Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions by Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A. Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

“…Summary: The transcription factor interferon regulatory factor 4 (IRF4) is crucial for the fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing group of immunomodulatory regulatory T (Treg) cells. …”
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Efficient Maturation and Cytokine Production of Neonatal DCs Requires Combined Proinflammatory Signals by Doreen Krumbiegel, Jan Rohr, Peter Schmidtke, Markus Knuf, Fred Zepp, Claudius U. Meyer

“…Specific functional properties of dendritic cells (DCs) have been suspected as being responsible for the impaired specific immune responses observed in human neonates. …”
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The local environment influences salt tolerance differently in four Salicornia europaea L. inland populations by Aleksandra Orzoł, Katarzyna Głowacka, Ricarda Pätsch, Agnieszka Piernik, Susana Dianey Gallegos-Cerda, Stefany Cárdenas-Pérez

“…This study is essential for advancing saline agriculture, developing restoration strategies for saline areas, and exploring S. europaea as a potential functional food. The strong association between halophyte salinity tolerance, high biomass production, and enhanced cellular antioxidant defenses highlights its resilience and suitability for these applications.…”
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Hybridization in Metal Wire Additive Manufacturing: A Case Study of an Impeller by Shahu R. Karade, Siddhartha Siddhartha, Neel Kamal Gupta, Ganesan G, K. P. Karunakaran, Henning Zeidler

“…Additive manufacturing (AM) has evolved to enable the direct production of functional components through the hybridization of additive and subtractive processes. …”
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Understanding the Influence of Secondary Metabolites in Plant Invasion Strategies: A Comprehensive Review by Rasheed Akbar, Jianfan Sun, Yanwen Bo, Wajid Ali Khattak, Amir Abdullah Khan, Cheng Jin, Umar Zeb, Najeeb Ullah, Adeel Abbas, Wei Liu, Xiaoyan Wang, Shah Masaud Khan, Daolin Du

“…The invasion of non-native plant species presents a significant ecological challenge worldwide, impacting native ecosystems and biodiversity. …”
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Determination of Probiotics Prescription Indications in Patients with Irritable Bowel Syndrome (Materials of the Expert Council and Literature Review) by V. T. Ivashkin, I. V. Maev, O. P. Alekseeva, S. A. Alekseenko, N. V. Korochanskaya, E. A. Poluektova, V. I. Simanenkov, A. S. Trukhmanov, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin, T. L. Lapina, R. V. Maslennikov, A. I. Ulyanin

“…To review the main indications for probiotics prescription in patients with irritable bowel syndrome and to present the materials of an Expert Council, which was held on 18 March 2022 in Moscow.Key points. …”
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Delphinidin upregulates microRNA-let-7b expression through family with sequence similarity 222 member B by Motoki Murata, Yuki Marugame, Shuhei Yamada, I-Chian Lin, Shuya Yamashita, Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana

“…However, the mechanism regulating its activity is yet to be completely elucidated. The present study aimed to identify the molecules responsible for the effects of delphinidin. …”
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POSSIBILITIES OF ORGAN-PRESERVING TREATMENT OF PATIENTS WITH MULTIPLE RENAL TUMORS by B. Ya. Alekseev, A. S. Kalpinskiy, I. A. Taraki, A. A. Mukhomed’yarova, K. М. Nyushko, N. V. Vorobyev, A. A. Kostin, A. D. Kaprin

“…The m ost justified option for the treatment of bilateral RCC is the implementation of bilateral organ-preserving treatment, which allows achieving the optimal functional results. This article presents a clinical case of successful surgical treatment of a patient with bilateral RCC with multiple tumors.…”
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Evolution of temporomandibular joint reconstruction: from autologous tissue transplantation to alloplastic joint replacement by Hanghang Liu, Liwei Huang, Shibo Liu, Linyi Liu, Bolun Li, Zizhuo Zheng, Yao Liu, Xian Liu, En Luo

“…Abstract The reconstruction of the temporomandibular joint presents a multifaceted clinical challenge in the realm of head and neck surgery, underscored by its relatively infrequent occurrence and the lack of comprehensive clinical guidelines. …”
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Structural basis of CXCR4 assembly and regulation by Aijun Liu, Yezhou Liu, Richard D. Ye

