In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction by Shafaat Hossain, Omar Hamza Bin Manjur, Mst Sharmin Sultana Shimu, Tamanna Sultana, Mustafizur Rahman Naim, Shahariar Siddique, Abdullah Al Mamun, Md Miftaur Rahman, Md Abu Saleh, Md Rakibul Hasan, Tania Rahman

“…The root mean square fluctuation (RMSF) of the E94K mutant showed insufficient flexibility, indicating a reduced capacity to suppress CTSB. These findings suggest that the E94K mutation could affect the protein structure and cathepsin B interaction, potentially leading to pathological consequences as evidenced by colorectal adenocarcinoma patients in the COSMIC (Catalogue of Somatic Mutations in Cancer) database.…”
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Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study by John Kinuthia, R Scott McClelland, Barbra A Richardson, Elizabeth Maleche-Obimbo, Brent R Collett, Sarah Benki-Nugent, Faridah H Were, Anne M Riederer, Michael Gatari, CJ Karr, Edmund YW Seto, Beatrice C Mutai, Susan Wamithi, Priscilla Wanini Edemba, Timothy V Larson, Julian D Marshall

“…This study aims to determine the association between prenatal ambient air pollutant exposure and neurodevelopment in children aged 12, 24 and 36 months through a collaborative, capacity-enriching research partnership.Methods and analysis This observational cohort study is based in Nairobi, Kenya. …”
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Towards fiscal sustainable practices in Mexico: The quality of municipal tax regulation and tiered tariffs improve income from solid waste management services by Sergio López-Olvera, Juan Carlos Olivo-Escudero, Mauricio Hernández-Marroquín, Fausto Rafael López-Olvera, Yessica Lourdes Vallejo-Rivera, Marco Antonio Rodríguez-Gómez, Pedro Hipólito Rodríguez-Herrero

“…This study analyzed the impact of municipal tax regulation and sustainable taxation practices—specifically differentiated and progressive tariffs—on the income generation capacity of 240 Mexican municipalities. Data from municipal financial reports was extracted from official government websites and analyzed using statistical methods in R, including variance analysis and t-tests. …”
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Professional experiences on use of the mental health act in ethnically diverse populations: a photovoice study by Roisin Mooney, Paul McCrone, Rose McCabe, Kamaldeep Bhui, Brian Brown, Colin King, Andrew Molodynski, Nusrat Husain, Jacqueline Sin, Karen Newbigging, Michael Larkin, Neil Caton, Raghu Raghavan, Doreen Joseph, Anthony Zigmond, Michelle Yeung, Julie Carr, Phuong Hua, Frank Keating, Tara Morey, Claire Dempsey, Rahul Battacharya, Nuwan Dissanyake, Rochelle Ramkisson, Laura Dixon, Kopal Tandon, Gary Roberts, Paul Illingworth, Jo White, Karen Persaud, Sayeeda Basharat, Tripti Kandia, Sandra Griffiths, Michael Molete

“…We undertook a thematic analysis.Results Ineffective communications between inpatient and community services, insufficient staff capacity, a lack of continuity of care and language and cultural constraints meant MHA assessments were lacking information, leading to elevated perceptions of risk. …”
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Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer by Yuankui Zhu, Yaxi Yang, Linghe Yue, Lei Wan, Xuqian Ma, Qing Yang, Xuan Tian, Yuguan Li, Ke Wang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei, Dianbao Zuo, Mingqian Feng, Mingqian Feng

“…In light of these concerns, there is a growing interest in exploring alternative T cell types, natural killer T (NKT) cells and gammadelta (γδ) T cells, that possess the capacity to lyse tumors while potentially offering a safer therapeutic profile with fewer side effects. …”
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An overview of RE-Mg-based alloys for hydrogen storage: Structure, properties, progresses and perspectives by Dongsheng Zhou, Chunling Zheng, Yanghuan Zhang, Hanfeng Sun, Peng Sheng, Xin Zhang, Jun Li, Shihai Guo, Dongliang Zhao

