Heat shock proteins related signature characterizes immune status and predicts prognosis of gliomas by Zhiyan Sun, Haibin Wan, Minghui Du, Yiding Guo, Rui Tao, Xuzhe Zhao, Yutao Zhang, Pei Yang, Dabiao Zhou

“…Immunoenrichment analysis revealed a correlation between the risk score and the immunosuppressive status of glioma. In the functional assays, HSPA5 was identified as a key participant in several critical biological processes associated with glioma. …”
Get full text

Hydrochar Prepared from Aquatic and Terrestrial Biomass: Comparative Analysis of Characteristics and Applications by Libing Gao, Zifei Wang, Jinyu Guo, Yifan Qiao, Shuai Wang, Mengke Cui, Xuan Zhang, Yuhan Guo, Jianghao Wang, Tong Zhang, Kenji Ogino, Bing Wang

“…The benefits of hydrothermal carbonization (HTC) for carbon sequestration, energy, and soil remediation are widely recognized. Up to the present, there has been much research on hydrochar from terrestrial biomass residues, but there is little research on hydrochar based on aquatic plants. …”
Get full text

Quantum dot molecular beacons achieve sub-10 pM CRISPR-Cas detection in field-ready assays by Drew P. Lysne, Michael H. Stewart, Kimihiro Susumu, Tomasz A. Leski, David A. Stenger, Igor L. Medintz, Sebastián A. Díaz, Christopher M. Green

“…Abstract CRISPR-Cas systems have revolutionized molecular diagnostics through their specificity and programmability, yet their broad adoption is hindered by the reliance on expensive and complex instrumentation. Here, we present an optimized quantum dot (QD) molecular beacon (QD-MB) platform that integrates Förster resonance energy transfer (FRET)-based detection with CRISPR-Cas functionality, achieving sub-picomolar sensitivity without the need for target amplification. …”
Get full text

Advancements and Challenges in Electrical Impedance Myography (EIM): A Comprehensive Overview of Technology Development, Applications in Sports Health, and Future Directions by Pan Xu, Junwei Zhou, Zhizhang Chen, Xudong Yang, Hongli Yan, Zeljka Lucev Vasic, Mario Cifrek, Sio Hang Pun, Mang I Vai, Yueming Gao

“…By measuring muscle impedance parameters, this method characterizes the physiological state of muscles, functioning as a biomarker for muscle contractility, injuries, and the progression of neuromuscular diseases. …”
Get full text

Security Enhancement for Smartphone Using Biometrics in Cyber-Physical Systems by Seung-Hoon Chae, Daesung Moon, Kyeong-Ri Ko, JuHyun Shin, Sung Bum Pan

“…Along with the communication functions and mobility of cellular phones, smartphones have various sensors in addition to greatly enhanced performances and storage space compared with existing cellular phones. …”
Get full text

Osteocutaneous clavicular free flap: A modified approach for compound defects reconstruction by Thadeu Fernandes Rangel, Mustafa Saleh, Youssef El Orra, Guilherme F.  F. Alves, Gregory Nicolas, Rogério Rafael da Silva Mendes, Fabio F. Busnardo, Rolf Gemperli

“…The patient has not reported any functional or sensory complaints. This case report presents a modified alternative approach for CD reconstruction in the face, using a clavicular osteocutaneous free flap to reconstruct a mandibular defect and mouth floor. …”
Get full text

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation by Huang-Ju Tu, Min-Wu Chao, Cheng-Chung Lee, Chao-Shiang Peng, Yi-Wen Wu, Tony Eight Lin, Yu-Wei Chang, Shih-Chung Yen, Kai-Cheng Hsu, Shiow-Lin Pan, Wei-Chun HuangFu

“…Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. …”
Get full text

Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure by E. D. van Deel, M. Snelders, N. van Vliet, L. te Riet, T. P. P. van den Bosch, L. R. Fiedler, A. C. C. van Spreeuwel, N. A. M. Bax, N. Boontje, C. M. Halabi, T. Sasaki, D. P. Reinhardt, J. van der Velden, C.V.C. Bouten, J. H. von der Thüsen, A. H. J. Danser, D. J. Duncker, M. D. Schneider, I. van der Pluijm, J. Essers

“…In conclusion, we demonstrate functions for fibulin-4 in cardiac homeostasis and show that reduced fibulin-4 expression drives myocardial disease in response to cardiac pressure overload, independent of aortic valvular pathology.…”
Get full text

Integrated Software Environment for Pressurized Thermal Shock Analysis by Dino Araneo, Paolo Ferrara, Fabio Moretti, Andrea Rossi, Andrea Latini, Francesco D'Auria, Oscar A. Mazzantini

“…The last step of the methodology is the Fracture Mechanics (FM) analysis, using weight functions, aimed at evaluating the stress intensity factor (KI) at crack tip to be compared with the critical stress intensity factor KIc. …”
Get full text

Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up‐to‐date review by Rabia Javed, Noor ul Ain, Ayesha Gul, Muhammad Arslan Ahmad, Weihong Guo, Qiang Ao, Shen Tian

“…Abstract Titanium dioxide (TiO2) nanoparticles (NPs) are one of the topmost widely used metallic oxide nanoparticles. Whether present in naked form or doped with metals or polymers, TiO2 NPs perform immensely important functions. …”
Get full text

