Vaccination as a solution of the issue of resistance S. pneumoniae by H. P. Ruban, S. V. Struch

“…The publication of the results of three parallel studies in Finland evaluated the effectiveness of PCV10 in reducing the number of IPD caused by vaccine-specific serotypes of PCV10 by 93%, 98% and 100%, respectively. …”
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Effectiveness of a Mobile Health Intervention (DOT Selfie) in Increasing Treatment Adherence Monitoring and Support for Patients With Tuberculosis in Uganda: Randomized Controlled... by Juliet Nabbuye Sekandi, Esther Buregyeya, Sarah Zalwango, Damalie Nakkonde, Patrick Kaggwa, Trang Ho Thu Quach, David Asiimwe, Lynn Atuyambe, Kevin Dobbin

“…ObjectiveThis study aims to evaluate the effectiveness of VDOT compared with usual care directly observed therapy (UCDOT). …”
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Enhancing Quality of Life in Patients With Hypothyroidism Using a Scientific Yoga Module: Randomized Controlled Trial by Savithri Nilkantham, Amit Singh, Vijaya Majumdar, Harini K N, Snigdha Atmakur

“…MethodsA single-blinded, 2-arm, parallel-group randomized controlled trial was conducted for 6 months (April 1, 2022-September 30, 2022) with 134 clinically diagnosed patients with hypothyroidism recruited from the Arogyadhama Holistic Health Home registry (2013-2021). …”
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REMCARE: Pragmatic Multi-Centre Randomised Trial of Reminiscence Groups for People with Dementia and their Family Carers: Effectiveness and Economic Analysis. by Robert T Woods, Martin Orrell, Errollyn Bruce, Rhiannon T Edwards, Zoe Hoare, Barry Hounsome, John Keady, Esme Moniz-Cook, Vasiliki Orgeta, Janice Rees, Ian Russell

“…<h4>Methods</h4>This multi-centre, pragmatic randomised controlled trial had two parallel arms: intervention group and usual-care control group. …”
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Forensic Genetics: A Machine Learning Algorithm for Mutation Modelling by Sofia Antão Sousa, Leonor Gusmão, Marisa Faustino, António Amorim, Nádia Pinto

“…Therefore, interlaboratory studies are crucial to produce and gather important amounts of data, in parallel to the establishment of publication guidelines to assure the release of data with the proper level of detail. …”
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Comparison of outcomes of coronary artery stenting in acute myocardial infarction due to massive coronary thrombosis by A. V. Azarov, M. G. Glezer, A. S. Zhuravlev, I. R. Rafaeli, S. P. Semitko, K. V. Gyulmisaryan, S. A. Kurnosov

“…Comparative study in parallel groups, a total of 153 patients with ST-elevation myocardial infarction and massive coronary thrombosis (TTG 3), 75 patients in the delayed coronary artery stenting group, 78 patients in the immediate coronary artery stenting group. …”
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Effects of pH on Oat Protein Isolate and Pickering Emulsion Stabilized by the Protein by Jing WANG, Yingxue JIAO, Wei GAO, Lipeng FAN, Sunshuo LIANG, Huiting WANG, Lijuan LU, Wenhui QI, Zhisheng ZHANG

“…Concurrently, the emulsification performance, oxidative stability, and in vitro digestibility profiles of Pickering emulsions stabilized by OPI were comprehensively evaluated under fixed oil-water phase ratio of 3:7. …”
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Ongoing presence of Leishmania major cutaneous leishmaniasis in Mauritania, 2016–2024 by Aminetou El Moctar, Mohamed Ouldabdallahi Moukah, Abdoulaye Kassoum Koné, Mona Saout, Magalie Demar, Mamadou Dramani Fofana, Taleb Khyar Cheikh Mohamed Vadel, Mariem Kébé, Mahamadou Ali Thera, Romain Blaizot, Ali Ould Mohamed Salem Boukhary

“…Further studies should be conducted to better determine the disease burden, identify vectors and reservoirs and evaluate therapeutic options.…”
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A Novel Supraglottic Suction Device in Mechanically Ventilated Patients: A Randomized Controlled Trial by Orozco-Levi M, Tiga-Loza DC, Aya O, Reyes CF, Cáceres-Rivera D, Espitia A, Rey D, Pedrozo Arias KP, Pizarro C, Sanabria-Barrera SM, Serrano-Díaz N, Castillo VR, Ramírez-Sarmiento A

