Proficiency testing and cross-laboratory method comparison to support standardisation of diatom DNA metabarcoding for freshwater biomonitoring by Valentin Vasselon, Sinziana F. Rivera, Éva Ács, Salomé Baja Almeida, Karl B. Andree, Laure Apothéloz-Perret-Gentil, Bonnie Bailet, Ana Baričević, Kevin K. Beentjes, Juliane Bettig, Agnès Bouchez, Camilla Capelli, Cécile Chardon, Mónika Duleba, Tina Elersek, Clémence Genthon, Maša Jablonska, Louis Jacas, Maria Kahlert, Martyn G. Kelly, Jan-Niklas Macher, Federica Mauri, Marina Moletta-Denat, Andreia Mortágua, Jan Pawlowski, Javier Pérez-Burillo, Martin Pfannkuchen, Erik Pilgrim, Panayiota Pissaridou, Frédéric Rimet, Karmen Stanic, Kálmán Tapolczai, Susanna Theroux, Rosa Trobajo, Berry Van der Hoorn, Marlen I. Vasquez, Marie Vidal, David Wanless, Jonathan Warren, Jonas Zimmermann, Benoît Paix

“…Under the guidance of a reference laboratory, 17 participants from 14 countries performed DNA extraction and PCR amplification in parallel, using the same fixed protocol and their own choice of protocol. …”
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Patient and provider preferences for long-acting TB preventive therapy by M. Vermeulen, K.K. Scarsi, R. Furl, H. Sayles, M.J. Anderson, S. Valawalkar, A. Kadam, S.R. Cox, V. Mave, M. Barthwal, C. Schutz, A. Ward, J. Dountio Ofimboudem, G. Meintjes, S. Rannard, A. Owen, S. Swindells, on behalf of the LONGEVITY consortium

“…METHODS: We conducted a cross-sectional in-person survey in two high TB burden countries to evaluate preferences and concerns about LA formulations for TPT. …”
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Comparison of the prophylactic antithrombotic effect of indobufen and warfarin in patients with nephrotic syndrome: a randomized controlled trial by Xin-Yi Gao, Yue-Ming Liu, Dan-Na Zheng, Yi-Wen Li, Hua Li, Xiao-Ling Xiong, Hong-Yu Chen, Hua Wang, Xiao-Yong Yu, Kai Qu, Juan Jin, Bo Lin, Qiang He

“…Indobufen, a selective cyclooxygenase-1 inhibitor, is currently being evaluated for the prevention of thromboembolic events in nephrotic syndrome. …”
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Agreements and controversies of national guidelines for bronchiolitis: Results from an Italian survey by Sara Manti, Amelia Licari, Ilaria Brambilla, Carlo Caffarelli, Mauro Calvani, Fabio Cardinale, Giorgio Ciprandi, Claudio Cravidi, Marzia Duse, Alberto Martelli, Domenico Minasi, Michele Miraglia Del Giudice, Giovan B. Pajno, Maria A. Tosca, Elena Chiappini, Eugenio Baraldi, Gianluigi Marseglia

“…Abstract Introduction Significant variations in the management of bronchiolitis are often recorded, and, in parallel, to recommend a univocal clinical approach is challenging and still questioned. …”
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Effects of a CrossFit Training Program on Body Composition and Physical Fitness in Novice and Advanced Practitioners: An Inter-Individual Analysis by Pablo Aravena-Sagardia, Mauricio Barramuño-Medina, Bárbara Palma Vásquez, Sebastián Pichinao Pichinao, Paula Rodríguez Sepúlveda, Tomás Herrera-Valenzuela, Jordan Hernandez-Martinez, Álvaro Levín-Catrilao, Francisca Villagrán-Silva, Edgar Vásquez-Carrasco, Braulio Henrique Magnani Branco, Cristian Sandoval, Pablo Valdés-Badilla

