Long-Term Impact of Recurrent Acute Otitis Media on Balance and Vestibular Function in Children by Mirko Aldè, Pietro Bosi, Stefanie Muck, Thomas Mayr, Paola Di Mauro, Valentina Berto, Beatrice Gaia Aleandri, Francesco Folino, Stefania Barozzi, Diego Zanetti, Paola Marchisio

“…Background/Objectives: Recurrent acute otitis media (rAOM) is a common disease in childhood, but its impact on the vestibular system remains poorly understood. The present study aimed to evaluate the long-term effects of rAOM on balance and vestibular function in pediatric patients. …”
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Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome by Jiao Sun, Jin-Young Kim, Semo Jun, Meeyeon Park, Ebbing de Jong, Jae-Woong Chang, Sze Cheng, Deliang Fan, Yue Chen, Timothy J. Griffin, Jung-Hee Lee, Ho Jin You, Wei Zhang, Jeongsik Yong

“…Collectively, our findings underscore intronic APA events as a discrete molecular signature present in both normal tissues and cancer transcriptomes, highlighting the contribution of APA to the multifaceted functionality of the cancer proteome.…”
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Dysphagia is a strong predictor of death and functional dependence at three months post-stroke by Aline Cristina PACHECO-CASTILHO, Rubia Poliana Crisóstomo MIRANDA, Ana Maria Queirós NORBERTO, Diandra Bosi FAVORETTO, Brunna Pileggi RIMOLI, Luciana Bezerra de Mello ALVES, Karina Tavares WEBER, Taiza Elaine Grespan SANTOS, Julio Cesar MORIGUTI, João Pereira LEITE, Roberto Oliveira DANTAS, Rosemary MARTINO, Octávio Marques PONTES-NETO

“…Dysphagia (OR=3.78; 95%CI 2.16-6.61; p<0.001) and stroke severity (OR=1.05; 95%CI 1.00-1.09; p=0.024) were independently associated with death or functional dependence at three months. Conclusions: Dysphagia was present in almost half of stroke patients. …”
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The impact of frailty on functional recovery after cardiac surgery—a case control study by M. Abdelmonem, M. Elsayed, D. Awadallah, O. Don, R. H. Bennett, O. G. Mackay, S. Pookayil, C. Archer, M. Mahgoub, M. J. Bennett

“…They depend on the preservation or early recovery of physiological and functional capacity, both of which may be lost in patients living with frailty. …”
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Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment by Juan-Juan Lu, Jie Ma, Mou-Xiong Zheng, Jia-Jia Wu, Yun-Ting Xiang, Jing Jin, Qi-Hao Guo, Xu-Yun Hua, Jian-Guang Xu

“…Given its role in regulating memory along internal-external axis, understanding metamemory and underlying neural mechanisms in amnestic mild cognitive impairment (aMCI) is crucial for memory improvement. The present study was aimed to explore metamemory alterations and structural and functional remodeling characteristics underlying metamemory, as well as key brain regions that potentially moderated its intrinsic associations with age, education, and first-order cognition in aMCI. …”
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Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation by Kristína Mitterová, Eva Výtvarová, Anežka Kovářová, Martin Lamoš, Jan Fousek, Irena Rektorová

“…Abstract Dementia with Lewy bodies (DLB) is marked by multidomain cognitive impairments, with fluctuations in cognition and alertness being among the most common clinical features. Disruptions in functional connectivity are thought to underlie these fluctuations, but it remains unclear whether such patterns are already present at prodromal stages. …”
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Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function by Sophie L. Russell, Mushidur Rahman, Charles J. Steward, Amy E. Harwood, Gordon McGregor, Prithwish Banerjee, Nduka C. Okwose, Djordje G. Jakovljevic

“…Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx in healthy individuals. …”
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Fermentation and Functional Properties of Plant-Derived <i>Limosilactobacillus fermentum</i> for Dairy Applications by Batchimeg Namshir, Gil-Ha Kim, Natsag Lkhagvasuren, Seon-A Jeong, Narangerel Mijid, Woan-Sub Kim

“…Lactic acid bacteria (LAB) isolated from plant sources are gaining increasing attention due to their potential probiotic and postbiotic functionalities. In the present study, <i>Limosilactobacillus fermentum</i> isolated from <i>Prunus padus</i> (bird cherry) was evaluated for its physiological, functional, and technological attributes for application in fermented dairy products. …”
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Small- to Large-Scale Electron Beam Powder Bed Fusion of Functionally Graded Steels by Carlos Botero, William Sjöström, Emilio Jimenez-Pique, Andrey Koptyug, Lars-Erik Rännar

“…The ability to control process parameters over time and build space in electron beam powder bed fusion (PBF-EB) opens up unprecedented opportunities to tailor the process and use materials of a different nature in the same build. The present investigation explored the various methods used to adapt the PBF-EB process for the production of functionally graded materials (FGMs). …”
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Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina by Tatyana Appelbaum, David A. Smith, Kei Takahashi, Jennifer C. Kwok, Hannah Sorenson, William A. Beltran

