Innovative CDR grafting and computational methods for PD-1 specific nanobody design by Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan

“…IntroductionThe development of nanobodies targeting Programmed Cell Death Protein-1 (PD-1) offers a promising approach in cancer immunotherapy. …”
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Traveling Wave Vibration and Experimental Analysis of the Diaphragm Disc Sun-gear Shaft of High-speed Planetary Gearbox by Wang Xiaopeng, Liu Shijun

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Pesticide Toxicity Profile: Organophosphate Pesticides by Frederick M. Fishel

“…This document is PI-50, one of a series of the Pesticide Information Office, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. …”
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The effect of continuous positive airway pressure (CPAP) application on airway problems in pediatric patients with subglottic stenosis who undergo balloon dilatation by Zeliha Tuncel, Şenay Göksu, Özlem Deligöz, Kemal Tolga Saracoglu, Abdulatif Albasha, Bushra M. Abdallah, Ayten Saracoglu

“…Abstract Background Subglottic stenosis is a significant clinical challenge in pediatric anesthesia, often necessitating interventions that can lead to various postoperative complications. …”
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The effects of disordered edge and vanishing friction in microscale structural superlubric graphite contact by Hengqian Hu, Jin Wang, Kaiwen Tian, Quanshui Zheng, Ming Ma

“…Abstract Structural superlubricity (SSL), a state of ultralow friction and no wear between two solid surfaces in contact, offers a fundamental solution for reducing friction and wear. …”
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Unveiling the link between NADPH oxidase 2 activation and mitochondrial superoxide formation in leukemic cell killing induced by arsenic trioxide by Andrea Spina, Andrea Guidarelli, Gloria Buffi, Mara Fiorani, Orazio Cantoni

“…These mechanistic insights provide a rationale for the disparate responses of APL and AML cells to ATO, offering potential avenues for the development of therapeutic intervention tailored to specific leukemia subtypes.…”
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Liangxue Tongyu Prescription exerts neuroprotection by regulating the microbiota-gut-brain axis of rats with acute intracerebral hemorrhage by Yingying Sun, Dandan Zhou, Anlan Liu, Yu Zhou, Yang Zhao, Yuan Yuan, Weifeng Guo, Jianxiang Li

“…In summary, this research provides evidence suggesting that LTP’s influence on AICH may involve modulation of the microbiota-gut-brain axis, offering a potential scientific rationale for its therapeutic efficacy in improving outcomes of AICH.…”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…Introduction: Ultra-high-field magnetic resonance (MR) systems (7 T and 9.4 T) offer the ability to probe human brain metabolism with enhanced precision. …”
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Nootkatone Derivative Nootkatone-(E)-2-iodobenzoyl hydrazone Promotes Megakaryocytic Differentiation in Erythroleukemia by Targeting JAK2 and Enhancing JAK2/STAT3 and PKCδ/MAPK Cro... by Yang Pan, Feng Xiao, Chaolan Pan, Hui Song, Peng Zhao, Meijun Chen, Liejun Huang, Jue Yang, Xiaojiang Hao

“…In conclusion, N2 shows great promise as a differentiation therapy for erythroleukemia, offering a novel approach by targeting JAK2-mediated signaling pathways to induce megakaryocytic differentiation.…”
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Framework Using Multicriteria Analysis for Evaluating the Risk of Musculoskeletal Disorders by Karolis Senvaitis, Aušra Adomavičienė, Kristina Daunoravičienė

“…., it is the proof of concept that offers a new approach to assessing MSD risk at work using motion tracking data in combination with statistics. …”
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Bandwagons and Quiet Corners in Regulatory Governance by Caelesta Braun, Adrià Albareda, Bert Fraussen, Moritz Müller

“…Stakeholder engagement is often considered an essential component of regulatory policymaking and governance. …”
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Phase Transition, Magnetocaloric Effect, and Critical Behavior of Room Temperature Magnetic Refrigerant Material Mn5Ge2.7Zn0.3 by XU Tongjie, LIU Zhenhua, JIN Huaiyu, LIU Jie, JIANG Xiuli, LI Zhe, LIU Yongsheng

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Time pressure in surgical teams, a help or a hindrance to patient safety? by Annet van Harten, Theo J.H. Niessen, Jur J. Koksma, Hein G. Gooszen, Tineke A. Abma

“…Creating shared Situational Awareness (SA) helped prevent or mitigate time pressure, though it was not a consistently embedded routine. New routines were often compromised under time pressure, while established habits showed resilience to time constraints. …”
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Achieving precipitation strengthening and retained austenite thinning via strain induced precipitation to improve fatigue wear resistance of bainitic steel by Sida Chen, Zulai Li, Quan Shan

“…A Solid Solution-Forging-Austempering (SFA) process was presented aimed at breaking the trade-off between fatigue performance and hardness of Ti-containing wear-resistant bainitic steel, and the impressive strength-ductility balance of 26.16GPa% was achieved. …”
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Advanced perspective on heavily phosphorus-doped diamond layers via optical emission spectroscopy by Kil-dong Sung, Stefan Andrei Irimiciuc, Michal Novotný, Zdeněk Weiss, Pavel Hubík, Jaromír Kopeček, Martin Vondráček, Vincent Mortet

“…This novel growth approach offers valuable insights for optimizing PDD synthesis, enabling more efficient phosphorus incorporation for electronic, electrochemical, and quantum applications.…”
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２０１４—２０１６年广州海域咸潮入侵状况浅析 by 马荣华, 黄云峰, 杨巧玲, 范儒彬

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Several Problems in the Deposition Stage of the Water Resource Comprehensive Planning by CHEN Bin

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Elevating Student Voice and Levelling Traditional Power Hierarchies Through Open Textbook Co-Creation: What Do Students Say? by Bianca Masuku, Glenda Cox, Michelle Willmers

“…Collaboration with students offers the potential for creating a more inclusive higher education environment, and open textbook development initiatives can be a vehicle for change. …”
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美托洛尔对心力衰竭大鼠心脏β3肾上腺素能受体 mRNA 表达水平的影响

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Occupational burn-out, fatigue and stress in professional rescuers: a cross-sectional study in Kazakhstan by Denis Vinnikov, Zhangir Tulekov, Gulnara Kapanova, Zhanna Romanova, Ilya Krugovykh, Sundetgali Kalmakhanov, Aliya Ualiyeva, Kaini Baigonova, Damet Ongarbaeva

“…Objectives To find predictors of burn-out in a cohort of rescuers.Design Cross-sectional study.Setting Republican Rescue Squad (N=105) and Republican Mudslide Rescue Service under the Ministry of Emergency Situations (N=480) in Almaty, Kazakhstan.Participants In total, we included 268 (80% men, median age 38 (IQR 22) years) rescuers from both organisations.Primary and secondary outcome measures We offered a questionnaire to rescuers, which included Maslach Burnout Inventory, quantifying emotional exhaustion (EX), cynicism (CY) and professional efficacy (PE) along with fatigue, stress and health-related quality of life (HRQL) tools.Results Lower scores of HRQL (Physical Component Score (PCS) beta −0.04 (95% CI −0.06 to −0.02); Mental Component Score beta −0.03 (95% CI −0.05 to −0.01)), higher fatigue (Fatigue Severity Scale (FSS) score beta 0.03 (95% CI 0.03 to 0.04)) and stress (Perceived Stress Score-10 beta 0.04 (95% CI 0.02 to 0.06)) independently predicted greater EX. …”
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