“…<b>Methods:</b> A quasi-experimental design was used, with single-blinded (evaluators) and 2 parallel groups: novices (n = 10; age = 22.30 ± 0.81) and advanced practitioners (n = 11; age = 22.80 ± 1.41). …”
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In situ active sampling of steroid hormones in water using a novel TIMFIE device: Validation and applicability by Paul Löffler, Ove Jonsson, Annika S. Niemeyer, Anna-Karin Dahlberg, Oksana Golovko, Oscar Götlind, Inga Haalck, Lutz Ahrens, Karin Wiberg, Foon Yin Lai

“…Comparison of TIMFIE samples and the parallel flow-based composite samples confirmed the consistency of E1, estradiol (E2), 17α-ethinylestradiol, and dienogest measurements in effluent wastewater. …”
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Microinvasive pars plana vitrectomy versus panretinal photocoagulation in the treatment of severe non-proliferative diabetic retinopathy (the VIP study): study protocol for a rando... by Xiaohu Ding, Tao Li, Lin Lu, Ling Jin, Yuan Ma, Yizhi Liu, Ying Lin, Yuqing Wu, Bingqian Liu, Shida Chen, Wenbin Zheng, Kunbei Lai, Sainan Xiao, Jizhu Li

“…In this trial, we aim to compare the effectiveness of microinvasive PPV with that of PRP for sNPDR progression control.Methods and analysis This single centre, parallel group, randomised controlled trial aims to evaluate the clinical efficacy of microinvasive PPV in preventing the progression of sNPDR compared with PRP. …”
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A character-strengths based coaching intervention to improve wellbeing of rural community health workers in Madhya Pradesh, India: Protocol for a single-blind randomized controlled... by Ameya P. Bondre, Azaz Khan, Abhishek Singh, Spriha Singh, Ritu Shrivastava, Narendra Verma, Aashish Ranjan, Jyotsna Agrawal, Seema Mehrotra, Rahul Shidhaye, Anant Bhan, John A. Naslund, Steve D. Hollon, Deepak Tugnawat

“…Methods: This protocol is for a single-blind, parallel group randomized controlled trial comparing the effectiveness of a five-day residential workshop focusing on the use of character-strengths and subsequent 8- to 10-week remote telephonic coaching (weekly) to individually support ASHAs to improve their wellbeing, against routine health system support. …”
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Improving sleep and learning in rehabilitation after stroke, part 2 (INSPIRES2): study protocol for a home-based randomised control trial of digital cognitive behavioural therapy (... by Nele Demeyere, Simon D Kyle, Colin A Espie, Sara Ajina, Heidi Johansen-Berg, Anton Pick, Ben Seymour, BARBARA ROBINSON, Matthew Weightman, Ricky Fallows, Alasdair L Henry, Emma Garratt, Rachel Teal, Melanie K Fleming

“…Therefore, the aim of this trial is to evaluate the potential for sleep improvement using a dCBT programme, to improve rehabilitation outcomes after stroke.Methods and analysis We will conduct a parallel-arm randomised controlled trial of dCBT (Sleepio) versus treatment as usual among individuals following stroke affecting the upper limb. …”
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Reducing the risk of perinatal depression using an app-based cognitive behavioral therapy program: protocol of a randomized controlled trial by Li Tang, Hua Qing, Hong Li, Chunfeng Liu, Haijin Wang, Yao Sun, Qian Tan, Yanqiong Wu, Yang Xiao, Jianying Lai, Ling Wang, Li Zhong, Fei Huang, Chunrong Li

“…This study aims to determine if pregnant women using an app-based CBT program report reduced depressive and anxious symptoms compared to a control group.MethodsA two-arm parallel randomized controlled trial of 290 pregnant women will be conducted at Jintang County Maternity and Child Health Hospital in Chengdu, China. …”
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Automatic Potato Crop Beetle Recognition Method Based on Multiscale Asymmetric Convolution Blocks by Jingjun Cao, Xiaoqing Xian, Minghui Qiu, Xin Li, Yajie Wei, Wanxue Liu, Guifen Zhang, Lihua Jiang

