Optimization of phenolic extraction method and in vitro bioaccessibility of microencapsulated pigmented rice bran extracts and their antioxidant and anticancer properties by Rhowell Navarro Tiozon, Jr., Glenn Vincent P. Ong, Kristel June D. Sartagoda, Sheba Mae M. Duque, Saleh Alseekh, Aldrin P. Bonto, Shem Gempesaw, Jr., Vipin Pratap, Florencio C. Reginio, Jr., Jonina Marie J. Tengco, Christian Seagan, Joel H G Tolentino, Dennis Marvin O. Santiago, Alisdair R. Fernie, Nese Sreenivasulu

“…The results support the integration of rice bran extracts into the rice value chain, promoting their use in functional health applications.…”
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Lacticaseibacillus rhamnosus LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial by Ke Chen, Kaihong Zeng, Shanshan Jin, Yu Ma, Limei Cai, Ping Xu, Yang Nie, Li Luo, Qinghua Yu, Changqi Liu

“…LRa05 treatment upregulated the functional genes of gut microbiota involving immunity regulation.DiscussionAdministration of the Lacticaseibacillus rhamnosus LRa05 at a dose of 5 × 109 CFU/day to children aged 0-3 years resulted in shorter duration of diarrhea, faster improvement in fecal consistency, and beneficial changes in gut microbiome composition and gene functions.Clinical trial registrationThe present study has been approved and registered in the Chinese Clinical Trial Registration Center with the registration number of ChiCTR2100053700 (https://www.chictr.org.cn/showproj.html?…”
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Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung by Maria Jordan, Maria Jordan, Kevin Schmidt, Kevin Schmidt, Maximilian Fuchs, Maximilian Fuchs, Annette Just, Angelika Pfanne, Lena Willmer, Lena Willmer, Lavinia Neubert, Christopher Werlein, Patrick Zardo, Andreas Pich, Thomas Thum, Thomas Thum, Jan Fiedler, Jan Fiedler

“…We validated drug-mediated effects on key features of fibroblast activation in functional assays and gene expression analyses in human embryonic lung fibroblasts (MRC-5). …”
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Efficacy and safety of herbal medicine Gongjin-Dan and Ssanghwa-Tang in patients with chronic fatigue: A randomized, double-blind, placebo-controlled, clinical trial by Jun-Yong Choi, Bom Choi, Ojin Kwon, Chang-Seob Seo, Ae-Ran Kim, Hyeun-kyoo Shin, Kibong Kim

“…A significant improvement in the Social Functioning (SF) score of Short-Form 36 Health Survey (SF-36) at week 4 was observed in the GJD group; similarly, a significant improvement compared with that in the Control group was observed in the Role Emotional (RE) score of SF-36 at weeks 4 and 6 and the Physical Functioning (PF) score of SF-36 at week 6 in the SHT group. …”
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Multiple Acquisitions of XopJ2 Effectors in Populations of Xanthomonas perforans by Anuj Sharma, Fernanda Iruegas-Bocardo, Shaheen Bibi, Yun-Chu Chen, Jung-Gun Kim, Peter Abrahamian, Gerald V. Minsavage, Jason C. Hurlbert, Gary E. Vallad, Mary B. Mudgett, Jeffrey B. Jones, Erica M. Goss

“…We demonstrated that XopJ2b is a functional T3E and triggers a hypersensitive response (HR) when translocated into pepper cells. …”
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Multilayer Double Emulsion Encapsulation of <i>Limosilactobacillus reuteri</i> Using Pectin-Protein Systems by Kattya Rodríguez, Diego Catalán, Tatiana Beldarraín-Iznaga, Juan Esteban Reyes-Parra, Keyla Tortoló Cabañas, Marbelis Valdés Veliz, Ricardo Villalobos-Carvajal

“…The development of bakeable foods supplemented with probiotics requires novel strategies to preserve the functionality of probiotic cells during thermal and gastrointestinal stress conditions. …”
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Single-cell transcriptomics unveils leukocyte heterogeneity in the gills of Larimichthys crocea in response to parasitic infection by Qiuhua Li, Qiuhua Li, Meiyan Wang, Chenhao Li, Ngoc Tuan Tran, Jingqun Ao, Shengkang Li, Xinhua Chen

“…Neutrophils increased in number and oxidative activity, while cpa5+ granulocytes highlighted immunomodulatory functions. Macrophages, dendritic cells, and B cells exhibited compartmentalized activation states, upregulating gene modules associated with pathogen recognition, antigen processing/presentation, chemotactic activity, and antibody defenses.ConclusionsThese findings describe a multi-layered immune cell defense strategy in the gills of teleosts against parasitic infection, showing conserved and fish-specific adaptations. …”
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Outcome in Patients with Isolated Moderate to Severe Traumatic Brain Injury by D. Jochems, K. J. P. van Wessem, R. M. Houwert, H. B. Brouwers, J. W. Dankbaar, M. A. van Es, M. Geurts, A. J. C. Slooter, L. P. H. Leenen

“…Gathered data included demographics, mortality, cause of death, WLST, and Glasgow Outcome Scale (GOS) score after three months. Good functional outcome was defined as GOS > 3. Results. …”
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Pathway activation model for personalized prediction of drug synergy by Quang Thinh Trac, Yue Huang, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Osterroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Backvall, Santeri Kiviluoto, Lukas Orre, Mattias Rantalainen, Janne Lehtiö, Soren Lehmann, Olli Kallioniemi, Yudi Pawitan, Trung Nghia Vu

