Identification of dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4) as antagonist of NEK-Family... by Mubashir Aziz, Syeda Abida Ejaz, Pervaiz Ali Channar, Ali G. Alkhathami, Tahir Qadri, Zahid Hussain, Mumtaz Hussaain, Rabail Ujan

“…Abstract The purpose of the current study was to analyze and validate the existing gap in knowledge, by conducting a differential expression analysis and validation of NEK6, NEK7, and NEK9 in breast, cervical, and glioblastoma cancer and targeting these proteins through development of novel site specific inhibitor with favorable pharmacokinetic and safety profile, using open-source databases. The analysis revealed that the targeted kinases were overexpressed in all three types of cancer. …”
Get full text

A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity by Victoria Shevchenko, R. Austin Benn, Robert Scholz, Wei Wei, Carla Pallavicini, Ulysse Klatzmann, Francesco Alberti, Theodore D. Satterthwaite, Demian Wassermann, Pierre-Louis Bazin, Daniel S. Margulies

“…To this end, we leveraged data of 936 individuals from three large open-access datasets: COBRE, LA5c, and SRPBS-1600. …”
Get full text

Toward Digital Twin of Off-Road Vehicles Using Robot Simulation Frameworks by Arianna Rana, Antonio Petitti, Angelo Ugenti, Rocco Galati, Giulio Reina, Annalisa Milella

“…The first one is based on Gazebo, an open-source 3D robotics simulator, to test and validate the algorithms developed in the ROS framework; the second one adopts the vehicle mechanical assembly in MSC Adams, a multibody modeling software used to study the dynamics of complex mechanical systems. …”
Get full text

CLINICAL AND MORPHOLOGICAL APPROACH TO DIAGNOSIS OF "IDIOPATHIC" ARRHYTHMIAS AND DILATED CARDIOMYOPATHY SYNDROME AS A BASIS FOR DIFFERENTIATED THERAPY. Part I (Diagnostics) by O. V. Blagova, A. V. Nedostup, E. A. Kogan, V. A. Sulimov, Yu. V. Osipova, V. P. Sedov, A. G. Kupriyanova, V. A. Zaydenov, A. E. Donnikov, V. V. Kadochnikova

“…Patients (n=320) with IA (n=190; 117 women, age 45.3±14.8 years) and DCM (n=130, 41 women, age 46.9±12.5 years) were included in the main group. 51 people (patients with ischemic heart disease; heart valve disease, hypertrophic cardiomyopathy, who underwent open-heart surgery; healthy volunteers) were included in the control group. …”
Get full text

Learning motif features and topological structure of molecules for metabolic pathway prediction by Jianguo Hu, Yiqing Zhang, Jinxin Xie, Zhen Yuan, Zhangxiang Yin, Shanshan Shi, Honglin Li, Shiliang Li

“…An external validation further corroborates this observation. MotifMol3D is an open-source tool that is available at https://github.com/Irena-Zhang/MotifMol3D.git . …”
Get full text

Machine-learning based quantification of lung shunt fraction from 99mTc-MAA SPECT/CT for selective internal radiation therapy of liver tumors using TriDFusion (3DF) by Daniel Lafontaine, Finn Augensen, Adam Kesner, Raoul Vincent, Assen Kirov, Simone Krebs, Heiko Schöder, John L. Humm

Get full text

A novel lightweight 3D CNN for accurate deformation time series retrieval in MT-InSAR by Mahmoud Abdallah, Xiaoli Ding, Samaa Younis, Songbo Wu

“…We also developed a separable convolution operator to reduce the computational costs without compromising performance. …”
Get full text

MCPA: multi-scale cross perceptron attention network for 2D medical image segmentation by Liang Xu, Mingxiao Chen, Yi Cheng, Pengwu Song, Pengfei Shao, Shuwei Shen, Peng Yao, Ronald X. Xu

“…Considering the high computational cost of using 3D neural network models, and the fact that many important clinical data can only be obtained in two dimensions, our MCPA focuses on 2D medical image segmentation. …”
Get full text

Naringin from Citrus maxima peel: a potential therapeutic agent for breast cancer via PKM2 inhibition by Flama Monteiro, Vijith Vittal Shetty, Ranjitha Acharaya, Sriram Naresh, Manne Munikumar, Shilpa S Shetty, Pradeep Nataranjan, Suchetha Kumari N

