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    Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

    Published 2024-07-01
    “…Objective To evaluate signal transducer and activator of transcription 3 (STAT3) inhibition we conducted a co-clinical trial testing danvatirsen, a STAT3 antisense oligonucleotide (ASO) and checkpoint inhibition in conjunction with preclinical experiments.Methods and analysis Orthotopically implanted pancreatic cancer (pancreatic adenocarcinoma (PDAC)) was treated with STAT3 ASO with immune checkpoint inhibition. …”
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    Mathematical model of penetration of cylindrical electromagnetic fields with axial symmetry through the plane screen from permalloy by V. Т. Erofeenko

    Published 2020-06-01
    “…Roots (wave numbers) of a dispersion algebraic equations of four order, which characterizing electromagnetic fields with axial symmetry in layer made from the permalloy, is constructed. …”
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    A Modified Newmark Methodology for Permanent Deformation Analysis of Rock-Fill Dams by Hongjun Li, Hong Zhong, Zuwen Yan, Jianming Zhao

    Published 2018-01-01
    “…In the presented research, a modified Newmark methodology for sliding deformation analysis of rock-fill dams subjected to strong earthquake is proposed. In order to make the seismic safety evaluation of dams more realistic, the influence of cyclic shear strength (earthquake-induced reduction of shear strength) and time history vertical acceleration obtained from the dynamic response analysis on the critical acceleration and accumulative sliding displacement of the flexible sliding body is considered. …”
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    Pathological variants in HPV-independent vulvar tumours by Sanja A. Farkas, Alvida Qvick, Gisela Helenius, Gabriella Lillsunde-Larsson

    Published 2025-01-01
    “…The study included formalin-fixed paraffin-embedded (FFPE) samples from 32 cancer patients (16 HPV-negative and 16 HPV-associated), treated in Örebro, Sweden from 1988 to 2008. The Oncomine™ Comprehensive Assay v3 was used to detect variants across 161 different tumor relevant genes. …”
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    Computational antidiabetic assessment of Salvia splendens L. polyphenols: SMOTE, ADME, ProTox, docking, and molecular dynamic studies by Hatun A. Alomar, Wafaa M. El Kady, Asmaa A. Mandour, Amany A. Naim, Neveen I. Ghali, Taghreed A. Ibrahim, Noha Fathallah

    Published 2025-03-01
    “…Employing the SMOTE oversampling strategy confirmed that the generated dataset mirrored the activity pattern of the original data. An ADMET analysis of twelve compounds indicated that most complied with Lipinski's rule of five, demonstrating favorable oral bioavailability and safety profiles, except for two compounds, luteolin7-O-(4″,6″-di-O-α-L-rhamno-pyranosyl)-β-D-glucopyranoside and apigenin-7-O-β-D-rutinoside, which exhibited low solubility. …”
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