“…Mauricio Orozco-Levi,1– 3 Diana Carolina Tiga-Loza,1,3 Orlando Aya,4 Carlos Fernando Reyes,4 Diana Cáceres-Rivera,1 Angela Espitia,1 Diana Rey,1 Karen Patricia Pedrozo Arias,1,3 Camilo Pizarro,5 Sandra M Sanabria-Barrera,6 Norma Serrano-Díaz,7 Victor R Castillo,8 Alba Ramírez-Sarmiento1,2,7 1Department of Respiratory Medicine, International Hospital of Colombia, Fundación Cardiovascular de Colombia, Piedecuesta, Santander, Colombia; 2EMICON Research Group, Ministry of Science and Technology (MINCIENCIAS), Bogotá, Colombia; 3Department of Medicine, Universidad de Santander (UDES), Bucaramanga, Santander, Colombia; 4Department of Critical Care, International Hospital of Colombia, Fundación Cardiovascular de Colombia, Piedecuesta, Santander, Colombia; 5Department of Critical Care, Cardiovascular Institute, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia; 6Department of Innovation and Technological Development, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia; 7Department of Research, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia; 8Department of Cardiovascular Surgery, Cardiovascular Institute, Fundación Cardiovascular de Colombia, Floridablanca, Santander, ColombiaCorrespondence: Mauricio Orozco-Levi, Department of Respiratory Medicine, International Hospital of Colombia, Fundación Cardiovascular de Colombia, Kilómetro 7, Autopista Piedecuesta-Bucaramanga, Piedecuesta, Santander, 681004, Colombia, Tel +57 3175741421, Email mauricioorozco@fcv.orgObjective: To evaluate the efficacy and safety of the SUPRAtube innovation device in preventing ventilator associated events and fluid accumulation in the supraglottic region in patients receiving mechanical ventilation (MV) through orotracheal tubes.Methods: Multicenter, controlled, randomized, parallel, open-label clinical trial with a 1:1 allocation ratio of MV patients compared the use of the SUPRAtube elastomeric device with standard care and aspiration techniques. …”
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Heterogeneity and efficacy of immunotherapy in multiple cancer: insights from a meta-analysis by Weidong Wu, Bin Liu, Qing Zhang, Xiaojuan Zhang, Pengya Feng, Yongliang Jia, Xia Xue

“…Subgroup analysis based on cancer type revealed that ORR was higher in multiple myeloma (86.77%, 400/461) compared with leukemia (84.92%, 259/305) and lymphoma (67.92%, 36/53). In parallel, heterogeneity observed based on case origins suggested that Chinese cases showed significantly higher ORR, CRR, and survival rates compared with American ones. …”
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Scientific Research on the Issue of Soft Skills Development (Review of the Data in International Databases of Scopus, Web of Science) by I. K. Tsalikova, S. V. Pakhotina

“…Diverse ways of soft skills development are offered: organisation of special courses taught out of the subject context (which have already shown their inefficiency), mastering soft skills in parallel with the process of subject-based training or through the potential of particular disciplines. …”
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Web-Based Application for Reducing Methamphetamine Use Among Aboriginal and Torres Strait Islander People: Randomized Waitlist Controlled Trial by Rachel Reilly, Rebecca McKetin, Federica Barzi, Tayla Degan, Nadine Ezard, Katherine Conigrave, Julia Butt, Yvette Roe, Handan Wand, Brendan Quinn, Wade Longbottom, Carla Treloar, Adrian Dunlop, James Ward

“…MethodsThe web app was evaluated using a randomized waitlist controlled parallel group trial. …”
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Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.) by Junxuan Zhu, Ming An, Weiting Wang, Jingjing Guo, Mengting Chen, Longlong Fang, Cen Wang, Dong Zhang, Guodong Wu

“…Despite extensive studies on their detoxification effects, the role of cytochrome P450 (CYP450) modulation remains unclear.AimThis study aimed to systematically evaluate the regulatory effects of Zhicaowu and Hezi combination on both enzymatic activity and mRNA expression of CYP450 isoforms (CYP1a2, CYP2b1, CYP2c11, CYP2c13, CYP2d2, CYP2e1, and CYP3a1), and to explore their correlation with hepatoprotective effect.MethodsThe effects of Zhicaowu-Hezi formulation on CYP450 enzymes were systematically evaluated through integrated in vivo and in vitro approaches. …”
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Overhaul Scheduling Approach for Metro Vehicles Based on Genetic Algorithms by WANG Bingjing, LI Bingxin

