Cardiopulmonary resuscitation practices amid COVID-19 in four Gauteng public hospitals by Almien Smit, Andreas Engelbrecht, Suma Rajan

“…Of particular concern is that a high number of respondents who tested positive for COVID-19 reported symptom onset within 5 days of performing CPR on COVID-19-positive patients. Contribution: This research will assist in the training of HCWs on appropriate CPR practices to prevent transmission of respiratory infections transmitted via droplet and airborne routes.…”
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Drug administration errors among anaesthesia providers in South Africa: a cross-sectional descriptive study by René van Wyk, Ryan Alroy Davids

“…DAEs are often not reported (40.3%, n = 114/N = 283), with knowledge of correct reporting procedures lacking. 70.5% (n = 198/N = 281) of DAEs were never discussed with the patient. Conclusions DAEs in anaesthesia remain prevalent. …”
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Rectal versus vaginal progesterone administration for luteal phase support in the hormone replacement therapy frozen embryo transfer (HRT-FET) cycle: protocol for a non-inferiority... by Peter Humaidan, Birgit Alsbjerg

“…The reason for comparing the two routes of administration is that rectal administration has been suggested to be more patient friendly.Methods and analysis This study is a randomised controlled trial comparing the ongoing pregnancy rate (OPR) at week 12 in HRT-FET cycles after rectal administered progesterone as the only administered progesterone compared with a vaginal luteal phase support regimen. …”
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Approaches and applications in transdermal and transpulmonary gene drug delivery by Anni Zhang, Xuran Zhang, Jiahui Chen, Xianbao Shi, Xijuan Yu, Zhonggui He, Zhonggui He, Jin Sun, Jin Sun, Mengchi Sun, Mengchi Sun, Zhijun Liu

“…Last but not least, the opportunities and outlooks of gene therapy through both administrated routes are highlighted.…”
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Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach by Ronghua Bei, Justin Thomas, Shiven Kapur, Mahlet Woldeyes, Adam Rauk, Jason Robarge, Jiangyan Feng, Kaoutar Abbou Oucherif

“…Subcutaneous injections are an increasingly prevalent route of administration for delivering biological therapies including monoclonal antibodies (mAbs). …”
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Cardiopulmonary Resuscitation in Interfacility Transport: An International Report Using the Ground Air Medical Quality in Transport (GAMUT) Database by Utpal S. Bhalala, Neeraj Srivastava, M. David Gothard, Michael T. Bigham

“…The overall CPR rate was 0.42% (777 CPR episodes/184,272 patient contacts) from 115 programs reporting transport volume and CPR events from the GAMUT database during the study period. …”
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Gallstone Ileus following Endoscopic Stone Extraction by Yoshiya Yamauchi, Noritaka Wakui, Yasutsugu Asai, Nobuhiro Dan, Yuki Takeda, Nobuo Ueki, Takahumi Otsuka, Nobuyuki Oba, Shuta Nisinakagawa, Tatsuya Kojima

“…Subsequent CT imaging verified the disappearance of the incarcerated stone from the ileum, suggesting that the stone had been evacuated naturally via the transanal route. Although it is extremely rare for gallstone ileus to develop as a complication of ERCP, physicians should be aware of gallstone ileus and follow patients carefully, especially after removing huge stones.…”
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Efficacy of Intramuscular versus Intravenous Dexmedetomidine on Attenuation of Haemodynamic Responses to Laryngoscopy and Endotracheal Intubation: A Randomised Clinical Trial by Anupama Kumari, Paras Anand, Jigisha Mehta, Sara Mary Thomas

“…Intravenous dexmedetomidine can cause major adverse effects such as bradycardia, hypotension, cardiac arrhythmias and biphasic response when used as premedication for attenuation of the laryngoscopy and intubation response which mandates exploration of other routes of administration of dexmedetomidine. Aim: To evaluate the efficacy of intramuscular dexmedetomidine and intravenous dexmedetomidine to attenuate the stress response of laryngoscopy and endotracheal intubation in patients undergoing general anaesthesia via these routes. …”
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Oncolytic Viruses and Immunotherapy for the Treatment of Uveal Melanoma and Retinoblastoma: The Current Landscape and Novel Advances by Merve Kulbay, Nicolas Tuli, Massimo Mazza, Armaan Jaffer, Sarinee Juntipwong, Emily Marcotte, Stuti Misty Tanya, Anne Xuan-Lan Nguyen, Miguel N. Burnier, Hakan Demirci

