MOLECULAR CHARACTERIZATION OF CARBAPENEM RESISTANT KLEBSIELLA PNEUMONIAE AT A TERTIARY CARE LABORATORY IN KERALA, INDIA by Swapna C. Senan, Jithu Paul Jacob, Ramani Bhai

“…Background: Isolates of Klebsiella pneumoniae resistant to Carbapenem appears to be most commonly transmitted by hospitalized patients. This may cause infections which lead to mortality. …”
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Recombinant production platform for Group A Streptococcus glycoconjugate vaccines by Sowmya Ajay Castro, Ian J. Passmore, Didier Ndeh, Helen Alexandra Shaw, Alessandro Ruda, Keira Burns, Sarah Thomson, Rupa Nagar, Kathirvel Alagesan, Mark Reglinski, Kieron Lucas, Sherif Abouelhadid, Ulrich Schwarz-Linek, Fatme Mawas, Göran Widmalm, Brendan W. Wren, Helge C. Dorfmueller

“…Abstract Group A Streptococcus (Strep A) is a human-exclusive bacterial pathogen killing annually more than 500,000 patients, and no current licensed vaccine exists. Strep A bacteria are highly diverse, but all produce an essential, abundant, and conserved surface carbohydrate, the Group A Carbohydrate, which contains a rhamnose polysaccharide (RhaPS) backbone. …”
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COVID-19: Gastrointestinal Manifestations and Complications by Angel Yun-Kuan Thye, Priyia Pusparajah, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Vengadesh Letchumanan, Learn-Han Lee

“…However, mounting evidence demonstrates detection of SARS-CoV-2 RNA in stool samples of COVID-19 patients. It has also been demonstrated that the host receptor angiotensin-converting-enzyme-2 (ACE-2) is highly expressed not just in respiratory cells but also in gastrointestinal sites involving the glandular cells of gastric, duodenal, and rectal epithelium. …”
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Information avoidance by younger adults with Type 1 diabetes: a preliminary empirical study by Bruce Ryan, Gemma Webster

“…Frequency of appointments and routes to information could be improved.…”
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An Endometrioid Ovary Cyst and Fallopian Tube in the Inguinal Canal: Conservative or Surgical Management? by Sema Ovalı, Ahmet Yılmaz, Gürkan Zorlu

“…Asymptomatic cases may be managed expectantly but in symptomatic patients, surgical removal is indicated. …”
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Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells by Yi-Yang Chen, Ying-Hsuan Wang, Chih-Cheng Chen, Cih-En Huang, Chia-Chen Hsu, Shu-Huei Hsiao, Yu-Wei Leu

“…More than 50%–90% of MPN patients had a dominant negative valine (V) to phenylalanine (F) mutation at the Janus kinase 617 codon (JAK2V617F) within the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway; however, this mutation was also found in a high percentage of the general population, its penetrance varied, and its onset was shown to be polygenic. …”
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A Hepatitis C Educational Needs Assessment of Canadian Healthcare Providers by Reza Naghdi, Karen Seto, Carolyn Klassen, Didi Emokpare, Brian Conway, Melissa Kelley, Eric Yoshida, Hemant A. Shah

“…Physicians most frequently screened patients who had abnormal liver enzymes, while nurses tended to screen based on lifestyle factors. …”
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Comparison of Individualized Rescue Luteal Phase Support Strategies with Vaginal and Combined Vaginal & Subcutaneous Progesterone Administration in Artificial Frozen-Thawed Blastoc... by Secil Irem Arik Alpcetin, Onur Ince, Bengisu Akcay, Munire Funda Cevher Akdulum, Erhan Demirdag, Ahmet Erdem, Ahmet Erdem, Mehmet Erdem, Mehmet Erdem

“…The aim of this study is to investigate whether individualizing luteal support through rescue protocols in patients with low serum P4 levels improves pregnancy outcomes in HRT-FET cycles.Material and methodThis retrospective, single-center cohort analysis includes 1257 cycles involving 942 patients undergoing HRT-FET. …”
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Nurses’ Knowledge in the Prevention and Management of Nasointestinal Tube Obstruction: A Cross Sectional Study by Wang L, Hou W, Liu Z, Chen L, Lin R, Huang Y

“…Lun Wang,1,2 Wanling Hou,1 Zhong Liu,2 Li Chen,2 Ruidua Lin,2 Yinying Huang1 1Department of Nursing, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province, People’s Republic of China; 2Neurosurgery Department, Zhong Shan Hospital, Xiamen University, Xiamen, Fujian Province, People’s Republic of ChinaCorrespondence: Wanling Hou, Department of Nursing, Women and Children’s Hospital, School of Medicine, Xiamen University, 10 Zhen Hai Road, Si Ming District, Xiamen, Fujian Province, People’s Republic of China, Tel +8613705033186, Email hwldyx2007@126.comBackground: The nasointestinal tube is a route of nutritional support for patients and maintaining patency is essential. …”
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Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection. by Kiran Bala Sharma, Chandru Subramani, Khashpatika Ganesh, Anshula Sharma, Brohmomoy Basu, Shivani Balyan, Ghanshyam Sharma, Shouri Ka, Arundhati Deb, Mitul Srivastava, Saurabh Chugh, Sapna Sehrawat, Kanchan Bharadwaj, Archana Rout, Pankaj Kumar Sahoo, Suman Saurav, Rajender K Motiani, Ramandeep Singh, Deepti Jain, Shailendra Asthana, Renu Wadhwa, Sudhanshu Vrati

