Elements and evolutionary determinants of genomic divergence between paired primary and metastatic tumors. by Ruping Sun, Athanasios N Nikolakopoulos

“…Can metastatic-primary (M-P) genomic divergence measured from next generation sequencing reveal the natural history of metastatic dissemination? This remains an open question of utmost importance in facilitating a deeper understanding of metastatic progression, and thereby, improving its prevention. …”
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HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data. by Sára Sáray, Christian A Rössert, Shailesh Appukuttan, Rosanna Migliore, Paola Vitale, Carmen A Lupascu, Luca L Bologna, Werner Van Geit, Armando Romani, Andrew P Davison, Eilif Muller, Tamás F Freund, Szabolcs Káli

“…We address these problems for the representative case of the CA1 pyramidal cell of the rat hippocampus by developing an open-source Python test suite, which makes it possible to automatically and systematically test multiple properties of models by making quantitative comparisons between the models and electrophysiological data. …”
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Low-dimensional spike rate models derived from networks of adaptive integrate-and-fire neurons: Comparison and implementation. by Moritz Augustin, Josef Ladenbauer, Fabian Baumann, Klaus Obermayer

“…The low-dimensional models also well reproduce stable oscillatory spike rate dynamics that are generated either by recurrent synaptic excitation and neuronal adaptation or through delayed inhibitory synaptic feedback. The computational demands of the reduced models are very low but the implementation complexity differs between the different model variants. …”
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Modelling 3D saccade generation by feedforward optimal control. by Akhil John, Carlos Aleluia, A John Van Opstal, Alexandre Bernardino

“…We performed a numerical linearization of the nonlinear system dynamics around the origin using system identification techniques, and developed open-loop controllers for 3D saccade generation. …”
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Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death. by Irina Veith, Arianna Mencattini, Valentin Picant, Marco Serra, Marine Leclerc, Maria Colomba Comes, Fathia Mami-Chouaib, Jacques Camonis, Stéphanie Descroix, Hamasseh Shirvani, Fatima Mechta-Grigoriou, Gérard Zalcman, Maria Carla Parrini, Eugenio Martinelli

“…A live fluorescent dye (red) is used to selectively pre-stain the cancer cells before co-cultures and a live fluorescent reporter for caspase activity (green) is used to monitor apoptotic cell death. The here described open-source computational method, named STAMP (spatiotemporal apoptosis mapper), extracts the temporal kinetics and the spatial maps of cancer death, by localizing and tracking cancer cells in the red channel, and by counting the red to green transition signals, over 2-3 days. …”
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NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. by Padraig Gleeson, Sharon Crook, Robert C Cannon, Michael L Hines, Guy O Billings, Matteo Farinella, Thomas M Morse, Andrew P Davison, Subhasis Ray, Upinder S Bhalla, Simon R Barnes, Yoana D Dimitrova, R Angus Silver

“…To overcome these problems we have used an Open Source software approach to develop NeuroML, a neuronal model description language based on XML (Extensible Markup Language). …”
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Sorting misorganized books in libraries based on ant colony algorithm by Ling Chen

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Mapping context of sedentary behaviour in older adults who are prefrail and frail: an analysis of secondary outcomes from a longitudinal study (MAPS-B) by Rong Zheng, Jonathan D Adachi, Alexandra Papaioannou, George Ioannidis, Alexander Rabinovich, Isabel B Rodrigues, Mayank Kalra, Dylan Kobsar, Steven R Bray, Qiyin Fang

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Non-communicable airway disease and air pollution in three African Countries: Benin, Cameroon and The Gambia by B. Awokola, H. Lawin, O. Johnson, A. Humphrey, D. Nzogo, L. Zubar, G. Okello, S. Semple, E. Awokola, G. Amusa, N. Mohammed, C. Jewell, A. Erhart, K. Mortimer, G. Devereux, B.H. Mbatchou-Ngahane

