Nonlinear association between proteinuria levels and the risk of cardiovascular disease events and all-cause mortality among chronic kidney disease patients by Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan

“…Background The association between proteinuria levels and cardiovascular disease (CVD) development and all-cause mortality in chronic kidney disease (CKD) patients remains controversial.Methods In this investigation, we conducted a retrospective analysis involving 1138 patients who were registered in the CKD-Research of Outcomes in Treatment and Epidemiology (ROUTE) study. …”
Get full text

Shorter versus longer durations of antibiotic treatment for patients with community-acquired pneumonia: a protocol for a systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Mark Loeb, John Basmaji, Ya Gao, Maryam Ghadimi, Layla Bakaa, Luis Enrique Colunga Lozano, Saad Asif, Aninditee Das

“…Eligible studies will compare durations with a minimum difference of two days of antibiotic therapy, irrespective of antibiotic agent, class, route, frequency or dosage, and will report on any patient-important outcome of benefit or harm. …”
Get full text

Is There a Real Relationship between the Presence of Helicobacter pylori in Dental Plaque and Gastric Infection? A Genotyping and Restriction Fragment Length Polymorphism Study on... by Mojtaba Moosavian, Elyas Kushki, Tahereh Navidifar, Eskandar Hajiani, Mahdi Mandegari

“…This study aimed to determine the genotype and evaluate the association between the presence of H. pylori in dental plaque and gastric biopsy specimens in dyspeptic patients in Ahvaz, Southwest Iran. Methods. In this study, 106 patients with recruited dyspeptic complaints were selected, and from each patient, two gastric antral biopsy specimens and two dental plagues were examined. …”
Get full text

Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

Get full text

Development and effectiveness evaluation of an interactive e-learning environment to enhance digital health literacy in cancer patients: study protocol for a randomized controlled... by Lukas Lange-Drenth, Hellena Willemer, Mirjam Banse, Anke Ernst, Anne Daubmann, Anja Holz, Christiane Bleich, Susanne Weg-Remers, Holger Schulz

“…Concerns about the generalizability of the results, since a disproportionate number of inquiries to the CIS come from breast cancer patients, are addressed by a proportionally stratified randomization strategy and diversified recruitment routes.…”
Get full text

Innovative MOF-enhanced electroanalytical approach for sensitive sunitinib malate detection in renal carcinoma patients using CuO/lanthanum MOF-modified carbon paste electrode by Azza H. Rageh, Mohamed I. Said, Asmaa Abdeltawab, Fatma A.M. Abdel-aal

“…The proposed method was successfully applied for the determination of SUN in pharmaceutical formulations and serum samples of renal cancer patients. Moreover, the proposed methodology via modification of CPE with the synthesized MOFs tailors them to be applied for clinical analysis and therapeutic drug monitoring of SUN, providing a valuable tool for personalized medicine and improving the treatment outcomes for renal cancer patients.…”
Get full text

Correction: Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcino... by Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nufel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stéphanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwé, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frédéric Amant, Katrien Vandecasteele, Hannelore G. Denys

Get full text

Clinical efficacy of Methylene Blue mediated antimicrobial Photodynamic Therapy (PDT) using 680 nm Diode Laser in patients undergoing Open Flap Debridement: An Original Research by Soundarya Singh, Manisha Rout, Mayur Kaushik, Shilpa Sharma, Aprajita Srivastava

Get full text

Practice on Metered Dose Inhaler Techniques and Its Associated Factors among Asthmatic Patients at Debre Markos Comprehensive Specialized Hospital, East Gojjam, Ethiopia: A Prospec... by Tadele Asmare, Anteneh Belayneh, Bekalu Dessie

“…Result. A total of 166 patients had involved in the study, of which 52.4% were females. …”
Get full text

The pattern of antibiotic utilisation among intensive care unit patients hospitalised in a Gauteng (South African) provincial tertiary hospital: Comparing findings before and durin... by L Spinickum, Z Booth, S Leigh-de Rapper

“…Descriptive statistics were used to examine patient characteristics and antibiotic prescribing variables (antibiotic selection, dosage, route of administration, frequency, duration of course and indication for which antibiotic was prescribed). …”
Get full text

Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe Complicated Clostridium difficile Infection in Elderly Patients in Poo... by Tae-Geun Gweon, Jinsu Kim, Chul-Hyun Lim, Jae Myung Park, Dong-Gun Lee, In Seok Lee, Young-Seok Cho, Sang Woo Kim, Myung-Gyu Choi

