Clinical and cost-effectiveness of an online-delivered group-based pain management programme in improving pain-related disability for people with persistent pain—protocol for a non... by Anthony Dowell, Sarah Gerard Dean, Leigh Hale, Andrew R Gray, Tristram Ingham, Bernadette Jones, Cheryl Davies, Rebecca Grainger, William Leung, Meredith Perry, Hemakumar Devan, Dagmar Hempel, Jessica Mills, Barbara Saipe, Edward Shipton

“…Phase II: The proposed iSelf-help trial is a pragmatic, multicentred, assessor-blinded, two-arm, parallel group, non-inferiority randomised controlled trial. …”
Get full text

Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial by Kenny A Rodriguez-Wallberg, Judith Bruchfeld, Michael Runold, Peter Lindholm, Anders Kjellberg, Jan H Kowalski, Adrian Hassler, Sara El Gharbi, Sarah Al-Ezerjawi, Emil Boström, Marcus Ståhlberg, Malin Nygren-Bonnier, Anna Schening, Katarina Fischer

“…Objectives To evaluate if 10 sessions of hyperbaric oxygen treatments (HBOTs) improve short- and long-term health related quality of life, symptoms and physical performance in long covid patients compared with placebo.Design Parallel, randomised, placebo-controlled, double-blind trial.Setting Single-centre, university hospital, Sweden.Participants Previously healthy subjects aged 18–60 years, diagnosed with long covid were included. …”
Get full text

Efficacy of a Mobile Health–Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial by Ana Maria Ruiz-Leon, Rosa Casas, Sara Castro-Barquero, Sofia Alfaro-González, Petia Radeva, Emilio Sacanella, Francesc Casanovas-Garriga, Ainhoa Pérez-Gesalí, Ramon Estruch

“…MethodsA 12-week, parallel, single-blind randomized controlled trial was conducted with 123 participants (62/123, 50%, female; mean age 58.25 years, SD 9.46 years) recently diagnosed with T2D. …”
Get full text

Impact of mobile health-based nutritional education on hemoglobin levels in anemic adolescent girls in rural Bangladesh: a randomized controlled trial by Md Jiaur Rahman, Md Moshiur Rahman, Mohammad Habibur Rahman Sarker, Ryota Matsuyama, Masayuki Kakehashi, Miwako Tsunematsu, Mohammad Ali, Ashir Ahmed, Mohammad Delwer Hossain Hawlader, Hiromi Kawasaki, Yoko Shimpuku

“…Methods This open-label, parallel-group, randomized controlled trial was conducted at two schools in Chandpur district, Bangladesh from late May 2022 to January 2023. …”
Get full text

Isolated “on-pump” tricuspid valve repair through right-sided anterolateral thoracotomy by modified femoral-monocaval cannulation in patients with repeated heart intervention – a s... by V. V. Osaulenko, V. O. Hubka, K. O. Chmul, R. I. Budahov

“…Improving the immediate and long-term outcomes of patients with a cardiac surgical profile by evaluating the efficacy and safety of isolated tricuspid valve repair on the working heart by right anterolateral thoracotomy with reintervention. …”
Get full text

Effects of oat β-glucan-based prebiotic blended formulas on defecation and gut microbiota in Chinese adults: a randomized clinical trial by Aiqi Li, Lei Jin, Hui Xia, Meiyuan Feng, Xirui Zhou, Yifang Chu, Feng Liu, Lanxing Jia, Ximin Chen, Dengfeng Xu, Shanjie Ma, Xiaofan Xu, Xinyu Wang, Xiaoqing Li, Guiju Sun, Liegang Liu

“…Fecal samples were collected on day 0 and day 14 to evaluate gut bacteria using 16S rDNA analysis. Both formulas improved defecation frequency, stool quality, defecation symptoms, defecation satisfaction, and on digestive health of human, compared with baseline (P < 0.05). …”
Get full text

An Experimental Model of Acute Pulmonary Damage Induced by the Phospholipase A₂-Rich Venom of the Snake <i>Pseudechis papuanus</i> by Daniela Solano, Alexandra Rucavado, Teresa Escalante, Edith Bastos Gandra Tavares, Suellen Karoline Moreira Bezerra, Clarice Rosa Olivo, Edna Aparecida Leick, Julio Alejandro Rojas Moscoso, Lourdes Dias, Iolanda de Fátima Lopes Calvo Tibério, Stephen Hyslop, José María Gutiérrez