“…By comparing the differences and characteristics between the organizational structures and hydrogen storage properties of different RE-Mg systems, a feasible idea and solution for the rational design and development of RE-Mg-based alloys with high hydrogen storage capacity, low cost, and fast hydrogen absorption and desorption kinetics was proposed.…”
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Redox-mediated reverse water gas shift integrated with ammonia cracking over Ni/La0.75Sr0.25Cr0.5Mn0.5O3−δ by Martin Keller, Shih-Yuan Chen, Atul Sharma

“…The Ni catalyst exhibits undesirable nitrogen uptake at ∼500 °C, and the redox capacity of LSCM with NH3 and CO2 decreases with temperature. …”
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Maximum power point tracking enhancement for PV in microgrids systems using dual artificial neural networks to estimate solar irradiance and temperature by Ahmad M.A. Malkawi, Zuhour A.B. Alsaqqa, Tareq O. Al-Mosa, Wa'el M. JadAllah, Mohannad M.H. Sadeddin, Ayman Al-Quraan, Mohammad AlMashagbeh

“…The ANNs integrated with the adaptive block were evaluated to validate the system's capacity to estimate solar irradiance, temperature, and maximum power point. …”
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Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer by Tanya Tripathi, Apoorva Chaudhary, Divya Janjua, Udit Joshi, Nikita Aggarwal, Chetkar Chandra Keshavam, Alok Chandra Bharti

“…The anti-tumor potential of psoralidin has been well-documented. Its capacity to effectively target cancer stem cells (CSCs) in general adds to its therapeutic potential. …”
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Towards equitable carbon responsibility: Integrating trade-related emissions and carbon sinks in urban decarbonization by Junliang Wu, Yafei Wang, Shuya Zhang, Yu Zhu, Bingyue Fu, Zhihui Zhang, Hanxi Chen, Shaoqing Chen

“…Our proposed CMR framework provides a robust basis for incentivizing coordinated mitigation efforts, promoting decarbonization in supply chains and enhancement of urban carbon sink capacities.…”
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Prediction model, risk factor score and ventilator-associated pneumonia: A two-stage case-control study by Hua Meng, Yuxin Shi, Kaming Xue, Di Liu, Xiongjing Cao, Yanyan Wu, Yunzhou Fan, Fang Gao, Ming Zhu, Lijuan Xiong

“…Results: LASSO, RF and XGBoost consistently revealed significant associations of length of stay before MV, MV time, surgery, tracheotomy, multiple drug resistant organism infection, C-reactive protein, PaO2, and APACHE II score with VAP. RFS was significantly linearly associated with VAP risk [odds ratio and 95 % confidence interval = 2.699 (2.347, 3.135)], and showed good discriminations for VAP both in discovery stage [area under the curve (AUC) = 0.857] and validation stage (AUC = 0.879). …”
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Ddx21 mutant peptide is an effective neoantigen in prophylactic lung cancer vaccines and activates long-term anti-tumor immunity by Zhe Zhang, Yimeng Xia, Yimeng Xia, Zhihong Wang, Yaxing Sun, Dan Pu, Yijia He, Ruixian Liu, Yanru Zhang, Yan Liu, Junzhi Yu, Shiyang Ning, Baisui Feng, Yaohe Wang, Na Wang

“…While the vaccine based on KPL 160424S, derived from advanced-stage murine lung cancer tissues, failed to extend survival time and demonstrated limited capacity to stimulate anti-tumor immunity. MethodsTo investigate the fundamental reason for the difference between KPL 160302S and KPL 160424S vaccines, we employed bioinformatics methods and immune related experiments to explore the effects and mechanisms of the screened neoantigens. …”
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The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells by Minghao Sui, Tiantian Liu, Xuanli Song, Ji Li, Han Ding, Yuqian Liu, Xinyu Wang, Huimin Liu, Yuchan Xue, Jianni Qi, Miao Zhang, Songbo Zhao, Qiang Zhu

