A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR by Lior Peri, Donna Matzov, Dominic R. Huxley, Alon Rainish, Fabrizio Fierro, Liel Sapir, Tara Pfeiffer, Lukas Waterloo, Harald Hübner, Yoav Peleg, Peter Gmeiner, Peter J. McCormick, Dorothee Weikert, Masha Y. Niv, Moran Shalev-Benami

“…Abstract Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs) expressed orally and extraorally, elicit signaling in response to a large set of tastants. Among 25 functional TAS2Rs encoded in the human genome, TAS2R14 is the most promiscuous, and responds to hundreds of chemically diverse ligands. …”
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In vitro regeneration and phytochemical evaluation of pippali (Piper longum) for conservation and therapeutic applications by ARIJITA MOHANTY, JYOTI PRAKASH SAHOO, KAILASH CHANDRA SAMAL

“…Infrared (IR) absorption analysis identified functional groups such as alcohols, amides, alkanes and carboxylic acids. …”
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Explainable AI-driven assessment of hydro climatic interactions shaping river discharge dynamics in a monsoonal basin by Prashant Parasar, Akhouri Pramod Krishna

“…This novel framework presents a reproducible and climate-resilient decision support tool, particularly suitable for monsoon-influenced, data-limited basins susceptible to extreme hydroclimatic events.…”
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Entrepreneurship and Creative Destruction by Cathleen Johnson, Robert Lusch, David Schmidtz

“…The research is carried out in the following logical sequence: the first stage presents William Baumol’s hypothesis about why entrepreneurship makes some societies richer and some poorer. …”
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Life cycle greenhouse gas emissions of diesel oil and zero-emission trucks: Systematic review of status and perspectives by Gaia Gentilucci, Antonella Accardo, Ezio Spessa

“…However, when comparing ZEVs to diesel Internal Combustion Engine Vehicles (ICEVs), it is crucial to rely on robust results to ensure comparability. The present study presents a systematic literature review of LCA applications to Heavy-Duty Vehicles (HDVs), employing a rigorous methodology to provide an unbiased and comprehensive overview. …”
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Group 2 Innate Lymphoid Cells in Allergic Rhinitis by Wang S, Liu X, Lin X, Lv X, Zhang H

“…ILC2s have the ability to interact with various immune cells and are essential in promoting both type 2 immune response and tissue repair, contributing to normal homeostatic functions within the body. This article presents a summary of the latest advancements in comprehending the activity of ILC2s, with particular emphasis on their potential role involvement in AR. …”
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Impact of the Internet Using Experience on the Peculiarities of the Internet Texts Understanding by Наталія Акімова, Катерина Олександренко

“…The peculiarities of the Internet texts include enhanced dialogue, divisibility, external informativity, reduced connectivity and comprehension, pragmatic and mostly formal integrity, conditional completeness, complicated structural, as well as hybrid and high degree of permeability, multimedia, presentation, inclination to speech game and collective authorship, saturation with neologisms, emoticons and abbreviations, fragmentation, non-compliance with linguistic norms, and the functioning of a special language etiquette. …”
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Boosting catalytic efficiency of nanostructured CuO-supported doped-CeO2 in oxidative coupling of benzyl amines to N-benzylidenebenzyl amines and benzimidazoles: impact of acidic a... by Sailatha Sakinala, Naga Pranava Sree Kothoori, Suman Jeedi, Mohan Varkolu, Mallesham Baithy

“…This study presents the rational synthesis of Cu-supported doped-CeO2 catalysts designed for the oxidation of benzylamine, both in the absence and presence of 1,2-diaminobenzene. …”
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A preliminary bioinformatic screen to identify SRI SMC2 PSIP1 TLE4 and MSX1 as potential diagnostic and prognostic markers of osteoarthritis by Jolanta Kryczka, Ewa Brzeziańska-Lasota, Michał Pikuła, Joanna Boncela, Jakub Mateusz Kryczka

