SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency by Brendan Connolly, Cleo Isaacs, Lei Cheng, Kirtika H. Asrani, Romesh R. Subramanian

“…Currently there is no specific treatment for liver disease associated with AAT deficiency. AAT lung disease is often treated with one of several serum protein replacement products; however, long-term studies of the effectiveness of SerpinA1 replacement therapy are not available, and it does not reduce liver damage in AAT deficiency. mRNA therapy could potentially target both the liver and lungs of AAT deficient patients. …”
Get full text

Predictors of recurrence of ventricular tachycardia and the effectiveness of endocardial ablation at the patients with sudden cardiac death and history of myocardial infarction by O. M. Grytsay, Ya. V. Skybchyk

“…Recurrent VT was recorded more often in patients with partial intraoperative effect than in those with complete effect (26.7 % versus 5.9 % of patients, p < 0.05). …”
Get full text

STUDENT ENGAGEMENT, CHALLENGES AND COPING MECHANISMS IN HIGH SCHOOL ONLINE DISTANCE LEARNING DURING COVID-19 PANDEMIC by Aurielle Lisa Z. Maypa, Dave E. Marcial, Jade O. Montemayor

“…It shows that attendance and quizzes are what students often visit. Quiz and Wiki are where students spend their time. …”
Get full text

Sustainable Battery Biomaterials by Frank N. Crespilho, Carlos M. Costa, Senentxu Lanceros‐Méndez

“…Despite challenges such as scalability and long‐term stability, biomaterials hold the key to reshaping the landscape of energy storage technologies, offering a path toward a greener, safer, and more efficient future.…”
Get full text

Integration of NMR and NMRC in the Investigation of the Pore Size Distribution of Tight Sandstone Reservoirs: A Case Study in the Upper Paleozoic of Dongpu Depression by Ning Zhu, Suping Yao, Xuejun Wang, Binfeng Xia, Yunxian Zhang

“…An integration analysis comprising X-ray diffraction (XRD), three beams of argon ion (TIB) polishing approach, scanning electron microscopy (SEM), high-pressure mercury intrusion (HPMI), nuclear magnetic resonance (NMR), and nuclear magnetic resonance cryoporometry (NMRC) was applied to determine the pore structure of the tight sandstone reservoirs in the Upper Paleozoic of Dongpu Depression as well as their relationship with the physical properties of the reservoirs. NMRC offered the possibility to obtain the nanoscale (4-1400 nm) pore structure of the reservoirs directly and accurately. …”
Get full text

Designing a cyber insurance implementation model using foundational data theory by Behzad Esmaeilifar, manouchehr Ansari

“…With the expansion of the Internet in the business of organizations, a space called cyber was created, which boosted business activities and interactions (Swiss Re, 2014; Chief Risk Officers Forum, 2014). On the other hand, the expansion of virtual spaces increased the concern of the managers of Internet companies. …”
Get full text

Chemical catalyst manipulating cancer epigenome and transcription by Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo R. Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, Atsushi Kaneda, Shigehiro A. Kawashima, Motomu Kanai

“…Therefore, this histone acetylation catalyst provides a unique tool for elucidating the time-resolved consequences of histone PTMs and may offer a modality for cancer chemotherapy.…”
Get full text

A Graphical Approach for Hybrid Simulation of 3D Diffusion Bio-Models via Coloured Hybrid Petri Nets by Amr Ismail, Mostafa Herajy, Elsayed Atlam, Monika Heiner

“…Coloured Hybrid Petri Nets (HPNC) are a high-level representation of classical Petri nets that offer hybrid as well as spatial modelling of biological systems. …”
Get full text

A Series on Diseases in the Florida Vegetable Garden: TOMATO by Ken Pernezny, Tim Momol

“…The very minute size of these disease-causing pathogens accounts for the mystery that often surrounds their presence and impact in the garden. …”
Get full text

