Oxidative DNA Damage and Repair Dynamics in Multiple Sclerosis: Insights from Comet Assay Kinetics, Base Excision Repair Gene Expression, and Genotype Analysis by Beata Filipek, Anna Macieja, Aleksandra Binda, Rafal Szelenberger, Leslaw Gorniak, Elzbieta Miller, Mariola Swiderek-Matysiak, Mariusz Stasiolek, Ireneusz Majsterek, Tomasz Poplawski

“…Our findings suggest that impaired oxidative DNA repair is present in MS, likely driven by functional deficits in repair kinetics and alterations in the expression of BER genes and polymorphisms. …”
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The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study by Violante Di Donato, Ottavia D'Oria, Andrea Giannini, Maria Scudo, Carmel Sher, Margherita Fischetti, Giorgia Perniola, Innocenza Palaia, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici

“…Conclusions: Fractional CO2 laser improves vaginal health as well as signs and symptoms associated with GSM, while significantly elevating quality of life and sexual functionality among postmenopausal symptomatic women.…”
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Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals by Ricardo D'Oliveira Albanus, Xiaoshan Zhang, Zeping Zhao, Henry J. Taylor, Xuming Tang, Yuling Han, Peter Orchard, Arushi Varshney, Tuo Zhang, Nandini Manickam, Michael R. Erdos, Narisu Narisu, Leland Taylor, Xiaxia Saavedra, Xinyi Liu, Aaron Zhong, Bo Li, Ting Zhou, Ali Naji, Chengyang Liu, Francis S. Collins, Stephen C.J. Parker, Shuibing Chen

“…Subsequently, we validated the functional impact of these genes and regulatory regions using isogenic human embryonic stem cells (hESCs). …”
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Augmenting insights into heat transfer performance of direct-contact evaporator: An interpretable data-driven hybrid strategy by Yinzhen Tan, Bo Yu, Jianxin Pan, Wuliang Yin, Min Wang, Hua Wang, Kai Yang, Qingtai Xiao

“…Then, the steam flow rate was decomposed into a series of intrinsic mode functions by intrinsic computing expressive empirical mode decomposition with adaptive noise (ICEEMDAN) and the intrinsic mode functions were divided into high-complexity and low-complexity components by fuzzy entropy (FE). …”
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Rosa rugosa R2R3-MYB transcription factors RrMYB12 and RrMYB111 regulate the accumulation of flavonols and anthocyanins by Yufeng Shi, Yufeng Shi, Taoran Lu, Sanyan Lai, Song Li, Ling Zhang, Rong Liu, Rong Liu, Lin Ouyang, Lin Ouyang, Xinxin Zhao, Xinxin Zhao, Yuqin Jiang, Zhen Yan, Zhen Yan, Ju Zhang, Ju Zhang, Baohe Miao, Baohe Miao

“…Furthermore, it was observed that RrMYBs displayed binding specificity to the promoter region of CsFLS.The functional characterization of the flavonol synthesis regulatory factors RrMYB12 and RrMYB111 offers a deeper understanding of the regulatory mechanism governing flavonol biosynthesis in roses, while also presenting an effective tool for genetic manipulation aimed at creating new varieties.…”
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Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights by Daphné Citherlet, Sami Heymann, Maya Aderka, Katarzyna Jurewicz, B. Suresh Krishna, Manon Robert, Alain Bouthillier, Olivier Boucher, Dang Khoa Nguyen

“…Additionally, it provides an avenue to study brain functions by analyzing cerebral responses during neuropsychological paradigms. …”
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An overall study on efficient Cr (VI) adsorbents for improving of the application value of Chlorella pyrenoidosa by Yi-Tong Wang, Liang-Yi Zhang, Le-Le Kang, Ya-Jun Wang, Jun-Guo Li, Hang Zhao, Kai-Li Dong, Hong-Peng Li, Xuan Guo, Ren-Long Dong, Ming-Ming Chen, Zhen Fang

