Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst by Lu Pan, Bufu Tang, Xuan Zhang, Paolo Parini, Roman Tremmel, Joseph Loscalzo, Volker M. Lauschke, Bradley A. Maron, Paola Paci, Ingemar Ernberg, Nguan Soon Tan, Ákos Végvári, Zehuan Liao, Sundararaman Rengarajan, Roman Zubarev, Yuxuan Fan, Xu Zheng, Xinyue Jian, Ren Sheng, Zhenning Wang, Xuexin Li

“…To address this challenge, we present single‐cell analyst, a user‐friendly, web‐based platform to facilitate comprehensive multi‐omics analysis. …”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Incorporating the expectation that coral cryptic taxa with incomplete species boundaries will frequently be encountered is critical to the long-term success of coral conservation and restoration programs. Studying these phenomena in more detail will directly benefit conservation and restoration goals. …”
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Workplace violence in Italian healthcare organizations: A multicenter survey on prevention measures and incident reporting by Jessika CAMATTI, Francesco CHIRICO, Franco PUGLIESE, Mario GIACOMAZZI, Piero BORGIA, Anna Maria MINICUCCI, Nicola PINELLI, Eva COLOMBO, Giovanni MIGLIORE

“…Further research is needed to evaluate the effectiveness of prevention programs and the psychological impact of violence on healthcare workers.…”
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Oral delivery of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in alginate spheres to captive white-tailed deer by Paola M. Boggiatto, Haley Sterle, Luis Fernandes, Hayden Hamby, Kurt VerCauteren, Abigail Feuka, Henry Campa, Carly Kanipe, Steven C. Olsen, Mitchell V. Palmer

“…Long-standing eradication programs have been successful at lowering prevalence of disease in many countries; however, disease eradication has not been achieved. …”
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Model Identification, Dynamic Positioning, and Thrust Allocation System for the milliAmpere1 Autonomous Ferry Prototype: Field Trial Results by Miguel Hinostroza, Camilla Fruzzetti, Andreas Gudahl Tufte, Simon J. N. Lexau, Alexey Gusev, Egil Eide, Edmund F. Brekke, Anastasios M. Lekkas, Roger Skjetne, Michele Martelli, Morten Breivik

“…The TA is formulated as a quadratic programming problem, which includes cost functions for power consumption. …”
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Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis) by A John Simpson, Paul Dark, Katie Booth, Ranjit Lall, Gavin Perkins, Timothy Walsh, Manu Shankar-Hari, David McDonald, Daniel F McAuley, Andrew Conway Morris, Andrew Filby, Ronan McMullan, Thomas P Hellyer, Jonathan Scott, Loredana Trevi, Hannah McNeil, Tom Ewen, Phil Mawson, Gert Boschman, Vesna Melkebeek, Iain J McCullagh, Anthony Rostron

“…The primary outcome measures are monocyte human leucocyte antigen-DR; neutrophil CD88; programmed cell death-1 on monocytes, neutrophils and T lymphocytes and the percentage of regulatory T cells. …”
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Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome by Jiao Sun, Jin-Young Kim, Semo Jun, Meeyeon Park, Ebbing de Jong, Jae-Woong Chang, Sze Cheng, Deliang Fan, Yue Chen, Timothy J. Griffin, Jung-Hee Lee, Ho Jin You, Wei Zhang, Jeongsik Yong

“…Notably, our analyses of protein length changes resulting from intronic APA events revealed two distinct phenomena in proteome programming: a loss of functional domains due to significant changes in protein length or minimal alterations in C-terminal protein sequences within unstructured regions. …”
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Unveiling the Silent Crisis Amidst Tackling Hepatitis B in African Prisons ‐ A Public Health Emergency by Godfred Yawson Scott, Abdullahi Tunde Aborode, Ridwan Olamilekan Adesola, Chime Onyinye Hope, Olayide Dipeolu, Favour Akinfemi Ajibade, Abraham Olutumininu Akiyode, Stephen Tetteh Engmann, Abdullahi Jamiu, Awoyemi Praise‐God Adetunji, Joseph Agyapong, Toluwalope Yinka Oni, Mpanga Derick Denis, Isreal Onifade Ayobami, Adetolase Azizat Bakre

