Things are not always what they seem by Massimo Barakat, Stefania Sartoni Galloni, Nilde Di Paolo

“…A 80-year-old woman, heavy ex-smoker (60 pack-years) affected by chronic obstructive pulmonary disease (COPD), presented to the emergency department with worsening dyspnea in the previous three hours, metabolic alkalosis (pH 7.55, pO2 33 mmHg, pCO2 34 mmHg, HCO3 30 mmol/L, lactates 3.3 mmol/L) and persistent epigastric pain for one week. …”
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Screening of COPD patients using the COPD diagnostic questionnaire and a portable spirometer in primary healthcare institutions: a cross-sectional, diagnostic study by Feng Chen, Qingrong Nie, Xuefeng Han, Chunjuan Li, Qimeng Liu, Feifei Xu, Li Zhang, Le Qiao, Maoxin Li, Ying Zhang, Haiyan Wang

“…Abstract Background Portable spirometers and chronic obstructive pulmonary disease (COPD) diagnostic questionnaires are commonly used for screening patients with COPD in primary healthcare institutions, but their accuracy is often inadequate. …”
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Cognitive disorders in patients with atrial fibrillation by O.A. Yepanchintseva, A.S. Solonovych, O.S. Solonovych

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Using 21st century diagnostics to overcome barriers for lung function testing in primary care: it is time to consider oscillometry by Janwillem W. H. Kocks, Grietje H. Prins, Samuel Bardsley, Deesha Ghorpade, Sundeep Salvi

“…Obstructive airways diseases, including asthma and COPD as the most commonly encountered respiratory diseases in primary care, are both diagnosed by lung function testing using spirometry as the gold standard. …”
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Alpha-1 Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Clinical Practice Guideline by DD Marciniuk, P Hernandez, M Balter, J Bourbeau, KR Chapman, GT Ford, JL Lauzon, F Maltais, DE O’Donnell, D Goodridge, C Strange, AJ Cave, K Curren, S Muthuri, Canadian Thoracic Society COPD Clinical Assembly Alpha-1 Antitrypsin Deficiency Expert Working Group

“…Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 of the North American population. …”
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Prediction of clinical deterioration within one year in chronic obstructive pulmonary disease using the systemic coagulation-inflammation index: a retrospective study employing mul... by Ling Hou, Ming Min, Rui Hou, Wei Tan, Minghua Zhang, Qianfei Liu

“…Background Inflammatory response and the coagulation system are pivotal in the pathogenesis of clinical deterioration in chronic obstructive pulmonary disease (COPD), prompting us to hypothesize that the systemic coagulation-inflammation (SCI) index is associated with clinical deterioration in COPD. …”
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Intestinal current measurement and nasal potential difference to make a diagnosis of cases with inconclusive CFTR genetics and sweat test by Tobias Welte, Rebecca Minso, Angela Schulz, Christian Dopfer, Nadine Alfeis, Andrea van Barneveld, Lena Makartian-Gyulumyan, Gesine Hansen, Sibylle Junge, Carsten Müller, Felix C C Ringshausen, Annette Sauer-Heilborn, Frauke Stanke, Cornelia Stolpe, Stephanie Tamm, Anna-Maria Dittrich, Burkhard Tümmler

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Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma by Novković Dobrivoje, Škuletić Vesna, Vulin Aleksandra, Cvetković Gordana

“…A statistically significant relation between the amount of histamine needed to induce bronchial obstruction and the results of the exercise stress test (p < 0.01) was also observed after the testing. …”
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Does Pre-Existing Chronic Obstructive Pulmonary Disease Increase the Risk of Checkpoint Inhibitor Pneumonitis in Advanced/Metastatic Non-Small Cell Lung Cancer Treated with Immune... by David Spillane, Carmela Pepe, Goulnar Kasymjanova, Diane Cruiziat, Sara Cohen, Jeremy Naimer, Jason Agulnik

“…We explored associations between risk factors and CIP using the Mann–Whitney U test or Fisher’s exact test. Analysis of prognostic factors was performed using a logistic regression model. …”
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Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population by Ankita Mitra, Sangeetha Vishweswaraiah, Tania Ahalya Thimraj, Mahendra Maheswarappa, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Jayaraj Biligere Siddaiah, Koustav Ganguly, Mahesh Padukudru Anand

“…Background. Chronic obstructive pulmonary disease (COPD) is a devastating condition with limited pharmacotherapeutic options and exceptionally high public-health burden globally as well as in India. …”
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Diagnostic Yield of Comprehensive Coronary Function Testing in Patients with Angina and Unobstructed Coronary Arteries: Endotype Characterisation and Clinical Implications by Johanna McChord, Astrid Hubert, Raffi Bekeredjian, Peter Ong, Andreas Seitz