“…Specifically, it comprises several multiscale asymmetric convolution blocks, which are designed to extract features at multiple scales, mainly by integrating different-sized asymmetric convolution kernels in parallel. We evaluated the MSAC-ResNet through comprehensive model training and testing on a beetle image dataset of 11,325 images across 20 beetle categories. …”
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Benralizumab Depletes IL‐5Rα‐Bearing Cells in Skin Lesions of Patients With Atopic Dermatitis by Christiane E. Whetstone, Ruth P. Cusack, Emma L. Price, Karen J. Howie, Caitlin Stevens, Dhuha Al‐Sajee, Suzanne Beaudin, Jennifer Wattie, Nadia Alsaji, Abbey Schlatman, Vanessa Luk, Paul M. O'Byrne, Mark D. Inman, Roma Sehmi, Hermenio Lima, Gail M. Gauvreau

“…ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by tissue eosinophilia and itch. We evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in the skin of patients with AD. …”
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Effect of building direction and heat treatment on the wear behavior of H13 tool steel processed by laser powder bed fusion by Adriel P. Oliveira, Tales Ferreira, Reginaldo T. Coelho, Claudemiro Bolfarini, Piter Gargarella

“…The specific wear rate showed a slight variation between different building directions in the as-printed conditions, with values of 1.7 × 10^−4 and 1.2 × 10^−4 mm³/N·m for perpendicular and parallel directions to the building direction, respectively. …”
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Effect of Diacerein on Metabolic Control and Inflammatory Markers in Patients with Type 2 Diabetes Using Antidiabetic Agents: A Randomized Controlled Trial by Glaucia S. Tres, Sandra C. Fuchs, Fabiana Piovesan, Patricia Koehler-Santos, Fernanda dos S. Pereira, Suzi Camey, Hugo K. Lisboa, Leila B. Moreira

“…This is a double-blind, parallel, placebo-controlled trial with 72 participants randomly assigned to diacerein 50 mg or placebo for 12 weeks. …”
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del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial: protocol for a multicentre randomised controlled trial in children undergoing cardiac surgery by Massimo Caputo, Serban Stoica, Kelly Handley, Timothy J Jones, Nigel E Drury, Barnaby R Scholefield, Martin Kostolny, Alex Robertson, Yongzhong Sun, Carin Van Doorn, Warwick B Dunn, John V Pappachan, Hugh Jarrett, Carly Tooke, Tina Griffin, Indie Bilkhoo

“…Thomas’ blood cardioplegia in the young (DESTINY) trial will evaluate whether one solution is better than the other at improving myocardial protection by reducing myocardial injury, shortening ischaemic time and improving clinical outcomes.Methods and analysis The DESTINY trial is a multicentre, patient-blinded and assessor-blinded, parallel-group, individually randomised controlled trial recruiting up to 220 children undergoing surgery for congenital heart disease. …”
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Effects of tai chi on postural control during dual-task stair negotiation in knee osteoarthritis: a randomised controlled trial protocol by Bo Chen, Feng Xiong, Xiangbin Wang, Meijin Hou, Shaoqing Chen, Jiao Yu, Dalu Qi, Yanxin Zhang, Shengxing Fu, Zhenhui Li, Fengjiao Yang, Alison Chang, Anmin Liu, Xuerong Xie

“…Postural control deficits in performing a primary motor task may be more pronounced when required to simultaneously attend to a cognitive task. This single-blind, parallel design randomised controlled trial (RCT) aims to evaluate the effects of a 12-week tai chi programme versus balance and postural control training on neuromechanical characteristics during dual-task stair negotiation.Methods and analysis Sixty-six participants with KOA will be randomised into either tai chi or balance and postural control training, each at 60 min per session, twice weekly for 12 weeks. …”
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Effect of a High-Protein High-Fibre Nutritional Supplement on Lipid Profile in Overweight/Obese Adults with Type 2 Diabetes Mellitus: A 24-Week Randomized Controlled Trial by Rachana Bhoite, Anitha Chandrasekaran, Varalakshmi Lalithya Pratti, Vinita Satyavrat, Shivani Aacharya, Amey Mane, Suyog Mehta, Ravindra Machhindra Kale, Gayathri Nagamuthu, Sasikala Selvaraj, Gayathri Rajagopal, Sudha Vasudevan, Shobana Shanmugam, Anjana Ranjit Mohan, Ranjit Unnikrishnan, Kamala Krishnaswamy, Viswanathan Mohan