“…The transmission is further exacerbated by limited access to vaccination, insufficient screening programs, and a lack of awareness among inmates and prison staff. …”
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Meta-analysis of antifungal resistance patterns of Aspergillus species in Iran by Ibrahim Bahrami Mianrood, Farid Javandoust Gharebagh, Sadegh Khodavaisy, Maryam Ahmadian, Ilad Alavi Darazam

“…We recommend establishing antifungal stewardship programs to develop evidence-based guidelines. Based on our findings, we suggest posaconazole or voriconazole for A. fumigatus and A. flavus, amphotericin B as alternative therapy, and caspofungin as salvage therapy.…”
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C reactive protein impairs adaptive immunity in immune cells of patients with melanoma by Jeffrey Weber, Michelle Krogsgaard, Tatsuya Yoshida, Junya Ichikawa, Iulia Giuroiu, Andressa S Laino, Yuhan Hao, Melinda Vassallo, David M Woods, F Stephen Hodi

“…Background High C reactive protein (CRP) levels have been reported to be associated with a poor clinical outcome in a number of malignancies and with programmed cell death protein 1 immune checkpoint blockade in patients with advanced cancer. …”
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Trade-off between resistance and persistence in high cell density cultures by F. Beulig, J. Bafna-Rührer, P. E. Jensen, S. H. Kim, A. Patel, V. Kandasamy, C. Steffen, K. Decker, D. Zielinski, L. Yang, E. Özdemir, S. Sudarsan, B. Palsson

“…This study deepens our understanding of high-density physiology, illustrates a common link between biomanufacturing and infection, and suggests that persistence phenotypes are programmed as hidden transcriptional states in E. coli.IMPORTANCEThis study presents the first systems-level characterization of Escherichia coli high-cell-density physiology, using an integrated experimental and computational approach. …”
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Effects of home-based slow-paced breathing on functional performance in middle-aged women: A randomized controlled trial study by Karama Masmoudi, Fatma Chaari, Haithem Rebai, Sonia Sahli

“…Given the low adherence to traditional exercise programs among this population, home-based slow-paced breathing (SPB) presents a promising accessible alternative. …”
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Serplulimab combined with gemcitabine, nab-paclitaxel and stereotactic body radiotherapy as the first-line treatment for patients with metastatic pancreatic adenocarcinoma in China... by Dan Cao, Ke Cheng, Chenyan Zhang, Deying Kang, Ruizhen Li, Chen Chang, Heqi Yang, Junjie Xiong, Du He, Xi-Jiao Liu

“…Introduction Patients with pancreatic ductal adenocarcinoma (PDAC) remain a poor prognosis despite the development of chemotherapy. Although programmed cell death 1 (PD-1) blockade has shown great efficacy in various solid tumours, its application in treating PDAC is limited. …”
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Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay by Julia Faillace Thiesen, Elise Jacquemet, Pascal Campagne, Denis Chatelain, Etienne Brochot, Yves-Edouard Herpe, Nolwenn M. Dheilly, Fabrice Bouilloux, Bénédicte Rognon, Alexandre Douablin, Guillaume Leboucher, Florent Percher, Marc Eloit, Philippe Pérot