“…Venom caused pulmonary edema, with the accumulation of a protein-rich exudate, as observed histologically and by analysis of bronchoalveolar lavage fluid (BALF). In parallel, venom induced an increase in all of the pulmonary mechanical parameters evaluated, without causing major effects in terms of tracheal and bronchial reactivity. …”
Get full text

Efficacy of the cigarette-burning application combined with medication intervention for smoking cessation in China: A randomized controlled trial by Xiao-Wen Wei, Rui Qin, Yong-Zhuang Liu, Zhao Liu, An-Qi Cheng, Xin-Mei Zhou, Zheng Su, Zi-Yang Cui, Jin-Xuan Li, Liang Zhao, Dan Xiao, Chen Wang

“…Methods A parallel, open-label randomized clinical trial was conducted with a ratio of 1:1 allocation into the bupropion plus app group and bupropion group. …”
Get full text

Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits by Dennis Witt, Marc Sturm, Antje Stäbler, Benita Menden, Lisa Ruisinger, Kristin Bosse, Ines Gruber, Andreas Hartkopf, Silja Gauß, German Demidov, Nicolas Casadei, Elena Buena Atienza, Kira Mehnert, Janna Witt, Caspar Gross, Leon Schütz, Christopher Schroeder, Stephan Ossowski, Andreas Dufke, Tobias B. Haack, Olaf Riess, Ulrike Faust

“…This single-center real-world study aims to evaluate advantages of short-read genome sequencing (GS) in HBOC families. …”
Get full text

Early Start Denver Model effectiveness in young autistic children: a large multicentric randomised controlled trial in two European countries by Marie-Maude Geoffray, Sandrine Sonié, Mario Speranza, Bruno Falissard, Sandrine Touzet, Angelique Denis, Lucie Jurek, Marie-Joelle Oreve, Carmen Schroder, Amélie Zelmar, Sabine Manificat, Stephane Bahrami, Flavia Mengarelli, Véronique Delvenne, Sophie Carlier, Mikail Nourredine, Jay Agathe, Gallifet Natacha, Nicolas Petit, Laetitia Bouveret, Sara Linda Dochez, Pauline Auphan, Olivia Febvey-Combes

“…Further research is required to evaluate the long-term effectiveness of ESDM and identify subgroups that may benefit more, thereby guiding optimal implementation strategies.Trial registration number NCT02608333.…”
Get full text

High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array by Hannah Viola, Liang-Hsin Chen, Seongbin Jo, Kendra Washington, Cauviya Selva, Andrea Li, Daniel Feng, Vincent Giacalone, Susan T. Stephenson, Kirsten Cottrill, Ahmad Mohammad, Evelyn Williams, Xianggui Qu, Wilbur Lam, Nga L. Ng, Anne Fitzpatrick, Jocelyn Grunwell, Rabindra Tirouvanziam, Shuichi Takayama

“…Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress toward therapeutics. …”
Get full text

Modulation of Brain Kynurenic Acid by N-Acetylcysteine Prevents Cognitive Impairment and Muscular Weakness Induced by Cisplatin in Female Rats by Teminijesu Dorcas Aremu, Daniela Ramírez Ortega, Tonali Blanco Ayala, Dinora Fabiola González Esquivel, Benjamín Pineda, Gonzalo Pérez de la Cruz, Alelí Salazar, Itamar Flores, Karla F. Meza-Sosa, Laura Sánchez Chapul, Edgar Rangel-López, Saúl Gómez-Manzo, Adrián Márquez Navarro, Gabriel Roldán Roldán, Verónica Pérez de la Cruz

“…This study aimed to evaluate the effects of modulating brain KYNA levels by the administration of N-acetylcysteine (NAC), an inhibitor of kynurenine aminotransferase II (KATII), an enzyme responsible for KYNA biosynthesis on the cognitive and neuromuscular deficits induced by CIS. …”
Get full text

Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke by Ahmet Alptekin, Mohammad B. Khan, Mahrima Parvin, Hasanul Chowdhury, Sawaiz Kashif, Fowzia A. Selina, Anika Bushra, Justin Kelleher, Santu Ghosh, Dylan Williams, Emily Blumling, Roxan Ara, Asamoah Bosomtwi, Joseph A. Frank, Krishnan M. Dhandapani, Ali S. Arbab

