Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes by Pei-Chen Hou, Hong-Ren Yu, Ho-Chang Kuo, Lin Wang, Li-Yan Lin, Jiunn-Ming Sheen, Te-Yao Hsu, Chia-Yu Ou, Yi-Jyun Jheng, Kuender D. Yang, Wen-Hsin Cheng

“…As with adult PMNs, adenosine could suppress the CD11b expressions of neonatal PMNs, but had no significant suppressive effect on phagocytosis. …”
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Sustainable alternative of palm wine analogue from different tiger nut milk-sugar syrup blends for local production by Adindu O. Onyeodili, Gabriel I. Okafor, Chigozie F. Okoyeuzu, Onyekachukwu Chukwuebuka Nduka, Queency N. Okechukwu, Mouandhe Imamou Hassani, Szymon Juchniewicz, Katarzyna Leicht, Charles Odilichukwu R. Okpala, Małgorzata Korzeniowska, Raquel P.F. Guiné

“…Importantly, the tiger nut milk-sugar syrup medium has been pitched with palm wine dreg (inoculum source) between fermentation time 26–30 h, and temperature 29.8°–32°C. Results: Considering all the analytical outcomes, from proximate, microbiological, physicochemical, to sensory data, the control appeared to somewhat resemble those of the experimental samples of this study. …”
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Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2<small.letters>dmepda</small.letters>H<mml:math> <mml:mrow> <mml:msub> <mml:mi></mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:math>) and 3,3-Dimethylpentanedioic acid(3<small.letters>dmepda</small.letters>H<mml:math> <mml:mrow> <mml:msub> <mml:mi></mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:math>): X-Ray Crystal Structures of [C<small.letters>u</small.letters>(3<small.letters>dmepda</small.letters>)(<small.letters>bipy</small.letters>)]<mml:math> <mml:mrow> <mml:msub> <mml:mi></mml:mi> <mml:mn>2</mml:mn> </mml:msub> <mml:mo>&#x22C5;</mml:mo><mml:msub> <mml:mrow> <mml:mtext>6H</mml:mtext> </mml:mrow> <mml:mtext>2</mml:mtext> </mml:msub> <mml:mtext>O</mml:mtext> </mml:mrow> </mml:math> and [C<small.letters>u</small.letters>(2<small.letters>dmepda</small.letters>)(<small.letters>bipy</small.letters>)(E<small.letters>t</small.letters>OH)]<mml:math> <mml:mrow> <mml:msub> <mml:mi></mml:mi> <mml:mn>2</mml:mn> </mml:msub> <mml:mo>&#x22C5;</mml:mo><mml:mn>4</mml:mn><mml:mtext>EtOH</mml:mtext><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:mtext>bipy=</mml:mtext><mml:mn>2</mml:mn><mml:mo>,</mml:mo><mml:msup> <mml:mn>2</mml:mn> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:mrow></mml:mrow> </mml:mrow> </mml:math>Bipyridine)

“…Reaction of (<bold>1</bold>) and (<bold>2</bold>) with 1,10-phenanthroline and 2,<mml:math> <mml:msup> <mml:mn>2</mml:mn> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:math>-bipyridine yielded [Cu(2dmepda)(phen)<mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mrow><mml:mrow> <mml:mrow><mml:mo>(</mml:mo> <mml:mrow><mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:mtext>O</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:mrow> <mml:mo>]</mml:mo></mml:mrow> </mml:mrow> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:math>0.5phen (<bold>3</bold>), [Cu(2dmepda)(bipy)<mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mrow><mml:mrow> <mml:mrow><mml:mo>(</mml:mo> <mml:mrow><mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:mtext>O</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:mrow> <mml:mo>]</mml:mo></mml:mrow> </mml:mrow> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:math> (<bold>4</bold>), [Cu(2dmepda)(bipy)(EtOH)]<mml:math> <mml:mrow> <mml:msub> <mml:mi></mml:mi> <mml:mn>2</mml:mn> </mml:msub> <mml:mo>&#x22C5;</mml:mo><mml:mn>2</mml:mn><mml:mtext>EtOH</mml:mtext> </mml:mrow> </mml:math> (<bold>4A</bold>), [Cu(3dmepda)(phen)<mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mrow><mml:mrow> <mml:mrow><mml:mo>(</mml:mo> <mml:mrow><mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:mtext>O</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:mrow> <mml:mo>]</mml:mo></mml:mrow> </mml:mrow> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:math> (<bold>5</bold>), and [Cu(3dmepda)(bipy)<mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mrow><mml:mrow> <mml:mrow><mml:mo>(</mml:mo> <mml:mrow><mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:mtext>O</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:mrow> <mml:mo>]</mml:mo></mml:mrow> </mml:mrow> <mml:mn>2</mml:mn> </mml:msub> <mml:mo>&#x22C5;</mml:mo> </mml:mrow> </mml:math> (<bold>6</bold>). …”
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Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures by Mian Horvath, Ruoyu Yang, Diana Cadena Castaneda, Megan Callender, Elizabeth S. Aiken, Anita Y. Voigt, Ryan Caldwell, José Fachi, Blanda Di Luccia, Zoe Scholar, Peter Yu, Andrew Salner, Marco Colonna, Karolina Palucka, Julia Oh