“…Numerous factors such as the vector choice, route of administration, dosing, and patient characteristics must be considered when engineering an oncolytic virus or other forms of immunotherapy vectors. …”
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Blockchain Technology Applications in Healthcare Supply Chains—A Review by Sarthak Dhingra, Rakesh Raut, Koteswararao Naik, Kamalakanta Muduli

“…Further, it presents potential repercussions and the potential routes it may open for future research initiatives in this area. …”
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Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 He... by S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart

“…While the intravenous formulation is primarily used for general anaesthesia and intensive care settings, the drug’s high lipophilic properties also allow various noninvasive routes of administration. Published data suggest that intranasal administration is also attractive for use as intranasal patient-controlled analgesia (PCA). …”
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Changes in nutritional management after gastrointestinal cancer surgery over a 12-year period: a cohort study using a nationwide medical claims database by Yoshikuni Kawaguchi, Kenta Murotani, Nahoki Hayashi, Satoru Kamoshita

“…For each period, feeding routes in all patients and prescribed doses of parenteral energy and amino acids in fasting patients during postoperative days (POD) 1–7 were determined. …”
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Enhancing safety in CT-guided lung biopsies: correlation of MinIP imaging with pneumothorax risk prediction by Michael P. Brönnimann, Leonie Manser, Bernhard Gebauer, Timo A. Auer, Dirk Schnapauff, Federico Collettini, Alexander Pöllinger, Alois Komarek, Miltiadis E. Krokidis, Johannes T. Heverhagen

“…Methods We retrospectively analyzed 72 procedures from January 2019 to December 2023, categorizing patients by pneumothorax and the severity of hemorrhage (grade 2 or higher). …”
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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. The study objectives are to: (1) map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL, (2) develop a prognostic model to predict recovery for patients with idiopathic SSNHL and (3) establish the impact of idiopathic SSNHL on patients’ quality of life (QoL).Methods and analysis Study design: national multicentre prospective cohort study across 97 NHS trusts.Inclusion criteria: adult patients presenting to NHS ENT and hearing services with SSNHL.Outcomes: change in auditory function; change in QoL score.Analysis: multivariable prognostic model, using prespecified candidate predictors. …”
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Nutritional and Pharmacological Enhancement of the Gut-Associated Lymphoid Tissue by M Keith Hanna, Kenneth A Kudsk

“…Clinical studies have demonstrated the effectiveness of providing nutrition by the enteral route in reducing septic morbidity in critically ill patients. …”
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Breast Magnetic Resonance Imaging and Its Impact on the Surgical Treatment of Breast Cancer by Georgia Tsina, Philippe Simon

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Smallpox vaccination in a mouse model by S. N. Shchelkunov, A. A. Sergeev, S. A. Pyankov, K. A. Titova, S. N. Yakubitskiy

“…The monkeypox epidemic, which became unusually widespread among humans in 2022, has brought awareness about the necessity of smallpox vaccination of patients in the risk groups. The modern smallpox vaccine variants are introduced either intramuscularly or by skin scarification. …”
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Alzheimer's Disease Clinical and Research Update for Health Care Practitioners by Philip A. DeFina, Rosemarie Scolaro Moser, Megan Glenn, Jonathan D. Lichtenstein, Jonathan Fellus

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Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials by Francisco Moniche, Paulo Henrique Rosado-de-Castro, Irene Escudero, Elena Zapata, Francisco Javier de la Torre Laviana, Rosalia Mendez-Otero, Magdalena Carmona, Pilar Piñero, Alejandro Bustamante, Lucía Lebrato, Juan Antonio Cabezas, Alejandro Gonzalez, Grabriel R. de Freitas, Joan Montaner

“…Intra-arterial route was used in 77.3% of cases. A higher number of cells injected were associated with better outcomes at 180 days (390 × 106 [320–422] BM-MNCs injected in those patients with mRS of 0–2 at 6 months versus 130 × 106 [89–210] in those patients with mRS 3–6, p=0.015). …”
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Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Gina Mejía-Abril, Manuel Roman, Sergio Luquero-Bueno, David Piñeiro, Marc Ribó, Francisco Abad-Santos, Dolores Ochoa

“…ApTOLL, a new modulator of Toll-like receptor 4, has demonstrated safety and efficacy in healthy subjects and in stroke patients; however, the route of administration used so far (30 min infusion) can potentially be an issue in the acute stroke units where “time is brain.” …”
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