CO24 | Extracellular vesicles profiles in patients with wild-type transthyretin amyloidosis

“…The study aims: i) to compare plasma-derived EVs in ATTRwt patients vs. healthy controls by new generation flow cytometry (CytoFLEX S); ii) to evaluate their potential involvement in disease progression. …”
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Exploring exhaled breath biomarkers for lactose intolerance diagnosis: the Lactobreath pilot study protocol by Daniel Pohl, Stamatios Giannoukos, Kathryn Jane Burton-Pimentel, Roxane Guillod, Guy Vergères

“…Symptoms of lactose intolerance will be assessed using a standardised questionnaire and mechanistically linked to specific key metabolites of the discriminating breath profile. In parallel, a solid-state sensor will measure postprandial hydrogen gas in breath samples, while GI gases (CH4, H2, O2) and intestinal transit time will be monitored using a novel ingestible gas sensor (Atmo Gas capsule). …”
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Multisite Randomized Controlled Trial of CareSTEPS: A Supportive Care Intervention for the Family Caregivers of Patients With Advanced Lung Cancer by Maria L. Rangel, DrPH, Kathrin Milbury, PhD, Karen Kayser, PhD, Robert Taylor Ripley, MD, Elizabeth Kvale, MD, Hoda Badr, PhD

“…Methods: In this multisite, open-label, parallel-group randomized controlled trial, 174 caregivers (74.1% female individuals, 40.2% from a racial or ethnic minority group) of patients with stage IIIB or IV NSCLC or extensive-stage SCLC completed baseline surveys and were randomly assigned to CareSTEPS (n = 87) or usual care (n = 87) using stratified block randomization. …”
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Effects of an e-Learning Program (Physiotherapy Exercise and Physical Activity for Knee Osteoarthritis [PEAK]) on Chinese Physical Therapists’ Confidence and Knowledge: Randomized... by Zi-Ru Wang, Yunqi Wang, Shuning Duan, Xier Chen, Guoxin Ni

“…MethodsThis was a randomized controlled trial with 2 parallel arms involving 81 rehabilitation practitioners from 18 Chinese provinces. …”
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Prevalence of Bovine Mastitis and Its Associated Risk Factors among Dairy Cows in Ethiopia during 2005–2022: A Systematic Review and Meta-Analysis by Abayeneh Girma, Dessalew Tamir

“…Heterogeneity and publication bias were evaluated using Cochran’s Q, inverse variance (I2), and funnel plot asymmetry tests. …”
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Patient-Centered Care in Family Medicine: Strategies for Continuity and Comprehensive Care for Older Adults – A Mixed-Methods Study by Alodhialah AM, Almutairi AA, Almutairi M

“…Abdulaziz M Alodhialah,1 Ashwaq A Almutairi,2 Mohammed Almutairi1 1Department of Medical-Surgical Nursing, College of Nursing, King Saud University, Riyadh, Saudi Arabia; 2School of Nursing & Midwifery, Monash University, Melbourne, AustraliaCorrespondence: Abdulaziz M Alodhialah, Email aalodhailah@ksu.edu.saIntroduction: Patient-centered care (PCC) is a crucial approach in family medicine, particularly for older adults with complex health needs. This study evaluates the implementation of PCC strategies and their impact on health outcomes for older adults in family medicine settings.Methods: A convergent parallel mixed-methods study was conducted, involving 47 healthcare providers and 126 older adult patients in Riyadh, Saudi Arabia. …”
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Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma by Susan Park, Manali Vora, Annemieke van Zante, Joseph Humtsoe, Hyun-Su Kim, Sue Yom, Shweta Agarwal, Patrick Ha

“…Methods A tissue microarray constructed from archival tissue from 64 patients with ACC was stained for Myb and β-catenin; both localization and intensity were evaluated. In parallel, we abstracted demographic data, tumor characteristics, survival data, and outcomes, including local recurrence, regional recurrence, and distant metastasis from the medical record. …”
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Improvement of sports nutrition knowledge by a dual method education program in track and field athletes: a randomized controlled trial by Ranil Jayawardena, Kalani Weerasinghe, Indu Nanayakkara, Terrence Madhujith, Andrew P. Hills, Nishan Sudheera Kalupahana

“…This study aimed to evaluate the effectiveness of a dual-method personalized nutrition education program in improving sports nutrition knowledge (SNK) among Sri Lankan track and field athletes.Methods This parallel-group, randomized controlled trial recruited national-level track and field athletes aged 18 and above. …”
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Endorsement of reporting guidelines and clinical trial registration across urological medical journals: a cross-sectional study by Alex Hagood, Joseph Case, Trevor Magee, Caleb Smith, Danya Nees, Griffin Hughes, Matt Vassar

“…Introduction Over the years, funding for urologic diseases has witnessed a steady rise, reaching $587 million in 2020 from $541 million in 2018. In parallel, there has been a notable increase in the total number of urology journals from 2011 to 2018. …”
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Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap a... by José M. Lasso, Daniel Poletti, Batolomé Scola, Pedro Gómez-Vilda, Ana I. García-Martín, María Eugenia Fernández-Santos

“…This is the first phase I-IIA clinical trial (phase I/IIA clinical trial, unicentric, randomized, controlled, and two parallel groups), to evaluate the safety of a new therapy with ADRC-enriched fat grafting (ADRC: group I) for laryngoplasty after unilateral vocal fold paralysis. …”
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PHARMACOECONOMIC JUSTIFICATION OF A WIDER USE OF PREVENTIVE HEMOPHILIA THERAPY IN THE RUSSIAN FEDERATION by M. Yu. Frolov, V. A. Rogov