“…Abstract Background The microbiome regulates the respiratory epithelium’s immunomodulatory functions. To explore how the microbiome’s biodiversity affects microbe-epithelial interactions, we screened 58 phylogenetically diverse microbes for their transcriptomic effect on human primary bronchial air–liquid interface (ALI) cell cultures. …”
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Transforaminal Epiduroscopic Basivertebral Nerve Laser Ablation for Chronic Low Back Pain Associated with Modic Changes: A Preliminary Open-Label Study by Hyeun Sung Kim, Nitin Adsul, Farid Yudoyono, Byapak Paudel, Ki Joon Kim, Sung Ho Choi, Jeong Hoon Kim, Sung Kyun Chung, Jeong-Hoon Choi, Jee-Soo Jang, Il-Tae Jang, Seong-Hoon Oh

“…The preoperative VAS score of 7.79 ± 0.97 changed to 1.92 ± 1.38, postoperatively (P<0.01). …”
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The risk of repeated self-harm and suicide after emergency department presentation with self-harm in mental health presenters: a retrospective cohort study with data linkage in Queensland, AustraliaResearch in context by Richard A.F. Pellatt, David R. Painter, Jesse T. Young, Kairi Kõlves, Gerben Keijzers, Stuart A. Kinner, Ed Heffernan, Julia Crilly, Marc Broadbent, Amy Johnston, Melinda Martin-Khan, Paul Scuffham, Marianne Wallis, Ping Zhang

“…The suicide risk was 0.7% (95%CI, 0.6%–0.7%) at 12-months and 1.0% (95%CI, 0.9%–1.1%) at 24-months. …”
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Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells by Taekhee Jung, John Hwan Lee, Soonjung Park, Yong-Jin Kim, Joseph Seo, Hye-Eun Shim, Ki-Suk Kim, Hyon-Seok Jang, Hyung-Min Chung, Seong-Geun Oh, Sung-Hwan Moon, Sun-Woong Kang

“…Herein, to investigate the effect of delivery mode on osteogenic differentiation of BM-MSCs in this study, we fabricated bottom-up release and top-down release systems for culture plate delivery of BMP-2. …”
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Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb by Xinyue Wang, Ning Li, Lu Han, Ou Qiao, Xin Chen, Pengtao Wang, Lancao Zhang, Yingjie Hou, Fengjiao Bao, Herui Hao, Sania Saeed, Li Zhang, Zizheng Li, Xiaohong Duan, Shuquan Rao, Zichuan Liu, Yanhua Gong

“…A single dose of anti-Mb RabMAb injection is sufficient for emergency rescue in both homologous and heterologous RM/CS-AKI male animal models. …”
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Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts by Kelley Weinfurtner, David Tischfield, George McClung, Jennifer Crainic, John Gordan, Jing Jiao, Emma E. Furth, Wuyan Li, Erena Tuzneen Supan, Gregory J. Nadolski, Stephen J. Hunt, David E. Kaplan, Terence P.F. Gade

“…HCC tumors in humanized NOG-EXL mice exhibited greater human immune cell infiltration (57.6% vs. 30.2%, p = 0.04) with higher proportions of regulatory T cells (14.6% vs. 6.8%, p = 0.04), CD4+ PD-1 expression (84.7% vs. 32.0%, p <0.01), macrophages (1.2% vs. 0.6%, p = 0.02), and neutrophils (0.5% vs. 0.1%, p <0.0001). …”
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Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study by Ruizhi Jiajue, Shuying Liu, Yu Pei, Xuan Qi, Yan Jiang, Qiuping Wang, Wenbo Wang, Xiran Wang, Wei Huang, Xin Zheng, Zhiwei Ning, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Ling Xu, Weibo Xia

“…Further classifying the population based on the median value of OC and PTH, low OC and low PTH subgroup had the highest OR, 95% CI for diabetes (1.873, 1.287–2.737) and the lowest OR, 95% CI for hypercholesterolemia (0.472, 0.324–0.688) and for high LDL-C (0.538, 0.376–0.771). …”
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Corrigendum: Organizational readiness for change towards implementing a sepsis survivor hospital to home transition-in-care protocol by Elaine Sang, Elaine Sang, Ryan Quinn, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Jiyoun Song, Jiyoun Song, Jiyoun Song, Karen B. Hirschman, Karen B. Hirschman, Karen B. Hirschman, Sang Bin You, Sang Bin You, Katherine S. Pitcher, Katherine S. Pitcher, Nancy A. Hodgson, Nancy A. Hodgson, Nancy A. Hodgson, Patrik Garren, Melissa O'Connor, Sungho Oh, Sungho Oh, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles

