Combination Low-Dose Pilocarpine/Diclofenac Sodium and Pilocarpine Alone for Presbyopia: Results of a Randomized Phase 2b Clinical Trial by Farid M, Rowen SL, Moshirfar M, Cunningham D, Gaddie IB, Smits G, Ignacio T, Gupta PK

“…Marjan Farid,1 Sheri L Rowen,2 Majid Moshirfar,3 Derek Cunningham,4 Ian B Gaddie,5 Gerard Smits,6 Teresa Ignacio,6 Preeya K Gupta7 1UCI Health, Irvine, CA, USA; 2NVISION Eye Centers, Newport Beach, CA, USA; 3Hoopes Vision Research Center, Hoopes Vision, Draper, UT, USA; 4Dell Laser Consultants, Austin, TX, USA; 5Gaddie Eye Centers, Louisville, KY, USA; 6Orasis Pharmaceuticals, Ponte Vedra, FL, USA; 7Triangle Eye Consultants, Raleigh, NC, USACorrespondence: Marjan Farid, UCI Health, 850 Health Sciences Road, Irvine, CA, 92617, USA, Tel +1-949-824-2020, Fax +1-855-376-5057, Email mfarid@hs.uci.eduPurpose: To evaluate the efficacy of 0.2% and 0.4% pilocarpine HCl (CSF-1) for the treatment of presbyopia and to determine the contributions of pilocarpine HCl and diclofenac sodium on the efficacy of fixed-dose combination (FDC) formulations.Patients and Methods: This was a Phase 2b, multicenter, randomized, double-masked, parallel-group clinical trial. …”
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1,25(OH)2D3 increase osteogenic potential of human periodontal ligament cells with low osteoblast potential* by Bruno Cazotti PEREIRA, Catharina Marques SACRAMENTO, Enilson Antonio SALLUM, Mabelle de Freitas MONTEIRO, Renato Corrêa Viana CASARIN, Marcio Zaffalon CASATI, Karina Gonzales SILVÉRIO

“…After 14 days of 1,25(OH)2D3 treatment, the mRNA levels for ASPN and VDR decreased (P<0.05), while BMP-2 transcripts and extracellular expression increased (P<0.05). In parallel, RUNX2, ALP, and OCN gene expression was upregulated by 1,25(OH)2D3 treatment, resulting in an increase of mineral nodule deposition in vitro (P<0.05). …”
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Spasm and electromyography intensity of bilateral extensor during relaxation period in trunk anterior flexion–extension performance response to sustained asymmetry spinal loading by Longzhen Wang, Jingyuan Wang, Wenjin Wang, Xiangrong Cheng, Wenrong Wang, Xinhai Shan

“…After loading, the NEMG has a significant increase, in parallel with spasms elicited in multiple extensors in relation period in flexion–extension performance, with no significant difference between bilateral sides. …”
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A pilot study of a gratitude journaling intervention to enhance spiritual well-being and exercise self-efficacy in Black breast cancer survivors by Lakeshia Cousin, Dejana Braithwaite, Stephen Anton, Zhongyue Zhang, Ji-Hyun Lee, Christiaan Leewenburgh, Debra Lyon

“…Methods This pilot study employed a two-group, parallel random-assignment experimental design to compare a gratitude journaling intervention with a general memory journaling control group. …”
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Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinica... by Si-Jing Chen, Jian-Yu Que, Ngan Yin Chan, Le Shi, Shirley Xin Li, Joey Wing Yan Chan, Weizhen Huang, Chris Xie Chen, Chi Ching Tsang, Yuen Lam Ho, Charles M Morin, Ji-Hui Zhang, Lin Lu, Yun Kwok Wing

