Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…However, complexity of its structural composition poses a greater difficulty for drug design studies.ObjectivesPharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.MethodsFrom the assessment of the ADC action process based on PK/PD, we introduce the main research strategies of ADCs. …”
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Venetoclax-Based Regimens in CLL: Immunoglobulin G Levels, Absolute Neutrophil Counts, and Infectious Complications by Wojciech Szlasa, Monika Kisielewska, Anna Sobczyńska-Konefał, Emilia Jaskuła, Monika Mordak-Domagała, Jacek Kwiatkowski, Katarzyna Tatara, Agnieszka Kuś, Mateusz Sawicki, Izabela Dereń-Wagemann, Mariola Sędzimirska, Ugo Giordano, Jarosław Dybko

“…<b>Background:</b> Chronic lymphocytic leukemia (CLL) is a prevalent hematologic malignancy that predominantly affects elderly individuals, posing significant clinical challenges due to patient comorbidities and inherent resistance to conventional chemotherapy. …”
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Analysis of Potential Genes, Acute Phase Proteins and Hormonal Profiles Associated with Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Isolation from Pneumonic Sheep by Hanan M. Alharbi, Eman A. Noaman, Ahmed El-Sayed, Mohamed T. Ragab, Amani Hafez, Attia Eissa, Ahmed Ateya, Khairiah M. Alwutayd, Manal A. Babaker, Asmaa Darwish

“…These findings underscore the zoonotic risk posed by MRSA and emphasize the need for robust surveillance and antibiotic stewardship to control its spread. …”
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Predictive Modelling of H2S Removal from Biogas Generated from Palm Oil Mill Effluent (POME) Using a Biological Scrubber in an Industrial Biogas Plant: Integration of Artificial Ne... by Joanna Lisa Clifford, Yi Jing Chan, Mohd Amran Bin Mohd Yusof, Timm Joyce Tiong, Siew Shee Lim, Chai Siah Lee, Woei-Yenn Tong

“…These fluctuations can lead to inconsistent biogas quality, variable methane content and fluctuating hydrogen sulphide (H2S) concentration. This poses significant challenges for bioscrubbers in removing H2S to meet quality standards for gas engines used for electricity generation. …”
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A French maritime pine bark extract alleviates cellulite: A double-blinded, randomized, placebo-controlled clinical study by Qi Liu, Jinhao Wu, Nan Wang, Carolina Burki, Susanne Grether-Beck, Jean Krutmann

“…It mainly affects women, for whom it often poses a cosmetically unfavorable skin condition. …”
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Process Optimization and Characterization of β-Carotene-Calcium Carbonate Colorant Lake by Yifen FU, Yuhan LIU, Le JING, Jiaqi CUI, Xu ZHAI, Dongdong YUAN, Chengtao WANG

“…Nevertheless, their inherent chemical reactivity compromises their stability, posing significant challenges for their application. …”
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Laser Applications in Metal Orthodontic Bracket Debonding: A Systematic Review by Patryk Woś, Sylwia Kiryk, Tomasz Dyl, Jan Kiryk, Tomasz Horodniczy, Magdalena Szablińska, Magdalena Aleksandra Dubowik, Wojciech Dobrzyński, Marcin Mikulewicz, Jacek Matys, Maciej Dobrzyński

“…Conclusions: In conclusion, laser-assisted orthodontic metal bracket debonding, when conducted with appropriately calibrated parameters, is a safe method for preserving tooth tissue. …”
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Assessing Habitat Suitability for the Invasive Species Lantana camara on Bali Island: A Model Using the Biodiversity and Climate Change Virtual Laboratory (BCCVL) by Rajif Iryadi, Sutomo, Muhammad Hadi Saputra, Nida Humaida, Eko Pujiono, Jalma Giring Sukmawati, Aditya Hani, Komang Kartika Indi Swari, Dewa Ayu Intan Sari, Muhammad Bima Atmaja, Wieke Herningtyas, Reni Setyo Wahyuningtyas, Eddie van Etten

“…Potential improvements through additional environmental parameters were suggested. While L. camara has some potential benefits as a medicinal plant in Balinese culture, its invasive nature poses significant threats to native ecosystems. …”
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Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre... by Julia Katharina Schleifenbaum, Janis Morgenthaler, Shachi Jenny Sharma, Jens Peter Klußmann, Philipp Linde, Simone Wegen, Johannes Rosenbrock, Christian Baues, Emmanouil Fokas, Richard Khor, Sweet Ping Ng, Simone Marnitz, Maike Trommer

“…Abstract Introduction Locoregional recurrence (LR) is common in locally advanced head and neck cancer (HNSCC), posing challenges for treatment. We analysed outcome parameters and toxicities for patients being treated with radiotherapy (RT) for LR-HNSCC and investigated patient and disease related prognostic factors in this prognostically unfavourable group. …”
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Morphological features of postoperative biopsies of scar tissue of the subdermal structures of the abdominal wall in patients with diastasis of the rectus abdominis by K.L. Gaft, V.V. Tsiliurik, N.О. Remnyova, Ye.V. Nakonechnyi