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Versatile physiological functions of the Nudix hydrolase family in berry development and stress response in grapevine by Pei-pei WANG, Zhao-ke WANG, Le GUAN, Muhammad Salman HAIDER, Maazullah NASIM, Yong-bing YUAN, Geng-sen LIU, Xiang-peng LENG

“…Although Nudix hydrolases are involved in plant detoxification processes in response to abiotic and biotic stresses, the biological functions of Nudix hydrolases remain largely unclear in grapevine. …”
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Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function by Jinli Huang, Hongyu Qiao, Qiuhong Li, Yi Zhang, Chenyu Zhang, Hui Su, Xin Sun

“…We further discovered that OPN deficiency reduces FOXP3 expression and decreases Lactobacillus colonization through activation of the PD-1/PD-L1 pathway in the intestine and lung. The present study suggests that OPN may moderate OVA-induced asthma by modulating the gut and lung microbiota.IMPORTANCEOsteopontin deficiency exacerbated asthmatic airway inflammation, an effect associated with microbiota dysbiosis, impaired intestinal barrier function, and increased PD-1/PD-L1 expression and thus decreased Treg cell function. …”
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Metagenomic insights into the microbial communities and functional traits of hot springs in Guizhou Province, China by Feng Chen, Min Cheng, Dongyun Rong, Yanyan Wang, Yanyan Wang, Rubing Liang, Muhammad Irfan, Yingqian Kang, Yu Cao, Yu Cao

“…The highest predicted functions were observed for amino acid metabolism, followed by carbohydrates. …”
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Fc-effector functional antibody assays for SARS-CoV-2 variants of concern by Xuemin Chen, Grace Li, Caroline Ciric, Theda Gibson, Larry J. Anderson, Larry J. Anderson, Christina A. Rostad, Christina A. Rostad

“…Serum samples from 20 healthy adult volunteers pre- and post-monovalent XBB.1.5 COVID-19 vaccine were analyzed for pseudovirus neutralizing and Fc-effector antibodies.ResultsPrior to administration of the COVID-19 XBB.1.5 booster vaccination, cross-neutralizing antibodies against XBB.1.5 and EG.5 variants were minimally detectable, while cross-functional Fc-effector antibodies were present at higher baseline levels. …”
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Diagnostic value of the urea-to-creatinine ratio for gastrointestinal bleeding source: influence of renal function by Philipp Russ, Julian M. Koppenhöfer, Simon Bedenbender, Thomas S. Tarawneh, Ulrike W. Denzer, Ivica Grgic, Martin Rußwurm, Christian S. Haas

“…Patients were stratified by renal function: normal renal function, chronic kidney disease (CKD), acute kidney injury (AKI), and AKI with pre-existing CKD (acute-on-chronic). …”
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Assessment of structural and functional changes in recipient's transplanted heart in the long-term postoperative period by M. Sh. Khubutiya, Kh. G. Alidzhanova, A. V. Dyatlov, A. A. Ivannikov, S. Yu. Shemakin, D. A. Kosolapov

“…Patients in the study sample showed a decrease in the left ventricular global function index to 25 (24.2;29.6)%. The diastolic dysfunction of a restrictive type was present in 10 patients (76.9%).Conclusions. …”
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Phase angle as a predictor of motor function decline in children with Duchenne muscular dystrophy by Qin Hu, Xiaoyong Chen, Shaojie Luo, Yanhong Wang, Peicong Fan, Xiaona Wu, Hui Zhou, Huayan Xu, Na Li, Xiaotang Cai

“…Conclusion 1) The phase Angle (PhA) increases first and then decreases with the progression of DMD disease; the phase Angle (PhA) changes earlier than motor function and presents a good correlation, which is a sensitive index to predict the progression of DMD disease. …”
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Structural and functional characteristics of the T helpers 17 subpopulation in allergic diseases of the respiratory organs in children by E. V. Prosekova, N. G. Plekhova, A. I. Turyanskaya, V. A. Sabynych

“…Therefore, the studies on the pathogenesis in various phenotypes of allergic respiratory diseases, and assessment of structural and functional characteristics of Th17 lymphocytes and interleukin 17 are relevant. …”
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Evaluation of Functional and Radiological Outcome of Different Cephalomedullary Nail Designs in Intertrochanteric Fractures of Femur by Adarsh U Thuppad, Harsh Kirthi Rao, Gaurav C Mendon, Santosha Manjunatha, Suraj M Revankar, Kaveesh P Shetty

“…Subjects are patients with IT fracture presenting to Srinivas Institute of Medical Sciences and Research Centre. …”
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5′-Guanidino Xylofuranosyl Nucleosides as Novel Types of 5′-Functionalized Nucleosides with Biological Potential by Jennifer Szilagyi, Tânia Moreira, Rafael Santana Nunes, Joana Silva, Celso Alves, Alice Martins, Rebeca Alvariño, Niels V. Heise, René Csuk, Nuno M. Xavier

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