The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, dou... by Mohammad Ali Mohsenpoor, Karim Parastouei, Maryam Taghdir, Marzieh Akbarzadeh, Sepideh Abbaszadeh, Mohammad Ali Abyazi Heris, Mohammad Reza Mansouri Rad, Mohammad Amin Jafari, Ronak Borzooei

“…Methods Seventy-two adults with NAFLD were randomly assigned to consume either 1.5 g/day chitosan or placebo along with a low-calorie (− 500 kcal/day) diet for 8 weeks in a parallel, randomized, double-blinded, placebo-controlled, clinical trial. …”
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Effect of vitamin D supplementation on inflammatory status and behavioral symptoms in children with autism spectrum disorders: a double-blind randomized clinical trial by Zohreh Javadfar, Shahin Soltani, Firoozeh Khamoushi, Maryam Sharifi, Shima Moradi, Shahab Rezaeian, Ali Akbar Foroughi, Sahar Cheshmeh, Mehdi Taghaddosi, Fariborz Bahrehmand

“…Since vitamin D has an anti-inflammatory role, this trial was aimed to evaluate the effects of vitamin D supplementation on TNF-α and IL-37 status and behavioral problems in children with ASD. …”
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The Evolution of Ophthalmological Healthcare System in Premature Children by A. V. Tereshhenko, I. G. Trifanenkova, M. S. Tereshhenkova, Yu. A. Yudina, S. V. Isaev, P. L. Volodin, N. N. Yudina, A. A. Vydrina, Yu. A. Sidorova, E. V. Erohina, V. V. Shaulov

“…Multicenter clinical studies evaluating the possibilities of anti-VEGF therapy for active ROP have being performed. …”
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Practical Anemia Bundle for Sustained Blood Recovery (PABST-BR) in critical illness: a protocol for a randomised controlled trial by Laurie Meade, Andrea Cheville, Matthew A Warner, Phillip J Schulte, Daryl J Kor, Ognjen Gajic, Ronald S Go, William B Beam, Jonathan E Charnin, Kim A Droege, Brenda K Anderson, Matthew L Johnson, Brad Karon

“…In-person assessments will occur at 1 and 3 months post-hospitalisation for laboratory evaluations and multidimensional functional outcome assessments. …”
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Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study by Bingbing Lin, Jinglei Ni, Xiao Xiong, Lanlan Zhang, Jian Song, Mengxue Wang, Linsong Chai, Yunshi Huang, Jia Huang

“…Methods: This assessor-blinded, parallel-arm design, single-center, randomized clinical trial recruited 64 patients with post-stroke aphasia. …”
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Amplification of Higher-Order Salivary Gland Volume Effects from External Beam Radiotherapy in Normal Tissue Complication Probability Modeling of Radiopharmaceutical Therapy by Chunming Gu, Robert F. Hobbs, Ana P. Kiess, Junghoon Lee, Todd McNutt, Harry Quon, Zhuoyao Xin, Tahir I. Yusufaly

“…In EBRT, salivary glands are usually assumed to be parallel organs, with QUANTEC guidelines based on <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>D</mi><mrow><mi>m</mi><mi>e</mi><mi>a</mi><mi>n</mi></mrow></msub></semantics></math></inline-formula>, but this is known to be a gross over-simplification of the full complexity of the underlying functional organization. …”
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Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood culturesResearch in context by Vincenzo Di Pilato, Chiara Bonaiuto, Fabio Morecchiato, Alberto Antonelli, Tommaso Giani, Gian Maria Rossolini

“…We developed a analytical workflow named LC-WGS (Whole-Genome Sequencing of Liquid Colony) for rapid whole-genome sequencing-based diagnosis of BSI, evaluating its accuracy performance over standard of care (SoC) diagnostic procedures. …”
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Effectiveness of a Health Education Program to Reduce Recurrence of Stroke by Controlling Modifiable Risk Factors in a Specialized Hospital in Bangladesh: Randomized Controlled Tri... by Mahabuba Afrin, K A T M Ehsanul Huq, Sharif Uddin Khan, Subir Chandra Das, Mohammad Shah Jahirul Hoque Chowdhury, Yasuko Fukuoka, Yasuko Fukushima, Michiko Moriyama

“…MethodsA parallel (1:1), open-label, prospective randomized controlled trial was conducted in Bangladesh. …”
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Urine chloride trajectory and relationship with diuretic response in acute heart failure by Mateusz Guzik, Robert Zymliński, Piotr Ponikowski, Jan Biegus

“…Despite a strong pathophysiological background, the role of urine chloride excretion has not been described and established yet. We aimed to evaluate chloride trajectory during intensive diuretic treatment in AHF patients and examine its potential role in predicting poor diuretic response. …”
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A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes by Mark Weatherall, Julian Crane, Jeremy Krebs, Mark Huthwaite, Christine Barthow, Fiona Hood, Amber Parry-Strong