TRANSFORMATION OF POLITICAL DISCOURSE IN THE CONTEXT OF MEDIATIZATION: CHALLENGES FOR SOCIAL ORDER IN UKRAINE by Руслан ВЕЛИЧКОВСЬКИЙ

“…The study employs a comprehensive application of systemic approach, institutional, comparative and historical methods, as well as content analysis of official social media pages of state institutions. …”
Get full text

Open Government, Social Media and Western Balkan Countries by Mirela Mabić, Dražena Gašpar

“…The authors have analysed the official profiles of the respective countries on social media and calculated the Facebook Assessment Index (FAI) for WBCs, and Croatia and Slovenia as a benchmark. …”
Get full text

Covid-19 vaccine acceptance and hesitancy among medical students of Faisalabad by Mohi Ud Din, Umer Shahid, Abdul Qudoos, Roman Ahmed, Muazzama Sohail, Saima Javed

“…Significant relationship (p = < 0.05) was found in all factors related to ‘concerns regarding Covid-19 vaccines and trust of official information’; in all except one in factors related to ‘awareness and overall attitude regarding vaccine acceptance’ and in all except one in factors related to ‘perception of vulnerability to COVID-19 and attitude regarding usefulness of vaccine for community’. …”
Get full text

Bees and Fire: How does Fire in Longleaf Pine Savannas Affect Bee Communities? by Nicole Mitchell, Sarah Anderson Weaver, Raelene M. Crandall

“… Bees are efficient pollinators known to be key components of healthy forests. Thus, bees are often used as indicators of community response to restoration and disturbances, including fire. …”
Get full text

Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

“…Abstract Bladder cancer often recurs, necessitating innovative treatments to reduce recurrence. …”
Get full text

A Deep Learning Approach for Mental Fatigue State Assessment by Jiaxing Fan, Lin Dong, Gang Sun, Zhize Zhou

“…In comparison to traditional methods, such as Support Vector Machines (SVMs) and Random Forests (RFs), as well as other deep learning methods, including Convolutional Neural Networks (CNNs) and Long Short-Term Memory (LSTM), the proposed approach demonstrates significantly improved experimental outcomes. Overall, this study offers a promising solution for accurately recognizing fatigue through the analysis of physiological signals, with potential applications in sports and physical fitness training contexts.…”
Get full text

Worker Protection Standard: Personal Protective Equipment (PPE) by Frederick M. Fishel

“…This document is PI-119, one of a series of the Pesticide Information Office, UF/IFAS Extension. Original publication date April 2006. …”
Get full text

Production of biogas from co-substrates using cow dung, pig dung, and vegetable waste: A case study in Cambodia by Sokna San, Seyla Heng, Vanna Torn, Chivon Choeung, Horchhong Cheng, Seiha Hun, Chanmoly Or

“…Organic waste, including cow dung (CD), pig dung (PD), and vegetable waste (VW), offers a promising source for biogas production and clean and renewable energy. …”
Get full text

Questions and Answers about the National Flood Insurance Program by Thomas Ruppert

“… Established by Congress in 1968 because the private market stopped offering flood insurance, the NFIP provides federally backed flood insurance to property owners in participating communities. …”
Get full text

Quais et ouvrages portuaires romains de Rouen/Rotomagus (Seine-Maritime) by Marie-Clotilde Lequoy

“…These posts were spaced about 2 m apart and were planted very deeply, as is demonstrated by their height, often measuring over 2 m. The elevation of this portion of the dock is very poorly preserved, but medium sized limestone blocks, assembled at the base of the wooden pieces to form a solid external facing, remain visible. …”
Get full text

ERTELENMİŞ VERGİ ETKİLERİNİN İZLENMESİNDE ALTERNATİF YAKLAŞIMLAR: DURAN VARLIĞIN EK TAAHHÜTTE BULUNULARAK İKTİSABI ÖRNEK UYGULAMASI by Ergün Küçük

Get full text