“…Previous studies have shown a high prevalence of CFD in ANOCA cases, but often lacked comprehensive coronary functional testing (CFT), which ideally includes coronary spasm provocation testing and CMD assessment. …”
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POSTINFECTIOUS OBLITERANS BRONCHIOLITIS IN CHILDREN by E. V. Boitsova, D. Yu. Ovsyannikov

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To evaluate the minimum number of renal scans required to follow pediatric patient postpyeloplasty by Shashwat Verma, Payal Saxena, Sanjeet Singh, Sukhanshi Khandpur, Satyawati Deswal, Narvesh Kumar, Anjana Singh

“…Statistical analysis was performed using the Friedman ANOVA and Wilcoxon signed-ranks test as a post hoc test with Bonferroni correction and Kruskal–Wallis test with Mann–Whitney U-test as a post hoc test with Bonferroni correction. …”
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A 47-Year-old Asian female with tracheobronchial space-occupying lesions caused by chronic lymphocytic leukemia by Ji-Wei Zhu, Guo-Hong Cao, Fu-Quan Gao, Zhang Cao, Yan Feng, Hong-Kun Sun, Lu Liu, Pan Xu, Chang-Jun Lv, Lei Pan

“…Pulmonary function results suggestive of severe obstructive ventilatory dysfunction. Bronchoscopic findings showed the presence of multiple nodular lesions in the patient’s trachea and left and right main bronchi. …”
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A prospective cohort study assessing the clinical utility of the Cottle maneuver in nasal septal surgery by James P. Bonaparte, Ross Campbell

“…The Cottle maneuver is one of the most common methods to diagnose NVC; however, no study has assessed the efficacy of this physical exam finding. This study tests the hypothesis that patients with nasal obstruction due to a septal deviation with a negative pre-operative Cottle maneuver will demonstrate a greater improvement in their Nasal Obstruction Symptom Evaluation (NOSE) score, compared to patients who demonstrate a positive pre-operative Cottle maneuver, when assessed at 12 months following a septoplasty with turbinate diathermy. …”
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Septic shock caused by postpartum acute pancreatitis, a case report and literature review by Changiz Delavari, Delaram J. Ghadimi, Maryam Taheri, Harsh Kumar, Pouya Ebrahimi, Amir Nasrollahizadeh, Sepide Javankiani

“…Diagnostic imaging and laboratory tests confirmed the presence of biliary obstruction due to gallstones and biliary sludge, leading to acute pancreatitis. …”
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2020 Clinical practice guidelines for Hypertrophic cardiomyopathy by S. A. Gabrusenko, A. Ya. Gudkova, N. A. Koziolova, S. A. Alexandrova, M. I. Berseneva, M. L. Gordeev, S. L. Dzemeshkevich, E. V. Zaklyazminskaya, O. B. Irtyuga, V. Yu. Kaplunova, A. A. Kostareva, A. N. Krutikov, D. A. Malenkov, T. N. Novikova, M. A. Saidova, M. K. Sanakoev, O. V. Stukalova

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The Diagnostic and prognostic value of CXCL12 (SDF-1α) level in Mycobacterium tuberculosis infection and disease by Ilkay Koca Kalkan, Ayse Gozu, Ebru Tansel, Serife Nilgun Kalac, Belgin Samurkasoglu, Hulya Simsek

“…Conclusions: Our study demonstrates that CXCL12 may be a representative of active pulmonary infection regardless of the cause but correlated with the severity of the disease; enabling this test to be used as a prognostic factor rather than a diagnostic test for aTB. …”
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Echocardiographic Evidence of Left Ventricular Dysfunction in COPD: Relationship with Disease Severity by Rounak Bhattacharjee, Tanushree Deb, Prosenjit Roy, Prithwiraj Bhattacharjee, Israel Maldonado Rosas, Shubhadeep Roychoudhury

“…Statistical analysis utilized Student’s <i>t</i>-test, chi-square test, and multivariable logistic regression with 1000 bootstrapping iterations, considering <i>p</i> < 0.05 as significant differences. …”
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Effect of traditional Chinese medicine combined with conventional Western medicine for patients with severe/very severe chronic obstructive pulmonary disease: a multi-center, rando... by Jiansheng Li, Yang Xie, Minghang Wang, Suyun Li, Xuefeng Yu, Nianzhi Zhang, Zhengang Zhu, Wei Zhang, Jihong Feng, Zikai Sun, Lin Lin, Zhijia Sun, Hailong Zhang, Xueqing Yu

“…Acute exacerbations (AEs), lung function, dyspnea scores, the 6-min walking test (6MWT), and the COPD assessment test (CAT) were assessed over 12 months of treatment, with an additional 12 months of follow-up. …”
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