A randomized comparative feasibility study of neuromodulation and cognitive training for post-COVID fatigue by Silvia Oliver-Mas, Jordi A. Matias-Guiu, Cristina Delgado-Alonso, Lidia Gil-Martínez, Constanza Cuevas, Carmen Polidura, Lucía Fernández-Romero, Andreu Matias-Guiu, Natividad Gómez-Ruiz, María José Gil-Moreno, Miguel Yus-Fuertes, Jorge Matias-Guiu, Maria Diez-Cirarda

“…Abstract Fatigue and cognitive deficits are common and disabling symptoms in patients experiencing post-COVID condition. This randomized parallel study aimed to evaluate the effects of transcranial direct current stimulation (tDCS) over the primary motor cortex combined with cognitive training (M1 + CT), compared to tDCS over the dorsolateral prefrontal cortex with cognitive training (DLPFC + CT), on fatigue, cognition, and other clinical symptoms in post-COVID. …”
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Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson’s disease: study protocol for a randomised contro... by Hang Su, Xiaoyu Jiang, Limin Wang, Linlin Zhang, Qing Wang, Xihua Liu, Xiaoming Xi, Yuxiao Chen, Xinjie Qu, Haihao Cao, Wenyu Sun, Guoming Chen, Huifen Liu, Jiahui Jiang, Hongyan Bi

“…Studies have indicated that aerobic and resistance exercises alleviate PD movement disorders and improve aerobic capacity, but the effects of Qigong on PD static tremor and aerobic capacity remain unknown.Methods and analysis Objective To observe the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD, we established a rigorous randomised, parallel-controlled, assignment hidden, evaluator-blinded protocol.Methods Seventy-two patients with PD, at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, were recruited and randomly divided into a control (n=36) and experimental group (n=36). …”
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Machine learning-driven multi-omics analysis identifies a prognostic gene signature associated with programmed cell death and metabolism in hepatocellular carcinoma by Xiang Li, Donghao Yin, Jiahao Geng, Yanyu Xu, Zijing Xu, Xuemeng Yang, Quanwei Li, Zimeng Shang, Zhiyun Yang, Zhong Xu, Jiabo Wang, Enxiang Zhang, Xinhua Song

“…The model was subsequently evaluated in the context of the immune microenvironment and its relevance to immunotherapeutic responses. …”
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Rehabilitation effect on psycho-emotional well-being in women with surgically treated vulvar cancer: a randomised controlled trial by Blinov V. Dmitry, Antonina G. Solopova, Elena V. Gameeva, Nazim G. Badalov, Vsevolod N. Galkin, Mikhail A. Eremushkin, Alexandra M. Stepanova, Alexander E. Ivanov, Olga S. Gridasova

“…However, the results evaluating the impact of rehabilitation programmes on various components of quality of life in these patients remain limited. …”
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Splenic and portal venous flow associated with frailty and sarcopenia in older outpatients with cardiovascular disease by Joji Ishikawa, Shutaro Futami, Ayumi Toba, Aya Yamamoto, Keisho Kobayashi, Kana Takani, Hideko Ono, Teppei Maeda, Masuyo Kawano, Masaru Kiyomizu, Yoshiaki Tamura, Atsushi Araki, Hideaki Mori, Kazumasa Harada

“…Abstract Background Older patients with cardiovascular disease often experience frailty and sarcopenia. We evaluated whether a reduced blood flow in the splenic and portal vein is associated with frailty and sarcopenia in older patients with cardiovascular disease. …”
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Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial by Alicia Monreal-Bartolomé, Adoración Castro, M Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, María Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo, Jesus Montero-Marin

“…Differences between the groups were estimated using mixed effects linear regression models, and mediation evaluations were conducted using path analyses to evaluate the potential mechanistic role of positive and negative affectivity and openness to the future. …”
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Isolation of a Novel <i>Streptomyces</i> sp. TH05 with Potent Cyanocidal Effects on <i>Microcystis aeruginosa</i> by Xuhan Wang, Siqi Zhu, Shenchen Tao, Shaoyong Zhang, Ruijun Wang, Liqin Zhang