“…In this study, the effect of providing high-protein high-fibre (HPHF) nutritional supplement in addition to standard care of type 2 diabetes mellitus (T2DM) on lipid profile was evaluated. Methods. In this open-label, parallel-arm, prospective, randomized study, a total of 100 overweight/obese participants with T2DM were randomized to either an intervention group (25 g HPHF nutritional supplement given twice daily along with a standard care of T2DM) or a control group (standard care of T2DM) for 24 weeks. …”
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GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis by Asier Ortega-Legarreta, Alberto Maillo, Daniel Mouzo, Ana Rosa López-Pérez, Lara Kular, Majid Pahlevan Kakhki, Maja Jagodic, Jesper Tegner, Vincenzo Lagani, Ewoud Ewing, David Gomez-Cabrero

“…Computationally, the package is optimized for parallel processing, significantly reducing execution time. …”
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Multicentre, randomised waitlist control trial investigating a parent-assisted social skills group programme for adolescents with brain injuries: protocol for the friends project by Rose Gilmore, Leanne Sakzewski, Jenny Ziviani, Sarah Mcintyre, Hayley Smithers Sheedy, Nicola Hilton, Tracey Williams, Kirsten Quinn, Anne Marie Sarandrea, Elizabeth Laugeson, Mark Chatfield

“…This protocol describes a pragmatic, parallel two-group pre-test post-test randomised waitlist control trial across two sites in Australia, which aims to evaluate the feasibility, acceptability and efficacy of PEERS in adolescents with brain injury compared with usual care.Methods and analysis Forty adolescents with an acquired brain injury or cerebral palsy will be randomly assigned to either the 14-week PEERS group or waitlist care as usual group. …”
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COMPARISON OF THERAPIES BASED ON CARVEDILOL AND METOPROLOL IN HYPERTENSIVE PATIENTS WITH OVERWEIGHT OR OBESITY. THE FIRST RESULTS OF CAMELLIA TRIAL by S. Y. Martsevich, N. P. Kutishenko, E. V. Shilova, A. D. Deev, S. A. Shalnova, R. G. Oganov, I. A. Velishanina, E. G. Volkova, Yu. E. Voskanjan, L. I. Gapon, P. Ya. Dovgalevskij, V. Ya. Ermolina, E. M. Idrisova, N. N. Ilov, A. R. Kiseleva, S Yu. Levashov, V. A. Nevsorova, G. I. Nechaeva, T. N. Panova, I. I. Reznik, V. V. Skibickij, L. A. Sokolova, V. P. Terentev, N. V. Hailo, A. V. Shabalin, T. V. Shnyukova, V. V. Yakusevich, E. N. Akulina, V. A. Budanova, T. S. Bondarenko, V. P. Voronina, I. N. Gozhaja, I. I. Igricenco, A. V. Drogan, N. A. Dmitrieva, F. M. Dyshekova, A. I. Zaiceva, A. N. Ikovnikova, G. A. Ilicheva, I. S. Irhina, L. A. Kovaleva, O. N. Kutkina, E. A. Kudrjashev, A. Z. Leonidova, E. N. Loginova, M. P. Marganjan, O. V. Nastradin, A. N. Nikitina, I. N. Nikolskaja, I. E. Pashinceva, A. S. Petrochenko, O. M. Pasnenkova, E. S. Potapova, A. A. Serazhim, M. N. Sergeev, V. V. Sidorenko, V. A. Simonov, D. V. Sirotenko, I. N. Spanderashvili, A. N. Strunina, E. S. Timoschenko, S. N. Tolpygina, M. R. Redkina

“…Aim. To evaluate antihypertensive and metabolic effects of the therapy based on carvedilol (C) in comparison with metoprolol (M) in hypertensive patients with overweight or obesity.Material and methods. 320 patients were involved in multicenter, randomized open parallel study. …”
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