“…<h4>Methods and findings</h4>This was a randomized, assessor-blind, parallel group-controlled trial in Chinese youth (aged 15-25 years) with insomnia disorder and subclinical depressive symptoms. …”
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Erythrodermic Psoriasis in the Context of Emerging Triggers: Insights into Dupilumab-Associated and COVID-19-Induced Psoriatic Disease by Aya Fadel, Jayakumar Nithura, Zahraa F. Saadoon, Lamia Naseer, Angelo Lopez-Lacayo, Ligia Elena Rojas Solano, Chaveli Palau Morales, Robert J. Hernandez, Hussain Hussain

“…In a murine model of SARS-CoV-2 infection, we found notable cutaneous changes: dermal collagen deposition, hair follicle destruction, and subcutaneous adipose loss. Parallel findings were seen in a rare clinical case (only the third reported case) of EP in a patient with refractory psoriasis, who developed erythroderma after off-label initiation of dupilumab therapy. …”
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Efficacy and Acceptability of a Mobile App for Monitoring the Clinical Status of Patients With Chronic Obstructive Pulmonary Disease Receiving Home Oxygen Therapy: Randomized Contr... by Anisbed Naranjo-Rojas, Luis Ángel Perula-de Torres, Freiser Eccehomo Cruz-Mosquera, Guillermo Molina-Recio

“…MethodsA parallel-group, nonblinded, multicenter randomized controlled trial was conducted with 45 participants; the intervention group (IG), which used the mobile app in addition to conventional monitoring (n=23) and the control group, which received only conventional monitoring (n=22), administered by therapists over a duration of 3 months. …”
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Occupational therapy and registered dietitian services to reduce fall risk among home delivered meal clients: a randomized controlled feasibility trial by Lisa A. Juckett, Shivam Joshi, J. Madison Hyer, Govind Hariharan, Kali S. Thomas, Tejeswini Siva Sathya, Mequeil L. Howard, Leah E. Bunck, Melinda L. Rowe, Andrea Devier, Kelly Parrett, LifeCare Alliance SixtyPLUS Team

“…Methods A four-arm, parallel-group feasibility RCT was conducted with one home delivered meal agency in the Midwest United States. …”
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The impacts of transcranial direct current stimulation combined with aquatic neuromuscular training on pain, function, kinesiophobia, knee instability, and quality of life in knee... by Asma Tapeh Kaboodi, Farzaneh Gandomi, Parviz Soufivand, Shirin Assar

“…Methods This double-blind, randomized controlled trial with parallel-group and pre-test/post-test design involved 44 women diagnosed with KOA. …”
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Messenger App–Based Information Provision for Promoting Social Participation to Enhance Well-Being Among Community-Dwelling Adults: Randomized Controlled Trial by Atsushi Nakagomi, Noriyuki Abe, Yu-Ru Chen, Kazushige Ide, Shuhei Kobayashi, Masamichi Hanazato, Katsunori Kondo

“…MethodsA 2-arm, parallel-group randomized controlled trial was conducted from October 2022 to January 2023 in the Kashiwa-no-ha campus area, Japan—an urban community with active local events. …”
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Multidisciplinary clinician perspectives on peripheral artery disease (PAD) education and a PAD video education tool by Margaret A. Reilly, MD, MS, Isabel C. Cohen, BS, Megan E. Alagna, BS, Cassandra B. Iroz, MS, Julie K. Johnson, PhD, MSPH, Karen J. Ho, MD

“…Methods: We conducted a single-center convergent parallel mixed-methods study of vascular surgeons, advanced practice vascular nurses, and primary care physicians focused on their current PAD education strategies. …”
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A community-based intervention to challenge attitudes towards intimate partner violence: results from a randomised community trial in rural South-West Nigeria by Olusegun Awolaran, Funmilola OlaOlorun

“…The study employed a convergent parallel mixed-methods design and a three-stage sampling technique in selecting two local government areas, eight communities and the study participants. …”
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Azoximer bromide-modulated immune response in aerobic vaginitis by G. B. Dikke, V. V. Ostromenskii, Yu. G. Kucheryavaya