“…Abstract Background Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human papillomaviruses (hrHPV), the causative agents of cervix cancer. …”
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Greening rice-fallow areas: integrating pulses and oilseeds for sustainable cropping in eastern India by Rakesh Kumar, Anup Das, Surajit Mondal, Pravin Kumar Upadhyay, Bhagwati Prasad Bhatt, Janki Sharan Mishra, Anil Kumar Singh, Jaipal Singh Choudhary, Sanjeev Kumar, Prem Kumar Sundaram, Ashis Kumar Biswas, Sanjay Singh Rathore, Rajiv Kumar Singh, Puspa Parameswari, Dhiraj Kumar Singh, Santosh Kumar, Akram Ahmad, Kirti Saurabh, Kumari Shubha, Ajay Kumar, Manibhushan, Pawan Jeet, Ved Prakash, Bal Krishna Jha, Sushant Kumar Naik, Santosh Sambhaji Mali, Rakesh Kumar, Surendra Kumar Ahirwal, Vinod Kumar Singh, Devendra Mandal, Manoj Kumar Roy, Arbind Kumar Choudhary, Sudhir Kumar Rajpoot, Suresh Kumar Chaudhari

“…Eastern Indian states, which account for 82% of India’s rice-fallow area, presents significant opportunities for cropping intensification. …”
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Concurrent Validity of Wearable Nanocomposite Strain Sensor With Two-Dimensional Goniometer and Its Reliability for Monitoring Knee Active Range of Motion in Multiple Participants by Han-Byeol Choi, Yongjun Kim, Ji Young Lim, Seonghee Kim, Sang Yul Yang, Kihyeon Kim, Hyouk Ryeol Choi, Seunghyun Baik, Ji Hye Hwang

“…Future research should focus on enhancing the sensor attachment and calibration methods, along with broadening the application scope to more dynamic activities, other joints, and patients with specific pathologies. The strain sensor presents significant potential for real-time and continuous monitoring of joint angles during real-world activities as well as rehabilitation programs.…”
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Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease by I. K. Dzhumaniiazova, A. N. Meshkov, A. N. Meshkov, V.V. Daniel, M. V. Ezhov, E. A. Zelenova, U. V. Chubykina, D.A. Kashtanova, M. V. Ivanov, L. R. Matkava, O. I. Blinova, N. A. Kumar, A. Y. Fedorov, H. U. Ibragimova, T. A. Lavrikova, Y. O. Aksenova, T. M. Gurciev, N. V. Gomyranova, Y. S. Vorobeva, Z. B. Hasanova, V. S. Yudin, V. V. Makarov, A. A. Keskinov, S. A. Kraevoy, S. A. Boytsov, S. M. Yudin, V. I. Skvortsova

“…However, further research is needed to assess the clinical applicability and cost-effectiveness of such screening programs.…”
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LENGTH–WEIGHT RELATIONSHIPS AND BIOLOGICAL ASPECTS FOR 34 FISH SPECIES FROM TRÊS IRMÃOS RESERVOIR, LOWER TIETÊ RIVER BASIN, SP - BRAZIL by Paula Maria Gênova de Castro CAMPANHA, Anderson Arimura MATSUMOTO, Midiã Lima BRAZÃO, Lucas Matheus BASILIO, Lidía Sumile MARUYAMA

“…The length-weight relationship of fish species is widely used in fisheries monitoring programs and it is an important tool for proposing stock management measures. …”
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The association of PD-L1 expression status and the PD-1/PD-L1 inhibitor-related toxicity profile in non-small cell lung cancer by Qian Zhu, Hao Hu, Li-Ying OuYang, Rong Yang, Wen-Xiao Wei, Pin Huang, Xin-Rong He

“…Abstract Objective While PD-L1 expression serves as a predictive biomarker for programmed cell death 1 and its ligand (PD-1/PD-L1) inhibitor efficacy in patients with non-small cell lung cancer (NSCLC), its association with treatment-related adverse events (TRAEs) has yet to be fully elucidated. …”
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An analytical approach to modeling conjunctival viral disease using fuzzy logic and time-delay dynamics by Muhammad Tashfeen, Hothefa Shaker Jassim, Fazal Dayan, Muhammad Azizur Rehman, Alwahab Dhulfiqar Zoltán, Husam A. Neamah

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