An unsupervised online Tai Chi program for people with knee osteoarthritis (“My Joint Tai Chi”): Study protocol for the RETREAT randomised controlled trial by Shiyi Julia Zhu, Rachel K. Nelligan, Rana S. Hinman, Alexander J. Kimp, Peixuan Li, Anurika De Silva, Jenny Harrison, Kim L. Bennell

“…Methods: A two-arm, superiority parallel-design, pragmatic randomised controlled trial will be conducted involving 178 people with a clinical diagnosis of knee OA. …”
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Assessment of immunological response to digital dermatitis pathogen derived antigens following infection, recovery, and reinfection by John W. Coatney, Adam C. Krull, Patrick J. Gorden, Jan Shearer, Samuel Humphrey, Samuel Humphrey, Steven Olsen, Steven Olsen, Paul J. Plummer, Paul J. Plummer, Jennifer H. Wilson-Welder, Jennifer H. Wilson-Welder

“…The ability to reliably induce bovine digital dermatitis (DD) in naive calves provides unique opportunities to evaluate immune responses of the calves to infection after disease induction, during healing, and after subsequent re-infection. …”
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Feasibility and safety of upper limb extremity ergometer exercise in the cardiac intensive care unit in critically ill patients with cardiac disease: a prospective observational st... by Kotaro Hirakawa, Atsuko Nakayama, Takeshi Arimitsu, Kazuki Kon, Hiromichi Ueki, Kentaro Hori, Yuki Ishimoto, Ayaka Ogawa, Ryosuke Higuchi, Yumiko Hosoya, Mamoru Nanasato, Mitsuaki Isobe

“…Upper limb extremity ergometer exercise was performed with alternating intervals of exercise and rest, in parallel with the rehabilitation program focused on early mobilization. …”
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Digital twin-based modeling of natural gas leakage and dispersion in urban utility tunnels [version 2; peer review: 2 approved] by Jiansong Wu, Jitao Cai, Ziqi Han, Yanzhu Hu, Ming Fu, Yuefei Li, Xin Wang, Xiaofu Zou

“…Furthermore, a widely used twin experiment and statistical performance measures (SPMs) are used to evaluate and validate the effectiveness of the proposed approach. …”
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Effects of 5-Methyl-2′-Deoxycytidine in G-Quadruplex Forming Aptamers d(G₃C)₄ and d[GCG₂(CG₃)₃C]: Investigating the Key Role... by Veronica Esposito, Daniela Benigno, Carla Aliberti, Camilla Esposito, Elisabetta Panza, Antonella Virgilio, Aldo Galeone

“…STAT adopts a dimeric 5′-5′ end-stacked quadruplex structure, characterized by parallel strands, three G-tetrads and three propeller-shaped loops formed by a cytidine residue. …”
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Circular pOlyethylene drape in preVEntion of suRgical site infection (COVER trial): study protocol for a randomised controlled trial by Ri Na Yoo, Hyung Jin Kim, Jae Im Lee, Won-Kyung Kang, Bong-Hyeon Kye, Chang Woo Kim, Sung Uk Bae, Soomin Nam, Byung Mo Kang

“…The COVER trial is a multicentre, randomised controlled clinical trial with two parallel arms—one using a dual-ring wound protector with circular polyethylene drape and the other using conventional surgical dressing gauze. …”
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Magnetoelectric nanoparticle technology for mitigating motor deficits in Parkinsonian mice by David Dominguez-Paredes, Yasin Temel, Aleksandra Milojkovic, Daniëlle Mulder-Jongen, Prachi Kumari, Mario Ries, Kristen Kozielski, Ali Jahanshahi

“…Throughout a parallel study, mice were monitored longitudinally for up to 18 months post injection to assess MENPs retention, efficacy, and long-term local effects. …”
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Protein-enriched intermittent meal replacement combined with moderate-intensity training for weight loss and body composition in overweight women by Qisijing Liu, Yi Guo, Bo Peng, Dancai Fan, Jing Wu, Jin Wang, Ruican Wang, Jing-Min Liu, Jian Wu, Shuo Wang, Yanrong Zhao

“…This 8-week parallel randomized controlled trial investigated the impact of protein-enriched IMR combined with MICT on weight loss and body composition in overweight female adults. …”
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Chronic Pain Induced by Social Defeat Stress in Juvenile Mice Depends on TLR4 by Julia Borges Paes Lemes, Alisa Panichkina, Kaue Franco Malange, Carlos E. Morado-Urbina, Sara Anna Dochnal, Saee Jadhav, Maksim Dolmat, Marco Pagliusi, Juliana M. Navia-Pealez, Maripat Corr, Yury I. Miller, Tony L. Yaksh

“…In WT mice, SDS promotes chronic mechanical allodynia and thermal hyperalgesia assessed via von Frey testing and the Hargreaves test, respectively. In parallel, the stressed WT mice exhibited transient anxiety-like behavior and long-lasting locomotor activity reduction in the open-field test. …”
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Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: protocol for a multicentre randomised placebo-controlled non-inferior... by Marc Carrier, Christine Baumgartner, Drahomir Aujesky, Menno V Huisman, Frederikus A Klok, Jeanne Moor, Marc Righini, Jürg-Hans Beer, Martina Peluso, Damiana Rakovic

“…Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism, a multicentre randomised placebo-controlled non-inferiority trial) is an international, multicentre, placebo-controlled, double-blind, parallel-group non-inferiority trial conducted in Switzerland, the Netherlands and Canada. …”
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Tenecteplase Versus Alteplase in Acute Ischemic Stroke in Chinese Patients: Protocol for the ORIGINAL Study by Xia Meng, Shuya Li, Hongguo Dai, Guozhi Lu, Weiwei Wang, Fengyuan Che, Yu Geng, Minghui Sun, Xiyan Li, Yongjun Wang