“…In this study, we evaluated the cyanocidal activity and mechanism of a novel actinomycete strain, <i>Streptomyces</i> sp. …”
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Efficacy and safety of musculoskeletal manipulations in elderly population with musculoskeletal disorders: a systematic review by Alessandro Mauro, Donatella Bagagiolo, Michela Persiani, Luca Cicchitti, Luca Vismara, Irene Bruini, Francesca Buffone

“…No meta-analysis was performed.Results Five parallel randomised controlled trials were included, with a total sample size of 676 participants (41.6% women with a mean age of 77.3 years): 34 with chronic pain, 265 with neck pain and 377 with low back pain. …”
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Virtual Coach–Guided Online Acceptance and Commitment Therapy for Chronic Pain: Pilot Feasibility Randomized Controlled Trial by Erin D Reilly, Megan M Kelly, Hannah L Grigorian, Molly E Waring, Karen S Quigley, Timothy P Hogan, Alicia A Heapy, Charles E Drebing, Matias Volonte, Ummul-Kiram Kathawalla, Hannah E Robins, Katarina Bernice, Timothy Bickmore

“…ObjectiveThis study aims to evaluate the virtual coach–guided Veteran ACT for Chronic Pain (VACT-CP) online program compared to a waitlist and treatment as usual (WL+TAU) control group through a small pilot feasibility randomized controlled trial. …”
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An impact of neutrophil extracellular traps to the prothrombotic state and tumor progression in gynecological cancer patients by E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, N. D. Degtyareva, D. V. Shcherbakov, J.-C. Gris, I. Elalamy, A. D. Makatsariya

“…In addition, NET-related effect on tumor progression and metastasis has been actively studied.Aim: to evaluate NET-related procoagulant activity in gynecological cancer patients.Materials and Methods. …”
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BLACK HUMOUR: ORIGIN DESCRIPTION AND AN ATTEMPT OF IDENTIFICATION by Iryna A. Blynova.

“…Typical means at the syntactic level are overinterrogations and explanations based on repetitions with an evaluation of what was heard. This evaluation is expressed by declarative, exclamatory or interrogative sentences. …”
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VeloFHE: GPU Acceleration for FHEW and TFHE Bootstrapping by Shiyu Shen, Hao Yang, Zhe Liu, Ying Liu, Xianhui Lu, Wangchen Dai, Lu Zhou, Yunlei Zhao, Ray C. C. Cheung

“…For key switching, we address input-output parallelism mismatches, and offloading suitable computations to the CPU, effectively hiding latency through asynchronous execution. …”
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Optimizing CdS/Sb2S3 solar cells for enhanced performance: reaching 26.83% efficiency by Leticia Treviño Yarce, Enrique Rosendo Ándrés, Jose Carlos Zepeda Medina, María Josefina Robles Águila, Crisóforo Morales Ruíz, Reina Galeazzi Isasmendi, Antonio Coyopol Solís, Godofredo García Salgado

“…Furthermore, the effects of absorber and window layer thickness, series and parallel resistances, total defect density, acceptor concentration, and operating temperature on V _oc , J _sc , FF, and overall solar cell efficiency were systematically examined. …”
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Salivary lactoferrin levels in Down Syndrome: a case-control study by Desireé Antequera, Lucía Sande, Eliane García Mato, Deborah Romualdi, Laura Carrero, Cristina Municio, Pedro Diz, Eva Carro

“…Median of salivary lactoferrin were higher among DS individual, in parallel to salivary total protein, but there were no differences in the ratio of lactoferrin to total protein in saliva between groups. …”
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Assessment of clinical competency among TCM medical students using standardized patients of traditional Chinese medicine: A 5-year prospective randomized study by Jinhao Zeng, Shuang Liang, Xiaotong Zhang, Ran Yan, Chongli Chen, Lijuan Wen, Ting Xia, Wenyuan Li, Bingqing Lu, Qing Nian, Han Yang, Jing Guo

“…Methods: This study was a prospective, 2-group, parallel-training randomized trial over the course of 5 years. …”
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Electrochemical and quantum chemical investigation on the adsorption behavior of a schiff base and its metal complex for corrosion protection of mild steel in 15 wt% HCl solution by Badr El-Haitout, Ratnaningsih Eko Sardjono, Bouchra Es-Sounni, Maryam Chafiq, Rachid Salghi, Mohamed Bakhouch, Aisha H. Al-Moubaraki, Jamilah M. Al-Ahmari, Azza A. Al-Ghamdi, Mohammed Fahim, Belkheir Hammouti, Abdelkarim Chaouiki, Young Gun Ko