“…The obtained histological specimens were stained with hematoxylin and eosin. The morphometric parameters of collagen fiber bundles were measured using standard ocular microscopic morphometric rulers and grids. …”
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A Computational Analysis Based on Automatic Digitization of Movement Tracks Reveals the Altered Diurnal Behavior of the Western Flower Thrips, <i>Frankliniella occidentalis</i>, Su... by Chunlei Xia, Gahyeon Jin, Falguni Khan, Hye-Won Kim, Yong-Hyeok Jang, Nam Jung, Yonggyun Kim, Tae-Soo Chon

“…However, it remained unclear how the clock signal triggers the thrips behaviors. This study posed a hypothesis that the clock signal modulates cGMP-dependent protein kinase (<i>PKG</i>) activity to mediate the diurnal behaviors. …”
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Effect of virtual reality training on dual-task performance in older adults: a systematic review and meta-analysis by Xiaoyu Wei, Chun Huang, Xinyue Ding, Zhining Zhou, Yufeng Zhang, Xiaofan Feng, Suwang Zheng, Tingting Li, Jiaojiao Lü

“…Abstract Background Age-related decline in dual-task (DT) performance is closely associated with falls in older adults, posing a significant public health concern. Virtual reality (VR) training has emerged as a novel intervention to enhance motor-cognitive integration, yet its effects on dual-task performance require systematic evaluation. …”
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Adolescent PCOS and long-term metabolic risk: insights from triglycerides to high-density lipoprotein cholesterol ratio and high-density lipoprotein cholesterol profiles by Maria Nowak-Ciołek, Julia Jagoda Stachowiak, Katarzyna Krok, Julia Sokal, Żaneta Malczyk, Karolina Skrzyńska, Agnieszka Zachurzok

“…IntroductionPolycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 6–22% of women worldwide, with adolescent diagnosis posing significant challenges due to physiological differences between adolescents and adults. …”
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Gut microbiota’s role in the enhancement of type 2 diabetes treatment by a traditional Chinese herbal formula compared to metformin by Chengdong Xia, Liya Yue, Yinyu Wang, Cuidan Li, Guannan Ma, Yingjiao Ju, Peihan Wang, Jie Wang, Xiaoyuan Jiang, Xiaotong Wang, Fei Chen

“…ABSTRACT Type 2 diabetes mellitus (T2DM) is a rapidly increasing metabolic disorder that poses a significant threat to global public health. …”
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Consolidation characteristics of compacted clayey soils treated with various biomass ashes by Muhammad Abu-Bakr Jamil, Kimitoshi Hayano, Yoshitoshi Mochizuki, Cong Li

“…The increasing volume of surplus soil generated from excavation works in infrastructure projects such as roads, railroads, and subway facilities poses significant environmental and logistical challenges, particularly in terms of its disposal. …”
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Lightweight coal miners and manned vehicles detection model based on deep learning and model compression techniques: A case study of coal mines in Guizhou region by Beijing XIE, Heng LI, Zheng LUAN, Zhen LEI, Xiaoxu LI, Zhuo LI

“…Balancing between model detection performance and efficiency poses many challenges. This paper proposes a lightweight coal mine pedestrian detection model based on deep learning and model compression techniques. …”
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Deaths from Acute Respiratory Infections are Linked to High Fasting Blood Glucose and Decreased Levels of Low-Density Lipoprotein/Small Dense Low-Density Lipoprotein by Li L, Du W, Song J, Lu Y, Wan J, Wang W, Feng Y, Yin J

“…This study investigated the effect of glucose and lipid metabolism on mortality rates among individuals with ARIs.Patients and Methods: We collected clinical data including indicators related to glucose and lipid metabolism, liver and kidney function, complete blood count, coagulation function, and other parameters from 1675 hospitalized patients with ARIs who were consecutively admitted during the winter season. …”
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Routine Laboratory Markers-Based Machine Learning Model for Predicting Severe Kawasaki Disease in Pediatric Patients by Wu M, Chen J, Gao Y, Chen H, Li W

“…This study introduces a novel machine learning approach for the early prediction of SKD in pediatric populations, utilizing routinely collected laboratory parameters.Methods: We extracted patients’ age, sex, and 67 standard laboratory markers from the clinical records of 1,466 patients diagnosed with KD at the Children’s Hospital of Nanjing Medical University. …”
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Fine-Grained Classification of Pressure Ulcers and Incontinence-Associated Dermatitis Using Multimodal Deep Learning: Algorithm Development and Validation Study by Alexander Brehmer, Constantin Seibold, Jan Egger, Khalid Majjouti, Michaela Tapp-Herrenbrück, Hannah Pinnekamp, Vanessa Priester, Michael Aleithe, Uli Fischer, Bernadette Hosters, Jens Kleesiek

“… Abstract BackgroundPressure ulcers (PUs) and incontinence-associated dermatitis (IAD) are prevalent conditions in clinical settings, posing significant challenges due to their similar presentations but differing treatment needs. …”
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Spatial and Temporal Changes and Influencing Factors of Mercury in Urban Agglomeration Land Patterns: A Case from Changchun Area, Old Industrial Base of Northeast China by Zhe Zhang, Zhaojun Wang, Jing Zong, Hongjie Zhang, Yufei Hu, Yuliang Xiao, Gang Zhang, Zhenxin Li

“…Anthropogenic activities such as industrial emissions and coal combustion release large quantities of mercury into the environment, posing health risks to human populations. Strict implementation of the Minamata Convention and innovative remediation technologies can mitigate escalating environmental and public health risks. …”
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