Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication by Jessica J. Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavinia M. Sherrill, Iain Colquhoun, Gabrielle Cadoux, Devyn Thorne, Johan Pääkkönen, Nathaniel F. Schemmel, Joseph O’Connor, Pradtahna Saenjamsai, Mei Feng, Srivatsan Parthasarathy, Michael J. Hageman, David K. Johnson, Anuradha Roy, Lari Lehtiö, Dana V. Ferraris, Anthony R. Fehr

Get full text

SDNet: Sandwich Decoder Network for Waterbody Segmentation in Remote Sensing Imagery by Hao Ni, Jianfeng Li, Chenxu Wang, Zhiquan Zhou, Xinsheng Wang

“…The network’s sandwich-shaped decoder structure allows for easy integration with mainstream encoders. Compared to previous influential methods, SDNet exhibits superior sensitivity in detecting small waterbodies and delivers better overall performance. …”
Get full text

Enhancing Biomethane Yield and Metabolic Pathways in Kitchen Waste Anaerobic Digestion Through Microbial Electrolysis Cell Integration by Qing Zhao, Heran Wang, Rufei Liu, Hairong Yuan, Xiujin Li

“…This study developed a system (MEC-AD) by integrating a single-chamber microbial electrolysis cell (MEC) with anaerobic digestion (AD), aiming to enhance the conversion efficiency of kitchen waste (KW) into biomethane and optimize metabolic pathways. The performance and microbial metabolic mechanisms of MEC-AD were investigated and compared with those of conventional AD, through inoculation with original inoculum (UAD) and electrically domesticated inoculum (EAD), respectively. …”
Get full text

Co-expression of auxiliary genes enhances the activity of a heterologous O2-tolerant hydrogenase in the cyanobacterium Synechocystis sp. PCC 6803 by Sara Lupacchini, Ron Stauder, Franz Opel, Stephan Klähn, Andreas Schmid, Bruno Bühler, Jörg Toepel

“…Second, the entire set of hyp genes, encoding CnSH maturases, was co-expressed in Synechocystis to investigate, if CnSH maturation was limiting. …”
Get full text

A DNA vaccine candidate provides protection against Rift Valley Fever virus in sheep under natural field conditions by Moufid Mhamadi, Moufid Mhamadi, George (Giorgi) Babuadze, Aminata Badji, Marie-Edith Nepveu-Traversy, El Hadji Ndiaye, Alioune Gaye, Mignane Ndiaye, Moundhir Mhamadi, Frank William Mendy, Cheikh Talibouya Touré, Idrissa Dieng, Moussa Dia, Ndeye Sakha Bob, Marc-Antoine de La Vega, Ousmane Faye, Amadou Alpha Sall, Mawlouth Diallo, Gary Kobinger, Gary Kobinger, Oumar Faye, Hugues Fausther-Bovendo, Hugues Fausther-Bovendo

“…In this study, we designed a veterinary DNA vaccine encoding a consensus RVFV glycoprotein precursor (GPC), optimized for expression in sheep. …”
Get full text

TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1 by Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Sarah Nietzer, Karina Epting, Gabriele Vacun, Gudrun Dandekar, Catherine Botteron, Christian Werno, Thomas Grunwald, Susanne M. Bailer

“…Through genetic engineering, an attenuated herpes simplex virus type 1 (HSV1) was generated that showed increased safety compared to the wild-type strain. To demonstrate the modularity and the facilitated generation of new OVs, two transgenes encoding retargeting as well as immunomodulating single-chain variable fragments (scFvs) were integrated into the platform vector. …”
Get full text

Realistic Speech-Driven Talking Video Generation with Personalized Pose by Xu Zhang, Liguo Weng

“…We take a random sampling of audio clips, encode audio contents and temporal correlations using a more effective network structure, and optimize and iterate network outputs using differential loss and attitude perception loss, so as to obtain a smoother pose key-point sequence and better performance. …”
Get full text

Preserving Phase Coherence and Linearity in Cat Qubits with Exponential Bit-Flip Suppression by Harald Putterman, Kyungjoo Noh, Rishi N. Patel, Gregory A. Peairs, Gregory S. MacCabe, Menyoung Lee, Shahriar Aghaeimeibodi, Connor T. Hann, Ignace Jarrige, Guillaume Marcaud, Yuan He, Hesam Moradinejad, John Clai Owens, Thomas Scaffidi, Patricio Arrangoiz-Arriola, Joe Iverson, Harry Levine, Fernando G. S. L. Brandão, Matthew H. Matheny, Oskar Painter

“…Cat qubits, a type of bosonic qubit encoded in a harmonic oscillator, can exhibit an exponential noise bias against bit-flip errors with increasing mean photon number. …”
Get full text

All identical objects reduce memory load at the late maintenance stage in working memory by Lijing Guo, Hyung-Bum Park, Guofang Ren, Penglan Liu, Ruyi Liu, Dan Nie, Chaoxiong Ye

“…However, late CDA amplitudes were significantly reduced in the all-same condition compared to the partial-same and all-different conditions, indicating that the benefits of identical objects emerge during the late maintenance phase. …”
Get full text

