New Function for Safety Signal Monitoring in MID‐NET®: The Case of an Anti‐COVID‐19 Drug by Yusuke Okada, Takashi Ando, Fumitaka Takahashi, Kenichi Watanabe, Kazuhiro Kajiyama, Tomoaki Hasegawa, Satomi Inomata, Yuki Kinoshita, Shinya Watanabe, Yoshiaki Uyama

“…The customizable analytical conditions include exposure and control drugs, 46 outcomes related to liver and kidney functions, blood tests, biomarkers, and time period of interest. …”
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Functional Reproductive and Developmental Traits Differences Between Two Macrocystis Ecomorphs: Importance of Neutral Lipids by Camilo Rodríguez‐Villegas, Alejandro H. Buschmann, Mayra A. Barrios, Sandra Pereda, Carolina Camus, Pamela Fernández, María C. Hérnandez‐González, Ángela M. Baldrich, Cynthia Urrutia, Ailen M. Poza, Karina Villegas, Camila Martínez, Jaime Vargas

“…ABSTRACT The kelp genus Macrocystis presents populations recognizable by distinct morphological traits, which has raised discussions on its taxonomical status. …”
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Functional genomic analysis of Bacillus cereus BC4 strain for chromium remediation in contaminated soil by Zhiyi Liu, Yubing Cai, Xu Chen, Yan Cang, Jialiang Yu, Muhammad Shaaban, Yajun Cai, Qi-an Peng

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Myocardial iron is strongly associated with reproductive function in beta-thalassemic women under chelation therapy by M. A. Castaldi, C. Fulgione, L. Marino, S. G. Castaldi, L. Giugliano, C. Selleri, M. Guida, V. Frega, L. Cobellis, A. Filosa, M. Casale

“…Moreover multivariate logistic regression showed a significant correlation between uterine biometry, FSH, E2, parity and hearth iron T2*HSIV, but not with liver iron. Conclusion: The present data shows that myocardial iron loading could be putative of prolonged and severe iron overload in the female genital tract, impairing fertility and reproductive function in patients affected with beta-thalassemia major under chelation therapy.…”
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The power spectrum and functional connectivity characteristics of resting-state EEG in patients with generalized anxiety disorder by Hangwei Wang, Shaoqi Mou, Xuedan Pei, Xiaomei Zhang, Shanhong Shen, Jianfeng Zhang, Xinhua Shen, Zhongxia Shen

“…Abstract Recent studies have suggested a relationship between abnormal neurophysiological functions and generalized anxiety disorder (GAD). However, studies on its electrophysiological characteristics, such as its power spectrum and functional connectivity are relatively few and scattered than those on other mental disorders (e.g., depression, ADHD, etc.). …”
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Spontaneous mesoscale calcium dynamics reflect the development of the modular functional architecture of the mouse cerebral cortex by Davide Warm, Davide Bassetti, Levente Gellèrt, Jenq-Wei Yang, Heiko J. Luhmann, Anne Sinning

“…The mature cerebral cortex operates through the segregation and integration of specialized functions to generate complex cognitive states. In the mouse, the anatomical and functional correlates of this organization arise during the perinatal period and are critically shaped by neural activity. …”
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Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration by Wei Chen, Yifei Pan, Catherine Huihan Chu, Shuo Dong, Mingxi Wang, Long Wang, Lingxu Wang, Xuyang Lin, Chunbo Tang

“…Under physiological conditions, the functionalized implants display modest immunomodulatory properties without affecting oxidative balance, while C-Ca-SalB NPs remain relatively stable. …”
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Theoretical investigation on PD-L1-In-1 for cancer immunotherapy via density functional theory by Bijay Sijapati Magar, Kiran Pudasainee, Prakash Pandey, Mahesh Kumar Neupane, Rupak Raj Lamichhane, Basanta Gurung, Khagendra Tripathi, Binod Adhikari

“…Abstract This study presents a comprehensive theoretical analysis of PD-L1-In-1 (C21H23N5O2) using the B3LYP functional with the 6-311G(d) basis set, focusing on its structural, electronic, and spectroscopic properties. …”
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Electroless Copper Patterning on TiO₂-Functionalized Mica for Flexible Electronics by Bozhidar I. Stefanov, Boriana R. Tzaneva, Valentin M. Mateev, Ivo T. Iliev

“…Finally, the potential of Cu-ELD patterning on TiO₂-functionalized mica for creating functional sensing devices was demonstrated by fabricating a functional resistance temperature detector (RTD) on the titania surface.…”
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A functional analysis of two 3D-scanned antique pistols from New Zealand by John LaRocco, Dong-Guk Paeng