“…For example, increasing the share of prevention therapy leads to increased expenses for the replacement pharmacotherapy in parallel to a reduction in expenses associated with negative outcomes of the disease (endoprosthetics, disability, etc.). …”
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Development and attestation of a standard sample of calcium nadroparin by A. V. Zykova, S. V. Krivoshchekov, D. A. Isakov, A. M. Guryev, M. V. Belousov

“…For each batch of the certified standard sample, the molecular weight and molecular weight characteristics are calculated in 2 parallel definitions, and a representative chromatogram is presented. …”
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mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis in Bangladesh and Pakistan: protocol for an adaptive design, cluster r... by Rumana Huque, John Norrie, Kamran Siddiqi, Melanie Boeckmann, Mahmoud Danaee, Ai Keow Lim, Steve Parrott, Amina Khan, Saeed Ansaari, Maham Zahid, Fahmidur Rahman, Asiful Chowdhury, Shakhawat Hossain Rana

“…This paper summarises the methodology proposed to assess the effectiveness and cost-effectiveness of mTB-Tobacco (an mHealth intervention) in helping patients with TB stop smoking and have improved health outcomes.Methods and analysis A two-arm, parallel, open-label, multicentre, cluster randomised, two-stage adaptive design trial is proposed to first evaluate the superiority of mTB-Tobacco, compared with usual care and then the non-inferiority of mTB-tobacco compared with face-to-face behaviour support. …”
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Treatment outcomes of two surgical techniques in secondary reconstruction of unilateral cleft lip and ala nasi utilizing anthropometry assessment: a randomized controlled trial by Ebrahim Humadi, Mawia Karkoutly, Zafin Kara Beit

“…Methods It was a double-blinded, randomized, parallel-group, active-controlled trial with two arms. …”
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Children and adolescents’ experiences of mandatory SARS-CoV-2 testing in schools: a cross-sectional survey by Thorsten Langer, Anneke Haddad, Christian Kimmig, Johanna K. Loy, Stephan Bender

“…This study examines the evaluation of such mandatory testing.Methods We investigated the effects of test type (pooled PCR tests vs antigen rapid tests) and demographic and psychological factors on evaluations of the experience of being tested. …”
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Increasing Access to Mental Health Supports for 18- to 25-Year-Old Indigenous Youth With the JoyPop Mobile Mental Health App: Study Protocol for a Randomized Controlled Trial by Angela MacIsaac, Teagan Neufeld, Ishaq Malik, Elaine Toombs, Janine V Olthuis, Fred Schmidt, Crystal Dunning, Kristine Stasiuk, Tina Bobinski, Arto Ohinmaa, Sherry H Stewart, Amanda S Newton, Aislin R Mushquash

“…MethodsThe study is a pragmatic, parallel-arm randomized controlled superiority trial design spanning a 4-week period. …”
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Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experie... by Brett D. Thombs, Claire Adams, Elsa-Lynn Nassar, Marie-Eve Carrier, Meira Golberg, Kanika Bharthi, Amanda Wurz, Annabelle South, Linda Kwakkenbos, Sabrina Hoa, Danielle B. Rice, Geneviève Guillot, Amanda Lawrie-Jones, Maureen Sauvé, Susan J. Bartlett, Catherine Fortune, Amy Gietzen, Karen Gottesman, Marie Hudson, Laura K. Hummers, Vanessa L. Malcarne, Maureen D. Mayes, Michelle Richard, James Stempel, Robyn K. Wojeck, Kathleen Blagrave, Jill T. Boruff, Vanessa Cook, Nicole Culos-Reed, Ole Fröbert, Katie Gillies, Vera Granikov, Lars G. Hemkens, Elizabeth Yakes Jimenez, Agnes Kocher, Catarina Leite, Mathew A. W. T. Lim, Nancy Maltez, John Michalski, Tracy Mieszczak, Mwidimi Ndosi, Janet Pope, François Rannou, Ken Rozee, Sharon E. Straus, Matthew R. Sydes, Lehana Thabane, John Varga, Tami Yap, Merrick Zwarenstein, Luc Mouthon, Andrea Benedetti, SPIN Investigators

“…Methods An advisory team of people with systemic sclerosis (SSc, also known as scleroderma) participated in developing research questions, selecting outcomes, and designing the series of parallel-arm RCTs that will each compare two or more tools or tool variations to a plain-language summary comparator; the common comparator will facilitate across-trial comparisons. …”
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MRI Compatibility Research of Ultrasonic Motor and Material for DBS Surgical Robot by PENG Renyuan, ZHANG Juzhong, WANG Zhisen, CHU Yuyi, WU Yuwen, PENG Haoran, LIN Jun, YANG Hongbo

“…The evaluation includes assessing their interference with MRI scanning to prevent potential safety and imaging issues. …”
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Le camp légionnaire romain de Mayence/Mogontiacum (Allemagne) : nouveaux résultats sur l’enceinte et la chronologie by Daniel Burger-Völlmecke

“…New evaluation of the Mainz/Mogontiacum legionary fortress’ architectural defences includes a total of 25 sites covering some 150 years of research history. …”
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A Randomized Clinical Study of a Curcumin and Melatonin Toothpaste Against Periodontal Bacteria by Riccardo Pulcini, Antonio Maria Chiarelli, Bruna Sinjari, Jessica Elisabetta Esposito, Francesco Avolio, Riccardo Martinotti, Vittorio Pignatelli, Luca Pignatelli, Laura Berlincioni, Stefano Martinotti, Elena Toniato

“…The aim of this study was to evaluate the bacterial modulation potential of a toothpaste (bioredoxin) containing curcumin and melatonin. …”
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