The anti-inflammatory effects of oridonin in resisting esophageal cancer by Mengfan Peng, Mengfan Peng, Mengfan Peng, Xiaofang Zhang, Lei Yang, Baosong Liu

“…H&E staining was used for esophageal tissue to evaluate pathological status. The tumor markers, inflammatory factor, mRNA and protein expression of TLR4/NF-κB/NLRP3 inflammasome related indicators in serum and esophageal tissue was determined by ELISA, qPCR, and western blot (WB) respectively. …”
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Effects of Early Mobilization on Hemodynamics and Pain after Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial by Sevda Jalili, Atefeh Allahbakhshian, Azizeh Farshbaf Khalili, Khorshid Mobasseri

“…Methods: This was a randomized, blinded clinical trial with a three-arm parallel design, conducted on 105 patients who underwent CABG at Shahid Madani hospital in Tabriz. …”
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The feasibility of conducting a randomized controlled trial that compares immediate versus optional delayed surgical repair for treatment of acute Anterior cruciate ligament injury... by Feryal Ghafelzadeh Ahwaz, Annemie Smeets, Stijn Bogaerts, Pieter Berger, Koen Peers

“…Methods This is a pragmatic, multicenter, randomized, controlled pilot trial with two parallel groups funded by the Belgian Health Care Knowledge Centre (KCE trials). …”
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Seasonal effects of altitude and vegetation on litter and organic carbon in deciduous and coniferous forest soils by M. De Feudis, L. Massaccesi, C. Poesio, L. Vittori Antisari, R. Bol, A. Agnelli

“…However, while at 500 m altitude a significant SOM 13C fractionation and a parallel increase in soil CO2 emissions occurred in the warmer seasons, no seasonal δ13C variation was observed at 1000 m for both forests, despite the different quality of SOM derived from deciduous and coniferous forests. …”
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Cross-sectional study of Mycoplasma hyopharyngis, Mycoplasma hyopneumoniae, Mycoplasma hyorhinis and Mycoplasma hyosynoviae in the tonsils of fattening pigs from Central-Eastern Eu... by Eszter Zsófia Nagy, Dorottya Földi, Fruzsina Madzig, Enikő Wehmann, Adél Orosz, András Kempf, László Buza, János Mátyus, László Búza, Dénes Grózner, Zsuzsa Kreizinger, Miklós Gyuranecz

“…In parallel, a novel quantitative polymerase chain reaction (qPCR) assay was designed targeting M. hyopharyngis to facilitate the identification of this bacterium. …”
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Effect of adjunctive intraoral balance appliance in the usual care of patients with chronic temporomandibular joint disorders using Korean medicine in South Korea: study protocol f... by Jae-Heung Cho, Hyungsuk Kim, Woo-Chul Shin, Se yun Kim, Whisung Cho, Jaehyun Park, Won-Seok Chung, Mi-yeon Song

“…Although conservative treatments, such as acupuncture and occlusal splints, have been recommended, evidence for their effectiveness remains inconclusive, and the combined effects of these interventions are not well understood.This study aims to evaluate the efficacy of an intraoral balance appliance (IBA) combined with standard Korean medicine care, compared to Korean medicine care alone, in patients with chronic, painful TMD with myalgia.Methods and analysis A single-centre, two-arm, parallel, practitioner-blinded and evaluator-blinded, randomised controlled trial with a 1:1 allocation ratio will be designed to test the interventions. 76 patients with TMD with myalgia will be recruited and randomised. …”
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Patient navigation in German emergency care (NODE). Study protocol of a multi-center mixed-methods trial by Daniela Krüger, Maria Altendorf, Felix Holzinger, Cornelia Wäscher, Hanna Winkler, Martin Möckel, Christoph Heintze, Judith Stumm, Konrad Schmidt, Konrad Schmidt, Anna Slagman