“…This work evaluates the effectiveness of Schiff base derivatives, namely, 2,2'-((1E,1′E)-((2,2-dimethylpropane-1,3-diyl)bis(azaneylylidene))bis(methaneylylidene))diphenol (DAMD) and (2-((E)-((3-(((E)-2-hydroxybenzylidene)amino)-2,2dimethylpropyl)imino)methyl)phenoxy) zinc (HDMZ), as corrosion inhibitors for mild steel in a 15 % HCl solution. …”
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Efficacy and safety of electroacupuncture and electroacupuncture combined with warm needling for subjective tinnitus: A multicenter, three-arm randomized controlled trial by Lai Fun Ho, Yuanqi Guo, Liyi Chen, Herbert Fung, Wai Yan Mak, Siu Chuen Cheung, Ping Him Tsang, Min Chen, Kam Leung Chan, Hongwei Zhang, Wai Tsz Chang, Bacon Fung-Leung Ng, Zhi Xiu Lin

“…Methods: This multicenter, assessor-blinded, parallel-group, randomized clinical trial was conducted from December 2022 to April 2024 at three out-patient clinics in Hong Kong. …”
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PRESOLRE: study protocol for a primary school-based, cluster randomised controlled trial of three sun exposure risk prevention strategies on Reunion Island by Cyril Ferdynus, Léa Bruneau, Antoine Bertolotti, Charline Dugast, Adrian Fianu, Karim Boussaid, Juliette Vuichard, Floreana Duloutre, Jessica Dumez, Nathalie Sultan-Bichat

“…The early prevention of melanoma is based on sun protection in childhood, but French regulations are not adapted to the environmental conditions of this tropical region.The main objective of our study is to evaluate the effectiveness of three sun protection programs conducted in Reunionese primary schools through a pupil knowledge questionnaire.Methods and analysis PRESOLRE is an interventional, open-label, cluster-randomised controlled trial, in four parallel arms, that is being conducted throughout 2022–2023 on Reunion Island. …”
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Prognostic analysis according to European LeukemiaNet 2022 risk stratification for elderly patients with acute myeloid leukemia treated with decitabine by Mihee Kim, Seo-Yeon Ahn, TaeHyung Kim, Sung-Hoon Jung, Ga-Young Song, Deok-Hwan Yang, Je-Jung Lee, Mi Yeon Kim, Ju Heon Park, Myung-Geun Shin, Jae-Sook Ahn, Hyeoung-Joon Kim, Dennis Dong Hwan Kim

“…Survival analysis revealed distinctive overall survival (OS) outcomes among the ELN-2022 risk groups (6-month OS rate: 73.3%, 52.9%, and 47.7% for favorable, intermediate, and adverse risk, respectively; P = 0.101), with a parallel trend observed in the event-free survival (EFS) (6-month EFS rate: 73.3%, 52.9%, and 45.6% for favorable, intermediate, and adverse risk, respectively; P = 0.049). …”
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Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer by Chuan Wang, Kaïdre Bendjama, Stephen Schoenberger, Oliver Wood, Gareth Thomas, Pandurangan Vijayanand, Tilman Sanchez-Elsner, Nathalie Silvestre, Natalia Savelyeva, Christian Ottensmeier, Katy McCann, Adrian von Witzleben, Jaya Thomas, Divya Singh, Konstantinos Boukas, Finn Cilius Nielsen, Jason Greenbaum, Bjoern Peters

“…Thereafter, we assessed the autologous T-cell reactivity to the candidate neoantigens using a long peptide approach in a cultured interferon gamma ELISpot and tracked the neoantigen-specific T-cells in the tumor by T-cell receptor (TCR) sequencing. In parallel, identified gene variants were incorporated into a Modified Vaccinia Ankara-based vaccine, which was evaluated in the human leucocyte antigen A*0201 transgenic mouse model (HHD).Results Sequencing revealed a tumor with a low mutational burden: 2219 sequence variants were identified from the primary tumor, of which 23 were expressed in the transcriptome, involving 18 gene products. …”
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