“…Here, we present the cryoelectron microscopy (cryo-EM) structure of a CXCR4 homo-tetramer. …”
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Fluorescent Carbon Dots with Red Emission: A Selective Sensor for Fe(III) Ion Detection by Ángela Fernández-Merino, Miriam Chávez, Guadalupe Sánchez-Obrero, Rafael Madueño, Manuel Blázquez, Rafael Del Caño, Teresa Pineda

“…We present a procedure for the synthesis and purification of p-phenylenediamine-based carbon dots that can be used for the recognition of Fe(III) ions. …”
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Analysis of Delaminated Composite Plates Using 3D Degenerated Plate Element Considering Geometric Non-Linearity by Pratik Tiwari, Swarup K. Barman, Changduk Kong, Sungjin Ahn, Hyunbum Park

“…Delamination is modeled using Heaviside step functions, providing a clear representation of discontinuities. …”
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Necroptosis could serve as an indicator of therapeutic resistance in viral induced well-differentiated oral squamous cell carcinoma? by Nitya Krishnasamy, Ramya Ramadoss, Suganya Panneer Selvam, Sandhya Sundar, K. Hemashree

“…Discussion: Viral-induced oral squamous cell carcinoma (OSCC) presents with disrupted cellular functions, dysregulation of apoptotic pathways, evasion of programmed cell death and resistance to conventional anticancer treatments. …”
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Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted Ladybird <i>Henosepilachna vigintioctopunctata</i> by Quanxing Lei, Ziming Wang, Shuangyan Yao, Aili Lin, Yunhui Zhang, Chengxian Sun, Xiaoguang Liu, Mengfang Du, Xiaoming Liu, Shiheng An

“…Neuropeptides, along with their designated receptors, play a pivotal role in regulating diverse biological processes in insects, presenting a promising avenue for innovative pest management strategies. …”
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Automated Assembly Line with 2D Cartesian Robot and Conveyor Belt by Viviana Moya, María Maldonado, Juan Pablo Vásconez, Faruk Abedrabbo, David Pozo-Espin, Marcelo Moya

“…The results showed an accuracy of 100% in functional tests and the implications of the advances were to ensure considerable potential for reducing costs and improving learning in industrial and educational environments. …”
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Proton solvation: competition between acetone and dimethyl sulfoxide by Alexander Lebed, Nikolay Mchedlov-Petrossyan, Dmitriy Filatov, Sergey Goga

“…This paper presents results of quantum-chemical study of proton exchange equilibrium between acetone (AC) and dimethyl sulfoxide (DMSO). …”
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Innovative integration of biometric data and blockchain to enhance ownership and trust with NFTs by Sung-eun Heo, Manho Kim, Wijin Kim, Jongseok Choi, Sungwon Jung, Yoogyeong Oh, Bumgyu Choi, Eunji Choi, Deokjae Heo, Sangmin Lee, Ju Hyun Park, Jinkee Hong

“…However, its governance presents significant ethical challenges, particularly around individual ownership and privacy. …”
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Methodology for assessing and controlling the risk grade of structural columns threatened by blast incident by Peng Sun, Xiaomeng Hou

“…The framework establishes an indicator system and incorporates risk functions and a fuzzy transformation system for blast risk assessment. …”
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Seaweed extracts: enhancing plant resilience to biotic and abiotic stresses by Gagan Kumar, Satyabrata Nanda, Satyabrata Nanda, Sushil Kumar Singh, Sanjeet Kumar, Divya Singh, Bansh Narayan Singh, Arpan Mukherjee

“…We also address the functions of various bioactive compounds present in seaweed extracts and the mechanisms by which they promote plant growth and induce defense against different stresses.…”
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Cerebral Fat Embolism After Traumatic Long‐Bone Fracture: A Case Report by Mariachiara Ippolito, Vincenzo Benenati, Valentina Gambino, Maria Lapi, Dario Nicosia, Alessandro Pace, Gabriele Presti, Fiammetta Ronga, Noemi Spina, Marco Tutone, Rosaria Vanella, Antonino Federico, Antonino Giarratano, Andrea Cortegiani

“…Overall, the care provided lead to positive long‐term outcomes, as the patient was discharged alive and successfully completed neurological rehabilitation, regaining many functional abilities. The initial management, diagnostic pathway, and ICU management are here described.…”
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