“…Aim: to evaluate the efficacy of azoximer bromide along with a combined antimicrobial drug in treatment of patients with aerobic vaginitis (AV).Materials and Methods. …”
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Effect of osteopathic manipulative treatment on comorbid depressive symptoms in patients with chronic low back pain: study protocol for a randomised controlled trial by Meike Shedden-Mora, Robert Schleip, Francesco Cerritelli, Tobias Schmidt, Lucas Bohlen, Michael Eggart, Bruno Müller-Oerlinghausen, Jürgen Lorenz, Torsten Liem, Jorge E Esteves

“…Secondarily, interoceptive accuracy, sensibility and awareness will be evaluated using the Heartbeat Tracking Task (HTT), Multidimensional Assessment of Interoceptive Awareness (MAIA-2) and confidence-accuracy correspondence (CAC). …”
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Prevalence and Associated Risk Factors of Intestinal Parasites and Enteric Bacterial Infections among Selected Region Food Handlers of Ethiopia during 2014–2022: A Systematic Revie... by Abayeneh Girma, Aleka Aemiro

“…Heterogeneity and publication bias were evaluated using Cochran’s Q, inverse variance (I2), and funnel plot asymmetry tests. …”
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Connection between the effectiveness of ankylosing spondylitis treatment and the state of bone tissue metabolism by O. V. Syniachenko, Ye. D. Yehudina, M. V. Yermolaeva, O. O. Khaniukov, H. S. Taktashov, Yu. О. Potapov, K. Yu. Gashinova

“…The aim of the study – to evaluate the effectiveness of pathogenetic therapy in patients with ankylosing spondylitis (AS) and the prognostic value of the initial levels of osteoassociated hormones and chemical elements in hair and blood. …”
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Lactylation prognostic signature identifies DHCR7 as a modulator of chemoresistance and immunotherapy efficacy in bladder cancer by Yuanqiao Zhao, Zhuo Xing, Yongqi Zhao, Haozhe Xu, Ruilin Liu, Tiejun Yang, Yinhuai Wang, Xuan Zhu

“…Immune cell infiltration patterns and drug response profiles were systematically evaluated. Parallel analyses of lactylation related genes were conducted at the single-cell resolution. …”
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Effect of Two Weeks Scapular Stabilisation Exercises, Upper and Lower Limb Plyometrics as a Part of Warm up on Cricket Medium Paced Bowlers: A Research Protocol by Basavaraj S Motimath, Sanjiv Kumar

“…Materials and Methods: This research protocol is planned to conduct a randomised clinical trial in Belagavi, Hubli, and Dharwad in Karnataka, India, and will employ a randomised, parallel-armed clinical experimental design. The duration of the study will be approximately four years, from January 2023 to February 2027. …”
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Midpalatal suture osteotomy combined with microimplant-assisted rapid palatal expansion for adult maxillary transverse deficiency treatment: a study protocol of a randomised contro... by Lei Zhang, Yifeng Qian, Wenyi Zhang, Miri Chung, Yanfei Zhu, Lingyong Jiang

“…The results are expected to confirm MSO-MARPE as a novel minimally invasive alternative to SARPE in skeletally mature MTD patients.Methods and analysis A prospective, single-centre, parallel-group randomised controlled trial will be conducted, enrolling 20 adult MTD patients. …”
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Dendrobium catenatum Lindl. Water Extracts Attenuate Atherosclerosis by Jichun Han, Jing Dong, Rui Zhang, Xiaofeng Zhang, Minghan Chen, Xiangcheng Fan, Maoru Li, Jiajing Li, Junyi Zhu, Jing Shang, Yunyun Yue

“…The cholesterol accumulation and the levels of lipid, triglyceride (TG), and total cholesterol (TC) were measured to reflect lipid metabolism disorder. Then, parallel flow chamber was utilized to establish a low shear stress- (LSS-) induced endothelial cell (EC) dysfunction model. …”
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