“…We show evidence that higher synergy is associated with higher functional interaction between the drug targets, and this functional interaction information is captured by PAS. …”
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Optimizing adaptive responses through individualized interval hypoxic training by Abdrazak Babashev, Zhylkyshybaeva M. Malikovna, Kalekeshov A. Maralovich, Shaikhynbekova R. Mukhambetovna, Aigerim Bektemirova, Baibolatova L. Mukhatovna, Otarova N. I liyasovna7, Barmenkulova B. Bedelovna, Gaukhar Abdikarimova

“…Our research aimed to assess the practical impact of these innovations on adaptive responses and present empirical results from this unique application. …”
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Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes by Luca Di Nunno, Luca Di Nunno, Veronica Pagani, Elena Canciani, Gerardina Ruocco, Gerardina Ruocco, Mattia Spedicati, Mattia Spedicati, Maria Talmon, Luca Fusaro, Dalila Di Francesco, Dalila Di Francesco, Simona Casarella, Manuela Rizzi, Francesca Boccafoschi, Francesca Boccafoschi

“…IntroductionCurrent hemostatic agents face several limitations, including reduced effectiveness in controlling massive bleeding or preventing thrombogenic events. Functional bleeding control could allow time for further treatment and decrease mortality rates. …”
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Profile of Humoral Immunity and B Cell Pool in Infection with the SARS-CoV-2 Prototype Strain and AZD1222 (ChAdOx nCoV-19) Vaccination by Débora Familiar-Macedo, Elzinandes Leal de Azeredo, Elba Regina Sampaio de Lemos, Paulo Vieira Damasco, Luzia Maria de-Oliveira-Pinto

“…Conclusions: Vaccination and natural infection with COVID-19 induce a differential profile and functionality of B cells. We suggest that new vaccines against COVID-19 incorporate molecular adjuvants that regulate B lymphocyte functionality and consider the beneficial aspects of the IgA response in addition to IgG.…”
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Machine learning for discrimination of phase‐change chalcogenide glasses by Qundao Xu, Meng Xu, Siqi Tang, Shaojie Yuan, Ming Xu, Wei Zhang, Xian‐Bin Li, Zhongrui Wang, Xiangshui Miao, Chengliang Wang, Matthias Wuttig

“…This has led to a dilemma in materials design since an atomistic view of the arrangement in the amorphous state is the key to understanding and optimizing the functionality of these glasses. To tackle this challenge, we present a machine learning (ML) approach to separate electronic phase‐change materials (ePCMs) from other chalcogenides, based upon subtle differences in the short‐range order inside the glassy phase. …”
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Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait by Nicol Bernardinello, Federica Pezzuto, Lauren D’Sa, Luca Vedovelli, Chiara Giraudo, Anamaria Chelu, Anamaria Chelu, Cecilia de Chellis, Francesca Lunardi, Francesco Fortarezza, Francesca Boscaro, Elisabetta Cocconcelli, Paolo Spagnolo, Elisabetta Balestro, Fiorella Calabrese

“…PPF showed a higher prevalence of traction bronchiectasis (80% vs. 27%; p=&lt;0.001) at CT scan and lower functional parameters [FVC: 2.42 L vs. 3.37 L; p=0.004; TLC: 3.83 L vs. 4.65 L; p=0.027] at diagnosis. …”
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Dynamic epigenomic landscape and gene regulatory networks during embryonic development in Pacific white shrimp (Litopenaeus vannamei) as revealed by histone modification profiling... by Jiale Shi, Zhangru Qi, Miaomiao Yin, Qifan Zeng, Jingjie Hu, Zhenmin Bao, Zhi Ye

“…Results In this study, we present the first comprehensive histone modification landscape during L. vannamei embryogenesis using CUT&Tag (Cleavage Under Targets and Tagmentation). …”
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Examination and critique of bilingual dictionaries in linguistics by Ebrahim Badakhshan

“…The distinction between primary and secondary structures is also elucidated, with outer texts (such as introductions and indexes) serving as functional components that contribute to the dictionary's overall framework.   …”
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Graph coloring framework to mitigate cascading failure in complex networks by Karan Singh, V. K. Chandrasekar, Wei Zou, Jürgen Kurths, D. V. Senthilkumar

“…Abstract Cascading failures pose a significant threat to the stability and functionality of complex systems, making their mitigation a crucial area of research. …”
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Environmental Implication of Herbicide Use by Małgorzata Baćmaga, Jadwiga Wyszkowska, Jan Kucharski

“…Herbicides are major elements of plant production, indispensable to the functioning of modern agriculture. Nevertheless, their influence on all elements of the natural environment needs to be continuously controlled. …”
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EFFICACY OF FREE AUTOVENOUS TRANSPLANT IN FEMORAL-POPLITEAL BYPASS BELOW THE JOINT SPACE OF THE KNEE by B. S. Sykovatykh, L. N. Belikov, M. B. Sykovatykh, D. V. Sidorov, M. A. Inarkhov, E. B. Inikhodova

“…The article presents an analysis of complex examination and treatment of 60 patients with critical ischemia of the lower extremities due to atherosclerotic lesions of femoral-poplitealtibia segment. …”
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Management of an Endobronchial Pulmonary Paraganglioma via Bronchoscopic Resection by Khuyen Hoang, Michael V. Brown, Arash Badiei, Phan Nguyen

“…Paragangliomas can cause symptoms due to the secretion of catecholamines. Other ‘non‐functional’ paragangliomas may cause symptoms relating to mass effect or endobronchial obstruction. …”
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