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Nano-Hydroxyapatite Gel and Its Effects on Remineralization of Artificial Carious Lesions by Apa Juntavee, Niwut Juntavee, Ainaj Nuñez Sinagpulo

“…Clinical Significance: This study indicated that an application of nano-HA gel is an attractive route to deliver the material and can be more effective and less toxic than conventional formulations and provide its effectiveness directly at the site of action, especially for a noncooperative young child and medicinally intimidated patients who may face with inconvenience in using toothbrush and toothpaste for hygiene control.…”
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Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis by Ce Chen, Jialin Wang, Mengqin Cheng, Haifeng Xie, Wei Li, Chaofeng Zhang

“…Subsequently, the microbiota-dependent antifibrotic efficacy of HB was verified using various delivery routes, antibiotic treatments, and faecal microbiota transplantation. …”
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Environmental biocontamination by SARS-CoV-2 Virus in the hospital setting by M Espejo Mambié, D San Jose-Saras, C Bischofberger Valdés, C Díaz-Agero Pérez, JC Galán Montemayor, L Martínez-García, M Abreu Di-Berardino, P Moreno-Nunez, J Vicente-Guijarro, J.M Aranaz-Andrés

“…All positive air samples were identified within 2 m of patients who had recently developed symptoms (<5 days). …”
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Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study by Yanning Qu, Rui Tang, Zhuyan Duan, Mengyi Sheng, Hui Wang, Shuang Liu, Jiao Li, Linlin Guo, Linying Guo, Si Zheng, Si Zheng

“…Patients triaged to red zone had a higher proportion of clinical manifestation and required more aggressive treatments. …”
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Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review by Taisa Rocha Navasconi Berbert, Tatiane França Perles de Mello, Priscila Wolf Nassif, Camila Alves Mota, Aline Verzignassi Silveira, Giovana Chiqueto Duarte, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verziganassi Silveira

“…The majority of the articles included in this review showed that cure rate ranged from 70 to 100% in patients treated with the combinations. Serious adverse effects were not observed in patients treated with drugs combination. …”
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Adverse Effects of Intraparenchymal and Peritumoral Application of Isosulfan Blue Dye in Sentinel Lymph Node Mapping in Breast Cancer: A Systematic Review and Meta-Analysis by Joshua Agilinko, Aditya Borakati, Andrel Yoong, Ponnuthurai Pratheepan, Suzette Samlalsingh

“…Sensitivity analysis was conducted using fixed effect modelling. A total of 19,183 patients were identified from eight studies. The pooled total adverse event rate after isosulfan administration was 11.65 events per 1,000 patients [95% confidence interval (CI) 7.44–18.19]. …”
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Pharmacist prescriber in Italy and possible changes to current legislation: survey of attitudes among pharmacists, family doctors and users by Francesca Baratta, Irene Pignata, Lorenzo Ravetto Enri, Paola Brusa

“…Many obstacles remain to be overcome but, based on the procedures already experimented in other European countries and worldwide, a route leading to the introduction of the pharmacy prescriber role may be hypothesised.…”
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Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems by Bart Jonckx, Michael Porcu, Aurelie Candi, Isabelle Etienne, Philippe Barbeaux, Jean H. M. Feyen

“…Reversible in vitro effects on blood-retinal barrier permeability provide grounds for a hypothesis on the mechanisms behind transient subretinal fluid observed in ocriplasmin-treated patients.…”
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Prevalence of Intestinal Parasites and Gastrointestinal Carriage of Pathogenic Gram Negative Enteric Bacteria among Apparently Healthy Food Handlers of Public Hospitals, Addis Abab... by Tegegn Belhu, Kinfe Fissehatsion, Abraham Tesfaye, Dr Yohannes Woldekidan, Kassu Desta

“…Therefore, hospital administrators and other stake holders should put measures in place to break chain of transmission routes from silent carrier to other peoples particularly patients at hospital and the community at large.…”
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Simulating a travel-related origin of Candida auris in New York–New Jersey by Rita R. Verma, Edward Kiegle, Alexander C. Keyel, Sudha Chaturvedi, Vishnu Chaturvedi

“…Serious C. auris infections affect hospitalized patients and residents of long-term care facilities, although the pathogen can also be present on a healthy individual’s skin. …”
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