“…All active functional groups present the effective adsorption performance for removing the Cr (VI) ions from the wastewater due to their active negative adsorption energies, especially -OH and pyrrole N (O-H = −2.86 eV > pyrrole N = -2.80 eV > CO = −2.30 eV > C-O = −2.16 eV > C-O-C = −2.14 eV > pyridine N = -1.87 eV). …”
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Effectiveness and safety of traditional Chinese therapies intreating patients with amyotrophic lateral sclerosis: a protocol for systematic review and meta-analysis by Rui Li, Tingting Bao, Tingting Bao, Tingting Bao, Bei Li, Peng Xia, Peng Xia, Peng Xia, Tingting Zhang, Tingting Zhang, Tingting Zhang, Haoli Zhang, Fei Huang, Fei Huang, Fei Huang

“…The main endpoint evaluated was the decrease in the overall score of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R; scoring from 0 to 48, where higher scores denote greater functionality) over a period of 24 weeks. …”
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Sparse and continuous sampling approaches to fMRI of overt vocalization tasks by Dawn L. Merrett, Chris Tailby, David F. Abbott, Graeme D. Jackson, Sarah J. Wilson

“…Sparse temporal sampling has become the dominant paradigm for functional magnetic resonance imaging studies of auditory stimuli or verbal responses, as it allows the presentation or production of stimuli during the relatively quiet periods when there is no gradient switching and ensures that task-related movements are not occurring during scan acquisitions. …”
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A stable 15-member bacterial SynCom promotes Brachypodium growth under drought stress by Archana Yadav, Mingfei Chen, Shwetha M. Acharya, Grace Kim, Yuguo Yang, Tiffany Z. Zhao, Eunice Tsang, Romy Chakraborty

“…Most strains encoded multiple plant growth-promoting functions, and several of these were confirmed experimentally. …”
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Advancements in lamb wave high-frequency devices using diamond-like carbon (DLC) coatings by Jatinder Pal Singh, Ajay Kumar Sao, Babita Sharma, Satyam Garg, Anjali Sharma, Reema Gupta, Lokesh Rana, Mallika Verma, Akhilesh Pandey, Archibald Theodore Nimal, Upendra Mittal, Amit Kumar Vishwakarma, Monika Tomar, Arijit Chowdhuri

“…Theoretical studies suggest that DLC coatings can accelerate SAWs due to their high elastic constant and low mass density, making them highly desirable for enhancing SAW device performance. In the present work, a process for reliable deposition of DLC films on the SiO2/Si membrane has been investigated, aiming to optimize their functionality. …”
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A Novel Monoallelic ALG5 Variant Causing Late-Onset ADPKD and Tubulointerstitial Fibrosis by Elhussein A.E. Elhassan, Tereza Kmochová, Katherine A. Benson, Neil K. Fennelly, Veronika Barešová, Kendrah Kidd, Brendan Doyle, Anthony Dorman, Martina M. Morrin, Niamh C. Kyne, Petr Vyleťal, Hana Hartmannová, Kateřina Hodaňová, Jana Sovová, Dita Mušálková, Alena Vrbacká, Anna Přistoupilová, Jan Živný, Klára Svojšová, Martin Radina, Viktor Stránecký, Dmitry Loginov, Petr Pompach, Petr Novák, Zdislava Vaníčková, Hana Hansíková, Silvie Rajnochová-Bloudíčková, Ondřej Viklický, Helena Hůlková, Gianpiero L. Cavalleri, Aleš Hnízda, Anthony J. Bleyer, Stanislav Kmoch, Peter J. Conlon, Martina Živná

