its importance in medical and functional nutrition: A systematic review by Altynai N. Saalieva, Feruza A. Kochkorova, Marina K. Esenamanova, Aigul U. Usubalieva, Nadira M. Turgunbaeva, Dinara B. Isakova, Nurgul S. Dyusheeva, Sapargul K. Turdubekova, Rimma I. Elemanova

“…A review of the available modern information reveals the potential of yak milk as a source of nutrients and functional substances. The article presents the results of scientific studies of the chemical composition of yak milk and analyzes the data provided depending on the habitat of yaks. …”
Get full text

Looking at the Distant Universe with the MeerKAT Array: The H i Mass Function in the Local Universe by Amir Kazemi-Moridani, Andrew J. Baker, Marc Verheijen, Eric Gawiser, Sarah-Louise Blyth, Danail Obreschkow, Laurent Chemin, Jordan D. Collier, Kyle W. Cook, Jacinta Delhaize, Ed Elson, Bradley S. Frank, Marcin Glowacki, Kelley M. Hess, Benne W. Holwerda, Zackary L. Hutchens, Matt J. Jarvis, Melanie Kaasinen, Sphesihle Makhathini, Abhisek Mohapatra, Hengxing Pan, Anja C. Schröder, Leyya Stockenstroom, Mattia Vaccari, Tobias Westmeier, John F. Wu, Martin Zwaan

“…We present measurements of the neutral atomic hydrogen (H i ) mass function (H i MF) and cosmic H i density (Ω _H I ) at 0 ≤ z ≤ 0.088 from the Looking at the Distant Universe with MeerKAT Array (LADUMA) survey. …”
Get full text

Human congenital cataract mutation in MYH9 alters F-actin organization and cell functions by Hao Yuan, Zhen-Yu Wang, Jia-Rui Yang, Chen Huang, Liang Zhu, Xue-Min Li

“…Functional study revealed that the E1384Q mutation significantly inhibited cell proliferation (P=0.003) and migration (P<0.001), and promoted apoptosis (P<0.001). …”
Get full text

The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis by Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang

“…Consequently, it is important to utilize relevant coordinate data for a comprehensive meta-analysis to identify the shared patterns of structural, functional, and multimodal alternations in TUD.MethodThe present study conducted a systematic retrieval of studies published on PubMed, Web of Science, and Scopus from January 1, 2010, to December 12, 2023, to identify studies on voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) for TUD. …”
Get full text

Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV by Joanah Madzime, Joanah Madzime, Marcin Jankiewicz, Marcin Jankiewicz, Marcin Jankiewicz, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Peter Torre, Barbara Laughton, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes

“…We also report associations between the nodal efficiency of middle temporal and superior frontal regions and delayed recall, a neurocognitive marker of working memory, present in CHUU but not in CPHIV.DiscussionOur results demonstrate FC alterations in the PAC and between CAS regions and non-auditory regions involved in limbic, visual and motor processing, as well as disruptions to the regional properties of the CAS regions in the functional brain network. …”
Get full text