Calcific aortic stenosis: known facts and promising studies by N. Yu. Karpova, M. A. Rashid, T. V. Kazakova, N. S. Chipigina, A. E. Zudilina

“…A change in the nature of systolic murmur, underestimation of symptoms by doctors and patients themselves, the ambiguity of echocardiography data lead to late diagnosis of the disease and untimely surgical treatment. …”
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Acute Abdomen in Pediatric Patients Admitted to the Pediatric Emergency Department by Yu-Ching Tseng, Ming-Sheng Lee, Yu-Jun Chang, Han-Ping Wu

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Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation by Carla Luciana Padilla Franzotti, Carla Luciana Padilla Franzotti, Nicolas Palopoli, Nicolas Palopoli, Juliana Palma, Juliana Palma, Gustavo Pierdominici-Sottile, Gustavo Pierdominici-Sottile

“…As a consequence of this change, the C-terminal segment of LTSV40 obstructs access to the AB-cleft of pRb, the binding site for E2F.DiscussionOur findings suggest that the inactivation mechanism of pRb by LTSV40, as unveiled by MD simulations, could represent a broader strategy employed by other viral oncoproteins containing similar LXCXE motifs and adjacent disordered regions. …”
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AHG-YOLO: multi-category detection for occluded pear fruits in complex orchard scenes by Na Ma, Na Ma, Na Ma, Yile Sun, Yile Sun, Chenfei Li, Chenfei Li, Zonglin Liu, Zonglin Liu, Haiyan Song, Haiyan Song

“…Finally, the boundary box loss function is changed to Generalized Intersection over Union (GIoU), improving the model’s convergence speed and further enhancing detection performance.ResultsExperimental results show that the AHG-YOLO model achieves 93.5% (FCC), 95.3% (NO), and 93.4% (OBL) in AP, with an mAP@0.5 of 94.1% across all categories. …”
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Soil water, salt, and microplastics interact during migration: Performance and mechanism by Xuguang Xing, Haoxuan Feng, Sihan Jiao, Tianjiao Xia, Dongwei Li, Fengyue Zhao, Weihua Wang

“…Notably, MPs hindered the leaching of Na+ and SO42-, and a larger obstruction was observed for Na+ compared to SO42- leaching. …”
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Preliminary results in tracheal replacement using stented aortic matrices for primary extensive tracheal cancerCentral MessagePerspective by Ilaria Onorati, MD, Dana M. Radu, MD, Ana Maria Santos Portela, MD, Marine Peretti, MD, Patrice Guiraudet, MD, Jeremy Bardet, MD, Olivia Freynet, MD, Morgane Didier, MD, Yurdagül Uzunhan, MD, PhD, Kader Chouahnia, MD, Boris Duchemann, MD, PhD, Valérian Bourinet, MD, Hervé Dutau, MD, PhD, Jean-Philippe Berthet, MD, PhD, Charles-Hugo Marquette, MD, PhD, François Tronc, MD, PhD, Myriam Locatelli Sanchez, MD, Christophe Trésallet, MD, PhD, Clément Fournier, MD, PhD, Nicolas Vénissac, MD, PhD, Makoto Miyara, MD, PhD, Eric Vicaut, MD, PhD, Emmanuel Martinod, MD, PhD

“…The main late complications consisted of tracheal granulomas related to the stent and requiring repeated bronchoscopies (n = 9), pneumonia (n = 3), airway infection (n = 1), bronchoesophageal fistula (n = 1), mechanical stent obstruction requiring change (n = 2), and mediastinitis treated by antibiotics, drainage, and omentoplasty (n = 1). …”
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Influence of sensitization and allergen provocation procedures on the development of allergen-induced bronchial hyperreactivity in conscious, unrestrained guinea-pigs by R. E. Santing, C. G. Olymulder, B. van Diepen, H. Meurs, J. Zaagsma

“…Repetition of the allergen provocation during 4 subsequent days resulted in a decreased development of BHR after each provocation, despite a significant increase in the allergen provocation dose necessary to obtain similar airway obstruction. The number of inflammatory cells in the bronchoalveolar lavage was not significantly changed after repeated provocation, when compared with a single allergen provocation. …”
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Complete closure of a colo-duodenal fistula in a patient with advanced ascending colon cancer after pembrolizumab combined with radiation therapy: a case report by Tetsuro Tominaga, Takashi Nonaka, Akiko Fukuda, Masaaki Moriyama, Shosaburo Oyama, Mitsutoshi Ishii, Masato Nishimuta, Yuta Fujise, Terumitsu Sawai, Takeshi Nagayasu

“…Treatment was then changed to immunotherapy using pembrolizumab; after six courses, the tumor markers were decreased to within normal ranges, but the main tumor increased. …”
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Persuasive chatbot-based interventions for depression: a list of recommendations for improving reporting standards by Kerstin Denecke, Octavio Rivera Romero, Octavio Rivera Romero, Rolf Wynn, Rolf Wynn, Elia Gabarron, Elia Gabarron

