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  1. 621

    Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In emergency Department Sepsis (ARISE FLUIDS) trial: study protocol by Peter Jones, Gerben Keijzers, John F Fraser, Rinaldo Bellomo, Paul Young, Glenn Arendts, Diana Egerton-Warburton, Alisa Higgins, Anthony Delaney, Stephen P J Macdonald, Sandra L Peake, Daniel Fatovich, Patricia Williams, Belinda D Howe, Jonathon Burcham, Elissa Milford, Andrew Alexander Udy

    Published 2025-07-01
    “…The optimal approach in patients with septic shock is uncertain.Methods and analysis Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In emergency Department Sepsis is a 1000-participant multicentre, randomised, open-label, parallel group clinical trial conducted in patients with septic shock presenting to the emergency department in participating sites in Australia, New Zealand and Ireland. …”
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  2. 622
  3. 623

    LC-MS based analysis reveal antimicrobial compounds from Gabonese pharmacopoeia: chemical characterisation and cytotoxicity evaluation by Elvis Otogo N’nang, Elvis Otogo N’nang, Paulin N. Essone, Judicael Ella Ndong, Augustin Boueya, Kossiwa Kokou, Richard Kriz, Richard Kriz, Marie Andrée N’nengué, Félix Ovono Abessolo, Bertrand Lell, Peter G. Kremsner, Peter G. Kremsner, Selidji T. Agnandji, Selidji T. Agnandji

    Published 2025-01-01
    “…Based on botanical studies and the claims of traditional healers regarding the antimicrobial effects of these plants, a study to evaluate the antimicrobial activity and phyto-chemical profile of aqueous extracts of three plants (bark of H. ledermannii, G. barbadense root bark and P. angolensis bark) and methanolic extracts of two plants (S. ochocoa stem bark and D. gossweileri root bark). …”
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  4. 624

    Influence of vesicourethral segment reconstruction techniques in radical prostatectomy on urinary continence: evaluation of immediate and long-term outcomes by M. I. Kogan, I. I. Belousov, V. V. Mitusov, S. K. Tokhtamishyan, R. S. Ismailov

    Published 2023-01-01
    “…Design: single-centre, clinical, simple, comparative, parallel-group study with retrospective and prospective material evaluation, conducted in 2017 – 2022. …”
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  5. 625

    Comparative evaluation of BacT/ALERT VIRTUO and BACTEC FX400 blood culture systems for the detection of bloodstream infections by Yurong Qin, Yiwen Liao, Jingfang Zhou, Weijiang Liu, Huimin Chen, Xiaoli Chen, Weisha Wang, Ni Zhang, Yunhu Zhao, Liang Wang, Bing Gu, Suling Liu

    Published 2025-01-01
    “…These blood samples, collected from the same suspected sepsis patients, were cultured in parallel using both the BacT/ALERT VIRTUO and BACTEC FX400 systems. …”
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  6. 626

    Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae by Ai Guo, Dianbao Zuo, Li Shi, Ming Guo, Jinquan Li, Caili Li, Puqing Wang, Xiaodong Sun, Ming Sang

    Published 2025-08-01
    “…Methods We employed plaque assays, transmission electron microscopy, and whole-genome sequencing to systematically characterize the biological properties, morphology, and genomic profiles of the phages in parallel. The bacteriostatic curve, biofilm staining quantification, and biofilm inhibition rate assay were employed to evaluate the in vitro lytic efficacy of the phage. …”
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  7. 627

    Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial by Ingrid Muller, Miriam Santer, Beth Stuart, Paul Little, Matthew J Ridd, Karen Thomas, Nick Francis, Kim S Thomas, Gareth Griffiths, Natalia V Permyakova, Jacqui Nuttall, Irene Soulsby, Alison M Layton, Tracey H Sach, Sarah Pyne, Susanne Renz, Zina Eminton, Megan Lawrence

    Published 2023-12-01
    “…Objective This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks.Design Economic evaluation undertaken alongside a pragmatic, parallel, double-blind, randomised trial.Setting Primary and secondary healthcare, community and social media advertising.Participants Women ≥18 years with persistent facial acne judged to warrant oral antibiotic treatment.Interventions Participants were randomised 1:1 to 50 mg/day spironolactone (increasing to 100 mg/day after 6 weeks) or matched placebo until week 24. …”
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  13. 633

    Optimisation of Organ Preservation treatment strategies in patients with rectal cancer with a good clinical response after neoadjuvant (chemo)radiotherapy: Additional contact X-ray... by Jacobus W A Burger, Geerard L Beets, Corrie A M Marijnen, Femke P Peters, Brechtje A Grotenhuis, Jeltsje S Cnossen, Monique Maas, Barbara M Geubels, Baukelien van Triest, Petra A Custers, Harm J T Rutten, Jaqueline C M Theuws, An-Sofie E Verrijssen

    Published 2023-12-01
    “…Patients will be randomised (1:1) between two parallel single-arm phase II studies: study arm 1 involves additional contact X-ray brachytherapy (an intraluminal radiation boost), while in study arm 2 the observation period is extended followed by a second response evaluation and optional transanal local excision. …”
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    Evaluation of Surface Microhardness and Abrasion Resistance of Two Dental Glass Ionomer Cement Materials after Radiant Heat Treatment by Dimitrios Dionysopoulos, Kosmas Tolidis, Thrasyvoulos Sfeikos, Christina Karanasiou, Xanthippi Parisi

    Published 2017-01-01
    “…The aim of this study was to evaluate the effect of a radiant heat treatment using a dental LED unit on the surface microhardness and abrasion resistance after toothbrushing simulation of two conventional GIC materials. …”
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  18. 638

    Comparative evaluation of the biological response of conventional and resin modified glass ionomer cement on human cells: a systematic review by Shishir Singh, Gaurav Kulkarni, R S Mohan Kumar, Romi Jain, Ameya M Lokhande, Teena K Sitlaney, Musharraf H F Ansari, Navin S Agarwal

    Published 2024-11-01
    “…This review aimed to evaluate and compare the biological response (biocompatibility and cytotoxicity) of resin modified glass ionomer cement (RMGIC) in contrast to conventional glass ionomer cement (GIC) on human cells. …”
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  19. 639

    Mean Field Initialization of the Annealed Importance Sampling Algorithm for an Efficient Evaluation of the Partition Function Using Restricted Boltzmann Machines by Arnau Prat Pou, Enrique Romero, Jordi Martí, Ferran Mazzanti

    Published 2025-02-01
    “…The nature of AIS allows for an efficient and parallel implementation in Restricted Boltzmann Machines (RBMs). …”
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  20. 640

    Evaluation of clinical efficacy of Cention N and Tetric N-ceram in class I carious lesion in primary mandibular molars by Mayur Mhole, Sandeep Tandon, Shriya Gupta, Harshita Gosavi, A. Rizwan Ali, Mineet Kaul

    Published 2025-11-01
    “…Aim: The aim of the present study is to evaluate the performance of Tetric N Ceram and Cention N as restorative materials in Class 1 carious lesions in primary mandibular molars. …”
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