Potential active ingredients and mechanisms of Shufeitie ointment in the treatment of chronic obstructive pulmonary disease by integrating transdermal chemistry and network pharmac... by Jianing Sun, Jianing Sun, Di Zhang, Panpan Wang, Panpan Wang, Panpan Wang, Panpan Wang, Junhan Shi, Junhan Shi, Junhan Shi, Junhan Shi, Tan Xue, Tan Xue, Panpan Zhang, Panpan Zhang, Qi Wang, Qi Wang, Xinjing Gui, Xinjing Gui, Xinjing Gui, Xinjing Gui, Suyun Li, Suyun Li, Jiansheng Li, Jiansheng Li, Xuelin Li, Xuelin Li, Xuelin Li, Xuelin Li, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu

“…PurposeThis study aims to identify the transdermal penetration components of Shufeitie ointment (SFTOT) and investigate the potential active components and mechanisms through which SFTOT exerts its effects on Chronic Obstructive Pulmonary Disease (COPD).MethodsAn in vitro permeation test (IVPT) of SFTOT was conducted using a modified Franz diffusion cell method. …”
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Comorbidity patterns and associated characteristics in children with obstructive sleep apnoea–hypopnoea syndrome in Shanghai, China: a cross-sectional study by Xiang Gao, Chen Chen, Yan Yang, Liang Zhou, Jianwei Shi, Dehua Yu, Hua Jin, Zhaoxin Wang, Jiaoling Huang, Ning Chen, Ziyun Li, Huining Zhou, Tianchun Hou

“…Objectives Paediatric obstructive sleep apnoea–hypopnoea syndrome (OSAHS), which usually cooccurs with various diseases, significantly impacts health and social resources. …”
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Screening and Management of Obstructive Sleep Apnea and Daytime Sleepiness Among Professional Drivers in Tunisia: Protocol for a Machine Learning Study by Sameh Msaad, Nesrine Kammoun, Rahma Gargouri, Rim Khemakhem, Amira Triki, Narjes Abid, Sonia Fehri, Kaouthar Kallel, Rim Kammoun, Leila Douik EL Gharbi, Sonia MaalejBellaj, Heni Bouhamed, Ahmed Abdelghani, Chiraz Aichaouia, Mohamed Turki, Samy Kammoun

“… BackgroundObstructive sleep apnea (OSA) is highly prevalent among professional drivers; however, its true burden in this population remains underexplored and likely underdiagnosed. …”
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Effects of Wenfei Guyuan umbilical moxibustion on patients with stable chronic obstructive pulmonary disease: A multicenter randomized controlled trial by Qionghua Xiao, Yuanyuan Meng, Gaoming Wang, Minghang Wang, Yong Meng, Miao Zhou

“…Background: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease. …”
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Smartphone delivered social media-based rehabilitation for people with COPD in Thar Desert, India: A feasibility study by Shrikant Dixit, S Suseendar, Neeti Rustagi, Naveen Dutt

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Intraoral appliance treatment modulates inflammatory markers and oxidative damage in elderly with sleep apnea by Alessandra Peres, João Carlos Fraga da Rosa, Joane Severo Ribeiro, Sofia de Lima Silva, Cristiane Bündchen, Gilson Pires Dornelles, Vania Fontanella

“…Abstract Obstructive sleep apnea (OSA) causes intermittent hypoxia, increased production of reactive oxygen species, and inflammation, which may elevate morbidity and mortality from cardiovascular disease. …”
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Association between Ventilation Disorder and Masticatory Dysfunction in the Korean Adult Population: A Cross-Sectional Study Using Data from the 2019 Korea National Health and Nutr... by So-Yeong Kim, Sun-A Lim

“…Additionally, of the 4119 adults aged ≥40 years who underwent dual lung function tests, those who did not respond to key independent confounding variables were excluded. …”
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Comparative efficacy of leukotriene modifier and inhaled corticosteroids in the complex treatment of steroid-naive patients with bronchial asthma combined with chronic obstructive... by Yu. I. Feshchenko, L. O. Yashyna, V. I. Ihnatieva, M. O. Polianska, S. H. Opimakh, I. V. Zvol, S. M. Moskalenko, H. L. Humeniuk, N. A. Vlasova, L. A. Halai

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Dynamics of respiratory system clinicofunctional scores among patients with COPD in the complex rehabilitation at the Health resort Belokurikha by K. V. Komissarov, Ye. V. Viktorova, G. V. Trubnikov

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Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity by Liu Zhang, Ya Ru Yan, Shi Qi Li, Ying Ni Lin, Yi Wang, Yu Qing Wang, Ning Li, Fang Ying Lu, Xian Wen Sun, Li Yue Zhang, Jian Ping Zhou, Yong Jie Ding, Qing Yun Li

“…ABSTRACT Background Obstructive sleep apnoea (OSA) occurs frequently among individuals with obesity, which is attributed to upper airway muscle dysfunction. …”
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Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease by R. A. Müller, F. Klimeš, A. Voskrebenzev, L. Behrendt, T. F. Kaireit, M. Wernz, M. Zubke, A. L. Kern, M. R. Prince, W. Shen, C. B. Cooper, R. G. Barr, J. M. Hohlfeld, J. Vogel-Claussen

“…Hyperinflation in chronic obstructive pulmonary disease (COPD) patients worsens on exertion/exercise when breathing frequency increases. …”
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Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis by Shen Q, Huang JB, Zhu M, Ji DJ, Huang SJ, Li J

“…This study can provide a basis for further research on the role of cuproptosis in COPD.Keywords: chronic obstructive pulmonary disease, cuproptosis, gene expression…”
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A Machine Learning Approach to the Interpretation of Cardiopulmonary Exercise Tests: Development and Validation by Or Inbar, Omri Inbar, Ronen Reuveny, Michael J. Segel, Hayit Greenspan, Mickey Scheinowitz