“…Results. Of these seven patients who received FMT via the upper GI tract route, all patients were cured. …”
Get full text

Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Ind... by Hanlu Lin, Xiaobo Liu, Pengfei Sun

“…Polymyxin B has a good clinical effect in the treatment of MDR, but there is controversy about the administration route of this drug. In this study, we retrospectively analyzed the clinical data of 84 cases of MDR Gram-negative bacterial pneumonia, and aimed to explore the effects of aerosol inhalation combined with intravenous polymyxin B infusion on the bacterial clearance, symptom improvement, and serum infection indexes of MDR patients on the patients with Gram-negative (G−) bacterial pneumonia. …”
Get full text

Charting Your Course: A Roadmap to Select a Review Type for Your Research Journey by Jannette Bradley, Barbara E. Ruggeri, Karen L. Hanus

Get full text

Neurostimulation for Neurogenic Bowel Dysfunction by J. Worsøe, M. Rasmussen, P. Christensen, K. Krogh

“…SARS improves bowel function in some patients with complete spinal cord injury (SCI). Nerve re-routing is claimed to facilitate defecation through mechanical stimulation of dermatomes in patients with complete or incomplete SCI or myelomeningocele. …”
Get full text

The First Saint Petersburg Regional Inflammatory Bowel Diseases Registry on the Basis of the Regional Health Information System: Principles of Functioning, Testing Results, Plan of... by Yu. P. Uspenskiy, A. M. Sarana, L. N. Melentyeva, A. V. Yazenok, S. V. Petrov, Yu. A. Fominykh, S. V. Ivanov, A. V. Shotik, A. M. Segal, T. V. Gorbacheva, S. D. Plotnikova, K. V. Dronov

“…The General Statistical Module is intended to analyze the prevalence of ulcerative colitis and Crohn's disease, the number of patient visits to medical institutions; to assess the burden on the healthcare system, demographic characteristics, routing and mortality for the whole region. …”
Get full text

Heart rhythm disorders and features of their management at COVID-19 pandemic by Yu.M. Mostovoy, T.D. Danilevych

“…In addition, there are controversial questions about the features of their management, drug interactions, routing and prognosis of the patients. The review displays the latest data from both foreign and domestic scientists about the prevalence of rhythm disorders against the background of coronavirus infection and highlights the main problematic issues of the management of the patients…”
Get full text

Potential impact of coronaviruses upon cardiovascular system under COVID-19 pandemic by L.O. Tkachenko, O.A. Yepanchintseva, B.M. Todurov

“…The issues of routing, surgical and therapeutic treatment of patients with cardiovascular diseases, especially emergencies (acute myocardial infarction, decompensation of heart failure on the background of valvular heart disease) have become difficult. …”
Get full text

About difficulties in the examination of the quality of medical care in the complicated course of the postoperative period after cystectomy by K. N. Movchan, K. E. Chernov, B. S. Artyushin, A. V. Zharkov, A. Yu. Chernova

“…Outpatient health care specialists play a special role in routing patients with bladder diseases, and not only their formal referral and delivery to multidisciplinary medical and prophylactic institutions in an emergency mode with “on-duty” syndromic diagnoses such as “renal colic or hematuria”. …”
Get full text

PREVENTION OF ONCOLOGICAL DISEASES AS THE BASIS OF INTERACTION OF ONCOLOGICAL SERVICE WITH PRIMARY LINK OF HEALTH CARE by L. M. Aleksandrova, V. V. Starinsky, A. D. Kaprin, Yu. V. Samsonov

“…More than half of the working age population of deaths in Russia falls on the disease from the group of preventable death, and a third — to preventable causes, depending on the primary and secondary prevention, quality of care, along with a high prevalence of behavioral risk factors (RF), demographic characteristics, marked medical and social reasons for the high mortality rate of the MN: late uptake of the population for health care, lack of alertness in oncology healthcare professionals, patients defects in routing.The leading factor in increasing life expectancy is prevention. …”
Get full text

An Unusual Case of Ototoxicity with Use of Oral Vancomycin by Umut Gomceli, Srija Vangala, Cosmina Zeana, Paul J. Kelly, Manisha Singh

“…This case reflects that some patients may be more susceptible to increased systemic absorption via the oral route, and the possibility for ototoxicity should be considered and discussed with patients while prescribing oral vancomycin.…”
Get full text