“… • The method of making and analyzing digital models detailed in this study offers a way to facilitate historical preservation, experimental archaeology, and functional analysis.…”
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Condensed tannin from Caragana korshinskii extraction and protection effects on intestinal barrier function in mice by Xiaoyu Niu, Wei Qu, Zhiyu Chen, Hui Li, Peinan Liu, Mei Sun, Jing Yang, Yuanyuan Xing, Dabiao Li

“…Caragana korshinskii tannins (CKT) were extracted by response surface methodology and the protection effect of CKT on the jejunal mucosal barrier function of mice was investigated. Firstly, this work presents the extraction, purification and characterization of CKT. …”
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Post-stroke effects of IC87201 on neurobehavioral function and brain injuries: A stereological study by Maryam Mohammadian, Aminollah Bahaoddini, Mohammad Reza Namavar

“…Results: The administration of IC87201 significantly recovered post-ischemia damages, including neurobehavioral function, reduction of volume of the total hemisphere, cortex, and striatum in rat brain, and the percentage of infarcted areas. …”
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Is Autonomic Function Associated with (Central) Pain Processing in Individuals with Chronic Pain? A Systematic Review by Iris Meuwissen, Catharina Quaadvliet, Mira Meeus, Timo Meus, Michel GCAM Mertens

“…However, the interaction between (the) ANS (function) and CPP in these patients remains unclear, making it the focus of the present systematic review. …”
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Rhythmic Roots: The Adaptive Functions of Vocal Isochrony and Its Role in Human Music and Language Evolution by Julia V. Grabner, Anna E. Kempf, Alma M. N. Nederlof, Judith M. Varkevisser, Michelle J. Spierings

“…Thus, it represents a narrative synthesis of the adaptive functions of vocal isochrony. Here, we highlight three major possible functions of vocal isochrony: firstly, isochrony could improve communication by enhancing signal transmission from one individual and auditory detection by others and possibly function in conveying meaning. …”
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Cognitive cerebellum dominates motor cerebellum in functional decline of older adults with mild cognitive impairment. by Maria Devita, Alessandra Coin, Chiara Ceolin, Giulia Debiasi, Mariagiulia Anglani, Chiara Begliomini, Simone Cauzzo, Francesca Biasin, Carlo Gabelli, Alessandra Codemo, Michela Sarlo, Marina De Rui, Giuseppe Sergi, Alessandra Bertoldo, Daniela Mapelli

“…<h4>Objectives</h4>The present study aims to investigate the role that cognitive cerebellar lobules, compared to the motor ones, could have on performance abilities control in older individuals with Mild Cognitive Impairment (MCI).…”
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Impact of physical inactivity and sedentary behaviour on functional constipation in children and adolescents: a systematic review by Marc A Benninga, Morris Gordon, Shaman Rajindrajith, Wathsala Hathagoda, Shanaz Adil, Chandrani Kuruppu

“…Objective Lack of physical activity (PA) and sedentary behaviour (SB) have emerged as critical global health concerns in children and are believed to be associated with functional constipation (FC). The present study aims to explore this potential association.Design A comprehensive search of PubMed, Scopus, Web of Science, Embase, Cochrane Library and PsycInfo databases was conducted through 2023 using terms related to constipation and PA and SB in ages 0–18 years. …”
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De Novo transcriptome assembly of Diaprepes abbreviatus: foundations for functional genomics and targeted pest management by Lamiaa M. Mahmoud, Tejbhan Saini, Nabil Killiny

“…Additionally, genes related to mitochondrial function, muscle structure, and detoxification pathways exhibited clear sex-specific expression. …”
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Alterations in tear function and meibomian gland dysfunction across various phenotypes of polycystic ovary syndrome by Fatma Sumer, Beril Gurlek, Elif Yildiz, Feyzahan Uzun, Sabri Colak

“…Abstract The aim of this study was to investigate the relationship between tear function changes and meibomian gland dysfunction in various phenotypes of polycystic ovary syndrome (PCOS). …”
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Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. by Lingyu Zhan, Jiajin Li, Brandon Jew, Jae Hoon Sul

“…Late-onset Alzheimer's disease (LOAD) is the most common type of dementia causing irreversible brain damage to the elderly and presents a major public health challenge. Clinical research and genome-wide association studies have suggested a potential contribution of the endocytic pathway to AD, with an emphasis on common loci. …”
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Moderate alcohol consumption does not protect cognitive function when controlling for income and cultural factors by Kerri M. Gillespie, Eva Kemps, Melanie J. White, Selena E. Bartlett

“…The present study aimed to investigate the effect of alcohol on cognition, and the impact of different socioeconomic indicators on this relationship.MethodsAn online, cross-sectional survey, including an assessment of five domains of cognitive function, was conducted in 123 healthy adults between 18 and 70 years of age. …”
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