“…Therefore, three different patient navigation models in emergency care in Berlin, Germany will be evaluated regarding their efficiency, quality of care, patient safety, patient satisfaction, costs and cost-effectiveness: (1) a hospital-owned separate outpatient care model within the ED premises or on the hospital grounds, (2) an urgent care practice of the Regional Association of Statutory Health Insurance (SHI) Physicians at the ED location, and (3) a standard care ED with prospective assessment of patient-care and urgency levels by ED doctors.MethodsIn a convergent, parallel, mixed-methods, multi-center study design, patients' and health care providers' perspectives assessed by qualitative methods will be triangulated with the results of a quantitative prospective cohort study at six EDs in Berlin, Germany. …”
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Timosaponin AIII inhibits gastric cancer by causing oxidative stress and blocking autophagic flux by Chunyang Zhu, Shuming Chen, Yangyang Lu, Jialin Song, Shasha Wang, Jing Guo, Xiaoxi Han, YuanYuan Fang, Siyi Zhang, Wensheng Qiu, Weiwei Qi

“…Experiments related to cell viability, OS, and autophagy levels were performed on normal gastric mucosal epithelial cells (GES-1) as parallel controls. Finally, Nude mouse subcutaneous tumor model to evaluate the anti-GC ability in vivo. …”
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A Feasibility Randomized Controlled Trial of Nurse-Led Screening-Based Early Care Program from the Time of Diagnosis for Patients with Advanced Lung Cancer and Their Caregivers by Takashi Sato, Hiroya Manaka, Miyuki Kodama, Rina Nieda, Yasumi Kawamura, Mina Yamamoto, Yasuko Genkai, Yumiko Kezuka, Atsuko Watanabe, Nobuki Kaizuka, Hiroki Ito, Hideyuki Sone, Masayuki Shirasawa, Seiichiro Kusuhara, Mikiko Kakegawa, Yoshiro Nakahara, Daisuke Fujisawa, Jiichiro Sasaki, Katsuhiko Naoki

“…Measurements: Feasibility was evaluated using recruitment and interview execution rates. …”
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BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial by Simon J Davies, David Coyle, Elizabeth Lindley, David Keane, John Belcher, Fergus Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie MacDonald, Mandana Zanganeh, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim

“…Methods We undertook a multicentre, open-label, parallel, individually randomised controlled trial in incident haemodialysis patients, with clinicians and patients blinded to bioimpedance readings in the control group. …”
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Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program by Nora Penzel, Pablo Polosecki, Jean Addington, Celso Arango, Ameneh Asgari-Targhi, Tashrif Billah, Sylvain Bouix, Monica E. Calkins, Dylan E. Campbell, Tyrone D. Cannon, Eduardo Castro, Kang Ik K. Cho, Michael J. Coleman, Cheryl M. Corcoran, Dominic Dwyer, Sophia Frangou, Paolo Fusar-Poli, Robert J. Glynn, Anastasia Haidar, Michael P. Harms, Grace R. Jacobs, Joseph Kambeitz, Tina Kapur, Sinead M. Kelly, Nikolaos Koutsouleris, K. R. Abhinandan, Saryet Kucukemiroglu, Jun Soo Kwon, Kathryn E. Lewandowski, Qingqin S. Li, Valentina Mantua, Daniel H. Mathalon, Vijay A. Mittal, Spero Nicholas, Gahan J. Pandina, Diana O. Perkins, Andrew Potter, Abraham Reichenberg, Jenna Reinen, Michael S. Sand, Johanna Seitz-Holland, Jai L. Shah, Vairavan Srinivasan, Agrima Srivastava, William S. Stone, John Torous, Mark G. Vangel, Jijun Wang, Phillip Wolff, Beier Yao, Alan Anticevic, Daniel H. Wolf, Hao Zhu, Carrie E. Bearden, Patrick D. McGorry, Barnaby Nelson, John M. Kane, Scott W. Woods, René S. Kahn, Martha E. Shenton, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Guillermo Cecchi, Ofer Pasternak

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The Bonding Performance of Steel-UHPC after High Temperature with Water Cooling by ZHOU Chaofeng, ZHU Chongao, PANG Rui, FU Kaihe, ZHU Yan, GUO Liang