“…Methods This is a multicenter phase III study that employs a randomized (1:1), active‐controlled, parallel‐group, prospective, open‐label, blinded–end point design. …”
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Neuroprotective Potential of <i>Origanum majorana</i> L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru, Lucian Hritcu

“…We also investigated acetylcholinesterase (AChE) activity and the brain’s oxidative stress status. In parallel, we performed in silico predictions (research conducted using computational models) of the pharmacokinetic properties of the main compounds identified in OmEO, using platforms such as SwissADME, pKCSM, ADMETlab 2.0, and ProTox-II. …”
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Paraphrase and translation: the importance of being close [version 1; peer review: 2 approved] by Diana Santos, Anabela Barreiro

“…This article explores the concept of paraphrasing within computational linguistics, seeking to enrich its understanding by drawing parallels with translation studies and especially machine translation. …”
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Assisted Gene Flow Management to Climate Change in the Annual Legume Lupinus angustifolius L.: From Phenotype to Genotype by S. Sacristán‐Bajo, C. Lara‐Romero, A. García‐Fernández, S. Prieto‐Benítez, J. Morente‐López, M. L. Rubio Teso, E. Torres, J. M. Iriondo

“…We measured flowering onset, reproductive success, and other plant traits in all resulting lines. In parallel, we sequenced genes related to reproduction, growth, stress, nitrogen, and alkaloids. …”
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Integrative anticoagulation of nafamostat mesylate in double plasma molecular adsorption system plus sequential half-dose plasmapheresis for patients with liver failure: a randomis... by Lang Bai, Ling Zhang, Fang Wang, Yingying Yang, Juan Liao, Zhiwen Chen, Xiankun Sun

“…This study aims to comprehensively evaluate the safety and efficacy of NM-integrated anticoagulation during DPMAS plus sequential half-dose PE therapy for patients with liver failure.Methods and analysis A two-arm, open-label, parallel, randomised controlled trial involving 132 patients with liver failure will be conducted in China. …”
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Behavioural and neuronal substrates of serious game-based computerised cognitive training in cognitive decline: randomised controlled trial by Esther Brill, Alexa Holfelder, Michael Falkner, Christine Krebs, Anna-Katharine Brem, Stefan Klöppel

“…Aims To comprehensively evaluate the effectiveness of serious games-based CCT, integrating control conditions, neurophysiological and blood-based biomarkers, and subjective measures. …”
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Single and consecutive 10-day remote ischemic preconditioning modify physical performance, post-exercise exerkine levels, and inflammation by Magdalena Kochanowicz, Paulina Brzezinska, Jan Mieszkowski, Andrzej Kochanowicz, Bartlomiej Niespodzinski, Marcin Surmiak, Marcin Surmiak, Joanna Reczkowicz, Andzelika Borkowska, Jedrzej Antosiewicz

“…Thus, in this study, we analyzed the effect of a single- and consecutive 10-day RIPC procedure on a single leg, focusing on the exerkine levels and changes in inflammation markers following the Wingate Anaerobic Test (WAnT).MethodsTwo single-blinded, sham-controlled protocols were designed to evaluate the 1) single (crossover study) and 2) consecutive 10-day (parallel study) RIPC effects on the WAnT performance and exercise-induced lactate, glucose, exerkine, and inflammation markers (BDNF; IL-6; IL-10; IL-15; LIF; oncostatin M). …”
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Enhancing dyadic outcomes of stroke survivors and caregivers: protocol for a randomised controlled trial by Tsan-Hon Liou, Feng-Hang Chang, Valeria Chiu, Pengsheng Ni, Yen-Nung Lin, Jiunn-Horng Kang, Der-Sheng Han, Shih-Pin Hsu, Juleen Rodakowski

“…However, few interventions equally prioritise the outcomes of both survivors and caregivers. This study aims to evaluate the efficacy of a newly developed dyad-focused strategy training intervention in enhancing participation among stroke survivors and their caregivers.Methods and analysis This study employs a single-blind, parallel-group randomised controlled trial with allocation concealment and assessor blinding. …”
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New class of thio/semicarbazide-based benzyloxy derivatives as selective class of monoamine oxidase-B inhibitors by Namitha Chandran, Jiseong Lee, Prabitha Prabhakaran, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Della Grace Thomas Parambi, Tariq G. Alsahli, Manu Pant, Hoon Kim, Bijo Mathew

“…Abstract Sixteen thio/semicarbazide-based benzyloxy derivatives (BT1-BT16) were synthesized and evaluated for their inhibitory activities against monoamine oxidases (MAOs). …”
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ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people by Cassandra Brookes, Matthew Jones, Avril Drummond, Paul Leighton, Paul Hendrick, Terence Ong, Khalid Salem, Nasir Quraishi, Ana Suazo Di Paola, Opinder Sahota

“…Objective To determine the feasibility of designing and conducting a definitive trial to evaluate the effectiveness of sacral fracture fixation compared with non-surgical management among older people admitted with a lateral compression pelvic fragility fracture (PFF).Design Single-site, parallel, two-arm randomised controlled feasibility trial.Setting A UK tertiary centre hospital.Participants Patients aged ≥70 years who were ambulating pre-injury requiring hospital admission (within 28 days of injury) with a type 1 lateral compression PFF.Interventions The intervention group received sacral fracture fixation (cement augmentation±screw fixation) within 7 days of randomisation. …”
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