“…Introduction: Monoallelic variants in the ALG5 gene encoding asparagine-linked glycosylation protein 5 homolog (ALG5) have been recently shown to disrupt polycystin-1 (PC1) maturation and trafficking via underglycosylation, causing an autosomal dominant polycystic kidney disease-like (ADPKD-like) phenotype and interstitial fibrosis. In this report, we present clinical, genetic, histopathologic, and protein structure and functional correlates of a new ALG5 variant, p.R79W, that we identified in 2 distant genetically related Irish families displaying an atypical late-onset ADPKD phenotype combined with tubulointerstitial damage. …”
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A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…In conventional ADCs, the drug molecules are chemically attached randomly to antibody surface residues (typically Lys or Cys), which can interfere with epitope binding and targeting, and lead to overall product heterogeneity, long-term colloidal instability and unfavorable pharmacokinetics. Here, we present a more controlled process for generating ADCs where drug is specifically conjugated to only Fab N-linked glycans in a narrow ratio range through functionalized sialic acids. …”
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Aquaponics model can provide better productivity: Microorganisms affect the growth and health of tilapia by Dingyue Fan, Huimin Xu, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Dandan Li, Longxiang Fang, Zhuping Liu, Xuwen Bing

“…The relationships between fish immunological and digestive functions, water quality, and bacterial populations were not well understood. …”
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Locating eloquent sites identified during brain tumor intraoperative mapping on reference MRI atlas by Angela Elia, Alexandre Roux, Clément Debacker, Sylvain Charron, Giorgia Simboli, Alessandro Moiraghi, Bénédicte Trancart, Edouard Dezamis, Jun Muto, Fabrice Chretien, Marc Zanello, Catherine Oppenheim, Johan Pallud

“…Conclusions We propose a standardized methodology to locate with accuracy on a reference brain template subcortical eloquent sites identified intraoperatively during functional brain mapping using direct electrical stimulations under awake condition.…”
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Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis by Zhihong Zhao, Zhonghua Luo, Qian Yang, Hongbo Chang, Pengcheng Liu, Zhichao Li, Shengli Guo, Chunhui Zhou, Jian Song, Weidong Cao

“…Neutrophils have recently been proposed as cells with high functional plasticity and are involved in the pathogenesis of infections, malignancy, and autoimmune diseases. …”
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THE STRATEGIC ROLE OF GENERATIVE AI IN MANAGING COMPANY’S PROCESSES by Viorica Mirela ȘTEFAN-DUICU, Mihaela SUDACEVSCHI, Maria Zenovia GRIGORE

“…The main points of the research include: descriptive elements of AI technologies, exploration of generative AI capability in organizational environment processes, the strategic role of using these technologies, describing human resources in reshaping the results obtained and the conduct of work processes, identifying challenges and managing risks in this modern global framework of functioning in the human resources market. Generative AI technologies present a major potential in handling the company's business because it provides support on every operational level, being a strategic mechanism that facilitates adaptation to the innovative markets and resilient conditions.…”
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Artificial Intelligence Enabled Biomineralization for Eco‐Friendly Nanomaterial Synthesis: Charting Future Trends by Vaisali Chandrasekar, Anu Jayanthi Panicker, Ajay Vikram Singh, Jolly Bhadra, Kishor Kumar Sadasivuni, Omar M. Aboumarzouk, Abdulla Al Ansari, Sarada Prasad Dakua

“…In contrast, the use of biological systems provides a sustainable alternative for producing functional NPs by biomineralization process. The transformative power of artificial intelligence (AI) has been proven prudent in diagnosis, drug development, therapy, and clinical decision‐making. …”
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Degradation of IRAK4 for the treatment of lipopolysaccharide-induced acute lung injury in mice by Bijun Ye, Shiyan Chen, Xiaohao Huang, Yinhong Qiu, Ruixiang Luo, Lulu Zheng

“…However, due to the dual functionality of IRAK4 as both an active kinase and a scaffolding protein, inhibiting its kinase activity yield moderate anti-inflammatory results. …”
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scRL: Utilizing Reinforcement Learning to Evaluate Fate Decisions in Single-Cell Data by Zeyu Fu, Chunlin Chen, Song Wang, Junping Wang, Shilei Chen

“…The critic learns state-value functions that quantify fate intensity for each cell, while the actor traces optimal developmental routes across the manifold. …”
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