“…The objectives of the proposed studies were to determine whether LIPFUS-mediated increased delivery of EPC-derived exosomes enhances stroke recovery and functional improvement in mice with transient middle cerebral artery occlusion (tMCAo) stroke.MethodsTo enhance exosome delivery to the stroke area, we utilized LIPFUS. We evaluated stroke volume using MRI at different time points and conducted behavioral studies parallel to MRI to determine recovery. …”
Get full text

Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study by Rubina Sharma, Noa G. Holtzman, Iskra Pusic, Corey Cutler, Nathaniel Treister, Rohtesh S. Mehta, Amin S. Alousi, Nadarajah Vigneswaran, Ayesha Javaid, Francis Boksa, Drashty P. Mody, Ana C. Costa-da-Silva, Olivier Schueller, Sandrine Macé, Yu Yao, Ran Ji, Beifang Hu, Kathy Marshall, Bruce R. Blazar, Stephanie J. Lee, Steven Z. Pavletic, Jacqueline W. Mays

“…However, these studies did not evaluate immune responses within cGVHD-affected tissues. …”
Get full text

A noninvasive accelerated quantitative MR technique to distinguish drug resistance in prolactinomas: Early results by Rong Lu, Tingfang Hwang, Kaibo Tang, Qing Li, Caixia Fu, Ying-Hua Chu, Shangxuan Shi, Tobias Kober, Tom Hibert, Bin Lu, Yiming Li, Yao Lu, Weijun Tang, Lijin Ji

“…A noninvasive accelerated quantitative MR technique (GRAPPATINI, GeneRalized Autocalibrating Partially Parallel Acquisitions acceleraTed T2 mappINg) was applied to investigate the correlation between quantitative T2 values and DA resistance. …”
Get full text

Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to in... by Sophie Parker, Lydia Pearson, Rebekah Carney, Richard P. Bentall, Matthew R. Broome, Emma Cernis, Timothy Clarke, Steven Jones, Katherine Moran, Jonathan Wilson, Isabel Coleman, Catherine Hewitt, Wendy Jones, Heather Law, Sarah Peters, Gemma Shields, David Shiers, Luke Strachan, Anton Strong, Judith Watson, Chris J. Sutton

“…Methods A multicentre, rater-masked randomised controlled trial with two parallel arms will compare cognitive behaviour therapy (CBT) for young people meeting BAR criteria (CBTBAR) + Treatment as Usual (TAU) vs. …”
Get full text

Enhancing patient satisfaction and reducing nurse workload: the impact of multimedia health education in a prospective single-center randomized controlled trial by Liping Yang, Liping Yang, Liping Yang, Zilan Qin, Zilan Qin, Zilan Qin, Jia Yao, Jia Yao, Huan Xu, Jinhui Tian, Jinhui Tian, Yanxian Ren, Yanxian Ren, Yanxian Ren, Haiping Wang, Haiping Wang, Haiping Wang, Wenbo Meng, Wenbo Meng, Wenbo Meng

“…Thus, this study aims to evaluate whether multimedia health education reduces nurses’ workload without compromising patient and family satisfaction in a surgical context.MethodsWe conducted a parallel-group, prospective randomized controlled trial at the Hepatobiliary Surgery Institute of Lanzhou University’s First Hospital between July 2019 and May 2022. …”
Get full text

A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children by Chengliang Zhong, Qingyuan Liu, Shengxuan Guo, Deyang Sun, Boyang Wang, Siyuan Hu, Xinmin Li, Weibo Zhao, Ying Ding, Bin Yuan, Jing Liu, Long Xiang, Nan Li, Zheng Xue, Yan Li, Yiqun Teng, Rongsong Yi, Shao Li, Rong Ma

“…Under the instruction of computational analysis, we conducted a randomized, double-blind, three-armed, parallel-controlled, multicenter clinical study of different doses of JZOL combined with AZ for the treatment of MPP in children. …”
Get full text

Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

“…Methods A pilot, single-centre, open-label, parallel-group study included 132 patients with a history of at least two exacerbations. …”
Get full text

Applying kinetic models to the study of the influence of wood contact surface area/volume ratio on the ageing of Brandy de Jerez by Rocío Trillo-Ollero, Luis M. Trillo-Gutiérrez, M. Valme García-Moreno, M. Carmen Rodríguez-Dodero, Dominico A. Guillén-Sánchez

“…Regarding the diffusion models, the results were better fitted to the parabolic model, which suggests that during the ageing of the spirit a number of parallel reactions take place that affect the values actually reached by the parameters considered in our study. …”
Get full text