Get full text

Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism by Zhiyong Shi, Mingkai Yun, Binbin Nie, Enjun Zhu, Wei Fu, Baoci Shan, Sijin Li, Xiaoli Zhang, Xiang Li

Get full text

CT colonography: revisited after 30 years by Mehdi Cadi, Charles André Cuenod, Philippe A. Grenier, Aurélien Saltel, Mohamed Abdulbaki, Gilles Manceau, Mehdi Karoui

Get full text

Quantifying the spatial impact of an invasive Acacia on ecosystem functioning using remote sensing by André Große-Stoltenberg, Christiane Werner, Christine Hellmann, Jens Oldeland, Jan Thiele

Get full text

Assessing the biomechanics of scheuermann’s kyphosis affected thoracolumbar spine in forward flexion at the tissue-level using a finite element model by Chunli Wan, Xiaowen Shen, Xixi Wu, Cui Yu, Yi Shao, Ruiping Zhang, Jiao Shang, Jianan Li, Yuting Zhang, Yongqiang Li

“…Physiologic motions captured from in vivo experiment was simulated using OpenSim, with inverse dynamics and optimization used to calculate vertebral joint angles, muscle forces, and intervertebral reaction forces, serving as boundary conditions for ANSYS finite element models. …”
Get full text

Can positron emission tomography with 18F-FDG substitute bone marrow biopsy for detecting bone marrow infiltration in patients with large B-cell lymphoma? by Susan Adil Ali, Moustafa Mahmoud Abdelkawi, Merhan Ahmed Nasr, Haytham Abdelkader, Darine Amin, Safenaz Y. El Sherity, Mohamed Metkees, Samar Ramzy Ragheb Hanna

Get full text

Distributionally robust hybrid energy management in smart mining using process-coupled primal-dual mirror descent by Dawei Wang, Yifei Li, Cheng Gong, Tianle Li, Fang Wang, Shanna Luo, Jun Li

“…The proposed framework is validated using a synthetic open-pit mining benchmark incorporating real-world meteorological data, empirical process dynamics, and regulatory thresholds. …”
Get full text

THE ROLE OF PARASTERNAL MEDIASTINOTOMY IN THE DIAGNOSIS OF MEDIASTINAL TUMORS by O. V. Pikin, A. B. Ryabov, A. O. Alexandrov, D. A. Vursol, A. M. Amiraliev

“…At the stage of preoperative examination, all patients underwent standard diagnostic studies: computed tomography of the chest, abdominal cavity, and a comprehensive ultrasound. …”
Get full text

Cooperative control method for multi-agent ground fracturing truck group based on offline reinforcement learning by RuYi Wang, HuiShen Jiao, YingCheng Tian, Yi Zhao, SiQi Wang, Ke Zhang, Bo Huang, QinRui Sun, DanDan Zhu

Get full text

Fibular head osteotomy: A new technique for better exposure of postero-lateral tibial plateau fracture by Shaozheng Yang, Yong Lian, Li Yang, Sushuang Ma, Chao Ding, Feng Huang, Yongqiang Liu, Heng Li, Zhu Mutan, Hua Zhong, Hongfen Chen

Get full text

A Decoupled Segmentation-Classification Strategy Based on Semantic-SAM for Precise Semantic Segmentation in Coal Mine Areas by Libing Wang, Jihong Dong, Lei Wang, Feng Liu, Qingke Wen, Bekir Genc

“…Evaluating 18 models, SAM-SEF-ENet-B0 achieved the highest IoUs for Open-pit Coal Mining Sites (OCMS) (93.68%) and Composite Coal-related Sites (CCS) (81.52%), with an mIoU of 87.60%, significantly outperforming traditional models. …”
Get full text

Chest ultrasound vs. Radiograph for pneumothorax diagnosis performed by emergency healthcare workers in the emergency department: a systematic review and meta-analysis by Jean-Baptiste Bouillon-Minois, Coline Burlet, Resa E. Lewiss, Reza Bagheri, Christophe Perrier, Jeannot Schmidt, Frédéric Dutheil

Get full text