“…At present, there is no consensus on the best strategy for interpreting the cardiopulmonary exercise test’s (CPET) results. This study is aimed at assessing the potential of using computer-aided algorithms to evaluate CPET data for identifying chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD). …”
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Patient Insights on Integrating Sleep Apnea Testing into Routine Stroke and TIA Care by Nicholas A. Rattray PhD, K. Maya Story PhD, Laura Burrone BS, Ali E. Sexson MBA, Brian B. Koo MD, Dawn M. Bravata MD, Anthony J. Perkins MS, Laura Myers PhD, Joanne K. Daggy PhD, Stanley E. Taylor MA, Barry G. Fields MD, Ken M. Kunisaki MD, Joseph Daley MD, PhD, Santiago Palacio MD, Lisa D. Hermann MD, Jason J. Sico MD

“…Patients perceived OSA testing as an integrated component of stroke/TIA care and reported few barriers to OSA testing. …”
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Routine Pulmonary Function Test Can Estimate the Extent of Tuberculous Destroyed Lung by Eun Joo Lee, Sang Yeub Lee, Kwang Ho In, Se Hwa Yoo, Eun Jeong Choi, Yu Whan Oh, Sanghoon Park

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A comparison of magnetocardiography with noninvasive cardiac testing in the evaluation of patients with chest pain by Sharon E. Mace, Christopher Baugh, Margarita E. Pena, Robert Takla

“…Problems with NCI include limited availability, lengthy test delays, test duration, radiation exposure, adverse events, NPO (holding medications, caffeine/food/liquids/tobacco), exercise requirement, limitations for certain populations, inability to assess for ischemia with no obstructive coronary artery disease (INOCA), contrast/medication/needlestick-intravenous (IV) line needed.Magnetocardiography (MCG) advantages include faster, easier test administration, radiation avoidance, less resource utilization, safer, no needlestick/IV requirement, no NPO for caffeine/food/liquids/tobacco, and no holding medications. …”
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Does bladder outflow obstruction obfuscate the traditional clinical factors that are used to assess the risk of prostate cancer at rapid‐access diagnostic clinics? by Thomas Philip Cahill, Samuel Joseph Withey, Steve Hazell, Declan Cahill, Netty Kinsella

“…Materials and Methods We retrospectively analysed prospectively collected data from 307 suspected prostate cancer patients who underwent diagnostic biopsy from 2019 to 2023 at a single, high‐volume, specialist cancer centre. Uroflowmetry testing generated two cohorts: patients with bladder outflow obstruction and non‐obstructed patients. …”
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VNN1 promoted the secretion of transforming growth factor beta of renal tubular cell and aggravated renal fibrosis in obstructive renal injury by Wang Xiao-yue, Chen Min-jia, Feng Lei, Wang Li-ming, Luo Jia, Chen Jia, Chen Ke-hong, Wang Ling

“…Objective To elucidate the role and related mechanisms of VNN1 in the process of renal interstitial fibrosis after obstructive renal injury.Methods Balb/c wild-type and VNN1 gene knockout male mice were selected for sham operation and operation groups respectively.Urine and kidney tissue specimens from obstructed renal pelvis were collected at Day 0 and 14 post-operation and the urinary level of transforming growth factor beta（TGF-β）was detected.The expression level of VNN1 in renal tissue was measured by immunohistochemistry.Renal tissue is improved by periodic acid-Schiff（PAS）stain to determine the severity of renalinjury.Masson stain and immunohistochemistry were utilized for detecting the expression of α-smooth muscle actin（α-SMA）in renal tissue to determine the severity of renal tissue fibrosis.Primary renal tubular epithelial cells were harvested from wild-type and VNN1 knockout mice, propagated to the second generation and stimulated with angiotensin forsimulate anobstructive kidney injury model in vivo.Both cells and supernatant were collected for detecting the level of VNN1 protein and supernatant TGF-β level.Results At Day 14 after obstructive renal injury, PAS stain in operation group hinted at overt renal tissue damageand immunohistochemistry indicated a significant up-regulation of VNN1 in renal tissue.Masson stain of renaltissue was further improved and the level of α-SMA was detected by immunohistochemistry.The level of interstitial fibrosis worsened morein wild-type mice than that of VNN1 knockout counterparts while the level of α-SMA spiked greatly.Further testing the urinary level of TGF-β on the obstructive side indicated that the urinary level of TGF-β on the obstructive side of VNN1 gene knockout mice declined obviously.It was further confirmed through cell experiments that after a stimulation of angiotensin, there was a marked up-regulation of VNN1 protein in wild-type murine renal tubular cells and the supernatant level of TGF-β was significantly higher in wild-type murine renal tubular cells than that of VNN1 gene knockout counterparts.Conclusion VNN1 can promote the secretion of TGF-β and aggravate fibrosis in renal tubular epithelial cells after obstructive injury.…”
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Analysis of GNSS-RTK Monitoring Background Noise Characteristics Based on Stability Tests by Wencong Qi, Feilong Li, Lina Yu, Lilong Fan, Kai Zhang

“…This study investigates the monitoring accuracy and spectral characteristics of GNSS-RTK based on stability tests under different environments related to reflection and obstruction conditions (i.e., concrete, grass, an obstructed balcony, and a water area). …”
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Evaluation of gastric emptying by means of scintigra-phy using different test meals by Viviana Montoya, Viviane Parisitto, Mateus Fontes, Luiz Gonzaga, Luciene das Graças, Arnaldo Prata

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