“…The proposed calculation method can provide a basis for the performance evaluation and repair reinforcement of steel-UHPC composite structures after disasters.…”
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Implant-free loop tenodesis compared to arthroscopic anchor tenodesis for the treatment of long head of biceps tendon disorders (LOOPTEN trial): study protocol for a multi-center n... by Leopold Henssler, Florian Zeman, Doruk Akgün, Kathi Thiele, Stephan Pauly, Stefan Greiner, Andreas Voss, Christian Gerhardt, Lars-Johannes Lehmann, Gunnar Huppertz, Magdalena Elsner, Volker Alt, Michael Koller, Maximilian Kerschbaum

“…Methods A national multi-center, two-arm, parallel-group, randomized, controlled, non-inferiority trial will be conducted. …”
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Deep brain stimulation versus vagus nerve stimulation for the motor function of poststroke hemiplegia: study protocol for a multicentre randomised controlled trial by Bin Liu, Xinguang Yu, Qing Chang, Di Liu, Yanyang Zhang, Junpeng Xu, Haonan Yang, Zhiqi Mao, Guosong Shang, Shuzhen Liu, Zhebin Feng, Chen Yuhan

“…These patients must receive necessary support at home and consent to participate. The aim is to evaluate the effectiveness and safety of DBS and VNS therapies. …”
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Microbial and Physiochemical Profiling of Zarqa River Supplemented with Treated Wastewater: A High-Resolution PCR Analysis by Raha Alassaf, Alfred P. Blaschke

“…Background: This study aims to evaluate the quality of treated wastewater flowing in the Zarqa River to determine its suitability for agricultural use. …”
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Efficacy and Tolerability of a New Facial 2-Mercaptonicotinoyl Glycine-Containing Depigmenting Serum Versus Hydroquinone 4% over 3-Month Treatment of Facial Melasma by Thierry Passeron, Delphine Kerob, Guénaëlle Le Dantec, Anne-Laure Demessant-Flavigny, Alessandro R. do Nascimento, Renato Moura, Samir Salah, Mariana Feiges, Erika Fernandez, Andrew Alexis

“…Methods This comparative, non-inferiority, randomized, investigator-blind, parallel-group investigation included adult women with mild-to-severe epidermal or mixed facial melasma. …”
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Extended Reality Gaming for Exercise and Mindfulness Throughout Pediatric Cancer Rehabilitation: Protocol for a Randomized Controlled Trial by Byron Lai, Kelli Chaviano, Joshua S Richman, Mahmoud Ahmad, Ashley Wright, Raven Young, Drew Davis, James H Rimmer, Avi Madan-Swain, Joseph H Chewning

“…An ancillary aim is to evaluate the feasibility of the program through participant engagement. …”
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Hybrid liquid–PCM thermal management for high–capacity lithium–ion batteries under fast charging: A parametric comparative study by Houssein Ammar, Mahdi Delbani, Farouk Fardoun, Bassem El Zoghbi, Hussein Mouzanar, Jalal Faraj, Mahmoud Khaled

“…A 3D numerical model is developed using COMSOL Multiphysics to evaluate the system under 1C, 2C and 3C charging rate. …”
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Psychosocial and physiological health outcomes of outdoor green exercise versus indoor exercise in knee osteoarthritis patients coexisting with type 2 diabetes mellitus: a randomiz... by Yilin Jin, Yilin Jin, Xiang Geng, Qiaojie Wang, Feng Xue, Shengdi Lu, Lihua Huang

“…The purpose of this study is to evaluate the psychosocial and physiological outcomes for green exercise in KOA patients coexisting with T2DM compared to indoor exercise.MethodA prospective, randomized, open-label, parallel, multi-center clinical trial conducted at two hospitals in Shanghai that included 82 patients T2DM and KOA. …”
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Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY) by Takumi Hirata, Kengo Tomita, Toshihide Kawai, Hirokazu Yokoyama, Akira Shimada, Masahiro Kikuchi, Hiroshi Hirose, Hirotoshi Ebinuma, Junichiro Irie, Keisuke Ojiro, Yoichi Oikawa, Hidetsugu Saito, Hiroshi Itoh, Toshifumi Hibi

“…This was a randomized, open-label, parallel-group comparison of therapy with telmisartan or losartan. …”
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