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Using artificial intelligence to improve healthcare delivery in select allied health disciplines: a scoping review protocol by Kristina Edvardsson, Sally Fowler-Davis, Claire Thwaites, Ken Ho, Kalpana Raghunathan, Meg E. Morris, Tafheem A. Wani, Casey Peiris, Jonathan P. McKercher, Sharon Bourke, Saadia Danish, Jacqueline Johnston, Nompilo Moyo, Julia Gilmartin-Thomas, Hazel Wei Fen Heng, Joanne Joyce-McCoach

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Safety and adherence to medications and self-care advice in oncology (SAMSON): pilot randomised controlled trial protocol by Penelope Schofield, Marliese Alexander, Nilmini Wickramasinghe, Kate Burbury, Prem Prakash Jayaraman, Thu Ha Dang, Ashley Whitechurch, Steve Quinn, Gail Rowan, Sally L Brooks

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Development of the continuous ambulatory vestibular assessment (CAVA) system to provide an automatic diagnosis for vestibular conditions: protocol for a multicentre, single-arm, no... by Lee Shepstone, Louisa Murdin, Peter Rea, Juliet High, Ian Nunney, John S Phillips, Gregory Howard, Stephen J Cox

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Lung ultrasound outperforms symptom-based screening to detect interstitial lung disease associated with rheumatoid arthritis by Wim Wuyts, Joseph Jacob, Patrick Verschueren, Veerle Taelman, Barbara Neerinckx, Heleen Cypers, Alexandros Kalkanis, Nico De Crem, Marie Vermant, Tinne Goos, Emanuela Elsa Cortesi, Tine Follet, Stefan Gogaert, Nathalie Veyt, Laurens J De Sadeleer

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Protocol for development of a checklist and guideline for transparent reporting of cluster analyses (TRoCA) by Ana Marusic, Bright I Nwaru, Syed Ahmar Shah, Meredith Wallace, Dat Tran, Daniil Lisik, Rani Basna, Tai Dinh, Ryan P Browne, Jeffrey L Andrews, Absalom Ezugwu, Joaquín Torres-Sospedra, Hieu-Chi Dam, Philippe Fournier-Viger, Christian Hennig, Marieke Timmerman, Matthijs J Warrens, Eva Ceulemans, Tina M Hernandez-Boussard

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Resistive switching mechanisms in BiFeO3 devices with YBCO and Ag as top electrodes by Santiago Ceballos Medina, Lorena Marín Mercado, Alexander Cardona-Rodríguez, Mario Fernando Quiñonez Penagos, César Magén, Luis Alfredo Rodríguez, Juan Gabriel Ramírez

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AlbaTraDIS: Comparative analysis of large datasets from parallel transposon mutagenesis experiments. by Andrew J Page, Sarah Bastkowski, Muhammad Yasir, A Keith Turner, Thanh Le Viet, George M Savva, Mark A Webber, Ian G Charles

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Tactile 3D-printed media interaction with the color surface features of paintings. The case of the Scream (1910?) painting by Petros Ioannis Stavroulakis, Alfonsina Pagano, Beatrice Boracchi, Panagiotis Siozos, Sophia Sotiropoulou, Sophia Sotiropoulou, Emilien Leonhardt, Vincent Sabatier, Giorgio Trumpy, Irina C. A. Sandu

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A network modelling approach to assess non-pharmaceutical disease controls in a worker population: An application to SARS-CoV-2. by Edward M Hill, Benjamin D Atkins, Matt J Keeling, Louise Dyson, Michael J Tildesley

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Structural detection of goaf based on three-dimensional ERT technology by Nan Jia

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Multilevel determinants of racial/ethnic disparities in severe maternal morbidity and mortality in the context of the COVID-19 pandemic in the USA: protocol for a concurrent triang... by Bankole Olatosi, Jiajia Zhang, Xiaoming Li, Chen Liang, Jihong Liu, Peiyin Hung, Shan Qiao, Berry A Campbell, Myriam E Torres, Neset Hikmet

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