“…However, the absence of technical information in papers on depression-related chatbots often obstructs study reproducibility and hampers evaluating intervention efficacy.ObjectiveThis study aims to identify specific characteristics of chatbots for depression and formulate recommendations for improving reporting standards.MethodsIn an initial step, a list of items that must be reported was defined based on a previous review on digital interventions for depression, the Behavior Change Wheel framework, and a taxonomy for defining archetypes of chatbots. …”
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Three-dimensional printing and virtual reconstruction in surgical planning of double-outlet right ventricle repairCentral MessagePerspective by Kevin Ponchant, Duy-Anh Nguyen, MD, Milan Prsa, MD, Maurice Beghetti, MD, Tornike Sologashvili, MD, Jean-Paul Vallée, MD-PhD

“…The secondary outcome was the change of surgical strategy through 3D modalities compared with multimodal imaging. …”
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Managing acidic mine water pollution in karst regions based on hydrogeological structures by Ren Hujun, Zhang Min, Li Xibin, Wang Hao, Yu Jinfeng, Zhou Chang

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Quantitative assessment of factors that influence heat vulnerability in residential areas using machine learning and unmanned aerial vehicle by Jawoon Gu, Dongwoo Kim, Chulmin Jun, Seungwoo Son

“…Climate change and urbanization have intensified the urban heat island (UHI) effect, significantly impacting urban living environments. …”
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Detection of Inadequately Controlled Asthma in Adults Using Impulse Oscillometry and Fractional Exhaled Nitric Oxide by Yang X, Liu M, Shi H, Hu M, Lu Y, Chang X, Huang K

“…IOS parameters, R5, R20, and AX, after bronchodilation identified patients with ICA, with areas under receiver operating characteristic curve (AUC) of 0.654, 0.690, and 0.708, respectively, adjusted for smoke exposure, variable airflow limitation and fixed airflow obstruction. Combining IOS parameters with FeNO significantly increased the AUC (0.728, 0.752, and 0.763) for detecting ICA compared to IOS parameters with R5, R20, and AX, alone. …”
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Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…The model predicted an increase in first-trimester terminations, and reductions in second-trimester terminations and live births of infants with anomalies. These changes led to reductions in infant healthcare costs and QALYs. …”
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Design of a phase III, double-blind, randomised, placebo-controlled trial of BI 1015550 in patients with progressive pulmonary fibrosis (FIBRONEER-ILD) by Toby M Maher, Michael Kreuter, Vincent Cottin, Daniel Wachtlin, Anna-Maria Hoffmann-Vold, Marlies S Wijsenbeek, Fernando J Martinez, Shervin Assassi, Luca Richeldi, Arata Azuma, Justin M Oldham, Claudia Valenzuela, Carl Coeck, Christina Schlecker, Florian Voss

“…Patients with clinically significant airway obstruction or other pulmonary abnormalities, and those using immunosuppressives that may confound FVC results (cyclophosphamide, tocilizumab, mycophenolate, rituximab) or high-dose steroids will be excluded. …”
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Difference in efficacy between pulmonary endarterectomy and balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension by Kenichi Yanaka, Kazuhiko Nakayama, Yu Taniguchi, Hiroyuki Onishi, Yoichiro Matsuoka, Hidekazu Nakai, Kenji Okada, Toshiro Shinke, Noriaki Emoto, Ken-ichi Hirata

“…Conclusions BPA did not change RC time and cardiac index, while PEA reduced RC time and improved cardiac index. …”
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Transanal Irrigation in Patients with Low Anterior Resection Syndrome After Rectal-Sphincter-Preserving Surgery for Oncological and Non-Oncological Disease: A Systematic Review by Andrea Morini, Massimiliano Fabozzi, Magda Zanelli, Francesca Sanguedolce, Andrea Palicelli, Alfredo Annicchiarico, Candida Bonelli, Maurizio Zizzo

“…The main outcome was improvement in low anterior resection syndrome after TAI assessed by change in LARS score. Results: After an initial screening of 3703 studies, 9 were included and underwent qualitative synthesis (among them, 3 were randomized clinical trials). …”
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The Relationship of Attitudes toward Other Religious Groups with Perceived Islamophobia, Intergroup Contact, and Social Identity: A Study among Muslims Living in Western Countries by Kenan Sevinç, Metin Güven

“…In this regard, the literature addressed verbal taunting, obstructing religious practices, workplace discrimination, travel discrimination, armed attacks, threats, bullying, and vandalism as significant problem instances. …”
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Improving retention of pediatric feeding tubes with a nasal bridle: a randomized controlled trial by Megan Foster, Veronica Armijo-Garcia, Jonathan Gelfond, Andrew D. Meyer

“…Exclusion criteria included facial trauma, nasal airway obstruction, or thrombocytopenia. After obtaining consent, patients were randomized to AMT Bridle Pro® nasal bridle or conventional tape to secure the feeding tube. …”
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Transurethral Sphincterotomy and an Artificial Urinary Sphincter – A Novel 2-Stage Surgery for Refractory Bladder Emptying Disorders: A Proof-of-Concept Study by Kyung Tak Oh, Avelyn Noble Lim, Alwadai Raed Ibrahim, Jang Hwan Kim

“…No patient demonstrated upper-tract damage or significant eGFR change. One patient developed an AUS infection requiring explantation; another remained CIC-dependent due to insufficient abdominal pressure. …”
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