“…Aims To evaluate the effect of the probiotic Lactobacillus rhamnosus HN001 and/or cereal enriched with oat-derived beta-glucan (OBG) on metabolic and mental health outcomes when administered to adults with pre-diabetes.Design 2×2 factorial design randomised, parallel-groups placebo-controlled; double-blinded for probiotic, single-blinded for cereals.Participants Community-dwelling adults aged 18–80 years with pre-diabetes: glycated haemoglobin (HbA1c) 41–49 mmol/mol.Interventions Capsules containing Lactobacillus rhamnosus (HN001) (6×109 colony-forming units/day), or placebo capsules; and cereal containing 4 g/day OBG or calorie-matched control cereal, taken daily, for 6 months. …”
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Lithium Chloride Effect on Mortality and Neurological Deficits in the Model of Ischemic Stroke in Rats by O. A. Grebenchikov, R. A. Cherpakov, A. K. Evseyev, A. V. Ershov, A. N. Kuzovlev, P. A. Lonchinsky, S. S. Petrikov, A. K. Shabanov

“…The drug was administered daily for 14 days with a parallel assessment of neurological deficits.Results. …”
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Pain control following impacted mandibular third molar surgery: a comparison of the effectiveness of two different protocols by Kamis Gaballah, Tuleen Eldohaji, Maha El Tannir, Roula Shaban, Ruaa Habib, Kamran Ali

“…A single-center, double-masked, parallel-group, randomized controlled clinical trial involved 56 patients undergoing scheduled surgical extraction of impacted mandibular third molars. …”
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A Preliminary Study on Effectiveness of Varying Dose of Paretic Upper Limb Training with Visual Deprivation in Poststroke Patients: A Randomised Clinical Trial by R Sampath Pulimoot, CKV Bhuvaneswari, G Harshavardhan, Kabilan Annadurai

“…However, the optimal dosage remains unclear. Aim: To evaluate the effectiveness of varying doses of paretic UL training with visual deprivation in stroke patients. …”
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Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The MB‐BP Study: A Randomized Clinical Trial by Eric B. Loucks, Zev Schuman‐Olivier, Frances B. Saadeh, Matthew M. Scarpaci, William R. Nardi, Jeffrey A. Proulx, Roee Gutman, Jean King, Willoughby B. Britton, Ian M. Kronish

“…Methods and Results Methods included a parallel‐group phase 2 randomized clinical trial conducted from June 2017 to November 2020. …”
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Knockout of glycerol metabolic pathways enables efficient mycolicibacterial phytosterol conversion using glycerol as cosovlent by Shikui Song, Ye Wang, Jinpeng Yu, Qianqian Ma, Xiyao Cheng, Baoguo Zhang, Zhengding Su

“…Our bioinformatic analysis revealed two parallel glycerol metabolic pathways in the HGMS6 strain. …”
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Comparison of muscle magnetic resonance imaging data with clinical and laboratory parameters in follow-up of patients with idiopathic inflammatory myopathy by A. A. Kolomeyichuk, L. P. Ananyeva, A. N. Helkovskaya-Sergeeva, A. D. Koltakova, L. V. Ptichkina, D. O. Kazakov

“…During dynamic follow-up of patients with idiopathic inflammatory myopathy (IIM), changes in disease activity and damage caused are assessed using several generally recognized instruments. In parallel, objective methods of visualization are used, in particular magnetic resonance imaging (MRI) of the muscles. …”
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A GAN Guided NCCT to CECT Synthesis With an Advanced CNN-Transformer Aggregated Generator by Haozhe Wang, Dawei Gong, Rongzhen Zhou, Junbo Liang, Ruili Zhang, Wenbin Ji, Sailing He

“…We evaluated GCTANet on two private datasets and one public dataset. …”
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Untargeted Metabolomics and Targeted Phytohormone Profiling of Sweet Aloes (<i>Euphorbia neriifolia</i>) from Guyana: An Assessment of Asthma Therapy Potential in Leaf Extracts and... by Malaika Persaud, Ainsely Lewis, Anna Kisiala, Ewart Smith, Zeynab Azimychetabi, Tamanna Sultana, Suresh S. Narine, R. J. Neil Emery

“…Full scan, data-dependent acquisition, and parallel reaction monitoring modes via liquid chromatography Orbitrap mass spectrometry were used for screening. …”
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Somatic acupressure for the management of the fatigue–sleep disturbance–depression symptom cluster in breast cancer survivors: a study protocol for a phase III randomised controlle... by Tao Wang, Xian-Liang Liu, Mengyuan Li, Li-Qun Yao, Jing-Yu (Benjamin) Tan, Ren-Li Deng, Wai Hang Kwok

“…This phase III randomised controlled trial (RCT) is designed to evaluate the effects, safety and cost-effectiveness of SA for managing the FSDSC in BC survivors.Methods This phase III RCT will be a partial-blinded, sham-controlled, three-arm, parallel clinical trial, involving a 7-week SA intervention period and a 12-week follow-up period. 108 BC survivors will be randomly allocated in a ratio of 1:1:1 to either a true SA group (self-administered acupressure plus usual care), a sham SA group (self-administered light acupressure at non-acupoints plus usual care) or a usual care group. …”
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Combining Super-Resolution Imaging and Shear Wave Elastography for Enhanced Risk Assessment of Moderate-to-Severe Renal Fibrosis in Chronic Kidney Disease Patients by Huang X, Zhang Y, Hu Y, Pan J, Huang X, Zhang J, Pu H, Chen Y, Deng Q, Zhou Q

“…Four diagnostic models—isolated, series, parallel, and integrated—were developed by combining elasticity values from SWE and vascular density values from SRI. …”
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