DGCLCMI: a deep graph collaboration learning method to predict circRNA-miRNA interactions by Chao Cao, Mengli Li, Chunyu Wang, Lei Xu, Quan Zou, Yansu Wang, Wu Han

“…First, it uses word2vec to encode sequences into word embeddings. Next, we present a joint model that combines an improved neural graph collaborative filtering method with a feature extraction network for optimization. …”
Get full text

Physicochemical profiling and ranking of parkinson’s disease drugs through QSPR and Fuzzy TOPSIS analysis by YuLan Chen, Abdul Rauf, Aqsa Shafique, Fairouz Tchier, Adnan Aslam, Keneni Abera Tola

“…The methodology offers a framework for prioritizing therapeutics based on physicochemical profiles, with implications for optimizing Parkinson’s disease management.…”
Get full text

Computational modelling and neural correlates of reinforcement learning following three-week escitalopram: a double-blind, placebo-controlled semi-randomised study by Christelle Langley, Graham K. Murray, Sophia Armand, Franziska Knolle, Rudolf N. Cardinal, Annette Johansen, Peter S. Jensen, Jianfeng Feng, Dea S. Stenbæk, Gitte M. Knudsen, Patrick M. Fisher, Barbara J. Sahakian

“…A key novel finding was that there was decreased activation of the intraparietal sulcus in the escitalopram group when compared to the placebo group during reward trials. …”
Get full text

Pasithea-1: An Energy-Efficient Sequential Reconfigurable Array With CPU-Like Programmability by Tobias Kaiser, Esther Gottschalk, Kai Biethahn, Friedel Gerfers

“…Its extensible instruction set uses sequential control flow in code fragments of up to 64 RISC-like instructions, which encode control and dataflow graphs in adjacency lists. …”
Get full text

Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy by LIU Siyu, LAI Yuezhao, GUO Wenting, CHEN Xuejin

Get full text

Deletion of succinic semialdehyde dehydrogenase sad and chromosomal expression of phosphoenolpyruvate carboxylase as metabolic requirements for improved production of 2,4-dihydroxy... by T. A. Stefanie Nguyen, Ceren Alkim, Nadine Ihle, Thomas Walther, Cláudio J. R. Frazão

“…Specifically, with the single knock-out of sad we could achieve a 3-fold increase in DHB production with a yield of 0.15 mol mol-1 compared to the wildtype host in shake flask experiments. …”
Get full text

Working-memory load decoding model inspired by brain cognition based on cross-frequency coupling by Jing Zhang, Tingyi Tan, Yuhao Jiang, Congming Tan, Liangliang Hu, Daowen Xiong, Yikang Ding, Guowei Huang, Junjie Qin, Yin Tian

“…On our collected three-class working memory dataset, the proposed model achieved higher classification accuracy compared to other state-of-the-art methods. Furthermore, by analyzing the model’s classification performance during different stages of working memory processes, this study emphasizes the significance of the encoding phase and confirms that behavioral response does not accurately reflect cognitive load.…”
Get full text

High-Resolution Melting PCR as a Fast and Simple Molecular Biology-Based Method for the Identification of Hypervirulent <i>Clostridioides difficile</i> Strains Directly in Stool Sa... by Tomasz Bogiel, Robert Górniak, Weronika Ambroziak, Szymon Zieliński, Dominika Anna Zieja, Piotr Kanarek

“…For this purpose, the <i>cdtA</i> and <i>cdtB</i> genes encoding CDT subunits, as well as the species-specific <i>gluD</i> gene, were detected to identify the presence of this bacterium in the tested samples. …”
Get full text

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models by Magdalena Surdyka, Żaneta Kalinowska-Pośka, Anna Niewiadomska-Cimicka, Ewelina Jesion, Agnieszka Fiszer, Elisabeth Singer-Mikosch, Lorraine Fievet, Lukasz Przybyl, Nicholas S. Caron, Michael R. Hayden, Huu Phuc Nguyen, Yvon Trottier, Maciej Figiel

“…We demonstrate that optimized CAG-targeted A4(P10) and A4(P10,11) shReagents can lower mutant huntingtin and ataxin-3 protein and its aggregates by targeting brain regions selectively and with diminished toxicity compared to other tested shRNAs. …”
Get full text

Dose prediction of CyberKnife Monte Carlo plan for lung cancer patients based on deep learning: robust learning of variable beam configurations by Yuchao Miao, Jiwei Li, Ruigang Ge, Chuanbin Xie, Yaoying Liu, Gaolong Zhang, Mingchang Miao, Shouping Xu

“…Methods This study proposed that the AB (anatomy and beam) model be compared with the control Mask (only anatomy) model. …”
Get full text

Res-ECA-UNet++: an automatic segmentation model for ovarian tumor ultrasound images based on residual networks and channel attention mechanism by Shushan Wei, Zhaoting Hu, Lu Tan

“…Comparative analyses of ROC curves and AUC values further indicate that Res-ECA-UNet++ exhibits superior segmentation accuracy and enhanced generalization capabilities on the test set. …”
Get full text