“…Our study showed that the molecular receptor NKBB conferred GPC3 CAR-T cells with enhanced migration and infiltration abilities towards HCC, higher central memory T (TCM) cell proportion and proliferation capacity, and reduced exhaustion level. GC3328z-NKBB CAR-T cells exhibited improved cytotoxicity against HCC cells and prolonged persistence. …”
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Study on flexural cracking characteristics of polypropylene fiber reinforced concrete beams with BFRP bars by Huayi Wang, Ming Zhou, Bingyan Wei, Chao Wu, Zhiyi Tang, Sitian Zhang, Jia He

“…When the flexural bearing capacity is 80 %, the average crack spacing is reduced by 6.1 % - 13.4 %. …”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…In in vitro models, we further demonstrated that ABA treatment elevates lipid droplet formation by enhancing the phagocytic capacity of macrophages. Additionally, in a mouse model of microglial activation, we showed that ABA-treated mice maintain a less inflammatory microglial phenotype.ConclusionOur findings highlight a crucial role for macrophages and microglia in enabling ABA to enhance the remyelination process. …”
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Sorption behavior of pomegranate polyphenols on surfactant-modified clays in aqueous solution by Houda Saad, Thouraya Turki, Mondher Srasra, Ezzeddine Srasra

“…Materials and methods: Organoclays were prepared by the intercalation of a cationic surfactant, hexadecylpyridinium bromide (HDPy), into purified Tunisian smectite clay at different Cation Exchange Capacities (CEC) degrees (0.5CEC, 1CEC and 2CEC). Surfactant-modified clays were characterized by X-ray diffraction (XRD) and Fourier Transform Infrared spectroscopy (FTIR). …”
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Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…Further, we elucidate the critical role of FGF signaling in odontoblast maturation and its biomineralization capacity using the de novo designed FGFR1/2c isoform specific minibinder scaffolded as a C6 oligomer that acts as a pathway agonist. …”
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Influencia de las universidades colombianas sobre la percepción de la Responsabilidad Social Empresaria de sus estudiantes by Oscar Licandro, Giselle Pinochet Sánchez, Margarita Ramírez Mariño, Ana Cecilia Chumaceiro Hernández, Gustavo Adolfo Rubio Rodríguez, Edy Lorena Burbano Vallejo, Adriana Zambrano, Diana Carolina Cabra Ballesteros, Juan Pablo Mariño Jiménez, Alejandro Echeverri Rubio

“…Se seleccionó una muestra de 925 estudiantes de carreras de gestión de nueve universidades colombianas, y se midió si eran capaces de reconocer 18 prácticas de Responsabilidad Social Empresaria. …”
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Exploration of the anti-inflammatory potential of Polygonum bistorta L.: protection against LPS-induced acute lung injury in rats via NF-ĸβ pathway inhibition by Sajida Parveen, Kashif ur Rehman Khan, Shahid Muhammad Iqbal, Hanan Y. Aati, Areej M. Al-taweel, Liaqat Hussain, Musaddique Hussain, Musaddique Hussain

“…ELISA testing on BALF found that the plant extract efficiently reinstated superoxide dismutase, total anti-oxidant capacity, malondialdehyde, and total oxidative stress. qRT-PCR indicated a decline in the endotoxin-induced overproduction of pro-inflammatory markers, oxidative stress, transcription factor, and downregulated antioxidant potential in extract-treated groups. …”
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Effect of tree size attributes on fruit production and animal-mediated seed dispersal web in Melia azedarach L. (Chinaberry) in north-west Himalaya, India by Sukumaran Arun, Sasidharan Sarath, Khanduri Vinod Prasad, Suraj, Rawat Shweta, Chand Vaisakhy Prem

“…Our findings indicate that the tree-size attributes like diameter, height, and crown length strongly affected fruit yield capacity in trees of Melia azedarach. Large trees are likely to be reproductively matured and are prioritising resources for reproduction rather than growth. …”
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