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Organizational readiness for change towards implementing a sepsis survivor hospital to home transition-in-care protocol by Elaine Sang, Elaine Sang, Ryan Quinn, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Jiyoun Song, Jiyoun Song, Jiyoun Song, Karen B. Hirschman, Karen B. Hirschman, Karen B. Hirschman, Sang Bin You, Sang Bin You, Katherine S. Pitcher, Katherine S. Pitcher, Nancy A. Hodgson, Nancy A. Hodgson, Nancy A. Hodgson, Patrik Garren, Melissa O'Connor, Sungho Oh, Sungho Oh, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles

“…Post-acute care informants had a mean 4.39-unit higher ORIC score compared to hospital informants (p = 0.03).ConclusionsPost-acute care informants had higher organizational readiness of change than hospital informants, potentially attributed to differences in health policies, expertise, organizational structure, and priorities. …”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…We inserted FE-FVIII with a human elongation factor-1 alpha (EF1α) promoter into the AAVS1 locus of HA patient-derived iPSCs via CRISPR/Cas9 (D10A) nickase to ensure expression in any cell type. …”
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Retraction Note: Establishment of an Acanthamoeba keratitis mouse model confirmed by amoebic DNA amplification by Heekyoung Kang, Hae‑Jin Sohn, A‑Young Park, A‑Jeong Ham, Jeong‑Heon Lee, Young‑Hwan Oh, Yong‑Joon Chwae, Kyongmin Kim, Sun Park, Hongseok Yang, Suk‑Yul Jung, Jong‑Hyun Kim, Ho‑Joon Shin

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Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…We find that overexpression of USP14 in clock cells reduces PER protein levels without altering its mRNA levels whereas USP14 knockdown increases PER protein levels, suggesting that USP14 regulates PER post-translationally. …”
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RETRACTED ARTICLE: Establishment of an Acanthamoeba keratitis mouse model confirmed by amoebic DNA amplification by Heekyoung Kang, Hae-Jin Sohn, A-Young Park, A-Jeong Ham, Jeong-Heon Lee, Young-Hwan Oh, Yong-Joon Chwae, Kyongmin Kim, Sun Park, Hongseok Yang, Suk-Yul Jung, Jong-Hyun Kim, Ho-Joon Shin

“…AK was induced with at least 0.3 × 105 A. castellanii cells (optimal number, 5 × 104), and the infection persisted for two months. …”
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Single‐Nucleus and Spatial Transcriptome Profiling Delineates the Multicellular Ecosystem in Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy by YeXing Huang, ZeFeng Du, ZhiCheng Lai, DongSheng Wen, LiChang Huang, MinKe He, ZiChao Wu, HuiFang Li, HanYue OuYang, WenChao Wu, Anna Kan, Ming Shi

“…Specifically, intermediate exhausted CD8+ T cells expressing Granzyme‐K and PD‐1 (PD‐1+CD8+ Tex‐int) expanded following HAIC and exhibited a functionally antitumor phenotype. …”
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Impact of starting alumina powders on densification peculiarities of reactive-sintered YAG:Sm3+ ceramics by O․O․ Matvienko, I․O․ Vorona, S․V․ Parkhomenko, A․E․ Balabanov, А․Т․ Budnikov, A․D․ Tymoshenko, P․V․ Mateychenko, А․V․ Tolmachev, V․N Baumer, G․V․ Grygorova, Ya. Korol, R․P․ Yavetskiy

“…The particles within the range of 100–300 nm presented in BMA15 and AKP-50 powders, act as proppant, enabling collapse of the Y2O3 agglomerates. …”
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Real-life use of delamanid: results from the European post-authorisation safety study by N. Schönfeld, L. Barkane, I. Davoliene, M. Danilovits, S. Miliauskas, F. Ader, O.M. Kon, C. Lange, A. Duvignaud, M. Heiss-Neumann, N. Hittel, N. Lazarević, I. Knebel, A. Martin, B. Eschenbach, E. van Heumen, V. George

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Experimental study and gyrokinetic simulations of isotope effects on core heat transport in JET tokamak deuterium and tritium plasmas by D. Brioschi, P. Mantica, A. Mariani, N. Bonanomi, E. Delabie, J. Garcia, N. Hawkes, I. Jepu, D. Keeling, E. Lerche, E. Litherland-Smith, C.F. Maggi, S. Menmuir, G. Szepesi, D. Taylor, D. Van Eester, JET Contributors

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