“…Abstract Osteoarthritis (OA) is the most common degenerative joint disease, leading to severe pain and functional disability for nearly 530 million people worldwide. …”
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Internal and External Dialogue: a Swedish Approach to Quality Work in Courts by Marie B. Hagsgård

“…One way is to engage all judges and staff in an internal and external dialogue about the way the court is functioning and how to improve it. When judges and staff are actively involved in evaluating the present situation, in analyzing, suggesting and implementing new measures and in evaluating the effects of those measures, improvements can be reached in the way the court operates in a range of areas. …”
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Sex differences in schizophrenia: symptomatology, treatment efficacy and adverse effects by Ivi Moniem, Vasilios Kafetzopoulos

“…Men typically experience illness onset approximately 3–5 years earlier than women, with more severe negative symptoms, worse social functioning, and higher rates of comorbid substance use disorders. …”
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Auto-Scenario Generator for Autonomous Vehicle Safety: Multi-Modal Attention-Based Image Captioning Model Using Digital Twin Data by Hojun Lee, Jaein Song, Keeyeon Hwang, Minhee Kang

“…Among the results, we exemplify six top-accuracy accidents as to formalized functional scenarios for assessing AV safety. The scenarios present two intersections and four road-related accidents, including the behaviors of lane changing and turning right. …”
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Efficacy of problem-solving therapy in treating late-life depression with potential cognitive impairment: a systematic review and meta-analysis by Xia Li, Tao Wang, Chun Huang, Jianjun Wang, Yuan Fang, Feng Yan, Dongbin Cai, Zhiling Zhang

“…Introduction Late-life depression (LLD) is a global public health issue, often accompanied by cognitive impairments that can exacerbate the severity of depression and impair social functioning. Despite being a well-established treatment for LLD, the suitability of problem-solving therapy (PST) for individuals with LLD and varying degrees of cognitive impairments warrants further investigation. …”
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The relevance of traditional knowledge for modern landscape management: Comparing past and current herding practices in Mongolia by Gantuya Batdelger, Beáta Oborny, Batbuyan Batjav, Zsolt Molnár

“…A book published 80 years ago by Sambuu Jamsran, a Mongolian agricultural minister in the 1930s, provides a unique opportunity to compare the past versus present knowledge and practices of semi‐nomadic herders. …”
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Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. by Daniel P Depledge, Lorna M MacLean, Michael R Hodgkinson, Barbara A Smith, Andrew P Jackson, Saufung Ma, Silvia R B Uliana, Deborah F Smith

“…While HASPs are antigenic in the host and can induce protective immune responses, the biological functions of these Leishmania-specific proteins remain unresolved. …”
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Gamification of the educational space: advantages and disadvantages (on the example of Kahoot!) by Svitlyk Myroslava

“…It is shown that the platform’s functionality allows both presenting new material and refreshing knowledge, repeating the passed material, and conducting ongoing knowledge assessments. …”
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CLINICAL PROFILES OF FROSTBITE IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL: A CASE SERIES by Thomas Eduardus Sudrajat Wahyu Nugroho, Beta Subakti Nata’atmadja

“…Highlights: • This study presents three cases of frostbite in adults who participated in a Mount Denali expedition, highlighting the treatment process and outcomes…”
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Integrated decision support system for optimizing time and cost trade offs in linear repetitive construction projects by Ahmed Gouda Mohamed, Ali Hassan Ali, Ahmed Adel Abdelhady

“…Abstract Linear repetitive construction projects present unique challenges in optimizing both completion time and cost performance. …”
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Laparoscopic median arcuate ligament section for median arcuate ligament compression syndrome initially detected as splenic infarction: a case report by Toru Takagi, Yoshifumi Morita, Akio Matsumoto, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi

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Prediction of technological properties of wheat flour by combination of UV-VIS-NIR spectroscopy and multivariate analysis methods by R. A. Platova, E. V. Zhirkova, D. A. Metlenkin, A. A. Lysenkova, Yu. T. Platov, V. A. Rassulov

“…UV-VIS-NIR spectra contain information on the combination and intensity of absorption bands assigned to functional groups of the composition components and determining the technological properties of wheat flour. …”
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