“…In this scheduling approach, an evaluation function is applied to transform the train overhaul scheduling into the tasks to optimize the resource allocation for the overhaul process, and the resource allocation to the overhaul process is optimized leveraging the inherent parallelism and global optimization ability of the genetic algorithm, and the optimal chromosome is deemed as the final result of the overhaul scheduling. …”
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Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mecha... by Joanne R Chalmers, Sanja Kezic, Zarif K Jabbar-Lopez, Nikeeta Gurung, Danielle Greenblatt, Annette Briley, Kim Suzanne Thomas, Tony Frost, John E A Common, Heidi H Kong, Julie A Segre, Simon Danby, Michael J Cork, Janet L Peacock, Carsten Flohr

“…A further aim is to explore the pathophysiological mechanisms for this in an embedded mechanistic study.Methods and analysis Multicentre parallel group assessor-blinded randomised controlled pilot trial. …”
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Deep learning enabled near-isotropic CAIPIRINHA VIBE in the nephrogenic phase improves image quality and renal lesion conspicuity by Qinxuan Tan, Jingyu Miao, Leila Nitschke, Marcel Dominik Nickel, Markus Herbert Lerchbaumer, Tobias Penzkofer, Sebastian Hofbauer, Robert Peters, Bernd Hamm, Dominik Geisel, Moritz Wagner, Thula Cannon Walter-Rittel

“…Background: Deep learning (DL) accelerated controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)-volumetric interpolated breath-hold examination (VIBE), provides high spatial resolution T1-weighted imaging of the upper abdomen. …”
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Establishing a new human pneumococcal standard reference serum, MPRSS-01 by Joseph M. Antonello, Rocio D. Murphy, Chitrananda Abeygunawardana, Juliana C. Malinverni, Rajam Gowrisankar, Tina Green, Rebecca Greway, Jenna Schmauch, Adrienne Howlett, Cyrille J. Bonhomme, Katrina M. Nolan

“…Serotype 7F was initially chosen as the reference calibrator for cross-standardization due to parallelism across dilution–response curves demonstrated across all 33 serotypes, and an evaluation of the single-calibrator approach was conducted for the 24 serotypes. …”
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DIAMONDS—a diabetes self-management intervention for people with severe mental illness: protocol for an individually randomised controlled multicentre trial by Tim Doran, Najma Siddiqi, Simon Gilbody, Rowena Jacobs, Patrick Doherty, Catherine Hewitt, Laura Mandefield, Simon Walker, Ian Kellar, Sarah Alderson, David Osborn, Vicki Johnson, Judith Watson, Gregor Russell, Steve Parrott, Jan Rasmus Boehnke, Peter A Coventry, Jinshuo Li, Richard Ian Gregory Holt, Judy Wright, David Shiers, Michelle Hadjiconstantinou, Keith Double, Claire Carswell, Jennifer V E Brown, Lucy Sheehan, Grace Catherine O’Carroll, Charlie Peck, R A Ajjan, Angela Ross, Mark Dawson

“…The DIAMONDS trial aims to evaluate the clinical and cost effectiveness of a novel, codesigned, supported diabetes self-management programme for people with T2DM and SMI.Methods and analysis This multicentre, two-armed, parallel, individually randomised controlled trial will be conducted in National Health Service mental health trusts across England. …”
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Artificial intelligence–enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial by Zhandos Kurban, Didar Khassenov, Didar Khassenov, Zhandos Burkitbaev, Sholpan Bulekbayeva, Azat Chinaliyev, Serik Bakhtiyar, Samat Saparbayev, Tokan Sultanaliyev, Ulzhalgas Zhunissova, Natalia Slivkina, Elena Titskaya, Luis Arias, Dana Aldakuatova, Gulfairus Yessenbayeva, Zhanerke Ermakhan

“…The International Classification of Functioning, Disability and Health (ICF) provides a standardized framework for evaluating patient functioning, yet AI-driven ICF mapping tools remain underexplored in routine clinical settings.ObjectiveThis study aimed to evaluate the efficiency and accuracy of the MedQuest mobile application—featuring integrated AI-based ICF mapping—compared to traditional paper-based assessment in hospitalized patients.MethodsA parallel-group randomized controlled trial was conducted in two medical centers in Astana, Kazakhstan. …”
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Protocol for a randomised controlled trial of a weight maintenance intervention to promote fat loss in pregnant individuals with obesity by Suzanne Phelan, Leanne M Redman, Aaron B Caughey, Daniel S Hsia, John W Apolzan, Robbie A Beyl, Abby D Altazan, Madison S Dickey, Emerson Simeon, Emily W Flanagan, Hannah E Cabre, Joshua R Sparks, Maryam Kebbe, Amy M Valent, Elaine Yin, Sarah K Keadle

“…Data from randomised clinical trials are needed to evaluate the efficacy of a fat mass loss intervention on pregnancy outcomes. …”
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