Reconstruction with free flaps in robotic head-and-neck onco-surgeries by Rajan Arora, Vinay Kumar Verma, Kripa Shanker Mishra, Hemant Bhoye, Rahul Kapoor

“…Aims and Objective: The aim of the present article is to highlight how reconstruction with free flaps is different and difficult in cases with robotic head-and-neck cancer surgery. …”
Get full text

Robotic Rehabilitation Devices in the Philippines: A Review of Recent Advancements by Czaryn Diane Ompico, Juliah Faye Dela Vega, Tonica Garcia, Christien Matthew Ramos, Enrique Mariano Perez, John Carlo Reyes, Julius Noel Banayo, Armyn Sy, Nicanor Jr. Roxas, Francisco Emmanuel Jr. III Munsayac, Nilo Bugtai

“…The country has gradually begun adapting technology, with rehabilitation robots introduced as assistive devices for clinical practice such as electromyogram (EMG)-assisted devices, Functional Electrical Stimulation (FES), Robotic Exoskeleton Hand, and Robot Exoskeleton for the Upper Limb. …”
Get full text

Neutral Sterols of Cephalic Glands of Stingless Bees and Their Correlation with Sterols from Pollen by Maria Juliana Ferreira-Caliman, Cláudia Inês da Silva, Sidnei Mateus, Ronaldo Zucchi, Fabio Santos do Nascimento

“…We analyzed the chemical composition of pollen stored in the colonies and the composition of the cephalic glands of workers in three adult functional phases (newly emerged, nurses, and foragers) by gas chromatography and mass spectrometry. …”
Get full text

Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability by David Naranjo-Hernández, Javier Reina-Tosina, Laura M. Roa, Gerardo Barbarov-Rostán, Jorge Calvillo-Arbizu, Alejandro Talaminos-Barroso, Miguel Ángel Pérez-Valdivia, Rafael A. Medina-López

“…This work presents an innovative bioimpedance spectroscopy device, developed as a support tool for decision-making during the evaluation of kidney viability for renal transplantation. …”
Get full text

A Layered Software Architecture for the Development of Smart Mobile Distributed Systems Oriented to the Management of Emergency Cases by Lizbeth Yesenia Contreras Rivas, Eduardo López Domínguez, Yesenia Hernández Velázquez, Saúl Domínguez Isidro, María Auxilio Medina Nieto, Jorge De La Calleja

“…The proposed software architecture was evaluated based on four main aspects: correctness and coverage of desirable requirements, functional suitability, usability assessment, and validation and verification of the reference architecture elements. …”
Get full text

Scalable and sustainable reductive amidation of nitroarenes, nitroalkenes, and nitroalkyls with acyl saccharins in aqueous media by Sunil L. Khamkar, Rayala Mohan, J. Santhosh, Harish M. Shinde, Kishor L. Handore, S. Venkata Mohan, D. Srinivasa Reddy

“…This atom-efficient approach avoids column chromatography, offers high yield, and is compatible with various functional groups. It is applicable to synthesize Dispyrin, a bromopyrrole alkaloid, amide-based drugs, and agrochemicals, including paracetamol, with solvent and saccharin recycling. …”
Get full text

Covalent Organic Framework Membranes for Ion Separation: A Review by Yutong Lou, Zhanyong Wang, Wanbei Yang, Shuchen Lang, Jiaxing Fan, Qiaomei Ke, Rui Wang, Zhen Zhang, Wentao Chen, Jian Xue

“…Covalent organic framework (COF) membranes have garnered significant attention in ion separation due to their high surface area, tunable pore size, excellent stability, and diverse functional groups. Over the past decade, various synthesis methods, such as solvothermal synthesis, interfacial synthesis, microwave-assisted solvothermal synthesis, and in situ growth, have been developed to fabricate COF membranes. …”
Get full text

Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus by Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja P. Völker, Svenja Müller, Anita C. Hansson, Thomas D. Meyer, Marcella Rietschel, Julia Ladewig, Rainer Spanagel, Ana M. M. Oliveira, Consuelo Walss-Bass, Rick E. Bernardi, Philipp Koch, Stephanie H. Witt

“…Abstract Structural and functional alterations in the brain’s reward circuitry are present in cocaine use disorder (CocUD), but their molecular underpinnings remain unclear. …”
Get full text

Effects of Different Fermentation and Clarification Methods on the Color, Physicochemical Characteristics, and Aroma Profile of Healthcare Cornus–Kiwifruit Composite Wine by Cuiyan Zeng, Xueru Zhang, Junxia Zhang, Shuiyan Pan, Keqin Chen, Yulin Fang

“…However, the rapidly growing trend of healthcare-oriented composite fruit wine with health functions and diverse flavors presents a way to address this issue. …”
Get full text

NCAM and attached polysialic acid affect behaviors of breast epithelial cells through differential signaling pathways by Wu Yurong, Yang Juhong, Wang Xin, Guo Jia, Tan Zengqi, Guan Feng, Cao Lin

“…Polysialylated NCAM occurs in many types of cancer, but rarely in normal adult tissues. The functional role of NCAM hypersialylation in the epithelial-mesenchymal transition (EMT) process remains unclear. …”
Get full text