Poly-ether-ether-ketone wear particles induce a pro-inflammatory phenotype in a human monocytic cell line by Shannon Jamieson, Shannon Jamieson, Philip Hyde, Patrick Card, David Deehan, John Kirby, Alison Tyson-Capper

“…ObjectivesThe aim of this study was to assess potential pro-inflammatory responses induced in a human monocyte cell line by poly-ether-ether-ketone (PEEK) particles. Investigations also focussed on the role of toll-like receptor 4 (TLR4) and reactive oxygen species (ROS) in immune responses to PEEK.MethodsPEEK particles were generated using a four-station multi-directional pin-on-plate wear simulator and used to treat THP-1 macrophages for 24 h at dosages of 0.5–50 μm3 per cell. …”
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